MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23...

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Transcript of MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23...

Page 1: MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23 " #4 &'5, 6 %723 8 9 / ,.: ;=< >@?a< bdcfehgjik?a?mlonqp rts)< lvumwdx

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Page 25: MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23 " #4 &'5, 6 %723 8 9 / ,.: ;=< >@?a< bdcfehgjik?a?mlonqp rts)< lvumwdx

Shrinkage Curves for Symmetric and Mixture Dirichlet Estimators

Observed counts (out of 49,610)

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Page 26: MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23 " #4 &'5, 6 %723 8 9 / ,.: ;=< >@?a< bdcfehgjik?a?mlonqp rts)< lvumwdx

Copies of tag per cell

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1 2 5 10 25 50 100 250 1000

0.01

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n=10,000

Copies of tag per cell

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1 2 5 10 25 50 100 250 1000

0.01

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Mixture DirichletSymmetric DirichletGoods Estimator

n=50,000Relative Efficiency of Shrinkage Estimators

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Page 27: MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23 " #4 &'5, 6 %723 8 9 / ,.: ;=< >@?a< bdcfehgjik?a?mlonqp rts)< lvumwdx

Relative Efficiency P=0.01

Copies of tag per cell

Rel

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1 2 5 10 25 100 500

0.01

0.10

0.25

0.50

1.00

2.00

5.00

10.00

20.00

Relative Efficiency P=0.03

Copies of tag per cell

Rel

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1 2 5 10 25 100 500

0.01

0.10

0.25

0.50

1.00

2.00

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Relative Efficiency P=0.0425

Copies of tag per cell

Rel

ativ

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1 2 5 10 25 100 500

0.01

0.10

0.25

0.50

1.00

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5.00

10.00

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Relative Efficiency P=0.06

Copies of tag per cell

Rel

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1 2 5 10 25 100 500

0.01

0.10

0.25

0.50

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Shrinkage Curve P=0.01

Observed counts (out of 10,000)

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0 5 10 15

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Shrinkage Curve P=0.03

Observed counts (out of 10,000)

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Observed counts (out of 10,000)

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0 5 10 15

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Shrinkage Curve P=0.06

Observed counts (out of 10,000)

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Page 28: MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23 " #4 &'5, 6 %723 8 9 / ,.: ;=< >@?a< bdcfehgjik?a?mlonqp rts)< lvumwdx

Relative Efficiency K=25,000, P=0.02

Copies of tag per cell

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1 2 5 10 25 100 500

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Relative Efficiency K=44,984, P=0.0425

Copies of tag per cell

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1 2 5 10 25 100 500

0.05

0.25

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Relative Efficiency K=65,000, P=0.09

Copies of tag per cellR

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1 2 5 10 25 100 500

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Shrinkage Curve K=25,000, P=0.02

Observed counts (out of 10,000)

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Shrinkage Curve K=44,984 P=0.0425

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Page 29: MD Anderson Cancer Centerodin.mdacc.tmc.edu/~jmorris/papers_files/SAGEmixture.pdf · ,.-0/ %1% %23 " #4 &'5, 6 %723 8 9 / ,.: ;=< >@?a< bdcfehgjik?a?mlonqp rts)< lvumwdx

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