MICHAEL Plus and the new members Iván Rónai (Ministry of Education and Culture, Hungary)
Michael Wehrhahn - Ministry of Health
Transcript of Michael Wehrhahn - Ministry of Health
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Arboviral arthritides
Michael Wehrhahn Microbiology registrar
Centre for Infectious Diseases and MicrobiologyICPMR
Westmead Hospital
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Fever and arthropathy
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Arboviruses in Australia
• Togaviridae - alphaviruses– Ross River virus
– Barmah Forest virus
– Sindbis
• Flaviviridae• Flaviviridae– Dengue
– Kunjin strain of West Nile
– Murray Valley Encephalitis
– Japanese Encephalitis
– Alfuy, Kokobera, Stratford, Edge Hill
• Bunyaviridae – GanGan, Trubanaman
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Arboviruses overseas
that can cause arthritis
• Alphaviruses
– Chikungunya (Asia/Africa)
– O’nyong-nyong (Africa)
– Mayaro (Central/S America)– Mayaro (Central/S America)
– West Nile virus (Americas, Europe, Asia,
Africa)
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Alphaviruses
• many have subclinical infection
• all ages; males/females affected equally
• incubation 2-15d
• typical symptoms:• typical symptoms:
– fever, headache, retro-orbital pain, myalgia,
malaise
– rash: maculopapular or morbilliform
– arthropathy
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Alphavirus arthropathy
• joint manifestations typically commence early and often incapacitating– soon after fever
– coincident with onset of rash
• symmetrical• symmetrical
• polyarticular: predom small jts– hands, wrists, feet and ankles
– may be migratory
– morning stiffness
• Last weeks to months
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• differentiating the different arboviruses based on clinical features let alone pattern of arthritis difficult
• Recent review:
Outhred, Kok, Dwyer. Viral arthritides. Expert Rev Anti Infect Ther. 2011
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Virus Location Mosquito
Vector
Incubatio
n Period
(days)
Distinguishing
Clinical
Features
Laboratory
Diagnosis
Ross River
(alphavirus)
Australia (PNG,
Pacific)
Aedes sp. and
Culex sp.5-15
Epidemic
polyarthritis,
chronicity, rash
Serology
(NAT, culture)
Barmah ForestAustralia
Aedes sp. and 5-15
Epidemic
polyarthritis, rash Serology
Arboviruses (Australia) associated with arthritis and rash
Barmah Forest
(alphavirus)Australia
Aedes sp. and
Culex sp.5-15
polyarthritis, rash
more prominent
than RRv, myalgia
Serology
(NAT, culture)
Sindbis
(alphavirus)
Europe, Africa,
Asia, AustraliaCulex sp. <7 Rash, paraesthesiae
Serology
(culture)
Chikungunya
(alphavirus)
Africa, Indian
Ocean, South and
SE Asia
Aedes sp. 1-12Arthritis
predominant
Serology, NAT
(culture)
Dengue
(flavivirus)
Asia, Central and
South America,
Nth Queensland
Aedes sp. 4-7
Fever, rash,
arthralgias, DHS in
repeat infections
ICT, NS1
antigen, serology,
NAT, (culture)
(rarely Kunjin/WNV, Kokobera, Alfuy, Edge Hill, Stratford viruses, Gan gan, Trubanaman)
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4%
56%
29%
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Ross River virus
• “Epidemic polyarthritis” first described in 1928 at Narrandera and Hay NSW
• isolated from Aedes mosquitoes trapped at Ross River, Townsville 1959
• Isolated from humans during large outbreak in • Isolated from humans during large outbreak in South Pacific Islands 1981
• Australia, – PNG, Soloman Islands, E Indonesia, Fiji, Samoa,
New Caledonia
• active throughout year in Qld, usually after summer rains/spring rest of Australia
• Aedes/Cules spp
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Arthritis in RRV
• Fever, arthritis, rash syndrome
• True arthritis in 40%
• Joints of the extremities
• Symmetrical (although pain may be asymmetric)• Symmetrical (although pain may be asymmetric)
• Effusions, tendinitis, plantar fasciitis less
commonly
• Persist for >6mths in about half (10% for BFV)
• Pathogenesis:
– Persistance of virus in synovial macrophages
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Barmah Forest virus
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Barmah Forest virus
• Barmah Forest on Murray, northern Victoria 1974
• pathogenicity established in 1988 in setting of RRV neg epidemic polyarthritissetting of RRV neg epidemic polyarthritis
• 10% of of epidemic polyarthritis
• seroprevalence 6% mid/far north coast NSW highest rates in Aust (68/100000)
• Culex/Culicoides/Aedes spp
