Mental Illness and Neuroscience Discovery (MIND) Consortium Data

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NA-MIC National Alliance for Medical Image Computing http://na-mic.org Mental Illness and Neuroscience Discovery (MIND) Consortium Data Randy L. Gollub, MD, PhD Training Core PI, MGH

description

Mental Illness and Neuroscience Discovery (MIND) Consortium Data. Randy L. Gollub, MD, PhD Training Core PI, MGH. This dataset in perspective. Clinical N~380 subjects Schizophrenics + Matched controls. Reliability N = 10. MGH DTI. MIND Who?. - PowerPoint PPT Presentation

Transcript of Mental Illness and Neuroscience Discovery (MIND) Consortium Data

Page 1: Mental Illness and Neuroscience Discovery (MIND) Consortium Data

NA-MICNational Alliance for Medical Image Computing http://na-mic.org

Mental Illness and Neuroscience Discovery (MIND) Consortium Data

Randy L. Gollub, MD, PhD

Training Core PI, MGH

Page 2: Mental Illness and Neuroscience Discovery (MIND) Consortium Data

National Alliance for Medical Image Computing http://na-mic.org

This dataset in perspective

ClinicalN~380 subjects

Schizophrenics +Matched controls

ReliabilityN = 10

MGHDTI

Page 3: Mental Illness and Neuroscience Discovery (MIND) Consortium Data

National Alliance for Medical Image Computing http://na-mic.org

MIND Who? MIND Clinical Imaging Consortium (MCIC) Partner SitesMCIC) Partner Sites

Harvard/Massachusetts General HospitalHarvard/Massachusetts General Hospital University of New MexicoUniversity of New MexicoUniversity of MinnesotaUniversity of MinnesotaUniversity of IowaUniversity of Iowa

DOE Grant No. DE-FG02-99ER62764

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MIND MCIC Why?

A federally funded multi-site consortium created to advance our understanding of schizophrenia by supporting the acquisition of clinical, cognitive, genetic, morphometric, diffusion weighted and functional neuroimaging data from schizophrenia patients and matched controls using a common experimental protocol.

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National Alliance for Medical Image Computing http://na-mic.org

MIND What?

• Two data sets– Reliability n =10 travelers to all 4 sites– Clinical n = 300+ Chronic and First

Episode (FE) schizophrenics and matched controls

• FE subjects and matched controls have follow-up data at 1 year (n = 46)

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MIND Reliability

• Healthy control subjects (n = 10, age 27-60, 5 female)

• Scanned twice at each site within 24 hour interval

• T1, T2, DTI, and 4 fMRI task paradigms

• Goal: calibrate for clinical study

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MIND Reliability DTI

UNM 1.5 T Minnesota 3T Minnesota 3T Iowa 1.5 T MGH 1.5T SonataDTIR1 DTIR2

Data AcquisitionTR 9800 ms 10000 ms 11500 ms 9999 ms 8900 msTE 86 ms 97 ms 111 ms 71.8 ms 80 msBandwidth 1502 Hz 2170 Hz 1302 Hz 1860 Hz/PxVoxel Size 2x2 mm 2.5x2.5 mm 2x2 mm 1.875x1.875 2 x 2 mmSlice Thickness 2 mm 2 mm 2 mm 4mm/0mm gap 2 mmMatrix Size 128x128x64 128x128x64 128x128x64 128x128x34 128x128x64FOV 25.6x25.6 cm 32x32 cm 25.6x25.6 cm 24x24 25.6x25.6 cmNEX 4 2 2 2 1Scan Time 5 min 6:42 min 7:40 min 8 min 10:32 minSlice Prescription Parallel to AC-PC Axial Axial Axial Parallel to AC-PCPhase partial Fourier (6/8) (6/8) (6/8) Full (6/8)Raw filter On (weak) OFF OFF NA on

Image parameters 1Marix Size 128x128x64 128x128x64 128x128x64 128x128x64Resolution 2x2x2 mm 2.5x2.5x2 mm 2x2x2 mm 2x2x2 mm

Diffusion parametersDiffusion gradients 0, 1000 0, 1000 0, 1000 0, 250, 500, 750, 1000 0, 700Diffusion directions 6 12 12 6 60Directions in order taken (1,0,1) (1,0,0.5) (1,0,0.5) (0,0,1) { 1.0000000000, 0.0000000000, 0.0000000000 },

