Chapter 10 Mendel and Meiosis Section 10.1 Mendel’s Laws of Heredity.
Meiosis and Sexual Life Cycle Chapter 13. Heredity (inheritance) - transmission of traits from 1...
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Transcript of Meiosis and Sexual Life Cycle Chapter 13. Heredity (inheritance) - transmission of traits from 1...
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Meiosis and Sexual Life Cycle
Chapter 13
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• Heredity (inheritance) - transmission of traits from 1 generation to next.
• Variation - siblings differ from 1 another.
• Genetics - study of heredity and variation.
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http://www.mssm.edu/genetics/fabry/images/figure1b.gif
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• Parents give offspring coded information - genes.
• Genes - segments of DNA.• 4 nucleotides found in DNA
create specific sequences determine traits.
• DNA in sperm and egg fuse together to create variation.
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http://library.thinkquest.org/19037/media/basics/gene.GIF
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• Each chromosome has thousands of genes - located at specific spot - locus (loci).
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http://www.cybered.net/library/Teaching_Resources/Biology/Evolution/Image_Gallery/Evolution-Loci.jpg
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• Asexual reproduction - 1 parent passes all genetic information on to offspring.
• Example: Hydra (eukaryotic) reproduce by budding cells produced by mitosis.
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• Sexual reproduction produces variation - combination of genes from parents unique.
• Siblings resemble each other because of similar genes.
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• Humans, somatic (non-sex) cells - 46 chromosomes.
• Each chromosome distinguished by size, position of centromere, by pattern of staining with certain dyes.
• Karyotype - picture of 23 pairs of chromosomes with centromeres and sizes.
• Chromosomes homologous - they have pair that matches them.
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• Sex chromosomes not homologous in male (X and Y)
• Females homologous (2 X’s).• Other 22 pairs autosomes (non-
sex chromosomes)• 1 chromosome of pair inherited
from each parent.
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http://www.brooklyn.cuny.edu/bc/ahp/LAD/C9/graphics/C9_homologous_2.GIF
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• Each egg and sperm (gametes) have 22 autosomes, 1 sex chromosome.
• Haploid - half the # of chromosomes.
• Cells fuse (syngamy) - fertilization.• Fertilized egg (zygote) has 2
haploid sets of chromosomes with genes from maternal and paternal family lines.
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http://faculty.sulross.edu/ericsson/img0067b.jpg
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• When zygote has all chromosomes (46), - diploid.
• Humans - diploid # of chromosomes 46 (2n = 46).
• Gametes (develop in gonads) and are produced through meiosis - chromosome # halved.
• Fertilization and meiosis alternate in sexual life cycles.
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• Meiosis and fertilization timing varies among species.
• Fungi, some protists have 2 life cycles.
• Zygote starts off diploid, then divides to haploid.
• Haploid adult goes through mitosis.
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Human life cycle
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• Plants - alternation of generations.
• Includes haploid (gametophyte) and diploid (sporophyte) multicellular stages.
• Meiosis by sporophyte produces haploid spores - develop by mitosis into gametophyte.
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• Meiosis - 2 consecutive cell divisions (meiosis I, meiosis II) - result in 4 daughter cells.
• Each daughter cell - only ½ as many chromosomes as parent cell.
• Meiosis reduces chromosome # by copying chromosomes once, but dividing twice.
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Meiosis I
• Stages are prophase, metaphase, anaphase, telophase.
• Interphase (preceding prophase) - chromosomes replicate to form sister chromatids.
• Single centrosome replicated.
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• Prophase I - chromosomes condense, homologous chromosomes pair up - form tetrads.
• Synapsis - proteins attach homologous chromosomes tightly together.
• Chromatids of homologous chromosomes cross (chiasmata), segments of chromosomes traded.
• Spindle forms from each centrosome.
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• Metaphase I - tetrads arranged at metaphase plate.
• Anaphase I - homologous chromosomes separate, pulled toward opposite poles.
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• Telophase I - movement of homologous chromosomes continues until haploid set at each pole.
• Each chromosome consists of linked sister chromatids.
• Cytokinesis - separates cytoplasm.
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• Prophase II - spindle apparatus forms, attaches to kinetochores of each sister chromatid, moves them around.
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• Metaphase II - sister chromatids arranged at metaphase plate.
• Anaphase II - centomeres of sister chromatids separate; travel toward opposite poles.
• Telophase II - separated sister chromatids arrive at opposite poles; nuclei form around chromatids.
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• Cytokinesis - cytoplasm separates; now 4 daughter cells.
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Differences between mitosis and meiosis
• Chromosome # reduced by ½ in meiosis, not in mitosis.
• Mitosis produces 2 genetically identical cells; meiosis produces 4 unique ones.
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http://ghr.nlm.nih.gov/handbook/illustrations/mitosismeiosis
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Other differences
• 1Crossing over: During prophase I, homologous chromosomes pair up (synapsis).
• At X-shaped regions (chiasmata) sections of nonsister chromatids exchanged.
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http://www.synapses.co.uk/genetics/crosso1.gif
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• 2Metaphase I homologous pairs of chromosomes, not individual chromosomes, aligned along metaphase plate.
• 3Anaphase I - homologous chromosomes, (not sister chromatids) separate, carried to opposite poles of cell.
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Contributions to Variation
• 1Independent assortment - tetrads arrange themselves randomly on metaphase plate.
• Each homologous pair of chromosomes positioned independently of other pairs at metaphase I.
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• 2Crossing over - homologous portions of 2 nonsister chromatids trade places.
• Crossing over begins early in prophase I as homologous chromosomes pair up gene by gene.
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• 3Random fertilization - any sperm can fertilize any egg.
• Each egg sperm is 1 of 8 billion gene combinations - 70 trillion possibilities of combinations in zygote (doesn’t include crossing over)
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