QING-LI WU

Department of Plant Biology and Pathology

Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901

E-Mail: qlwu@aesop.rutgers.edu

Telephone: 848-932-6238

Fax: (732) 932-9441

EDUCATION:

1994-1997 Ph.D. in natural products chemistry and chemotaxonomy, Peking

Union Medical College and Chinese Academy of Medical Sciences, China, 1997 1991- 1994 M.S. in pharmacognosy, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, 1994 1985 - 1989 B.S. in pharmacy, Anhui College of Traditional Chinese Medicine, Hefei, China, 1989

PROFESSIONAL EXPERIENCE:

2005-present, Assistant Research Professor, New Use Agriculture & Natural

Plant Products Program and Department of Plant Biology and Pathology,

Rutgers University

2001-2005, Research Associate, Department of Plant Sciences, Rutgers

University.

1999-2001, Postdoctoral Fellow in Department of Psychiatry, Harvard Medical

School.

1997-1999, Assistant professor, Institute of Medicinal Plant Development, Peking

Union Medical College and Chinese Academy of Medical Sciences, China

MAJOR AREA OF EXPERTISE:

My area of expertise is in plant-based medicines and nutraceuticals, with

specialization in natural product chemistry including bioactive compound

isolation, structure determination, analytical method development and validation

(HPLC & LC/MS), bio-directed fractionation, standardization and quality control of

botanicals, and plant genetic resources and plant taxonomy. With specialization

in polyphenols chemistry and the PK study, my research focuses on the

application and chemistry of natural compounds in traditional medicine and

expands to nutrition and food sciences related to public health in the

treatment/prevention of age-related diseases.

AWARDS AND HONORs: 2010-current: Editorial board member of American Journal of Analytical Chemistry. 2009-Research Team Award from Rutgers, SEBS and the NJAES for or the Research Team Award in the SEBS for the Research Project: Partnership for Sustainable Economic Growth in Africa Through Natural Plant Products (PFID/NP). Team Member.

2005-current: Visiting professor of Key Laboratory, Institute of Medicinal Plant

Development (IMPLAD), Chinese Academy of Medical Sciences.

State Administration of Traditional Chinese Medicine (SATCM), Awarded Silver

Prize for Master‘s Thesis: Species Systematization and Quality Evaluation of

Common used Traditional Chinese Drugs (12/1995).

AFFILIATION

Sino-American Pharmaceutical Professionals Association (SAPA)

American Chemical Society (ACS)

TEACHING AND TRAINING RESPONSIBILITY Graduate Involvement: Member, Graduate Faculty in Medicinal Chemistry, School of Pharmacy, Rutgers Current Graduate Students at Rutgers in this academic year MS Students: 2011-current Adolfo Pertuz, MS candidate, Plant Biology and Pathology, SEBS 2011-current Kelsey Gustafson, MS candidate, Medicinal Chemistry, School of Pharmacy 2012-current Daniel Giurleod, MS Candidate, Medicinal Chemisty, School of Pharmacy PhD Students: 2010-current Derek Hawkins, Ph. D. candidate, Medicinal Chemistry, School of Pharmacy 2011-current Thomas Villani, Ph.D. candidate, Medicinal Chemisty, School of Pharmacy Member of Graduate Students Committee and/or Co-Advisor Those Received Their Degrees:

2010. Yanping Xu, MS., Medicinal Chemistry, School of Pharmacy, Completion,

December, 2010.

Thesis: Identification of Polyphenols and Quantification of Anthocyanidins

in Grapes and Grape-derived Products.

2009. Cara Welch, Ph.D., Medicinal Chemistry, School of Pharmacy, Completion,

December, 2009.

Dissertation: Chemistry and Pharmacology of Kinkéliba (Combretum

micranthum), a West African Medicinal Plant.

2008. Diandian Shen, Ph.D., Medicinal Chemistry, School of Pharmacy,

Completion, August, 2008.

Dissertation: Development of anti-inflammatory agents from the aromatic

plants, Origanum spp. and Mentha spp., and analytical methods on the

quality control of bioactive phenolic compounds.

2008. Julia Coppin, MS., Medicinal Chemistry, School of Pharmacy, Completion,

April, 2008.

Thesis: Nutritional And Medicinal Values Of Moringa oleifera Leaves From

Sub-Saharan Africa: Ghana, Rwanda, Senegal And Zambia.

Provided training and service to other undergraduate and graduate students,

visiting scientists and post doctoral researchers in natural products chemistry. A

selected list of recent undergraduate students follow from 2011 (average

mentoring 2 undergraduates in hands-on research each year)

2012: Mark Sterlin, undergraduate student, SEBS

2012: Lisa Giordan, undergraduate student, SEBS

2011: Tham Peng Wai, undergraduate student, chemistry and Biochemistry

2011: Jasminder Singh, undergraduate student, chemistry and Biochemistry

2011: Fenxiao Liu, undergraduate student, chemistry and Biochemistry Current Teaching Activity in Undergraduate Education: Medicinal Plants, Plant Science 11:776:312, Fall Semester since 2005 to current. Instructors: J.E. Simon and Q.L. Wu. Wu has about 40% responsibility for this course. 3 Credits, upper division undergraduate course.

Plants and Human Health, Senior level undergraduate colloquia: Plant Science 11:015:408. Spring Semester since 2006 to current. Instructors: J.E. Simon and Q.L. Wu. Wu has about 60% responsibility for this course. 3 Credits, upper division undergraduate colloquia.

Plants Biology and Pathology, Spring Semester, with contributing lab practicum for B.R. Huang, undergraduate course. Wu assists in the training of undergraduate students in using HPLC, and natural products chemistry, extraction, analysis and botanical standardization. Plant Physiology, Spring Semester, with contributing lab practicum for Y Xu, Ramapo College, undergraduate course. Wu assists in the training of undergraduate students in using HPLC, and natural products chemistry. Guest Lecturer, Wu has provided guest lectures in Plant Science’s EthnoBotany and in MedChem, Herbal Medicines and Nutraceuticals which is a senior and MS level course in MedChem and School of Pharmacy largely for pharmacy students.

