Mechanism of hormonal action
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Transcript of Mechanism of hormonal action
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Mechanisms of Hormone ActionBy:
Mohamed Issam, Mohamed Elshafiei, Mohamed Hany
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Types of hormonal Action:
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Examples of hormones by action:
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Figure 45.6-1
Lipid-solublehormone
SECRETORYCELL
Water-solublehormone
VIABLOOD
Signal receptor
TARGETCELL
(a) (b)
Signalreceptor
Transportprotein
NUCLEUS
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Figure 45.6-2
Lipid-solublehormone
SECRETORYCELL
Water-solublehormone
VIABLOOD
Signal receptor
TARGETCELL OR
Cytoplasmicresponse Gene
regulation
(a) (b)
Cytoplasmicresponse Gene
regulation
Signalreceptor
Transportprotein
NUCLEUS
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Obvious answers aren’t always so
simple
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1. Adenylate cyclase System:
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2. Intracellular Ca++ A) Open Ca++ channel
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B) Increase intracellular Ca++ through IP3:
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Fate of the increased Ca++:
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3.Tyrosine Kinase system
JAK = Janus family of receptor-associated tyrosine kinase Growth hormone (GH) action: Targets of JAK include signal transducers and activators of transcription (STAT),which cause transcription of new mRNAs and new protein synthesis.
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Figure 45.8-1
EXTRACELLULARFLUID
Hormone(estradiol)
Estradiol(estrogen)receptor Plasma
membrane
Hormone-receptorcomplex
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EXTRACELLULARFLUID
Hormone(estradiol)
Estradiol(estrogen)receptor Plasma
membrane
Hormone-receptorcomplex
NUCLEUS
DNA
CYTOPLASM
VitellogeninmRNA
for vitellogenin
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