Two growing worldwide pandemics :

overweight and diabetes

Dialpha focus on prevention for populations at risk of developing

“diabesity” and related diseases

Source: World Health Organization

387

592

2014 2035

Diabetes(million)

Source: International Diabetes Federation

2014 2030

Overweight adults (billion; BMI ≥ 25)

1.9

3.3

2

Put carbs in check with MealShape®

The next generation starch blocker

• MealShape® is an innovative starch blocker that instantly blocks carb

absorption by more than 20%.

• By inhibiting enzymatic digestion of dietary starch, MealShape® helps

prevent glycemic spikes and sugar crashes, thus aiding the body to reduce

the conversion of excess sugar into fat.

3

Human clinical data

MealShape® significantly decreased postprandial glycemia by 21% in men and women without stimulating insulin secretion

Placebo-controlled, randomized

crossover, double-blind trial

Conducted in France

18 healthy subjects

Published in BMC Alternative &

Complementary Medicine*

(*p<0.05)

0

200

400

600

800

1000

Placebo MealShape 1g

- 21.2%

AUC 0-60 min

Blood sugar levels following a standard meal

-5

0

5

10

15

20

25

30

35

40

45

50

0 30 60 90 120

Delta glycemia (mg/dL)

Time (min)

Placebo

MealShape 1g

*

*Beejmohun et al. BMC Complementary & Alternative Medicines 2014 (http://www.biomedcentral.com/1472-6882/14/351)

*

4

Preclinical data / body weight

MealShape® taken on the long term is beneficial for weight management

24

28

32

36

40

44

0 7 14 21 28 35 42 49 56 63 70 77 84

Body weight (g)

Time (day)

Control group

MealShape 50 mg/kg bw

Body weight evolution in normal mice

STT STT STT

STT : starch tolerance test

5

Preclinical data / blood glucose

MealShape® effect on blood glucose level increases on the long term

Postmeal blood glucose evolution in normal mice

(*p<0.05; **p<0.01; ***p<0.001)

6

Proof of concept on bread

A significant efficacy demonstrated on a cooked food matrix

CONTROL 0.5% 1% 2%

Incorporation of MealShape® in a french baguette

(*p<0.05; **p<0.01; ***p<0.001)

-30%*

*****

0

20

40

60

80

100

Controlbread

BreadMealShape

0,5%

BreadMealShape

1%

BreadMealShape

2%

Glycemia (%)

Evolution of bread Glycemic index in rats

7

How does it work ?

Inhibition of alpha-amylase

Delays the digestion & the absorption of carbohydrates

Alpha-amylase

Long chain carbohydrates Simple sugars

MealShape®

-

MealShape® helps the body to reduce the conversion of excess sugar into fat

First uses of sugars:

As energy (cells)

Stored in the liver

Excess converted

into fat

8

The first and only cinnamon extract

working as a carb blocker

Raw material: Ceylon cinnamon

Safety guaranteed: only traces of coumarin

compared with Cassia species

More efficient than Cassia species on the

inhibition of starch digestion

Cinnamomum zeylanicum

MealShape®

Water-ethanol extract

Patented

Standardized at min 40% polyphenols

FDA GRAS status + Non Novel food in the EU

9

Various applications

Dietary supplements

1 g or 2 x 500 mg / day

To take before meal

Starchy food

0.5% of carbohydrates

Functional beverages

Pet food

10

In brief…

Reduce your blood sugar level

by more than 20% after a meal,

as of the first intake

Overall glycemia

Weight management

Cholestrol control

Oxidative stress

11

In brief… MealShape® is:

INNOVATIVE First starch-blocker extracted from cinnamon

EFFICIENT 1 g provides 20% reduction of blood sugar level after a meal (clinical data)

Unique cinnamon extract with an acute effect on glycemia

SAFE Low level of coumarin

QUALITATIVE Made by contract manufacturers with GMP certifications

12

www.dialpha.com

Dialpha SAS

Parc Agropolis 2 ▪ Batiment 6 ▪ 2196 boulevard de la Lironde ▪ 34980 Montferrier sur Lez ▪ France

Tel: +33 4 67 40 44 19 ▪ contact@dialpha.com