GRANTS

Federal Competitive Grants:

Current: 2012-2015. Alternative Utilization of Roselle Hibiscus as Small Farm and Niche Market Crop. USDA/NIFA-2012-38821-20092. Total Budget of Rutgers part: $50,000. Our role from Rutgers is in the phytochemical profiling, search for new bioactives and natural products and some value added product development. Wu as the Co-PI in Rutgers provides the leadership on chemistry investigation.

2012-2017. People, Rules and Organizations Supporting the Protection of

Ecosystem Resources (PROSPER) Program in support of the USAID-Liberia.

Wu serves as investigator. Total budget: $21.5 millions and Rutgers part is: $1.1

million). Rutgers will undertake work in Liberia for ARD, Inc. In particular, Rutgers

will collaborate with PROSPER partners ACDI/VOCA, Action for Greater Harvest

(AGRHA) and Agribusiness in Sustainable Natural African Plant Products

(ASNAPP) to conduct livelihood activities related to non-timber forest products;

and to support the development of educational curriculum and capacity building

in the forestry sector of Liberia. Wu’s role will be to lead the natural products

analyses and lab quality control procedures to aid in the commercialization

efforts overseas of Liberian medicinals, spices and botanicals.

2012-2013. A New Capacity to Advance Aquaculture Through Growout

Technology, Natural Product Development, and Science-based Management of

Coastal Restoration Efforts. USDA. Wu and Simon involved as leading the

chemical characterization of the algae and marine organisms. Most of funds are

earmarked for needed equipment for the production, processing of marine algae.

$97,000.

2012-2015. Sustainable African Indigenous Vegetable (AIV) Production and

Market-Chain Development for Improved Health and Nutrition and Income

Generation by Smallholder Farmers in Kenya, Tanzania and Zambia. HortCRSP

from USAID-Washington. Wu serves as an investigator, leading work on

nutritional composition and phytochemical analysis of the AIVs for health and

nutrition. $979,856.

2011-2014. Sustainable African Indigenous Vegetable Production and Market-

Chain Development for Improved Health and Nutrition and Income Generation by

Smallholder Farmers in Kenya, Tanzania and Zambia. USAID. 10/01/2011-

09/29/2014. $980,000 (Purdue prime lead, Rutgers co-leading this initiative).

USAID-International Horticultural CRSP initiative (from UC-Davis).

Our research seeks to support and strengthen the African Indigenous Vegetables

(AIVs) industry using a market-first approach to overcoming constraints along the

value chain leading to improved production practices, supply, postharvest

handling, distribution and consumer acceptability of AIVs in Kenya, Tanzania and

Zambia. Key ingredients are development of a strong public: private sector

partnership that ensures activities support needs of consumers and markets and

involve germplasm evaluation, development of sustainable production and seed

production/saving techniques, improved market access and building capacity of

stakeholders through outreach programs at all levels of the AIV value chain. This

project will both characterize nutritional attributes of AIVs as well as create

awareness of health and nutritional benefits of AIVs through household and

market surveys and educational programs about nutrition. We will bridge

information gaps through research and promotional activities cooperating with

private sector, farmer groups, government, research and NGO communities to

build confidence in AIV production and enhancement of farmer adoption of AIV

systems. Our activities will build capacity of African universities and institutions

involved in research and training of extension personnel who serve the farm

community. Improved AIVs will provide nutritional complements to diets. The

approach is tailored to local dietary needs and promotes biodiversity and sound

environmental management in production while providing affordable edible foods

that can be grown and consumed locally or processed. Activities will result in

improved income generation, new microenterprises across the value chain,

improved availability of nutritious AIVs for consumption and overall improved

quality of life. Wu, Q-L. (Co-PI).

2011-2012. Inventory and rapid throughput screening of indigenous utilized plant

species for development of new natural products Indigenous Natural Products.

MCA-Namibia Innovation Fund. Total funding: $230,000. Wu, QL. Investigator.

Project Period: 03/15/2011-03/14/2012.

The proposed action aims at surveying and inventorying the utilized indigenous

Namibian flora for the purpose of identifying potentially new uses as ingredients

for indigenous Namibian natural products in foods, flavours, health, nutrition,

cosmetic products for local sustainable economic development. Plant species

identified as suitable for consideration in terms of use will be further investigated

and subjected to Screens-to-Nature (STN) technology whereby we introduce 11

portable, field-deployable pharmacological screens, with all training associated in

its use into Namibia for screening in-country. Screens-to-Nature, guided by the

“Reversing the Flow” principle brings simple pharmacological screens to

developing countries. This approach does not remove any natural resources from

partnering countries. Instead, it trains and equips local scientists, students,

communities, others locally with innovative, cost-effective, and portable

nutraceutical, nutritional and drug-discovery tools. Further evaluation criteria

include chemical profiling, regional and international market assessments,

sustainability (wild-crafting vs. cultivation) and feasibility of creating a product

development value chain benefitting Namibia PPOs. This work will lead to a

shortlist of 10-20 candidate species for product development using a science-

based market strategies and public: private sector partnerships.

2007-2012. Complementary and Alternative Medicine (CERC) for Alzheimer’s

disease With an Emphasis on grape derived polyphenol. National Institute of

Health (NIH). Prime Award No. 1 PO1 AT004511-01. 09/30/07-09/29/2012.

As a key team member in the Bioanalytical and Bioavailability Core of this

national research program led by the New York Mt. Sinai Medical Center, in

concert with Purdue University, and the Albert Einstein School of Medicine,

Rutgers provides the leadership in: (1) characterizing and screening the raw

materials used in this CERC project, for the polyphenols in the grape samples

(grape fruit, grape seed, grape extracts, grape juice, grape fractions); (2) provide

assistance to Purdue in chemical analysis of the grape metabolites in human

plasma; and (3) archiving and authentication of the raw materials from grape and

wine and providing quality control oversight and guidelines for the botanical

products. (WU, QL serves as co-PI at Rutgers). Rutgers research as

subcontract with Purdue University from Mt. Sinai. $372,625.

