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Membranes in Biology Rob Phillips California Institute of Technology (McMahon)
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Transcript of Membranes in Biology Rob Phillips California Institute of Technology (McMahon)
Lipid Bilayers (In Vitro)Lipid Bilayers (In Vitro)
Hydrophobic tails and polar head groups.
Favorable for lipids to spontaneously assemble to form bilayers.
Molecular Continuum(Avanti Polar Lipids)
Quantitative Tools for Tomography: Quantitative Tools for Tomography:
Viral Budding as an ExampleViral Budding as an Example
Tomography producing wide range of images of deformed membrane systems.
Calculated Deformation of VesicleDue to Actin Polymerization
(Medalia et al.)
Observed Membrane DeformationDuring Cell Movement
(Dooher et al.)
HIV Budding
Ion Channels and Transient Ion Channels and Transient
PermeabilityPermeability
Channels open in response to a variety of different stimuli.Key mechanisms are voltage gating, ligand binding-induced gating and mechanical tension in the membrane.