in special chemicalsyour trusted european manufacturer

in special chemicalseuropean manufacturer

your trusted

R+D Labs cGMP API’s PlantIntermediates Plant

Established in 1970, Menadiona is an independent privately owned Spanish company.

Since then, the company has been involved in manufacturing active ingredients and key intermediates for the Pharmaceutical, Veterinary, Nutraceutical and Cosmetic industries.

In addition, Aziridine derivatives are one of our wide range of industrial products for polymers. Plant health, based on ACT-2® plant growth booster and pest resistance. Our Fine Chemicals Division offers contract manufacturing services.

With a highly qualified staff and two manufacturing plants in Spain, Menadiona is characterised by its strong worldwide export volume, which accounts for more than 80% of its sales.

Goods manufactured by Menadiona are distributed in more than 60 countries worldwide.

www.menadiona.com

Solvent Recovery Plant Head Offices

Philosophy

Our commitment to our corporate mission lies in our experience in constantly improving chemical synthesis processes. We achieve our aims by providing:

1. An open product list of active substances and fine chemicals that fully comply with current pharmacopoeias and industrial standards.

2. Customer manufacturing services for exclusive products.

SH&E

Menadiona complies with Responsible Care standards, and as such, is committed to the six codes of Management Practice: Employee Health and Safety, Process Safety Management, Pollution Prevention, Community Awareness and Emergency Response, Safe Product Distribution and Product Stewardship.

Environment-friendly materials are used instead of hazardous or toxic substances whenever possible. The most appropriate processes are selected from the very initial phases of project development in order to reduce to a minimum any emission of pollutants into the environment. The remaining emissions are eliminated with the appropriate following treatments:

• treatmentofnon-processwastewaters• treatmentofprocessfumes• treatmentofsolidresiduesassigned to specialised companies

Our professional Safety, Health & Environment staff will work with you to efficiently implement your most demanding processes, compliant with all government and environmental regulations.

HighQuality

At Menadiona we know that today’s customers expect the highest quality, every step of the way, from R&D through manufacturing, all the way to shipment of goods. This is why all our products and processes are monitored by a rigorous and comprehensive Total Quality System.

Menadiona’s Quality System complies with the riogorous GLP, GMP, FDA, regulatory requirements, as well as being an ISO-9001:2000 certified company.

Quality assurance function, oriented to total quality management, supervises all activities of Quality Control Department, which are well equipped with the most up to date analytical instruments. Quality assurance acts as an independent and autonomous function, guaranteeing that all manufacturing departments work in compliance with current Good Manufacturing Practices and all Menadiona’s products conform to specifications established by the most authoritative Pharmacopoeias and demanding customer standards.

Safety, Healthand Environment

company profile

cGMP Pharmaceutical Plant

EquipmentTechnology

Our main state of the art equipment includes:

Hastelloy, glass-lined and stainless steel multipurpose reactorsCentrifugesDryersMicronisation capacityMixersFilling machinesSolvent recovery plant

and all the required services:

WaterSteamColdPressurized airNitrogenVacuumHeat Transfer Fluid

as well as a wastewater treatment plant fully equipped with:

Physicochemical treatmentElectrochemical power plantBiological units

Menadiona’s expertise in the following chemical reactions:

Acid reductionAcylationAlcoholysisAlcoxylationAmidationAminationAmides reductionBrominationCarboxymethylationChlorinationChloromethylationDiazotisationElectrochemical oxidationEthoxylationFormylationFriedel Craft reactionsHydroxylationMannich reactionsMethylationMichael reactionsNitrationOxidation

Productioncapabilites

Menadiona’s two production plants are located in Spain, one in the North (Palafolls, Barcelona) and the other in the South (Málaga). The overall reaction capacity is more than 350,000 litres and both manufacturing plants are equipped with modern production facilities.

A carefully studied design allows wide combination possibilities with the different reactors, dealing with both liquid and solid products, with the goal of achieving product quality assurance, personnel safety and environmental protection. All manufacturing operations are carried out in accordance with current Good Manufacturing Practices (G.M.P.) and European environment protection laws.

Recover solvents equipment

production

Research & Development

Menadiona’s state of the art Research and Development Department, with its skilled and experienced staff, (PhD., Chemists and Technicians), is constantly striving to obtain new synthetic processes as well as improving existing ones.

This Department carries out tests and laboratory trials, co-operates with universities and research centres. When required, tailor-made products are developed to meet costumer needs.

Our many years of experience in the field of organic syntheses assures top quality customer support in Custom Synthesis.

PilotPlant

Menadiona’s versatile pilot plant facility is fully equipped with hastelloy, glasslined and stainless-steel multipurpose reactors, ranging from 30 to 1000 litres, capable of scaling up of main kinds of synthetic processes from laboratory scale to industrial production.

Contractmanufacturing

Menadiona has more than 30 years of experience offering contract manufacturing and custom synthesis services, having a long track record of successful projects in the development and production of fine chemicals, advanced intermediates and active pharmaceutical ingredients. Our high profile customers worldwide includes Innovator companies, Generic companies as well as Biotech companies.

Our state of the art cGMP facilities and our experienced staff allow us to be your trusted European manufacturing partner for early development, clinical and multi-ton production.

Menadiona’s process development team selects, develops and optimizes synthetic routes to provide you with fast, cost-effective and environmentally sustainable solutions.

All projects are carried out under Menadiona’s demanding quality standards and procedures and our services also can include development and validation of analytical methods, filing of drug master files and regulatory support.

services

Pharmaceutical Veterinary

Menadiona provides high quality products and services to pharmaceutical industries. From R&D kilo laboratory batches to commercial scale production, we can supply advanced pharmaceutical intermediates and active pharmaceutical ingredients (API) manufactured under cGMP requirements and with all necessary regulatory support.

Besides our open API product list, our versatile cGMP-FDA approved facilities allow us to offer contract manufacturing and custom synthesis services for any required volume (early development, clinical and commercial/multi-ton production).

With more than 40 years of experience manufacturing veterinary intermediates and active ingredients. Our veterinary customer list includes most main multinational companies and our products are sold in more than 60 countries around the world.

Our product range includes anthelmintics, antibacterials, coccidiostatics, antimicrobials, growth promoters as well as our well-known vitamin K range of products. In addition, we offer contract manufacturing and custom synthesis services meeting the most demanding needs of our customers.

business units

Plant Health

Based on ACT-2®, a new and patented health plant booster, Menadiona offers a wide range of special formulations, technical assistance and multi applications for horticultural, tropical fruits, green areas, ornamental flowers, parks and gardens.

These specialized agricultural products, with easy application and full environmental friendly, improve natural plant defence mechanisms, providing extra resistance against adverse or plant stress conditions.

SpecialtyChemicals

Crosslinkers

From Ethyleneimine (EI), we manufacture and supply many of their derivatives, such us Propyleneimine (PI), EI or PI Crosslinkers, Ultra Pure Crosslinkers (UPC) and innovative key intermediates for coatings, adhesives, leather and textile or printing inks industries.

Polígon Industrial Mas Puigvert, s/n08389 Palafolls, Barcelona, SPAIN

Tel.: (+34) 93 764 07 11Fax: (+34) 93 764 07 25

L 41º 41.4’ N - l 002º 44.0’ W

www.menadiona.commenadiona@menadiona.com