Poster Presentations: P2 P493

MMSE score for CT group, and walking speed and number of steps for PA

group.Conclusions: PA may be effective for improvement of physical abil-

ities of elderly people with MCI. Meanwhile, CT may improve cognitive

functions. Executive functions and QOL may improve regardless of inter-

vention type. Our findings suggest that intervention methods have their spe-

cific therapeutic targets.

P2-364 THE CHANGING FACE OF THE MEMORY CLINIC

IN SHEFFIELD, UNITED KINGDOM

Daniel Blackburn1, Sarah Wakefield2, Peter Walpole3, Kirsty Harkness3,

Markus Reuber2, Annalena Venneri2, 1Sheffield Institute for Translational

Neuroscience, University of Sheffield, Sheffield, United Kingdom;2University of Sheffield, Sheffield, United Kingdom; 3Sheffield Teaching

Hospitals, Sheffield, United Kingdom. Contact e-mail: d.blackburn@shef.

ac.uk

Background:There are approximately 800,000 people in the UK diagnosed

with dementia. In 2009, the National Dementia Strategy (NDS) sought to

improve awareness and access to services for the early diagnosis and support

of this patient group 3, with a key aim of a memory clinic in every town.

Data published by the Alzheimer Society (www.alzheimers.org.uk) suggest

that 63% of people with dementia in Sheffield have been identified and di-

agnosed. This is one of the highest diagnosis rates in the UK. The memory

clinics in Sheffield are divided into a clinic for patients older than 65 and run

by old age psychiatry that sees >800 new referrals and the <65 or working

age memory clinic run by neurologists, which sees >150 new referrals per

year. In this study we reviewed whether raised awareness of dementia has

altered the pattern of referrals to a memory clinic.Methods: Service review

for all new referrals seen in the <65 memory clinic in Sheffield from 2004,

2006 (both 6 months) & 2012. Results: In 2004 and 2006 showed that ap-

proximately 1/3 of patients, whom had been given a diagnosis did not have

dementia but had non-progressive memory complaints (either in the context

of a mood disorder or Functional Memory disorder defined as subjective

memory complaints of duration longer than 6 months, without organic or

major psychiatric cause, normal brain imaging and neuropsychological tests

of memory above 1.5 SD) but by 2012 this had increased to just over 50%.

Conclusions: An early analysis confirms factors previously described in

FMD such as work stress (in particular change in work pattern), chronic

pain (back pain and migraine) and pre-morbid high achievement with a cat-

astrophising misinterpretation of memory failures as the main triggers of

non progressive memory disorders. Raised awareness of the early symptoms

of dementia may be increasing the number of inappropriate referrals to

memory services and suggests that more should be done to inform practi-

tioners in primary care to achieve better triage. The current economic

climate and impact on employment and financial hardship may be contrib-

uting to FMD and is also worthy of exploration.

P2-365 MEMORYTRAINING INHEALTHYELDERLYAND

SENIORSWITHMILD COGNITIVE IMPAIRMENT:

BENEFITS ON COGNITIVE PARAMETERS

Paula Brum1, Monica Yassuda2, Orestes Forlenza3, 1Institute of Clinical

Psychiatry Hospital - Brazil, Limeira, S~ao Paulo, Brazil; 2University of S~ao

Paulo, S~ao Paulo, Brazil; 3University of S~ao Paulo, S~ao Paulo - S.P., Brazil.Contact e-mail: pa_brum@hotmail.com

Background: The cognitive interventions aimed at elderly healthy are little

studied in the national literature, despite having been investigated in other

countries. The memory training offered to seniors with mild cognitive im-

pairment (MCI) has received increasing attention from researchers and

also seems to benefit this population. It is not known whether the training

has long-term effect, nor whether the benefits are the same for healthy el-

derly and MCI. This study was aimed to evaluate the impact of eight mem-

ory training sessions offered to elderly normal controls (NC) and seniors

with MCI in cognitive parameters.Methods: For this, we had the participa-

tion of 61 older people accompanied by a multidisciplinary team of the Lab-

oratory of Neurosciences LIM 27, Institute of Psychiatry, FMUSP randomly

divided into experimental group - EG (including 17 NC and 18 with MCI)