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• inc 7-10d
• acute polyarthritis/arthralgia– symmetrical, lg and small jts
– less severe than RRV– less severe than RRV
– 90% resolution by 6mths (compare RRv)
• myalgia, fever, HA
• rash (often pruritic) in 50% (- 100%) sometimes vesicular (~7d)
• symptoms may persist for months
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Clinical features of
RRv and BFv
Ross River virusBarmah Forest
virus
Maculopapular rash ~100% 90%
Vesicular rash uncommon 10%
Joint pain >1 month 79-98% 49%
Flexman J et al Med J Aust 1998; 169:159-63
Joint pain >1 month 79-98% 49%
Joint pain >6 months 57% >10%
Joint swelling,
stiffness61-80% 30%
Myalgia 43-79% 70-80%
Lymphadenopathy 0.6-29% 7%
Fatigue 62-94% 80%
Fever 20-60% <50%
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Sindbis
• Sindbis village, Nile delta, Egypt 1952– subsequently Africa, India, SEAsia
– Australia 1960s – widespread seropositivity• seroprevalence less than RR
• majority are subclinical (a few Aust cases in lit)• majority are subclinical (a few Aust cases in lit)
• fever + rash (often vesicular), headache, sore throat, arthralgia/arthritis, parasthaesia
• ‘biblical 7 yr intervals’
• more recently cause of Pogosta disease (Finland)
• Sindbis-like viruses: Ockelbo (Sweden); Karelian (Russia) and Whataroa (NZ)
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86 pts with confirmed
infection
50% with joint symptoms for
>12 mths
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Chikungunya
• 1958 DR Congo; then 1999– becoming widespread
• fever, rash
• arthralgia/arthritis (~100%)
• symmetrical, predom smaller joints :– fingers, wrists, toes, ankles
– also large joints
– swelling and tenosynovitis common
– often incapacitating
• weeks to months (compare dengue)
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•“that which bends/contorts”
•2005-7: large outbreak in
Indian Ocean Islands
esp Reunion
•35% of inhabitants infected
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O’nyong-nyong
• “weakening of the joints”
• antigenically related to Chikungunya– transmitted by Anopheles spp
• initially isolated in Uganda 1959• initially isolated in Uganda 1959• epidemic involving >2 million in 1960s
• 2nd epidemic in 1995-6: 400 people
• Chad in 2006
• fever, polyarthritis and rash– also eye/chest pain, lymphadenopathy,
• related virus: Igbo-Ora “disease that breaks your wings”
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•2003: febrile rash illness amongst Liberian refugees
in Cote d’Ivoire
•consisted of:•consisted of:
fever 28/31 (90%),
pruritus (71%),
mac-pap rash (84%),
myalgias (71%),
arthralgias (58%).
•ONNV (PCR/serol)
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Mayaro virus
• first isolated in Caribbean
in 1950s as cause of
epidemic of febrile rash
illness causing
arthropathyarthropathy
• epidemics in Bolivia and
Brazil
– more recently Venezuela
2010 >70 cases
• TM: Haemagogus spp
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Dengue
• flavivirus: Swahili for “Break bone fever”
• biphasic illness: fever, rash,
• arthralgia in 60-80%
– “severe musculoskeletal/lumbar back pain”– “severe musculoskeletal/lumbar back pain”
• Widespread incl North Queensland
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West Nile virus & Kunjin
• flavivirus of JE group– isolated in 1937 from N
Uganda
• caused 200 deaths amongst 3500 cases in amongst 3500 cases in US in 2002
• widespread incl Aust (Kunjin subtype: 1960 Aborig tribe in Qld)
• Culex spp
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West Nile fever
• inc 2-14d
• sudden onset flu-like illness
– fever, headache, backache, myalgias
– arthralgias, retro-orbital pain– arthralgias, retro-orbital pain
– rash, conjunctivitis, lymphadenopathy
• indistinguishable from Dengue
• typically self limited within 10d
• Neurologic disease in <1% infected
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Summary
Arboviral arthritides– predominantly alphaviruses (togaviridae)
– symmetrical, predominantly smaller joints
– often associated with rash– often associated with rash
– may be incapacitating
– consider esp in epidemic setting
– Australian vs returned travellers
– prevention: mosquito avoidance
– supportive treatment
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Acknowledgements
• Dominic Dwyer for loan of some slides
• Jen Kok/Alex Outhred for proof of in press article:
– Viral arthritides. Expert Rev Anti Infect Ther. – Viral arthritides. Expert Rev Anti Infect Ther.
2011