Michael Jerosch-Herold, PhD Associate Professor of Radiology
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Transcript of Michael Jerosch-Herold, PhD Associate Professor of Radiology
![Page 1: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/1.jpg)
MRI-Based Assessment of Neovasculariation in Carotid
Plaque – A Novel Risk Marker for Plaque Rupture
Michael Jerosch-Herold, PhDAssociate Professor of Radiology
Director of Physics for the Cardiac Imaging ProgramBrigham & Women’s Hospital
![Page 2: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/2.jpg)
New 3.0 T Bilateral 8-Channel Carotid Array and Head-Holder for Reynold Carotid Study
Coil mounted on a frame with head-holder consists of two curved paddles
MGH DesignWiggins/Wald
Reference: Hinton-Yates et al., TMRI 2007
8- Coils = pair of four 4.8 cm loops
Head Holder
![Page 3: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/3.jpg)
MRI Protocol for Dynamic Contrast Enhancement
• T1-weighted 3D fast gradient echo– TR/TE/flip angle: 4.3/2.3 ms/ 20°– 3 mm slices– In-plane resolution: 0.7 x 0.7 mm– Time per dynamic view: 14 s
• With new 8-element neck phased array the time per dynamic view is reduced to 10 s.
![Page 4: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/4.jpg)
Post-Processing
Contrast-Enhancement in Carotid Wall
![Page 5: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/5.jpg)
Kinetic Modeling(Kety-Schmidt Model)
Arterial Input Venous Outflow
Tissue Extraction (Ktrans)
vb
Model Parameters Determined by Optimization at Pixel Level• vb vascular volume• Ktrans First order blood-to-tissue transfer rate constant
Measured in vessel lumen
Ktrans Parametric Map
Ktr
ans*
1e3
[1/m
in]
24
20
16
12
8
4
![Page 6: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/6.jpg)
Examp
Ktrans Parametric Map
Ktr
ans*
1e3
[1/s
]
24
20
16
12
8
4
T2 TSE: carotid plaque
![Page 7: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/7.jpg)
Example of Test-Scan in Patient with 8-Channel Phased Array Coil
![Page 8: Michael Jerosch-Herold, PhD Associate Professor of Radiology](https://reader035.fdocuments.us/reader035/viewer/2022081801/56812bd0550346895d902f65/html5/thumbnails/8.jpg)