Estimated global number of new cases and deaths of melanoma in 2012

Lian & Mihm. Skin cancer chapter; 2014 World Cancer Report. WHO 2014

5-hmC 5-mC Melanocyte Melanoma cell Keratinocyte

Active

TET25-hmC

MelanomaNormal Skin/NevusGenetic

Epigenetic

5-hmC

TET

-KG Succinate

CO2

Isocitrate

CO2

5-mC 5-hmC

Lian et al. (2012). Cell 150: 1137

Metastatic melanoma(18 of 18)

5-hmC

Nodal nevus(10 of 10)

5-hmC

A B

C

Suspicious for micrometastasis

Lee JJ et al. (2015) Modern Pathology [Epub ahead of print]: 6

[MART-1]

[MART-1]5-hmC

DIFDouble-label