2011-2012. Standardize and Develop a Sickle Cell Disease Drug for Phase II

Clinical Trials. National Institute of Health (NIH). NIH-SBIR grant collaborated

with Cosimid Inc. Project Period: 09/01/2011-8/30/2012. To support the clinic

study of COS-130 (phase II), the NUANPP at Rutgers University has the leading

role in (1) developing a chemical fingerprint of the original botanical materials

using LC/MS, (2) elucidating the anti-sickling compound(s) to use as markers of

activity, (3) to develop quality control program for standardization of COS-103,

and (4) in growing authenticated plant material which provides the main

ingredients of COS-103 under controlled conditions. (WU, QL serves as co-PI at

Rutgers). $57,777.

Finished

2008-2011. Chin, K.L. High Value Specialty and Ethnic Medicinal Crops for the

Fresh and Processing Produce and Nutraceutical Industries. USDA SCRI grant

to Southern University. Cooperators: Wu (co-PI) at Rutgers have subcontract for

the chemistry work within this project. $137,500.00. As the co-PI in this project,

Wu provided leadership in plant sampling and chemical analysis and the

development of analytical protocols for foliar (leaf) and floral (calyx)

phytochemical analyses.

2005-2011. National Botanical Center for Age-Related Diseases (with Purdue

University and University of Alabama as the lead institutions). NIH-OD-00-04.

Project Period: 04/15/2005-9/30/2011. Research focus was on botanical

authentication, chemical analyses and natural product characterization and

standardization for botanicals and extracts used in the research cores of this

national botanical center. Our Rutgers unit led the Botanical and Educational

core of this center. We identify new and alternative plant sources for specific

polyphenols, characterize new anti-inflammatory and provide the leadership in

the botanical authentication using botanical taxonomic, molecular and chemical

approaches, and technical support and advice on products, plant species, and

botanical standardization. Simon, J.E. (PI) and Wu, Q-L. (Co-PI).

2009. Wu, Q.L. (PI) and Simon, J.E. (Co-PI) et al. Pilot grant of $25,000.00 from

NIH sponsored Pennington Botanical Center: Phytochemical Investigation on the

African Herbal Tea Kinkéliba (Combretum micranthum) with Focus on its Impact

on Metabolic Disorders.

2006-2009. Team member in Partnership in Food Industry Development for

Natural Products (PFID/NP), a 5-year global USAID-sponsored research and

development program where core and satellite countries were all in sub-Sahara

Africa. Wu’s leadership is in development of standards and chemical

characteriziation of new and traditional African medicinal plant products (Griffonia,

Voacanga, Kombo); flavorings, spices and herbal teas (Grains of Paradise,

hibiscus, paprika and chilis) anti-malarials (Artemisia annua) and nutritional

dietary supplements to improve human nutrition (Moringa). Wu leads the

analytical core of this team. The impact of the griffonia and vocanga work on

establishing standards were used by the government of Ghana in the

establishment of their national standards and currently it is our understanding

that a request has been made by Ghana to turn these into ISO standards.

2005.-2007. Moudgil, K (PI). Modulation of Autoimmunity by Green tea

Polyphenols. National Institute of Health SBIR Phase II Grant to University of

Maryland. Cooperators: Simon, J.E. (PI) and Q.L. Wu (co-PI) at Rutgers have

subcontract for the chemistry and botanical standardization work within this

project. Subcontract between Univ. of Maryland and Rutgers. $82,516.00.

2002. Wu, Q.L. and Simon, J.E. et al. Pilot grant of $10,000.00 from NIH

sponsored Purdue-UAB Botanical Center for purchasing laboratory equipment.

2001-2005. Botanical Center and Age-Related Diseases founded by NIH (OD-

00-004, Amount: $8 million, Period: 01/01/00-12/31/05). The Center focused the

diverse basic research and educational strengths on characterization the active

ingredients in botanical with the emphasis on polyphenolics and determine their

efficiency in reducing risk of age-related diseases including osteoporosis, cancer,

cardiovascular disease, and neurodegeneration. As a member of Botanical Core,

my responsibilities were to provide the leadership in plant identification, plant

sample sourcing and processing, and providing quality control and method

development for biological ingredients in the plant samples used in the Botanical

Center. (Wu as co-PI in Rutgers).

2006. USAID and Foundation grants to support research in anti-malarials

(Artemisia annua) and nutritional dietary supplements to improve human nutrition

(Moringa oliefera).

External Industry and/or NGO Grants:

2010. Noventis Company. Provided leadership in obtaining a donation of an

excellent LC/MS system including a Triple Quadrupole MicroMass Ultima,

Waters HPLC and operation software, approximately value of $500,000.00 and

led to install the instrument in 2010. (Wu served as PI and core contact that led

to the procurement of this instrument)

2003-current. As a service for fee, test the authenticity and botanical quality of a

wide range of botanicals and herbals from raw plant material through finished

product including assisting in the quality control (QC) research and service for

Herbalist and Alchemist, Inc., Clinton, N.J. $18,000. (Wu serves as PI and Simon

serves as co-PI).

2008, Xechem, Inc. Support of Natural Products Chemistry and Product

Standardization. $35,000. (J.E. Simon and Q.L. Wu)

2008. Sleepy Hollow Farms. Provided leadership in quality control in goldenseal

for alkaloids. $1,450. 00. (Wu and Simon, co-PIs)

2008. A.M. Todd Company. Provided leadership in quality control for 5-HTP

products. $1,000.00. (Wu and Simon, co-PIs)

2008. Response Products. Participated to developed processing method for

Enrichment of CMO from Kombo Butter. $17,000.00. (Simon and Wu, co-PIs)

2008. Wenbin Den’s Lab, Department of Cell Biology and Human Anatomy, UC

Davis. Provided leadership in collaboration on quality control on natural products

for biological study and obtain donation of various supplies of value $6,000.00.

2007, Xechem, Inc. Participated to obtain donation of various laboratory

instruments of value $210,450.00.

2007, Response Products, Inc. Provided leadership in method development for

enriching CMO from kombo butter, $25,000.00

2007. Herbalist and Alchemist, Inc. Provided leadership in quality control (QC)

research and service, $18,000.

2007, Provid, Inc. Provided leadership in chemical analysis based upon

utilization of the HPLC/UV/MS System, $5,000.00.

2006. Herbalist and Alchemist, Inc. Provided leadership in quality control (QC)

research and service, $18,000.

