Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI...

7
Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel Molecular Cell Volume 32, Issue 6, Pages 767-777 (December 2008) DOI: 10.1016/j.molcel.2008.12.003 Copyright © 2008 Elsevier Inc. Terms and Conditions

TAGS:

Transcript of Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI...

Page 1: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI 

Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel 

Molecular Cell Volume 32, Issue 6, Pages 767-777 (December 2008)

DOI: 10.1016/j.molcel.2008.12.003

Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Figure 1

Molecular Cell 2008 32, 767-777DOI: (10.1016/j.molcel.2008.12.003) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Figure 2

Molecular Cell 2008 32, 767-777DOI: (10.1016/j.molcel.2008.12.003) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Figure 3

Molecular Cell 2008 32, 767-777DOI: (10.1016/j.molcel.2008.12.003) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Figure 4

Molecular Cell 2008 32, 767-777DOI: (10.1016/j.molcel.2008.12.003) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Figure 5

Molecular Cell 2008 32, 767-777DOI: (10.1016/j.molcel.2008.12.003) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

Figure 6

Molecular Cell 2008 32, 767-777DOI: (10.1016/j.molcel.2008.12.003) Copyright © 2008 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

Monoubiquitination: A dynamic tag for protein regulation

Monoubiquitination: A dynamic tag for protein regulation

E3 ligase Rad18 promotes monoubiquitination rather than ... · ligase thattransfers theubiquitin moiety tothetarget.Within this ligase complex, over 30 E2 enzymes provide the enzyme

E3 ligase Rad18 promotes monoubiquitination rather than ... · ligase thattransfers theubiquitin moiety tothetarget.Within this ligase complex, over 30 E2 enzymes provide the enzyme

 · www. Job853. com , ID : job853cs ) APP , Fortress (Sales Advisor) (B FANCI- 2017#4B10B 11:00 am pm 2)ma2832 2230 2057 6051 2885 3)Whatsapp +852 6638 3569

 · www. Job853. com , ID : job853cs ) APP , Fortress (Sales Advisor) (B FANCI- 2017#4B10B 11:00 am pm 2)ma2832 2230 2057 6051 2885 3)Whatsapp +852 6638 3569

Structural and biophysical properties of h-FANCI ARM repeat proteinmicrobiology.ucdavis.edu/kowalczykowski/PDF_files... · 2017. 5. 2. · Structural and biophysical properties of

Structural and biophysical properties of h-FANCI ARM repeat proteinmicrobiology.ucdavis.edu/kowalczykowski/PDF_files... · 2017. 5. 2. · Structural and biophysical properties of

Feature 1: FANCL Renaissance...My Thought for FANCL Kenji Ikemori Founder, Chairman, Representative Director “ Delivering happiness to as many people as possible. Helping and pleasing

Feature 1: FANCL Renaissance...My Thought for FANCL Kenji Ikemori Founder, Chairman, Representative Director “ Delivering happiness to as many people as possible. Helping and pleasing

FAM/USP9x, a Deubiquitinating Enzyme …snewfeld.lab.asu.edu/pdf/newfeld_fam_print.pdfFAM/USP9x, a Deubiquitinating Enzyme Essential for TGFb Signaling, Controls Smad4 Monoubiquitination

FAM/USP9x, a Deubiquitinating Enzyme …snewfeld.lab.asu.edu/pdf/newfeld_fam_print.pdfFAM/USP9x, a Deubiquitinating Enzyme Essential for TGFb Signaling, Controls Smad4 Monoubiquitination

 · atelier haruka PLUS HAIRCUT Beauty Parlor FANCL FANCI- Cosmetic Shops Al NZÕTULPE COSMETIC SHIKARI) THE BODY SHOR LUSH FRESH THE BODY SHOP) HANNADE (IF LUSH) HOUSE? ROSE HOUSE

 · atelier haruka PLUS HAIRCUT Beauty Parlor FANCL FANCI- Cosmetic Shops Al NZÕTULPE COSMETIC SHIKARI) THE BODY SHOR LUSH FRESH THE BODY SHOP) HANNADE (IF LUSH) HOUSE? ROSE HOUSE

BIF English Floor Guide MATSUBISHI 'ATM FANCL ......BIF English Floor Guide MATSUBISHI 'ATM FANCL DECORTE K o S É c dc eau JHlfElDO REVITAL G SK-II CHANEL LAUDER COVERMARK CLINIQUE

BIF English Floor Guide MATSUBISHI 'ATM FANCL ......BIF English Floor Guide MATSUBISHI 'ATM FANCL DECORTE K o S É c dc eau JHlfElDO REVITAL G SK-II CHANEL LAUDER COVERMARK CLINIQUE

