MedKoo Biosciences Control Data Current Data Parameters F2 ...
6
1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 ppm 0.784 1.117 1.133 1.157 1.174 1.226 1.245 1.275 1.309 1.437 1.465 1.594 2.064 2.504 2.508 2.512 2.536 2.557 2.566 2.577 2.745 2.790 2.815 3.123 3.213 3.254 3.359 3.405 3.436 3.477 3.500 3.933 5.327 5.344 5.946 6.546 6.553 6.557 6.581 6.586 6.910 7.196 7.200 3.15 6.34 6.46 0.68 1.12 2.30 3.07 1.50 1.31 1.18 1.49 2.34 0.27 3.21 1.23 3.25 0.60 4.16 3.17 3.10 1.04 0.98 0.14 0.99 0.99 1.00 3.07 1.01 0.99 Current Data Parameters NAME 799840-96-3 EXPNO 1 PROCNO 1 F2 - Acquisition Parameters INSTRUM PROBHD PULPROG spect 5 mm PADUL 13C zg30 TD 65536 SOLVENT DMSO NS 8 DS 2 SWH 8012.820 Hz FIDRES 0.122266 Hz AQ 4.0894465 sec RG 128.35 DW 62.400 usec DE 6.50 usec TE 294.6 K D1 1.00000000 sec TD0 1 ======== CHANNEL f1 ======== SFO1 400.1324710 MHz NUC1 1H P1 10.00 usec PLW1 20.00000000 W F2 - Processing parameters SI 65536 SF 400.1300000 MHz WDW EM SSB 0 LB 0.30 Hz GB 0 PC 1.00 MedKoo Biosciences www.medkoo.com [email protected] MedKoo Biosciences Product Quality Control Data www.medkoo.com [email protected] MedKoo Biosciences Product Quality Control Data www.medkoo.com [email protected] MedKoo Biosciences Product Quality Control Data www.medkoo.com [email protected]
Transcript of MedKoo Biosciences Control Data Current Data Parameters F2 ...
1.01.52.02.53.03.54.04.55.05.56.06.57.07.5 ppm
0.784
1.117
1.133
1.157
1.174
1.226
1.245
1.275
1.309
1.437
1.465
1.594
2.064
2.504
2.508
2.512
2.536
2.557
2.566
2.577
2.745
2.790
2.815
3.123
3.213
3.254
3.359
3.405
3.436
3.477
3.500
3.933
5.327
5.344
5.946
6.546
6.553
6.557
6.581
6.586
6.910
7.196
7.200
3.15
6.34
6.46
0.68
1.12
2.30
3.07
1.50
1.31
1.18
1.49
2.34
0.27
3.21
1.23
3.25
0.60
4.16
3.17
3.10
1.04
0.98
0.14
0.99
0.99
1.00
3.07
1.01
0.99
Current Data ParametersNAME 799840-96-3EXPNO 1PROCNO 1
F2 - Acquisition Parameters
INSTRUM PROBHD PULPROG
spect 5 mm PADUL 13C
zg30TD 65536SOLVENT DMSONS 8DS 2SWH 8012.820 HzFIDRES 0.122266 HzAQ 4.0894465 secRG 128.35DW 62.400 usecDE 6.50 usecTE 294.6 KD1 1.00000000 secTD0 1
======== CHANNEL f1 ========SFO1 400.1324710 MHzNUC1 1HP1 10.00 usecPLW1 20.00000000 W
F2 - Processing parametersSI 65536SF 400.1300000 MHzWDW EMSSB 0LB 0.30 HzGB 0PC 1.00
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Maytansinoid DM4 NMR Analysis, Solvent = DMSO-d6
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MedKoo Cat#: 206839 Name: Maytansinoid DM4 CAS#: 796073-69-3 Lot# X7P06R08 Chemical Formula: C38H54ClN3O10S Exact Mass: 779.3218 Molecular Weight: 780.37
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Maytansinoid DM4 NMR Analysis, Solvent = CDCl3
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MedKoo Cat#: 206839 Name: Maytansinoid DM4 CAS#: 796073-69-3 Lot# X7P06R08 Chemical Formula: C38H54ClN3O10S Exact Mass: 779.3218 Molecular Weight: 780.37
MedKoo Biosciences, Inc., 2500 Gateway Centre Blvd. Suite#400, Morrisville, NC27560, USA
Tel: 919-636-5577, Fax: 919-9804831, http://www.medkoo.com, [email protected].