(-1,0,1) (0,0.5,1) (0,0.5,1) (1, 0, 0) { 0.5867917880, -0.3765825401, -0.7168409782 },(0,1,1) (0.5,1,0) (0.5,1,0) (0, 1, 0) { 0.8941946396, 0.0229172218, 0.4470914307 },(0,1,-1) (1,0.5,0) (1,0.5,0) (0.707, 0, 0.707) { 0.7292807003, -0.4109697317, 0.5470407112 },(1,1,0) (0,1.0,0.5) (0,1.0,0.5) (0, 0.707, 0.707) { -0.1542514872, 0.9643685389, -0.2149413870 },(-1,1,0) (0.5,0,1) (0.5,0,1) (0.707, 0.707, 0) { 0.1171358937, 0.7735388946, -0.6228296405 },

(1,0,-0.5) (1,0,-0.5) { -0.4075748558, -0.4149938010, -0.8134266298 },(0,-0.5,1) (0,-0.5,1) { 0.2113303675, 0.7537379261, 0.6222689246 },(-0.5,1,0) (-0.5,1,0) { 0.0953754479, -0.9695170076, 0.2256995700 },(1,-0.5,0) (1,-0.5,0) { -0.1354495929, -0.0334895243, -0.9902180869 },(0,1.0,-0.5) (0,1.0,-0.5) { -0.1421249090, -0.7505207879, -0.6453828764 },(-0.5,0,1) (-0.5,0,1) { -0.6370086516, 0.7461087590, -0.1937568003 },

{ 0.0805627090, 0.9716688439, 0.2221920516 },{ 0.1068711102, -0.0212132049, 0.9940465612 },

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MIND CICS

Over 300 subjects, Chronic and FE pts with matched controls

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National Alliance for Medical Image Computing http://na-mic.org

MIND MCIC DTI

• Patients (FE + chronic) n = 115

• Controls n = 138

• Demographics available upon request

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National Alliance for Medical Image Computing http://na-mic.org

MIND CICS DTI

3T (Siemens Trio) Scan Parameters using 8-channel coil (UNM, UMN, UI)

T1 (Coronal, MPRAGE) T2 (Coronal, TSE) DTI1 DTI2

TR 2530 ms 10000 ms 10500 8000TE 3.79 14 98 83FA 7 149 IPAT=2TI 1100Bandwidth 181 193 1346 1302voxel size (x,y) 0.625x0.625 mm 0.625x0.625 mm 2.0x2.0 mm 2.5x2.5 mmslice thickness (z) 1.5 mm 1.8 mm 2.0 mm 2.0 mmmatrix size (x,y,z) 256x256x128 256x256x128 128x128x64 128x128x64FOV (x,y) ^ 16x16 cm ^ 16x16 cm 25.6x25.6 cm 32x32 cmNEX 1 1 2 3scan time * 11 min (each) * 9 min (each) 04:45 06:10Slice prescription Full brain coverage Full brain coverage Align parallel to ACPC Align parallel to ACPCPhase partial fourier 1 1 6/8 6/8Raw filter Off Off weak weakDiffusion directions n/a n/a 12 12

(MGH)T1

(Coronal, GRE) T2 (Coronal, TSE) DTI Field Map (Phase) Field Map (Magnitude)TR 12 9000 ms 9800 ms 1180 1180TE 4.76 64 86 10,14.76 10,14.76FA 20 180 n/a 90 90TI n/a n/a n/aBandwidth 110 149 1502 260 260voxel size (x,y,z) 0.625x0.625 0.625x0.625 2.0x2.0 mm 2.0x2.0 mm 2.0x2.0 mmslice thickness 1.5 mm 1.8 mm 2.0mm 2.0mm 2.0mmmatrix size (x,y,z) 256x256x128 256x256x128 128x128x64 128x128x64 128x128x64FOV (x,y) ^ 16x16 cm ^ 16x16 cm 25.6x25.6 cm 25.6x25.6 cm 25.6x25.6 cmNEX 3 2 4 1 1scan time 22 minutes 18 minutes 5 minutes 4 minutes 4 minutesSlice prescription Full brain coverage Full brain coverage Align parallel to ACPC Align parallel to ACPC Align parallel to ACPCPhase partial fourier 1 1 6/8 6/8 6/8Raw filter Off Off On (weak) Off OffDiffusion directions n/a n/a 6 n/a n/a

1.5 T (Siemens Sonata) Scan Parameters using 8-Channel Coil

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MIND CICS Preliminary Results

Freesurfer segmentation:

PutamenThalamus Hippocampus AmygdalaCaudate

Morrow, et al International Congress on Schizophrenia Research, 2007

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FreesurferHippocampal segmentation

1= Controls, 2= Chronic schizophrenia

Log normalized volume vs. age

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National Alliance for Medical Image Computing http://na-mic.org

For Marty and Andy with

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Robust differences in fMRI activation indices between schizophrenic patients and controls Gollub et al, SFN 2007