Medical Diagnostics NIAID Funding Opportunities Maria Y. Giovanni ...
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Transcript of Medical Diagnostics NIAID Funding Opportunities Maria Y. Giovanni ...
Medical Diagnostics NIAID Funding Opportunities
Maria Y. Giovanni, Ph.D.Assistant Director for Microbial Genomics
and Advanced TechnologiesNational Institute of Allergy & Infectious Diseases
Department of Health and Human ServicesJuly 14, 2003
National Institute of Allergy and Infectious Diseases, NIH
Mission
Supports basic and applied research to prevent, diagnose and treat infectious and immune-mediated illness, including HIV/AIDS, and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies.
NIAID Medical Diagnostics
• Identify infectious agents in clinical samples including SARS coronavirus, NIAID Category A, B, C agents, other infectious agents, genetically engineered or manipulated organisms and toxins
• Rapid, highly sensitive, specific, easy to use and interpret, reliable, multi-plexed, and cost effective medical diagnostics for public health laboratories or point-of-care agents or their toxins.
• Identify early infection or exposure for early detection and intervention
• Identify/distinguish the agent from common infections• Fully integrated systems from front end sample preparation to
molecular detection systems with data acquisition and analysis.
Medical Diagnostics
Emerging,Innovative
TechnologiesDev
TechnologiesEarly Stage
Product Dev
TechnologiesLater Stage
Product /PlatformDev/Validation
Cooperative Initiative
Partnership Initiative
SBIR/STTR
Early Diagnosis/Pre-SymptomaticPathogen/Host
Monitoring Infection and TreatmentPathogen/Host
R Platform
NIH/NIAID
• Support basic and applied research by peer-reviewed grants and contracts to public or private institutions and for-profit and non-profit organizations
• Two approaches– Investigator-initiated grants– Targeted initiatives supporting both grants and
contracts-PA, RFA, RFP• Allows support for diverse research projects
NIAID Cooperative Research Program for Biodefense & SARS
GoalSupport research projects that will advance the
development a product in a cooperative program with NIAID- Vaccines- Adjuvants- Therapeutics- Diagnostics- Resources
NIAID Biodefense & SARS Partnerships
GoalAssist private sector in further development of high
priority products for biodefense in a cooperative program with NIAID- Vaccines- Adjuvants- Therapeutics- Diagnostics- Resources
NIAID Small Business Biodefense Grant Program
GoalTo support Small Business Innovation Research and
Small Business Technology Transfer Research grants to stimulate technological innovations to develop:
- Vaccines- Adjuvants- Therapeutics- Diagnostics- Resources
StrainIdentification
Molecular Genotyping
Early Identification of Targets Vaccines, Drugs and
DiagnosticsTech.Dev.
MicrobialBiology
Pathogenesis
HostResponse
HumanGenetic
Variations
Target Identification
Basic Research
Microbial Sequencing CentersGenomic Data
Bioinformatics Centers
Data WarehouseData Analysis
PFGRCResourcesReagents
ProteomicCenters
Early Target Ident.HT-Cloning/Expression
Goal: Rapid and cost efficient production of high quality genome sequences of human pathogens and invertebrate vectors of diseases
Features:– NIAID-supported Contract Sequencing Facility– Capacity to sequence genomes for:
• Scientific community• Responding to national needs • Other government agencies
– Anticipated Funding: Late 2003
NIAID Microbial Genome Sequencing Centers
NIAID Pathogen Functional Genomics Resource Center
Goal: Develop and distribute technologies and resources for functional analysis of pathogens at whole genome or whole cell/organism level
NIAID Pathogen Functional Genomics Resource Center
Genomic Resources Provided: – cDNA microarrays– Genetic Variation/SNP analysis– Develop computational tools for array and comparative
genomic data analysis– Web site– Distribute organism-specific arrays and protocols to
scientific community– Provide reagents-microbial strains, clones or isolates,
libraries, PCR primers
Goal: Provide the Scientific Community with a robust point of entry for access of genomic and related data in a user-friendly format.
Components- Database
• Genomic and Related Data- Analysis Center
• Develop and Provide Software Tools- Multi-disciplinary Team
• Bioinformatics and Database Experts and Organism-Specific Biologists
NIAID Bioinformatics Resource Centers
NIAID Proteomics Initiative
Title: Biodefense and Emerging And Re-emerging Proteomics Research Programs: Identifying Targets for Therapeutic Interventions Using Proteomic Technology
Goal: Characterize the pathogen and/or host cell proteome, identifying proteins associated with biology of microbes, mechanisms of microbial pathogenesis, and host response to infection with the goal of discovering targets for potential candidates for the next generation of vaccines, therapeutics, and diagnostics.