Metabolisme Senyawa N
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Transcript of Metabolisme Senyawa N
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Protein Metabolism
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Protein DIGESTION & ABSORPTION
Proteolysis (lysis of proteins !ataly"e# byproteases
$ Proteases !lea%e pepti#e bon#s to
release free amino a!i#s or smallerpepti#e fra&ments
$ 'n#opepti#ases !lea%e internal pepti#e
bon#s$ 'opepti#ases !lea%e terminal pepti#e
bon#s
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Protein DIGESTION & ABSORPTION
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*!ti%ation of protein #i&estion en"ymes
$ Pepsinogen Pepsin+,l
-astri! ui!e
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Trypsinogen Trypsin
Chymotrypsinogen Chymotrypsin
Procarboxypeptidase A & B
carboxypeptidase A & B
Pancreatic Juice
enterokinase/
tripsin
Trypsis
Trypsis
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pe!ifi!ity of protein #i&estion en"yme
Enzyme Type Speciicity
Pepsin en#opepti#ase *romati! or leu!ine
rypsine 'n#opepti#ase Lysine or ar&inine
,ymotripsin 'n#opepti#ase aromati!
,arboypepti#ase * eopepti#ase ,teriminal aromati! or neutral
,arboypepti#ase B eopepti#ase ,terminal ar&inin or lysine
Leu!ineaminopepti#ase
eopepti#ase Nterminal leu!ine or neutral
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Protein !igestion & Absorption
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$ Tissue protein are constant"y being brokendo#n and resynthesized$
$ The %nitrogen or amino acid poo"% is a grandmixture o amino acids aai"ab"e in the ce""deried rom dietary sources or thedegradation o protein$
$ Since proteins and amino acids are notstored in the body' there is a constantturnoer o protein$
!()A*+C E,-+.+B+-* T0E1(
12 B1!( P1TE+)S
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$ Some protein is constant"y being
synthesized #hi"e other protein isbeing degraded$
$ Each day' some o the amino acids are
catabo"ized producing energy andammonia$ The ammonia is conerted to
urea and excreted rom the body and
represents a drain on the nitrogen poo"$
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!()A*+C E,-+.+B+-* T0E1(
12 B1!( P1TE+)S
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$ Purposes o amino acid degradation6 supp"y energy6 supp"y intermediates or synthesis o other
compounds6 remoe harmu" excess o certain amino
acids
A*+)1 AC+! *ETAB1.+S*
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$ *ost amino acids are irst stripped o theiramino group by t#o steps
3$ transamination ia 4"u transaminasetransers amino group to a"pha5ketog"utarate 6rom TCA cyc"e7 and orms4"u
8$ oxidatie deamination ia 4"udehydrogenase9 re:uires )A!;co5actorto oxidize the a carbon o the amino acid toreorm a5ketog"utarate9 a"so re"eases
ammonium ion 6)0
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Transamination
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4"utamate
!ehyrogenase
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!eamination
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7ter amino a!i# metabolism
). erine #ey#ratase6 Non oi#ati%e #eamination of Lserine
4. De!arboylations
6 Parti!ularly #e!arboylation of #amino a!i# toremo%e potential toi! of #amino a!i#
5. -lutaminase an# aspara&inase
6 u! &lutami! a!i# an# asparti! a!i# in tissues
is foun# not as te free a!i# but in !orespon#
ami#e (aspara&ine an# &lutamine
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Serine !ehydratase
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!ecarboxy"ationo 4"utamic acid
= 5A*+)1 B-T(+C AC+!
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Amino Acid 1xidases
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The g"utaminase reaction proceeds essentia""y irreersib"y in the
direction o g"utamate and )0
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-EA C(C.E
Carbamyl phosphate
synthetase
9 2 *P
Ornithine
transcarbamylase
Argininosuccinate
synthetase
Argininosuccinase
Arginase
6key enzyme7
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The re"ationship o urea cyc"e to TCA
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The re"ationship o urea cyc"e to TCA
E)E4( -T+.+?AT+1) 21* A*+)1 AC+!S
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E)E4( -T+.+?AT+1) 21* A*+)1 AC+!S
Ab "iti A i A id * t b "i
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Abnorma"ities o Amino Acid *etabo"ism
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P-+)E CATAB1.+S*
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P(+*+!+)E CATAB1.+S*
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