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8. Enzyme - was written by

A. Kuhne B. Kunitz C. Haldane D. Wurtz

9. Lock and Key model was proposed by Emile Fisher in

A. 1890 B. 1891 C. 1892 D. 1894

10. Daniel Koshland gave which model?

A. lock and key B. induced fit. C. sequential model D. both B & C

E. only B

11. Allosteric enzymes are regulated by the binding of-

A. Allosteric modulators B. Allosteric effectors C. both of them D. regulators

12. Fine tuning of metabolic pathways are done by

A. Allosteric non covalent regulation B. Allosteric regulation

C. Covalent modification D. Irreversible regulation

13. When does the enzyme call as heterotropic?

A. same substrate and modulator B. different substrate and modulator

C. different substrate and inhibitor D. none of them

14. When the enzyme is homotropic?

A. same substrate and inhibitor B. same substrate and product

C. same substrate and modulator D. all of them

15. What is the property of homotropic enzyme?

A. same active site and regulatory site

B. active site and regulatory site both are in different subunits

C. modulator binds covalently

D. none of them

16. Which kinetic behavior belongs to Allosteric enzymes?

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A. follow Michaelis-Menten behavior fully

B. show hyperbolic curve in V0 vs. S

C. show sigmoid curve in V0 vs. S

D. show parabolic curve in V0 vs. S

17. The substrate concentration giving half maximal velocity of reaction

catalyzed by an allosteric enzyme is represented by-

A. km B. k0.5 C. S0.5 D. both B & C E. both A & C

18. Cooperative interactions between protein subunits are reflected by-

A. hyperbolic curve in V vs. S diagram

B. sigmoid curve in V vs. S diagram

C. linear relationship between V & S

D. all of them

19. Which two models explain sigmoid kinetic behave?

A. lock and key & induced fit model

B. concerted model & sequential model

C. MWC model & sequential model

D. both B & C

20. When does the k0.5 become lower in case of heterotropic allosteric enzymes?

A. when inhibitor binds to the enzyme

B. when the substrate concentration rises

C. when the activator binds to the enzyme

D. all of them

ANSWER

1.D 2.A. 3.B 4.C 5.C 6.B 7.C 8.C 9.D 10.D 11.C 12.A 13.B

14. C 15.A 16.C 17.C 18.B 19.D 20.C

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