Mining Event-Related Brain Dynamics Mining Event- Related Brain … · 2011-02-03 · to...
Transcript of Mining Event-Related Brain Dynamics Mining Event- Related Brain … · 2011-02-03 · to...
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1.! Consider, in so far as possible, the multi-dimensional dynamics of
the brain as expressed in the whole recorded signals.
2.! Un-mix source (and artifact) contributions of individual source
areas using independent component analysis (ICA).
3.! Visualize trial-by-trial relationships of source component activities
to experimental variables (using 2-D ‘ERP-image’ plots).
4.! Model the event-related dynamics of the source components
(using time/frequency analysis).
5.! Localize the separated source areas using biophysical inverse
modeling.
6.! Compare similarities in source dynamics and locations across
subjects using cluster analysis.
7.! Model transient source network dynamics and the contexts in
which they appear.
Mining Event-Related Brain Dynamics
S. Makeig 2010
Mining Event-Related Brain
Dynamics!
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1.! Consider, in so far as possible, the multi-dimensional dynamics of
the brain as expressed in the whole recorded signals.
2.! Un-mix source (and artifact) contributions of individual source
areas using independent component analysis (ICA).
3.! Visualize trial-by-trial relationships of source component activities
to experimental variables (using 2-D ‘ERP-image’ plots).
4.! Model the event-related dynamics of the source components
(using time/frequency analysis).
5.! Localize the separated source areas using biophysical inverse
modeling.
6.! Compare similarities in source dynamics and locations across
subjects using cluster analysis.
7.! Model transient source network dynamics and the contexts in
which they appear.
Mining Event-Related Brain Dynamics
S. Makeig 2010
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S. Makeig 2004
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ERP-Image Plotting
1.! Display single trials as
color-coded horizontal
lines (e.g., red is +!V,
blue is -!V, green is 0).
2.! Sort all trials according
to some variable of
interest (here, subject
RT).
3.! Smooth vertically.
Jung et al., Human Brain Mapping, 2001.
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dB
Time (ms)
Fre
qu
ency (
Hz)
10
ERSP
Makeig et al., PLOS ‘04
timef() tftopo()
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EVENT LOCAL PHASE
Inter-trial Coherence (ITC) (“phase-locking factor”)
•! Significant consistency of local phase of a
physiological waveform across successive trials.
delay
EVENT LOCAL PHASE
EVENT LOCAL PHASE
frequency
PHASE LOCKING
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AVERAGE ERP
SINGLE TRIALS µV
P = 0.02
P = 0.02
INTER-TRIAL COHERENCE
NO AMPLITUDE INCREASE
400 SIM. TRIALS ...
ERP-IMAGE PLOT
INTER-TRIAL COHERENCE
(phase resetting)
erpimage()
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NO AMPLITUDE INCREASE
ITC / PHASE LOCKING
TIME
FR
EQ
UE
NC
Y
ERSP
ITC
dB
µV2
r timef()
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Space of time / frequency changes …
ERS ERD Baseline
ITC
N
o IT
C
ERPs are produced by ITC>0, not by power increases
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“True” ERP (visual
P1)
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ITC
ERP
S. Enghoff
“True” PPR (visual ‘alpha
ringing’)
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Event-Related Coherence (ERC)
•! Significant consistency of local phase difference
between two concurrent physiological waveforms.
delay
frequency
PHASE1 EVENT PHASE2
!
PHASE1 EVENT PHASE2 !
PHASE1 EVENT PHASE2 !
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Event-related Coherence
TWO SIMULATED THETA PROCESSES
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FR
EQ
UE
NC
Y
TIME
EVENT-RELATED COHERENCE
COHERENCE LAG
r
deg
ERC
crossf()
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J Klopp, K Marinkovic, P Chauvel, V Nenov, E Halgren Hum Br Map
11:286-293 (2000)
Ant. Cing.
Fusiform
Post. Cing.
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Rossen, Makeig, et al..!
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Tim Mullen, S. Makeig et al. unpublished
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