2006. Covance Company. Provided leadership in obtaining a donation of an

excellent TRIPLE QUAD MS instrument, approximately value of $400,000 and

led to install the instrument.

2004. New Jersey Soy Council. Participated to help analysis of soy isoflavones in

different soy varieties collected from New Jersey farm, $3,500.

2004-2005. Sleepy Hollow Farms. USDA-SBIR Phase II. Provided leadership in

quality control in goldenseal for alkaloids. $25,000.

Internal Rutgers Support:

2011-2012. Developing a natural products nutraceutical industry using algae, sea

kelp and marine organims. Funded by the Marine Institute and the New Jersey

Agricultural Expertiment Station. Valued at $55,000/year including funds for

graduate research assistanship plus $10,000 for supplies. Wu serves as the PI.

PROFESSIONAL ACTIVITIES AND SERVICES

2011-current: Editorial board member of Pharmaceutical Crops. 2010-current: Editorial board member of American Journal of Analytical Chemistry.

2010-current: Editorial board member of Journal of Analytical Methods in Chemistry.

Reviewer for: J. Chromatogrphy A; J. Chromatogrphy B; J. Agric. Food Chem.;

Talanta; Journal of Pharmaceutical and Biomedical Analysis; Rapid

Communication on Mass Spectmetry; Natural Products Communications. J.

Separation Sciences.

PUBLICATION LIST

Published Scientific Journal Articles (*=graduate student involvement):

1. 2012. Ho, L., M. G. Ferruzzi, E.M. Janle, J.Wang, B. Gong, T.Y. Chen, J.

Lobo, B. Cooper, Q. L. Wu, S.T. Talcott, S.S. Percival, J.E. Simon and

G.M. Pasinetti Identification of brain-targeted bioactive dietary Quercetin-3-

O-Glucuronide as a novel intervention for Alzheimer’s Disease. FASEB. J.

(accepted and in press). 2. Yanping Xu*, James. E. Simon, Mario G. Ferruzzi, Lap Ho, Guilio M.

Passinetti, and Qingli Wu (2012), Quantification of anthocyanidins in the grapes and grape juice products with acid assisted hydrolysis using LC/MS. Journal of Functional Food. 4: 710-717.

3. Yanping Xu*, James. E. Simon, Cara Welch*, JoLynne D. Wightman, Mario G. Ferruzzi, Lap Ho, Guilio M. Passinetti, and Qingli Wu (2011), Survey of Poplyphenol Constituents in the Grapes and Grape derived Products, Journal of Agricultural and Food chemistry. 59 (19):10586–10593.

4. Qing-Li Wu, Yong-Hong Yang and James E. Simon (2011). Chemical profiling and quantification of isoflavones in kudzu by LC/UV/MS. American J. Anal. Chem., 2 (6): 665-674.

5. Diandian Shen*, Min-Hsiung Pan, Qing-Li Wu, Chung-Heon Park, H. Rodolfo Juliani, Chi-Tang Ho, and James E. Simon (2011). A Rapid LC/MS/MS Method for the Analysis of Nonvolatile Antiinflammatory Agents from Mentha spp. Journal of Food Science 76 (6):900-908.

6. Shen*, D., Q.L. Wu, W.J. Sciarappa and J.E. Simon (2011). Chromatographic fingerprints and quantitative analysis of isoflavones in Tofu-type soybeans. J. Food Chemistry.130 (4):1003-1009.

7. Andrej Jedinak, Shailesh Dudhgaonkar, Qing-li Wu, Jim Simon and Daniel

Sliva (2011). Anti-inflammatory activity of edible oyster mushroom is

mediated through the inhibition of NF-kB and AP-1 signaling. BMC Nutrition

Journal 10, 52-61

8. Shen* D, Pan MH, Wu QL, Park CH, Juliani HR, Ho CT, Simon JE. (2010)

LC-MS method for the simultaneous quantitation of the anti-inflammatory

constituents in oregano (Origanum species). J Agric Food Chem.

23;58(12):7119-25.

9. Jonathan G Mun, Michael D Grannan, Pamela J Lachcik, Randy B Rogers,

Gad G Yousef, Mary H Grace, Elsa M Janle, Qing Li Wu, James E Simon,

Connie M Weaver and Mary Ann Lila (2010). Tracking deposition of a 14C-

radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone.

Experimental Biology and Medicine. 235 (10), 1224-1235.

10. Vingtdeux, V., H. Zhao, P. Chandakkar, Q.L. Wu, J. E. Simon, E. M. Janle,

J. Lobo, M. G. Ferruzzi, P. Davies, and P. Marambaud (2010). MPK

signaling activation by resveratrol modulates amyloid-beta peptide

metabolism. The Journal of Biological chemistry, 19;285(12) 9100-13.

11. Li L, Tu YH, Xu LJ, Ma P, Peng Y. Wu QL and Xiao PG. (2009):

Detemination of polyphenols and antioxidant activities of Ehretia thyrsiflora.

Natural Products Research and Development, 21, 360.

12. Mario G. Ferruzzi, Jessica K. Lobo, Elsa Janle, Bruce Cooper, James E.

Simon, Qing-Li Wu, Cara Welch, Lap Ho, Connie Weaver and Giulio M.

Pasinetti (2009). Bioavailability of catechins and gallic acid from grape seed

extract is improved by repeated dosing in rats. Journal of Alzheimer

Disease 18:113.

13. H. Rodolfo Juliani, Cara R. Welch*, Qing-Li Wu, Babou Diouf, Diatta

Malainy, James E. Simon (2008). Chemistry and quality of hibiscus

(Hibiscus sabdariffa) for developing the natural product industry in Senegal,

Journal of Food Science 74: S113.

14. Min-Hui Li,Jian-Min Chen, Yong Peng, Qingli Wu, Pei-Gen Xiao (2008).

Investigation of Danshen and related medicinal plants in China. Journal of

Ethnopharmacology 120:419

15. H.R. Kim, R. Rajaiah, Q.L. Wu, S.R. Satpute, J.E. Simon, B.M. Berman and

K.D. Moudgil (2008). Modulation of autoimmune arthritis by polyphenols of

green tea (Camellia sinensis) involves the suppression of pro-inflammatory

IL-17 and the induction of immunoregulatory IL-10 cytokine response.

