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Mid-IR laser imaging for molecular recognition in security and medical applications
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Mid-IR laser imaging for molecular recognition in security and medical applications Lasers, Optics & Photonics, Oct 7-9, 2013 InfraSign Anadi Mukherjee InfraSign Fremont, CA
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Mid-IR laser imaging for molecular recognition in security and medical applications. Anadi Mukherjee. I nfra S ign Fremont, CA. I nfra S ign. Lasers, Optics & Photonics, Oct 7-9, 2013. I nfra S ign. Revealing the Invisible for a Safer World. Mid-IR laser imaging for - PowerPoint PPT Presentation
Transcript of Mid-IR laser imaging for molecular recognition in security and medical applications
Mid-IR laser imaging for molecular recognition in
security and medical applications
Lasers, Optics & Photonics, Oct 7-9, 2013 InfraSign
Anadi Mukherjee
InfraSignFremont, CA
Mid-IR laser imaging for
Molecular Recognition
www.infrasign.com
Security HAZMATs Food Safety
Medical Tagless Pathology Pharma QC/QA
Hand-held, battery operated system
2 InfraSignLasers, Optics & Photonics, Oct 7-9, 2013
Revealing the Invisible for a Safer World
InfraSign
LaserCamera
Trace MoleculesOr
Molecular Modifications
Strong fundamental Vibrations (MIR) vs. Weak Overtone (NIR) or Raman
Lasers, Optics & Photonics, Oct 7-9, 20133
Hyperspectral Imaging
l3
l2 l1
l4
MIRIS – Mid-IR Imaging Spectroscopy Diffuse Reflection
4 InfraSignLasers, Optics & Photonics, Oct 7-9, 2013
SecurityTrace HAZMATS & Narcotics
MedicalFood Safety - Biocontamination Sensor
Pharma - Real-time in-line Quantitative QC/QA
Laser Pathology - Antibody-free Diagnosis Body FluidsTissues – Cancer Biomarkers
In-vivo diagnosis/surgery, New Microarrays
Security
Lasers, Optics & Photonics, Oct 7-9, 20135
Hand-held, battery operated, 9”x7”x4”, < 4 lbs
12”
SPoT - Sensitive Picture of Traces
Lasers, Optics & Photonics, Oct 7-9, 20136
Explosive/Binder
AN
HMTD
TNT
Urea Nitrate
Sugar Urea NitrateTNT
AN
Sugar
Lasers, Optics & Photonics, Oct 7-9, 20138
9.5um7.38um
R
9.25um
7.38 mm 9.5 mm
9.25 mm
3 QCLs
7
FP
DFB
DFB
SPoT raw image results of AN trace on polyethylene
9.25um7.38um 9.5um
Abso
rptio
nIn
cide
nt b
eam
s
Very thin (cloudy) film of AN on polyethylene film
9.5um
9.25um
7.38um
R
6”
Lasers, Optics & Photonics, Oct 7-9, 20139
Validation
• First explosive trace imaging system sold for use by US Navy
• Customer quote: “(SPoT) continues to function well despite the traveling it has done. The hardware has proven to be remarkably robust.”
Lasers, Optics & Photonics, Oct 7-9, 201310
Safety & Medical
Industrial Plant Safety/TICs Food Safety
Medical Imaging
Pharmaceutical QC/QA
Lasers, Optics & Photonics, Oct 7-9, 201311
12 InfraSignLasers, Optics & Photonics, Oct 7-9, 2013
Fundamental Biomolecular Vibrations
Fatty Acids
Proteins
Sugars
Overlap
SensitivitySpecificity
PFA of 10-2 (PD of 99%)
77ug/cm2
Hyperspectral Imagingof Serum Protein
ROC Curve
PD of 99%
Anadi Mukherjee et al “Spectroscopic imaging of serum proteins using quantum cascade lasers”, Journal of Biomedical Optics 18(3), 036011 (March 2013).
Acknowledgements
Pathology Department UCSF
Professor Tarik Tihan, UCSF
Manu Prasanna
Steve Barnett
Quentin Bylund
Biswaroop Mukherjee
Block Engineering – Petros Kotidis
Adtech Optics – Mariano Troccoli
ThorLabs – John Bruno
ThanksLasers, Optics & Photonics, Oct 7-9, 201314
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