The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 … · 2017. 2. 23. · FAN1 (Fanconi anemia-associated nuclease 1, or FANCD2/FANCI-associated nuclease 1) [13–18]. Human

The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 … · 2017. 2. 23. · FAN1 (Fanconi anemia-associated nuclease 1, or FANCD2/FANCI-associated nuclease 1) [13–18]. Human

Post translational modification of Parkin · 2017. 4. 11. · the other hand, are the post-translational modifications that regulate lysosome dependent degradation [51, 52]. Monoubiquitination,

Post translational modification of Parkin · 2017. 4. 11. · the other hand, are the post-translational modifications that regulate lysosome dependent degradation [51, 52]. Monoubiquitination,

> y -fRB 972, FANCL FANCL FAN C L 055-997-3030 …> y ...-fRB 972, FANCL FANCL FAN C L 055-997-3030 E-mail info@susono-cc.co.jp

> y -fRB 972, FANCL FANCL FAN C L 055-997-3030 …> y ...-fRB 972, FANCL FANCL FAN C L 055-997-3030 E-mail [email protected]

FANCL Group Financial Results Briefing · 7 (Reference) Trends from summer 2016 Retail stores: Average number of items purchased per customer (YoY; excluding inbound) ... to expand

FANCL Group Financial Results Briefing · 7 (Reference) Trends from summer 2016 Retail stores: Average number of items purchased per customer (YoY; excluding inbound) ... to expand

NIH Public Access Woong Kim Verónica Yugo Sheyla González ... · MONOUBIQUITINATION OF RPN10 REGULATES SUBSTRATE RECRUITMENT TO THE PROTEASOME Marta Isasa1, Elijah J. Katz1, Woong

NIH Public Access Woong Kim Verónica Yugo Sheyla González ... · MONOUBIQUITINATION OF RPN10 REGULATES SUBSTRATE RECRUITMENT TO THE PROTEASOME Marta Isasa1, Elijah J. Katz1, Woong

FANCI : Feature-based Automated NXDomain Classification and Intelligence · uate the system on malicious data generated by 59 DGAs from the DGArchive, data recorded in a large university’s

FANCI : Feature-based Automated NXDomain Classification and Intelligence · uate the system on malicious data generated by 59 DGAs from the DGArchive, data recorded in a large university’s

HULFT Customer Case Study FANCL€¦ · Title: HULFT Customer Case Study FANCL Author: SAISON INFORMATION SYSTEMS CO., LTD. Created Date: 6/13/2017 6:22:16 PM

HULFT Customer Case Study FANCL€¦ · Title: HULFT Customer Case Study FANCL Author: SAISON INFORMATION SYSTEMS CO., LTD. Created Date: 6/13/2017 6:22:16 PM

ELIMINATED? CAN EXTREME POVERTY BE - … reach of eliminating extreme poverty altogether. This prospect will seem fanci- ... Geography —including natural ... M.A. and Ph.D. degrees

ELIMINATED? CAN EXTREME POVERTY BE - … reach of eliminating extreme poverty altogether. This prospect will seem fanci- ... Geography —including natural ... M.A. and Ph.D. degrees

Regulation of ubiquitin-binding proteins by monoubiquitination Presented by: Wouter Lokers, Cherina Fleming, Myrthe Braam Supervised by: Ger Strous Daniela.

Regulation of ubiquitin-binding proteins by monoubiquitination Presented by: Wouter Lokers, Cherina Fleming, Myrthe Braam Supervised by: Ger Strous Daniela.

Histone H2A monoubiquitination promotes ... - 4DCellFate

Histone H2A monoubiquitination promotes ... - 4DCellFate

NGS in Diagnostics · CHEK2 FANCG NF2 SDHC CYLD FANCI NSD1 SDHD LRGt1 LRGt1 LRGt1 LRGt1 LRGt1 . Test development ¾Database ... • Define limitations (i.e. indel size, large CNVs,

NGS in Diagnostics · CHEK2 FANCG NF2 SDHC CYLD FANCI NSD1 SDHD LRGt1 LRGt1 LRGt1 LRGt1 LRGt1 . Test development ¾Database ... • Define limitations (i.e. indel size, large CNVs,

FANCL CORPORATION · CYK 2002070260 FANCL AR2002 H2-3 7/19 KITAMURA. annual report 2002 1 ... The aim is to further differentiate the FANCL brand and put it back on the path to growth.

FANCL CORPORATION · CYK 2002070260 FANCL AR2002 H2-3 7/19 KITAMURA. annual report 2002 1 ... The aim is to further differentiate the FANCL brand and put it back on the path to growth.