Journal of Nutrition, 138(11):2111-2116.

16. Cara Welch*, Qing-Li Wu and James E. Simon (2007). Recent Advances

on Anthocyanin Analysis and Characterization. Current Analytical

Chemistry, 4: 75-101. (Wu was invited as senior author).

17. Cheng, K.W., Q.L. Wu, J.E. Simon, F. Chen and M. Wang (2007). Inhibitory

Effect of Fruit Extract on the Formation of Heterocyclic Amines. J.

Agricultural and Food Chemistry, 55(25):10359-65.

18. Qing-Li Wu, Yong-Hong Yang and James E. Simon (2007). Determination

of Proanthocyanidins in Areca Nuts by High-performance Liquid

Chromatography Combined with Mass Spectrometry, Chemistry and

Biodiversity, 4, 2817.

19. Wang, M., K.W. Cheng, Qing-Li Wu and J.E. Simon (2007). Quantification

of nepatalactones in catnip (Nepeta cateria L.) by HPLC coupled with

ultraviolet and mass spectrometric detection. Phytochemical Analysis. 18

(2): 157-160.

20. Diandian Shen*, Qing-Li Wu, Ming-Fu Wang, Yong-Hong Yang, Edmond

Lavoie J. and James E. Simon (2006), Quantification of the Predominant

Catechins in Leaves of Acacia Catechu by LC/ESI-MS. Journal of Food and

Agricultural Chemistry, 54: 3219-3224.

21. Zhongze Ma, Qing-Li Wu, David Y. W. Lee, Micheal Tracy and Scott E.

Lukas. (2005): Determination of puerarin in human plasma by high

performance liquid chromatography. Journal of chromatography B, 823:

108-114.

22. Mingfu Wang, ChungHeon Park, Qing-Li Wu, and James E. Simon. (2005):

Analysis of Artemisin in Artemisia annua L. by LC-MS with selected Ion

monitoring. Journal of Food and Agricultural Chemistry, 53: 7010-7013.

23. Qing-Li Wu, Mingfu Wang and James E. Simon. (2005): Liquid

chromatographic/mass spectrometric determination of proanthocyanidins in

fresh grape and grape products. Rapid Communications in Mass

Spectrometry, 19: 2062-2068.

24. Qing-Li Wu, Mingfu Wang and James E. Simon. (2004): Analytical methods

to determine phytoestrogenic compounds. Journal of chromatography B,

812: 325-355 (Wu was invited as senior author).

25. Qing-Li Wu, Mingfu Wang, William J. Sciarappa and James E. Simon.

(2004): LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu

soybeans. Journal of Agricultural and Food Chemistry, 52: 2763-2769.

26. Qing-Li Wu, Mingfu Wang and James E. Simon. (2003): Determination of

isoflavones in red clover and related species by high-performance liquid

chromatography combined with ultraviolet and mass spectrometric

detection. Journal of chromatography A, 1016: 195-209.

27. Mingfu Wang, Yaakov Tadmor, Qing-Li Wu, Chee-Kok Chin, Stephen A.

Garrison and James E. Simon (2003). Quantification of protodioscin and

rutin in asparagus shoots by LC/MS and HPLC Methods, Journal of

Agricultural and Food Chemistry, 51: 6132-6136.

28. Qing-Li Wu, Mingfu Wang and James E. Simon. (2003): Determination of

Proanthacyanidins in Grape Products by Liquid Chromatography/Mass

Spectrometric Detection under Low Collision Energy, Analytical Chemistry,

75: 2440-2444.

29. David E. Zaurov, James E. Simon, Chungheon Park, Wudeneh Letchamo,

Qing-Li Wu, Ming-Fu Wang, Igor V. Belolipov and Ishenbay Sodombekov.

(2002): Medicinal plants from central and western Asia, Korean J. Medicinal

Crop Sci. 10: 277-283.

30. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1999): Flavonoid

Glycosides from Thalictrum przewalskii. Journal of Asian Natural Products

Research, 1: 301-306.

31. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1999):

Constituents from from Thalictrum smithii. Zhong Cao Yao, 30 (5): 321-323.

32. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1999): New

Triterpene Glycosides from Thalictrum smithii. Chinese Chemical Letters,

10 (6): 485-486.

33. Shi-chun Yu, Qing-Li Wu, Li-Wei Wang and Pei-gen Xiao. (1998): New

Flavonoid Glycosides from Thalictrum przewalskii. Chinese Chemical

Letters, 10 (4): 295-296.

34. Qing-Li Wu, Sheng-ping Wang, Li-Jun Du, Jun-Shan Yang and Pei-gen Xiao.

Constituents of Hyperricum, (1998): Phytotherapy Research, 12, S164-S168.

35. Qing-Li Wu, Sheng-ping Wang, Jun-Shan Yang and Pei-gen Xiao.

Flavonoids from Hyperricum henry, (1998): Natural Products Research and

Development, 10 (4): 15-18.

36. Qing-Li Wu, Sheng-ping Wang, Li-Jun Du, Jun-shan Yang and Pei-gen Xiao.

(1998): Xanthones from Hyperricum japonicum and H. henryi.

Phytochemistry, 49(5): 1395-1402.

37. Qing-Li Wu, Sheng-ping Wang, Yong-hong Liao, Li-jun Du, Jun-shan Yang

and Pei-gen Xiao. (1998): New Phloroglucinol Glycosides from Hypericum

japonicum. Chinese Chemical Letters, 9 (5): 469-470.

38. Qing-Li Wu, Sheng-ping Wang, Li-Jun Du, Jun-Shan Yang and Pei-gen

Xiao. (1998): Chromone Glycosides and Flavonols from Hypericum

japonicum Thunb. exe Murray. Phytochemistry, 49(5), 1417-1420.

39. Qing-Li Wu, Yong-Hong Liao, Sheng-ping Wang, Li-Wei Wang, Yu-Xiu

Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1997): New

Prenylatedflavonol from Hypericum japonicum. Chinese Chemical Letters,

8(4): 317-318.

40. Qing-Li Wu, Sheng-ping Wang, Guang-zhong Tu, Jun-Shan Yang and Yu-

Xiu Feng. (1997): Alkaloids from Piper puberulum. Phytochemistry, 44(4):

727-730.

