MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic...
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![Page 1: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/1.jpg)
MCMP 407
Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS
Cholinergic Receptors
Nicotinic Muscarinic
Ganglionic Skeletal
Muscle
Neuronal
CNS
![Page 2: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/2.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Nicotinic ReceptorsNicotinic Receptors
ACH ACHNa+
![Page 3: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/3.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Nicotinic ReceptorsNicotinic Receptors
ACH ACHNa+
NH3
COOH
![Page 4: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/4.jpg)
MCMP 407
Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS
Cholinergic Receptors
Nicotinic Muscarinic
M1 M5M3 M4M2
![Page 5: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/5.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic receptors are 7 transmembrane domain, G-protein Muscarinic receptors are 7 transmembrane domain, G-protein coupled receptorscoupled receptors
![Page 6: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/6.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic receptorsMuscarinic receptors(M(M11, M, M33, M, M55))
NH3
COOH
Gq
Phospho -lipase C
(+)
PIP2
IP3 Diacylglycerol
Increase Ca2+ Activate ProteinKinase C
Response
![Page 7: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/7.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic ReceptorsMuscarinic Receptors
(M2 and M4)NH3
COOH
GI
(-)
ATP cAMP
Reduce cAMP-DependentProtein Kinase Activity
Response
Adenylate Cyclase
X(+)K+
![Page 8: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/8.jpg)
MCMP 407
Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS
Adrenergic Receptors
1A
1 2
1B 1D 2A 2B 2C 1 2 3
![Page 9: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/9.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: 11-Adrenergic-Adrenergic
ReceptorsReceptors
NH3
COOH
Gq
Phospho-lipase C
(+)
PIP2
IP3 Diacylglycerol
Increase Ca2+ Activate ProteinKinase C
Response
![Page 10: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/10.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: 22-Adrenergic-Adrenergic
ReceptorsReceptors
GI
(-)
ATP cAMP
Reduce cAMP-DependentProtein Kinase Activity
Response
Adenylate Cyclase
X(+)K+
NH3
COOH
![Page 11: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/11.jpg)
MCMP 407
Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: -Adrenergic-AdrenergicReceptorsReceptors
GS
(+)
ATP cAMP
Increase cAMP-DependentProtein Kinase Activity
Response
Adenylate Cyclase
NH3
COOH
![Page 12: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/12.jpg)
MCMP 407
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Heart Rate of Contraction Increase 1 Decrease M2
Force of Contraction Increase Decrease M2
Functional Responses Mediated by the ANS
1,
![Page 13: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/13.jpg)
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Arteries (most) Vasoconstriction 1 ---------- --Veins Vasoconstriction 2 ---------- --Skeletal Muscle Vasodilation 2 ---------- --Endothelium ---------- -- Release EDRF M3
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MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
LungBronchiolar
smooth muscle
Bronchodilation Bronchoconstriction M32
![Page 15: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/15.jpg)
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Bladder wall Relaxation 2 Contraction M3
Ureter Contraction 1 Relaxation M3
Sphincter Contraction 1 Relaxation M3
Uterus (pregnant) Relaxation 2 Variable
Penis/vas deferens Ejaculation
Genitourinary, smooth muscle
Contraction M311 M3
Erection
![Page 16: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/16.jpg)
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Salivary Glands Increase secretion 1 Increase secretionSmooth Muscle:
Relaxation 2 ,2 M3
Sphincters Contraction 1 Relaxation M3
Secretion ---------- -- Increase secretion M3
Gastrointestinal Tract
M3
Walls Contraction
![Page 17: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/17.jpg)
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Hair follicles,Smooth muscle
Contraction,Piloerection
1 -------------- --
Sweat glandsThermoregulation Increase secretion
Skin
----------------M3
Increase secretion 1Apocrine (stress) ----------------
![Page 18: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/18.jpg)
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
IrisRadial muscle Contraction
Eye
----------------1
-------------Circular muscle M3Contraction--
Ciliary muscle [Relaxation M3Contraction2]
Ciliary epithelium Increase secretionof aqueous humor
----------------2
![Page 19: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/19.jpg)
MCMP 407
Physiology of the eyePhysiology of the eye
LensIris
Radial muscle (1)
Circular muscle (M3)
Canal of Schlemm
Trabecularmeshwork
Ciliary muscle (M3)
Ciliaryepithelium (2)
![Page 20: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/20.jpg)
MCMP 407
Physiology of the eyePhysiology of the eye
![Page 21: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/21.jpg)
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Circular muscle
(M3 Receptors)
![Page 22: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/22.jpg)
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Contraction of circular
muscle leads to
miosis
![Page 23: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/23.jpg)
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Contraction of circular
muscle leads to
miosis
![Page 24: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/24.jpg)
MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Radial Muscle
( 1 Receptors)
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MCMP 407
Physiology of the eyePhysiology of the eye
Pupil
Contraction of radial
muscle leads to
mydriasis
![Page 26: MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS.](https://reader030.fdocuments.us/reader030/viewer/2022032516/56649c7b5503460f9492e797/html5/thumbnails/26.jpg)
MCMP 407
Functional Responses Mediated by the ANS
Effector OrganAdrenergicResponse Receptor
CholinergicResponse Receptor
Liver Glycogenolysis -------------- --
Fat cells Lipolysis -------------- --
Kidney Increase reninsecretion
1 -------------- --
Pancreas Decrease insulinrelease
Metabolic functions
----------------
1, 3
2
Gluconeogenesis1, 2