Glucocorticoid receptor expression in 20 solid tumor types ...
Membrane receptor types
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Transcript of Membrane receptor types
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Membrane receptor types
Cellmembrane
G protein
ReceptorChannel
Extracellularsignal
molecules
Receptor
Enzyme
Receptor-channel
Receptor-enzyme G protein-coupled receptor
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Amplification
Extracellularfluid
Intracellularfluid
Cellmembrane
Receptor-ligand complex activates an
amplifier enzyme (AE).Signal molecule
Receptor
Intracellularsignal molecules
Target proteins
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Intracellular pathways
alter
Signalmolecule
Membrane receptor
Signal transduction by proteins
Amplifier enzymes
Second messengermolecules
Protein kinasesIncrease
intracellular Ca2+
Phosphorylatedproteins
Calcium-bindingproteins
Extracellularfluid
Intracellularfluid
Cell response
initiates
binds to
Ionchannel
Signal molecule
Receptor
Intracellularsignal molecules
Target proteins
Response
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Central Nervous System
Temporal lobe
Parietal lobe
Occipital lobe
Frontal lobe
ANATOMY OF THE BRAIN
Cerebrum Thalamus
Cerebellum
Fig. 9-9
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Central Nervous SystemANATOMY OF THE BRAIN
Thalamus
Hypothalamus
Posterior pituitaryAnteriorpituitary
Fig. 9-10
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Central Nervous SystemANATOMY OF THE BRAINSTEM
Medullaoblongata
Thalamus
Spinal cord
Midbrain
Pons
Fig. 9-9
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Central Nervous SystemANATOMY OF THE SPINAL CORD Cerebral
hemispheres
CerebellumCervical spinal
nerves
Thoracic spinalnerves
Lumbar spinalnerves
Sacral spinalnerves
Fig. 9-4
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Overall Organization of Nervous System
Fig. 8-1
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Types of neurons
Sensory or afferent neuron Interneuron Motor or efferent neuron
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Types of neurons
Dendrites
Axon
Dendrites
Dendrites
Axon
Axon
Axon
Schwanncell
Somatic senses
Sensory or afferent neurons Interneurons of CNS Motor or efferent neuronsNeurons for
smell and vision
Axonterminal
Fig. 8-3
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Types of glial cells
GLIAL CELLS
form
contains
are found in
Central nervous system
AstrocytesOligodendrocytes Microglia (modifiedimmune cells)
provide help form secrete take up create
Scavengers
K+, water,neurotransmitters
Neurotrophicfactors
Blood-brain
barrierSubstrates for
ATP production
Ependymalcells
Barriersbetween
compartments
Source ofneural
stem cells
act as
contains
form
Peripheral nervous system
Myelin sheaths
Schwann cells
Neurotrophicfactors
Satellitecells
Supportcell bodies
secrete
Fig. 8-5
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Glial cells of the CNS
Interneurons
Astrocyte
Microglia
Oligodendrocyte
Capillary
Myelin(cut)
AxonNode
Ependymalcell
Fig. 8-5
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Schwann Cells
Cell body
1–1.5 mm
Node of Ranvier
Schwann cell nucleus
Axon
Nucleus
Axon
Myelin
Schwann cell
Fig. 8-6
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General structure of neurons
Dendrites
Cellbody
Nucleus
Axon hillock
Axon (initialsegment)Myelinsheath
Synapse
Presynapticaxon terminal
Postsynapticneuron
Synapticcleft
Postsynapticdendrite
Integration
Outputsignal
Inputsignal
Fig. 8-2