41. Qing-Li Wu, Yong-Hong Liao, Sheng-Ping Wang, Li-Wei Wang, Yu-Xiu

Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1997): New

Chromone Glycosides from Hypericum japonicum. Chinese Chemical

Letters, 8(1): 41-42.

42. Qing-Li Wu, Yong-Hong Liao, Sheng-Ping Wang, Li-Wei Wang, Yu-Xiu

Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1996): Novel

Pyrones from Hypericum japonicum. Chinese Chemical Letters, 7(11):

1011-1012.

43. Qing-Li Wu, Sheng-Ping Wang, Jun-Shan Yang and Yu-Xiu Feng.

Chemical Study on Piper (Piperaceae). (1998): Natural Products Research

and Development, (Review). 10(2): 84-89.

44. Qing-Li Wu, Sheng-ping Wang, Jun-Shan Yang and Pei-Gen Xiao. (1998):

Pharmacological Study on Hypericum (Clusiaceae). Zhong Cao Yao, (a

review). 29, supplement 135-137.

45. Qing-Li Wu, Sheng-Ping Wang, Yong-Hong Liao, Li-Wei Wang, Yu-Xiu

Feng, Jun-Shan Yang, Pei-Gen Xiao and Shao-Liang Hong. (1996): New

Constituents from Hypericum japonicum. Chinese Chemical Letters, 7(12):

1095-1096.

46. Qing-Li Wu, Jun-Shan Yang and Yu-Xiu Feng. (1994): Two New Alkaloids

from Piper puberulum. Chinese Chemical Letters, 5 (3): 203-206.

47. Qing-Li Wu and Yu-Xiu Feng. (1994): Comparative Study on Constituents

of Essential Oil from Traditional Chinese Drugs Haifenteng Attributed to

Piper. Natural Products Research and Development, 6 (3): 9-16.

48. Qing-Li Wu and Yu-Xiu Feng. Lignans from Piper Genus (Piperaceae) and

their Bioactivity. 1994. World Notes on Plant Medicine. (Review). 9 (2): 51-

56

49. Zhu-hua Wu, Chuan-Fu Cheng and Qing-Li Wu. (1991): Pharmacognostic

study of “Xin-Yi” (Magnolia) in Anhui. China Journal of Chinese Materia

Medica. 16: 13-17.

Scientific Papers- Submitted to Journals and under formal review or under

internal review prior to submission (copies of papers available and asterisks

indicate *graduate student):

50. 2012. Nichols, D.B., K.R. Gurukumar, B. Amartya, Q.L. Wu, J.C. Lee, N.

Sakamoto, J.E. Simon and N. Kaushik-Basu. Anti-Hepatitis C Virus NS5B

Polymerase Activity of Hibiscus Calyces Extract. (submitted and under

review)

51. 2012. Welch, C., E. Bassenne, I. Raskin, J.E. Simon and Q.L. Wu.

Kinkeliba: (Combretum microcanthum): Phytochemical composition,

bioguided separation and antidiabetic activity. J. Agriculure and Food

Chemistry (submitted and under review).

52. 2012. Coppin, J.P., Y. Xu, H. Chen, H.R. Juliani, Q.L. Wu and J.E. Simon.

Determination of Flavonoids in Moringa oleifera by LC/MS (ready for

submission).

53. 2012. Coppin, J.P., Y. Xu, H. Chen, H.R. Juliani, Q.L. Wu and J.E. Simon.

Determination of Polyphenols and Lipid Soluble Vitamins in Moringa

oleifera (ready for submission).

Patents:

54. 2012. Neerja Kaushik-Basu, Qing-Li Wu and James E. Simon.

IDENTIFICATION OF NATURAL PLANT EXTRACTS HARBORING ANTI-

HEPATITIS C VIRUS NS5B POLYMERASE ACTIVITY. Total 26 pages.

Office of Corporate Liaison and Technology Transfer, Attorney Docket

Number: RWJ 11-120. Provisional patent filed by UMDNJ in concert with

OTC, Rutgers University, New Brunswick.

55. 2009. Wu, Qing-Li, Wenbin Deng and James E. Simon. Office of Corporate

Liaison and Technology Transfer, Rutgers University Docket Number. 09-

041 Uses of African Plant Extract and Derived Compounds as Novel

Neuroprotective Agents. 37 pages. Provisional patent filed by Rutgers OTC,

Rutgers University, New Brunswick.

56. 2010. Wu, Qing-Li, Cara Welch and James E. Simon. Office of Corporate

Liaison and Technology Transfer, Attorney Docket Number:

70439.00459/RU10-087. Novel Type Alkaloids as anti-diabetic Agents and

Their Preparation from African Herb Tea. Provisional patent filed by

Rutgers OTC, Rutgers University, New Brunswick.

57. 2010. Shen, Diandian, Wu, Qing-Li and James E. Simon. Office of

Corporate Liaison and Technology Transfer, Attorney Docket Number:

70439.00461/09-038. OREGANO AND MINT ANTI-INFLAMMATORY

COMPOSITIONS AND METHODS CROSS REFERENCE TO RELATED

APPLICATIONS. Provisional patent being filed by Rutgers OTC, Rutgers

University, New Brunswick.

Scientific Reviews and Original Papers published in Scientific Books and

Proceedings as Chapters:

58. 2012. Tom Villani, H. Rodolfo Juliani, James E. Simon, Qingli Wu. Hibiscus

sabdariffa: Phytochemistry, Quality Control and Health Properties. In 2012,

Juliani H.R., J.E. Simon and C.T. Ho (eds). African Natural Plant Products.

American Chemical Society ACS Symposium Series, ACS Press,

Washington, D.C. USA (accepted).

59. 2012. Kelsey Gustafson, Qing-Li Wu, and James E. Simon. Pycnanthus

angolensis: Bioactive Compounds and Medicinal Applications. In 2012,

Juliani H.R., J.E. Simon and C.T. Ho (eds). African Natural Plant Products.

American Chemical Society ACS Symposium Series, ACS Press,

Washington, D.C. USA (accepted).

60. 2009. Swami Nathan, Prema Tripathy, Qingli Wu and Faith C. Belanger.