and control group - CG (being 12 NC and 14 with MCI). These groups were

evaluated at four different times, namely before the intervention (T0), one

week after the intervention (T1), one month after the last assessment (T2)

and six months after T1 (T3). EG received memory training with emphasis

on categorization and underline words between T0 and T1. The CG per-

formed all the assessments at the same time EG, but the training was offered

to them after T3. Results: Improvement was observed in both groups EG

from T0 to T1 when compared to the CG on tests of attention, processing

speed, mnemonic strategies, and memory tests. Conclusions: These effects

seem to keep the short and long term, showing, in different ways, the ben-

efits of training and the existence of cognitive plasticity in both populations

studied.

P2-366 HIGH NEUROTICISM IN CAREGIVERS IS

ASSOCIATEDWITH GREATER BURDEN

INDEPENDENT OF DEGREE OF COGNITIVE

IMPAIRMENT OR NEUROPSYCHIATRIC

SYMPTOMS

Kaycee Sink1, James Lovato1, Dana Chamberlain2, Rabeena Alli1,

Philip Clarke3, Daniel Hall4, Jose Villalba3, Edward Shaw2, 1Wake Forest

School of Medicine, Winston-Salem, North Carolina, United States; 2Wake

Forest School of Medicine, Winston Salem, North Carolina, United States;3Wake Forest University, Winston Salem, North Carolina, United States;4Wake Forest University, Winston Salem, North Carolina, United States.

Contact e-mail: kmsink@wakehealth.edu

Background: Caregivers (CG) have varying responses to the challenges

of caregiving, even under the most challenging of situations. We hypoth-

esized that personality of caregivers, specifically neuroticism, would be

associated with the degree of burden a CG experiences and with their

perception of the severity and distress associated with patient related be-

haviors (neuropsychiatric symptoms). Methods: 112 consecutive CG of

new patients being assessed in an academic Memory Assessment Clinic

were administered the NEO-Five Factor Inventory version 3 (NEO-

FFI3), Zarit Caregiver Burden Scale (CBS), and Neuropsychiatric Inven-

tory Questionnaire (NPIQ) while the patient was undergoing cognitive

testing. Scores on the NEO-FFI3 neuroticism domain were categorized

as low, normal, or high using recommended, gender specific cut-points.

The NPIQ asks about the presence of 12 neuropsychiatric symptoms. If

present, the CG rates the severity of the behavior (1-3) and their distress

level associated with the behavior (0-5). Using multivariate logistic regres-

sion, we assessed the relationship between neuroticism and CBS score,

NPIQ total severity score, and NPIQ total distress score, adjusting for

severity of cognitive impairment, measured with MMSE and patient

age. To determine if the relationship between neuroticism and CBS was

independent of neuropsychiatric symptoms we also created a model ad-

justing for NPIQ measures. Results: The mean (SD) CBS, NPIQ severity,

and NPIQ distress scores were 27.3 (18.3), 8.5 (7.3), and 10.0 (10.7), re-

spectively. High neuroticism was associated with significantly greater bur-

den, reported behaviors, and distress from those behaviors (all p <0.05;

Table). In analyses adjusted for patient age and MMSE, mean scores on

CBS for low, average, and high neuroticism were 20.4, 32.8, and 42.5, re-

spectively, p<0.001. When adjusting for NPIQ severity and distress, the

differences were attenuated, but remained significant: 23.4, 30.7, 38.0; p

<0.001. Conclusions: The CG personality trait of neuroticism is associ-

ated with higher reports of patient neuropsychiatric symptoms, greater re-

port of distress from those symptoms, and higher levels of burden,

independent of neuropsychiatric symptom severity. Given the adverse

health consequences of CG burden, developing counseling strategies for

caregivers with high neuroticism may be important.

High neuroticism sssociated with greater burden and report of

neuropsychiatric symptoms (unadjusted results)

Low Average High P

Neuroticism

Neuroticism Neuroticism value

Mean CG burden

19.7 33.5 43.9 <0.001

Mean NPIQ-severity

7.0 9.8 11.9 0.02

Mean NPIQ-distress

7.0 13.3 14.8 0.002