NMR compare of DM4 and DM1, solvent = CDCl3
MedKoo sample: Maytansinoid DM4 NMR in CDCl3
MedKoo sample: Maytansinoid DM1 NMR in CDCl3
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Tgt Mass(EZX) :Location : P1-C-08Inj : 0
Sample Name Acq. Operator Spec. Reported
: KSM: 8: Integration
Inj Volume : 3 ul
min2 4 6 8
mAU
0
500
1000
1500
2000
DAD1 A, Sig=214,4 Ref=off
6.13
5
6.63
8
6.93
4
min2 4 6 8
mAU
0
200
400
600
800
1000
1200
1400
1600
DAD1 B, Sig=254,4 Ref=off
6.13
5
6.63
8
6.93
4
Integration Results for DAD1 A, Sig=214,4 Ref=off
RetTim Width Area Height Area%|-------|--------|--------------|--------------|--------| 6.14 0.06 8717.04 2370.45 98.86 6.64 0.05 68.13 19.45 0.77 6.93 0.06 32.54 7.82 0.37
Integration Results for DAD1 B, Sig=254,4 Ref=off
RetTim Width Area Height Area%|-------|--------|--------------|--------------|--------| 6.14 0.06 6541.82 1788.09 98.81 6.64 0.05 49.41 14.16 0.75 6.93 0.08 29.46 5.58 0.44
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Maytansinoid DM4 HPLC Analysis
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MedKoo Cat#: 206839 Name: Maytansinoid DM4 CAS#: 796073-69-3 Lot# X7P06R08 Chemical Formula: C38H54ClN3O10S Exact Mass: 779.3218 Molecular Weight: 780.37
Page 1 MedKoo Biosciences, Inc., 2500 Gateway Centre Blvd. Suite 400, Morrisville, NC27560, USA
Tel: 919-636-5577, Fax: 919-9804831, http://www.medkoo.com, [email protected].
.
High Resolution MS Analytical Report
MedKoo Cat#: Product Name: Lot#:
206839 Maytansinoid DM4 X7P06R08
Sample is analyzed with high-resolution mass spectrometer (OrbiTrap) under both positive
and negative electrosprary ionization (ESI). See target ions for compound C38H54ClN3O10S
(NOT C39H56ClN3O10S as originally proposed) in both positive ion and negative ESI.
Chemical structure CAS# and Theoretical analysis
MedKoo Cat#: 206839
Name: Maytansinoid DM4
CAS#: 796073-69-3
Lot# X7P06R08
Chemical Formula: C38H54ClN3O10S
Exact Mass: 779.3218
Molecular Weight: 780.37
1. Full-scan mass spectrum (m/z 100-m/z 1,000) in positive electrospray ionization:
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Page 2 MedKoo Biosciences, Inc., 2500 Gateway Centre Blvd. Suite 400, Morrisville, NC27560, USA
Tel: 919-636-5577, Fax: 919-9804831, http://www.medkoo.com, [email protected].
.
High Resolution MS Analytical Report
MedKoo Cat#: Product Name: Lot#:
206839 Maytansinoid DM4 X7P06R08
2. Full-scan mass spectrum (m/z 100-m/z 1,000) in negative electrospray ionization:
[M +
H]+
[M +
Na]+
[M + H -
H2O]+
[M -
H]-
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