Mingu 12 Sistem Limfatik
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Transcript of Mingu 12 Sistem Limfatik
Lecture OverviewLecture Overview
Lymphatic System and Components– What is lymph and how does it travel?
General Immune Reaction- Inflammation– What is one function of the cells carried in
lymph?
Selected Topics in Immunity
Lymphatic SystemLymphatic System
Absorbs excess fluid from the tissues
Returns this fluid to the circulatory system or the heart
Additional function in Immunity
Components of the Lymphatic Components of the Lymphatic SystemSystem
LymphLymphatic TissueLymphatic VesselsThymusBone MarrowSpleen
LymphLymph
Lymph– The clear fluid
absorbed by the lymphatic system
Lymphatic Tissue– Clusters of
Lymphocytes and macrophages
Lymphatic TissueLymphatic Tissue
Malt: (Mucosa Associated Lymphatic Tissue) – Diffuse array of lymphocytes found along body
passages in mucous membranes.– Examples of malt: lining of the stomach and
respiratory tract
Lymph nodules: – Dense clusters of Lymphocytes – Transient: pop up during infection
Lymphatic VesselsLymphatic Vessels Carry and Transport
Lymph and proteins
Similar Structure to veins– Tunica Interna: Thin
inner lining and valves– Tunica Media: Elastic
fibers and Smooth Muscle
– Tunica Externa: Thin Outer Layer
Lymphatic FiltersLymphatic Filters
Lymph Nodes- Screen and Filter Lymph for infectious particles
Spleen- Screen and Filter Blood for old, dead cells and infectious particles
Subclavian
2 collecting Trunks
6 Lymphatic Trunks
More Collecting Vessels
Lymph Nodes
Collecting Vessels
Lymphatic Vessels
Lymphatic MovementLymphatic Movement
No pump
Rhythmic contraction of the lymph vessels
Skeletal Muscles
How is backflow prevented?
Immune Cell GeneratorsImmune Cell Generators
Bone Marrow- Makes B- Cells
Thymus- Makes T- Cells
ThymusThymus
Break for Dynamic Human
InflammationInflammation
Non-specific response to tissue trauma or infection
44 signs of Inflammation signs of Inflammation
44 signs of Inflammation signs of Inflammation
RednessSwellingHeatPain
What’s the purpose of pain?
Purpose of InflammationPurpose of Inflammation
Remove Invading Pathogens
Remove Debris of Damaged Tissues
Initiate Tissue Repair
Mediators of InflammationMediators of Inflammation
Chemical Messengers
Leukocyte
Chemical MessengersChemical Messengers
Released by mast cells in response to damage
Bradykinin, Histamine, and Leukotrienes– Increases Local Blood Flow to distressed area
Stimulates Vasodilation Increases Permeability of Capillaries
What’s Accomplished?
Chemical MessengersChemical Messengers
Bradykinin, Histamine, and Leukotrienes– Increases Local Blood Flow
Stimulates Vasodilation Increases Permeability of Capillaries
What’s Accomplished?– Heats area causes redness and swelling– Dilutes toxins and helps Remove waste– Supplies oxygen and nutrients for tissue repair
Pain ResponsePain Response
Purpose?
Causes?
Pain ResponsePain Response
Purpose? Prevents further injury to area.
Causes?– Direct Nerve Damage– Pressure from Swelling– Chemical Stimulation particularly bradykinin
Leukocyte DeploymentLeukocyte Deployment
Leukocyte: any white blood cell including T cells, B cells, granulocytes, platelets, basophils, mast cells, monocytes and macrophages
Leukocytes Migrate toward inflammed area
Why? TO KILL and RECRUIT
Leukocyte DeploymentLeukocyte DeploymentLeukocytes Migrate to inflammed tissue
How? 1. Margination or pavementing: To migrate to the wall of a capillary
2. Diapedesis: Passage of blood cells through vessel wall into tissue 3. Chemotaxis: Movement of a cell towards or away a chemical source
What do the leukocytes plan What do the leukocytes plan to do?to do?
Phagocytosis: release of toxic chemicals
Recruit more leukocytes
PhagocytosisPhagocytosis
Leukocytes consume and destroy foreign invaders and dead cells
Ejected as Pus
Break for Break for Dynamic HumanDynamic Human
Selected Topics in ImmunitySelected Topics in Immunity