Microbiology and Immunolgy - UWA€¦ · Immunology and Genetic Epidemiology. Current projects: 1)...
Transcript of Microbiology and Immunolgy - UWA€¦ · Immunology and Genetic Epidemiology. Current projects: 1)...
Microbiology and Immunology
Microbiology And
Immunology
Clinical Tom Riley Tim Inglis
Barry Marshall Ben Clarke
Immunology Manfred Beilharz
Alec Redwood Geoff Stewart Chris Peacock Allison Imrie
Bioinformatics and Genetics
Tim Perkins Michael Wise Chris Peacock
Alfred Tay
Host Pathogen Charlene Kahler Barbara Chang Geoff Shellam Alec Redwood Chris Peacock Allison Imrie
Translational Ondek
Cheryl Johansen Tom Riley Tim Inglis
Applied and Environmental
David Sutton Barbara Chang
Tom Riley Tim Inglis
Barry Marshall
Epidemiology Tom Riley
Alec Redwood Geoff Shellam
Cheryl Johansen Tim Inglis
Associate Professor Chris Peacock Research areas: Host Pathogen Interactions, Molecular Biology, Genomics. Current projects: 1. The role of pathogenic and commensal microbes in
otitis media using a metagenomics approach. 2. Effects of low level in utero exposure to
environmental arsenic on epigenetic reprogramming and susceptibility to infection.
3. Investigations into the use of the Australian marsupial Leishmania as an attenuated vaccine for human leishmaniasis.
4. Determination of the parasite genomic factors responsible for a new clinical drug insensitive phenotype in Brazilian cutaneous leishmaniasis. 5. Identification of novel protozoal pathogens in
Australian wildlife.
Associate Professor David Sutton Research area: Applied and Environmental Microbiology Current and recent projects: 1. Bacteriophages as alternative bacterial disease
control agents. 2. Novel antibacterial natural products with clinical and
industrial applications from marine bacteria and invertebrates.
3. Pollution control based on industrial-scale bacterial bioreactors.
4. A novel biotechnological approach to recovery of phosphorus from wastewater.
5. Prevention and monitoring of biofilm formation in drinking water distribution systems.
Cytomegalovirus Research Group Geoff Shellam, Alec Redwood and Megan Lloyd
Host Pathogen Interactions, Molecular Virology, Immunology and Genetic Epidemiology. Current projects: 1) Epidemiology of HCMV in human breast milk
2) Multi-strain CMV infection
1) Viruses hunting in packs 2) Natural killer cells mediating viral competition
3) Viral immune evasion
4) Effects of genetic variation on host pathogen
interactions
Prof Barry Marshall and the Ondek Research Team
Research area: Helicobacter pylori pathogenesis and delivery technologies Scientific projects: Oral delivery of biologics and vaccine antigens using H. pylori , immunotherapies, host-pathogen interaction, genetic tools construction, detection and containment of genetically modified organisms (GMOs) Collaborators: Assoc Prof Mohammed Benghezal, Dr. Alma Fulurija and the Ondek team
Ondek develops a delivery platform for vaccines and biologics based on live Helicobacter pylori
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Associate Professor Manfred Beilharz
Cancer Immuno- and Complementary therapies 1. Immunotherapy of cancer based on regulatory T cell manipulation. 2. Anti-cancer properties of tea tree oil, a natural renewable Australian product.
Type 1 Interferon and Influenza 3. Extension of low-dose oral interferon results from a phase IIb clinical trial for winter colds and flu.
Prof Barbara Chang
Research Area: Molecular bacteriology; bacteriophages; virulence factors; plasmids
Projects: 1. Virulence determinants of
WA Aeromonas isolates 2. Aeromonas phages and their
role in virulence 3. Moraxella catarrhalis
bacteriophages
Aeromonas infection
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Associate Professor Allison Imrie Research areas: Host Pathogen Interactions, Molecular Epidemiology, Emerging Infectious Diseases. Current projects: 1. Cross-reactivity in Flavivirus (Murray Valley
encephalitis virus, dengue virus and Japanese encephalitis virus) -specific immunity
2. Immunodominance and the dengue-specific memory T cell receptor repertoire 3. Long-term dengue virus-specific memory T cell phenotype and function, > 6 decades after infection 4. Molecular epidemiology of dengue and chikungunya viruses in Papua New Guinea, Malaysia and Bali
Professor Tim Inglis
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Research areas: • Clinical microbiology • Applied microbial bioinformatics • Field applications of molecular
microbiology • Antibiotic resistance mechanisms in Gram
negative bacteria • Drinking and recreational water
microbiology
Projects: the Burkholderia pseudomallei metabolome field investigation of mosquito-borne viruses molecular epidemiology of multi-resistant
Enterobacteriaceae
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Associate Professor Charlene Kahler
Research area: Bacterial pathogens causing sepsis (esp. Neisseria spp.) Projects:
1. Outer membrane and endotoxin biogenesis in Neisseria
2. Endotoxin synthesis in Neisseria
3. Gene regulation in Neisseria spp.
4. Cellular biology of the nasopharynx
5. Protein folding in the periplasm of Gram negative bacteria
Molecular Biology Microbiology
Structural Biology
A model for disease
Chemistry (Drug design)
Application (Disease treatment)
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W/Professor Geoff Stewart Research area: Immunology & Bacteriology
Inflammatory lung diseases, such as asthma and rhinitis; House dust mite and rye grass pollen allergy
Kallikrein-Kinin System
Projects:
1)Modulatory effects of proteases and protease activated receptors on respiratory epithelial cell function
2)Cloning, expression and characterisation of bacteriolytic enzymes and antimicrobial peptides
3)Characterisation of endosymbiotic bacteria from the house dust mite
4)Activation of the Kallikrein-kinin system on epithelial cells
Professor Tom Riley Major research areas: Clostridium difficile infection Antimicrobial and natural products research
Projects:
1. Epidemiology of C. difficile infection in Australia 2. New methods of detecting C. difficile 3. New treatments for C. difficile infection 4. C. difficile infection in animals 5. C. difficile in food 6. Effects of tea tree oil on Candida albicans
investigated by flow cytometry 7. Interference of essential oil terpenes with microbial
quorum sensing 8. Antimicrobial activity of Western Australian honeys
Niki Foster, Briony Elliott, Kate Hammer, Christine Carson, Kerry Carson, Dan Knight, Pim Putsathit