Nicosan: A Phytomedicinal Treament for Sickle Cell Disease. In 2009, Juliani

H.R., J.E. Simon and C.T. Ho (eds). African Natural Plant Products: New

Discoveries and Challenges in Chemistry and Quality. American Chemical

Society ACS Symposium Series of Herbs, ACS Press, Washington, D.C.

USA. pp 263-276.

61. 2009. Kwan Su Kim, H. Rodolfo Juliani, Michael Bucuk, Dan Acquaye, Julie

Asante-Dartey, Qingli Wu, and James E Simon. Quality Control and 5-HTP

(5-Hydroxy-L-tryptophan) Analysis of Griffonia (Griffonia simplicifolia (DC.)

Baill.) Seed Accessions Collected in Ghana. In 2009, Juliani H.R., J.E.

Simon and C.T. Ho (eds). African Natural Plant Products: New Discoveries

and Challenges in Chemistry and Quality. American Chemical Society ACS

Symposium Series of Herbs, ACS Press, Washington, D.C. USA. pp 381-

390.

62. 2008. Liang Zhou, Qing-Li Wu, James E. Simon, Chun-Yu Liu, Jun-Shan

Yang, Yong-Hong Lia. Phytochemistry and Quality Control of Black Cohosh,

other Medicinal Cimicifuga species and Their Derived Products, pp. 59-99.

In: 2008. Ho, C.T., J.E. Simon, F. Shahidi and Y. Shao (eds). Dietary

Supplements. American Chemical Society Symposium Series 987. American

Chemical Society, Washington, D.C. USA. Pp. 59-99

63. 2007. William J. Sciarappa, Laura K. Hunsberger, Diandian Shen, Qing-Li

Wu, Jim Simon, and Brian Hulme. Evaluation of Edamame Cultivars in New

Jersey and MArryland, New Crops and New Uses, Editor by J. Janick and A

Whipkey, Published by ASHS Pres. Pp.223-227.

64. 2007. Chung-Heon Park, Pirre Tannous, H. Rodolfo Juliani, Qing-Li Wu,

William J. Sciarappa, Rick Van Vranken, Peter Nitzsche, Dennis Dalponte,

and Jim Simon. Catnip as Source of Essential Oils, New Crops and New

Uses, Editor by J. Janick and A Whipkey, Published by ASHS Pres. Pp. 311-

315.

65. 2006. Mingfu Wang, Chia-pei Liang, Qing-Li Wu, James E. Simon and Chi-

Tang Ho. Instrumental Analysis of Popular Botanical Products in the US

MArket, ACS Symposium Series of Herbs: Challenges in Chemistry and

Biology, Editor by Mingfu Wang, Shengming Sang, Chi-Tang Ho, Published

by ACS. pp. 39-54.

66. 2005. Mingfu Wang, Yi Jin, Qing-Li Wu, James E. Simon and Chi-Tang Ho.

Chemistry, Pharmacology and quality control of selected popular oriental

herbs in the US market in Asian Functional Foods, CRC Press, 2005.

67. 2003. Qing-Li Wu, Mingfu Wang, James E. Simon Shi-Chun Yu, Pei-Gen

Xiao and Chi-Tang Ho. Studies on the chemical Constituents of Loquat

Leaves (Eriobotrya japonica), ACS Symposium Series of Oriental Herbs,

Editor by Chi-Tang Ho, Published by ACS. pp. 292-306.

68. 2002. Qing-Li Wu and Yu-Xiu Feng. Haifengteng (Kiper kadsura) in Species

Systematization and Quality Evaluation of Commonly used Chinese

Traditional Drugs, Volume IV, People Health Press, Beijing, China. Pp. 455-

522

69. 2002. Mingfu Wang, Qing-Li Wu, Yaakov Tadmor, James E. Simon,

Sengmin Sang and Chi-Tang Ho. Schisandra chinensis: Chemistry and

Analysis, ACS Symposium Series of Oriental Herbs, Editor by Chi-Tang Ho,

Published by ACS. pp. 234-245.

Presentation on National and International Conferences and Invited Oral

Presentation:

70. 2012. Tom Villani, Qingli Wu and James E. Simon. Preliminary Survey of

Bioactive Natural Products from Algae Species Cultured at NJAIC Relevant to

Human Health and Nutrition. Open House in New Jersey Aquaculture

Innovation CenterAt Rutgers University. 3920 BAYSHORE AVENUE. North

Cape May, New Jersey 08204, September 27, 2012.

71. Kelsey Gustafson, Daniel Giurleo, Chi-Tang Ho, Wenbin Dang, Min-Hsiung

Pan, Qingli Wu, James E. Simon. ANTIOXIDANT, ANTI-INFLAMMATORY

AND NEUROPROTECTIVE ACTIVITIES OF PLASTOQUINONES FROM

THE SEED FAT OF PYCNANTHUS ANGOLENSIS. 2012 International

Congress on Natural Products Research. New York, New York, USA 10017.

July 28-August 1, 2012.

72. Daniel Giurleo, Kelsey Gustafson, Jafar Chaudry, Jasminder Singh, Thomas

Villani, Albert Ayeni, Tom Orton, Ed Dager, Robert Pyne, Chung Park, Qingli

Wu, James Simon. Chemical diversity of Capsinoids and Polyphenols in

Capsicum spp. 245th ACS National Meeting & Exposition, Philadelphia,

Pennsylvania, August 19-23, 2012.

73. Villani, T., A. Pertuz, R. Fatto, J.E. Simon and Q.L. Wu. CHEMICAL

SURVEY OF COMMERCIAL GRAPE SEED DERIVED PRODUCTS. 245th

ACS National Meeting & Exposition, Philadelphia, Pennsylvania, August 19-

23, 2012.

74. Tom Villani, Tham Peng Wei, Qingli Wu and James E. Simon. Analysis of

Polyphenols in Green and Purple Basil. Flavor, Fragrances & Perception

Symposium .Rutgers, Busch Campus, Piscataway, NJ 08854, April 23, 2012.

75. Kelsey Gustafson, Daniel Giurleo, Chi-Tang Ho, Wenbin Dang, Qingli Wu,

James E. Simon. Novel substituted fatty acids from the seed fat of

Pycnanthus angolensis with antioxidant and anti-inflammatory properties.

