MD , DNB Neonatology Consultant Neonatology · Regulation Ot trophoblast proliferation and...
Transcript of MD , DNB Neonatology Consultant Neonatology · Regulation Ot trophoblast proliferation and...
Sterile Inflammation
Dr Nalinikant PanigrahyMD , DNB Neonatology
Consultant Neonatology
Inflammation: What Is It?
An adaptive response to restore homeostasis
Physiologic Inflammation is Central to Reproductive Success
Culture-Negative Early-Onset Neonatal Sepsis — At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship Frontiers of pediatrics ,2018
Two summaries1. Respect Blood culture -
Negative report2. Robust definition of sepsis
INFLAMMATION is NOT INFECTION
Chorioamnitis
• Hypoxia –Ischemia • Preterm delivery • IUGR
Placental swab negative Placenta biopsy – No infectionHigh TLC count Increased other inflammatory markers
Blood Culture Negative High count TLC , Increased CRP = persistent high CRP even after antibiotics
107 VLBW cases = 15 babies CMV= 03 babies Fungal after 2nd Culture = 09 Babies CMPI
Unpublished Unit auditing
Inflammasomes – Pandora Box ?
DAMP PAMP
Latest Research
Summary
• Early suspicion of Sterile inflammation
• Respecting Blood culture negative Reports , Sepsis marker positive cases
• Prevention of inflammation if possible
• Newer treatment modalities