Mitosis and Meiosis Cell Division Why Do Cells Divide? For growth, repair, and reproduction ...
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Mitosis and Meiosis
Cell Division
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Why Do Cells Divide?
For growth, repair, and reproduction
http://www.luc.edu/depts/biology/dev/regen2.htm
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Mitosis
• Organisms grow by the addition of cells
• In multicellular organism some of these cells perform functions different from other cells.
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• The process of a cell becoming different is differentiation.
• Under normal conditions once an animal cell becomes specialized it can no longer form an entire organism.
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When do cells divide?
• Most limiting factor in size is the size of the cell membrane.–Cells must obtain nutrients–as volume increases, cell surface
area does not increase as greatly–larger cells require a larger
surface area for survival
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Cell Division vs. Nuclear Division
• Cytokinesis: The actual division of the cell into two new cells.
• Mitosis: The division of the nucleus of the cell into two new nuclei.
• Note: Sometimes cells go through mitosis without going through cytokinesis. Describe a cell that did this.
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Terminology
• Chromatin - thin fibrous form of DNA and proteins
• Sister chromatids- identical structures that result from chromosome replication, formed during S phase
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Anatomy of a Chromosome
• Centromere - point where sister chromatids are joined together
• P=short arm; upward• Q=long arm;
downward• Telomere-tips of
chromosome
p -arm
centromere
q-arm
telomerechromatids
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How Do Cells Divide?
• Cell cycle - sequence of phases in the life cycle of the cell
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Getting ready to split
• Cell cycle has two parts:–growth and preparation
(interphase)
–cell division• mitosis (nuclear division)
• cytokinesis (cytoplasm division)
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Interphase
• Occurs between divisions
• Longest part of cycle
• 3 stages
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Interphase
• G1 or Gap 1–The cell just finished
dividing so in Gap 1 the cell is recovering from mitosis
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Interphase
• S or Synthesis stage–DNA replicates
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Interphase
• G 2 or Gap 2–This is preparation
for mitosis
–Organelles are replicated.
–More growth occurs.
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MITOSISMitosis begins after G 2 and ends before G 1
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Prophase
• Chromosome condense
• Microtubles form
• The nuclear envelope breaks down
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Metaphase
• Chromosomes are pulled to center of cell
• Line up along “metaphase plate”
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Anaphase• Centromeres divide
• Spindle fibers pull one set of chromosomes to each pole
• Precise alignment is critical to division
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Telophase• Nuclear envelope form around
chromosomes• Chromosomes uncoil• Cytokinesis
– animals - pinching of plasma membrane– plants- elongates and the cell plate forms(
future cellwall and cell membrane)
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http://www.sci.sdsu.edu/multimedia/mitosis/
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Meiosis
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What is Meiosis?
A division of the nucleus that reduces chromosome number by half.•Important in sexual reproduction•Involves combining the genetic information of one parent with that of the the other parent to produce a genetically distinct individual
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Terminology• Diploid - two sets of
chromosomes (2n), in humans 23 pairs or 46 total
• Haploid - one set of chromosomes (n) - gametes or sex cells, in humans 23 chromosomes
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Chromosome Pairing
• Homologous pair–each chromosome in pair are
identical to the other ( carry genes for same trait)
–only one pair differs - sex chromosomes X or Y
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Phases of Meiosis
• A diploid cell replicates its chromosomes
• Two stages of meiosis–Meiosis I and Meiosis II
–Only 1 replication
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–Synapsis - pairing of homologous chromosomes forming a tetrad.
–Crossing over - chromatids of tetrad exchange parts.
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Meiosis I
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Prophase I
• Chromosomes condense
• Homologous chromosomes pair w/ each other
• Each pair contains four sister chromatids - tetrad
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Metaphase I
• Tetrads or homologous chromosomes move to center of cell
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Anaphase I
• Homologous chromosomes pulled to opposite poles
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Telophase I
• Daughter nuclei formed
• These are haploid (1n)
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Meiosis II
• Daughter cells undergo a second division; much like mitosis
• NO ADDITIONAL REPLICATION OCCURS
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Prophase II
• Spindle fibers form again
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Metaphase II
• Sister chromatids move to the center
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Anaphase II
• Centromeres split
• Individual chromosomes are pulled to poles
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Telophase II & Cytokinesis
• Four haploid daughter cells results from one original diploid cell
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http://www4.ncsu.edu/unity/users/b/bnchorle/www/index.htm
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Review Mitosis & Meiosis• Both are forms of nuclear division
• Both involve replication
• Both involve disappearance of the nucleus, and nucleolus, nuclear membrane
• Both involve formation of spindle fibers
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DIFFERENCES• Meiosis produces daughter cells that
have 1/2 the number of chromosomes as the parent. Go from 2n to 1n.
• Daughter cells produced by meiosis are not genetically identical to one another.
• In meiosis cell division takes place twice but replication occurs only once.
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Value of Variation• Variation - differences between
members of a population.
• Meiosis results in random separation of chromosomes in gametes.
• Causes diverse populations that over time can be stronger for survival.