Flavor, Fragrances & Perception Symposium .Rutgers, Busch Campus,

Piscataway, NJ 08854, April 23, 2012.

76. 2011. Tom Villani, Kelsey Gustafson, Mario G. Ferruzzi, Elsa Janle, Lap Ho,

Giulio M. Pasinetti, Qingli Wu, James E. Simon. Determination of

polyphenols in grape derived superfood and characterization of the newly

collected GSE samples by LC/UV/MS. Presented at the 4th Annual Meeting

Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. New

York, NY, October 6-7, 2011.

77. 2011. Lap Ho, Mario G. Ferruzzi, Elsa Janle, TY Chen, Cooper B, Talcott S,

James E. Simon, Qingli Wu, Wang J, Giulio M. Pasinetti, Development of

brain-targeting grape derived polyphenolics for Alzheimer’s disease

prevention and therapy. 5th International Conferences on Polyphenols and

Health, Barcelona, Spain, October 17-20, 2011.

78. Tzu-Ying Chen, Jessica K. Lobo, Connie Weaver, James E. Simon, Qingli

Wu, Stephen Talcott, Giulio M. Pasinetti, Lap Ho, Mario G. Ferruzzi & Elsa

M. Janle, Bioavailability and Brain Distribution of Anthocyanin and

Quercetin Metabolites from Grape Juice and Wine, Experimental biology,

Washington DC, April 9-13, 2011.

79. Yangping Xu, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti,

Qing-Li Wu and James E. Simon. Identification of Anthocyanidins in grape

derived products by HPLC/UV/MSD. Presented at the 3rd Annual Meeting

Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. The

Samuel Roberts Noble Foundation, Ardmore, OK, September 15-17, 2010.

80. Julia Coppin, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti,

Qing-Li Wu and James E. Simon. Polyphenol Stability in Grape Seed

Extract and Consistency in Grape Juice using LC/UV/MS Profiling.

Presented at the 3rd Annual Meeting Symposium of the CERC NIH Grant,

Mount Sinai School of Medicine. The Samuel Roberts Noble Foundation,

Ardmore, OK, September 15-17, 2010.

81. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jessica Lobo, Tzu-Ying Chen,

Stephen T. Talcott, Jim Simon, Qing Li Wu, Jun Wang, Alice Cheng,

Connie M. Weaver, Susan S. Percival, Giulio Maria Pasinetti. Development

of brain-targeting grape-derived polyphenolics for Alzheimer’s disease

prevention and therapy. Invited oral presentation in 1st

Annual Conference

of the American Council for Medicinally Active Plants (ACMAP), Brunswick,

NJ. July 20-23, 2010.

82. Qingli Wu. Using natural products chemistry for QC and botanical

standardization. Invited oral presentation in 1st

Annual Conference of the

American Council for Medicinally Active Plants (ACMAP), New Brunswick,

NJ. July 20-23, 2010.

83. Jim Simon, Rodolfo Juliani, Chung H. Park, Christian A. Wyenandt, Julia

Coppin and Qingli Wu. Breeding for active principles in aromatic plants and

herbs. 1st

Annual Conference of the American Council for Medicinally Active

Plants (ACMAP), New Brunswick, NJ. July 20-23, 2010.

84. Christopher R Racine, Molly E Seidler, Dustin L Moore, Robert T Harris,

Qingli Wu, James E Simon, Kit L Chin, Gerald R Hankins. Anti-tumor

properties and effects on vascular smooth muscle cell proliferation and

migration of extracts of Hibiscus sabdariffa accessions. 1st

Annual

Conference of the American Council for Medicinally Active Plants (ACMAP),

New Brunswick, NJ. July 20-23, 2010.

85. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jessica Lobo, Tzu-Ying Chen,

Stephen T. Talcott, Jim Simon, Qing Li Wu, Jun Wang, Connie M. Weaver,

Susan S. Percival, Giulio Maria Pasinetti. Bioavailability of grape –derived

polyphenolics and implication in Alzheimer’s disease prevention and

therapy. Experimental and Biology Meeting, Anaheim, CA. April 24-28,

2010.

86. Lap Ho, Mario G. Ferruzzi, Elsa M. Janle, Jessica Lobo, Tzu-Ying Chen,

Stephen T. Talcott, Jim Simon, Qing Li Wu, Jun Wang, Alice Cheng,

Connie M. Weaver, Susan S. Percival, Giulio Maria Pasinetti. Development

of brain-targeting grape-derived polyphenolics for Alzheimer’s disease

prevention and therapy. Society for neuroscience Meeting. San Diego, CA.

November 13-17, 2010.

87. P. Marambaud, V. Vingtdeux,Giliberto L, H. Zhao, P. Chandakkar, Q. Wu,

J. E. Simon, E. M. Janle, J. Lobo, M. G. Ferruzzi and P. Davies, Resverptrol

lowers amyloid-beta accumulation and deposition in vivo by controlling

AMPK signaling. Presented at the International Conference on Alzhemer’s

Disease. Thessaloniki, Macedonia, Greece, March 10-13, 2010.

88. Qing-Li Wu. Plant and Human Heath-Case Studies on Polyphenol. Invited

oral presentation at Anhui College of TCM, Hefei, China. October 5, 2009.

89. J.K. Lobo, M.G. Ferruzzi, E.M. Janle, N. Whittaker, B.R. Cooper, C.M. Wea

ver, J.E. Simon, Q. Wu, C. Welch, L. Ho, G.M. Pasinetti. Bioavailability of

gallic acid and catechins from neuroprotective grape seed extract is

improved by repeated dosing in rats. Presented at the 2nd Annual Meeting

Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. New

York, NY, September 28-29, 2009.

90. Qing-Li Wu, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti and

James E. Simon. Chemical Profiling of Polyphenols in Grape Wine and

Grape Juice using LC/UV/MSD. Presented at the 2nd Annual Meeting

Symposium of the CERC NIH Grant, Mount Sinai School of Medicine. New

York, NY, September 28-29, 2009.

91. V. Vingtdeux, H. Zhao, P. Chandakkar, Q. Wu, J. E. Simon, E. M. Janle, J.

Lobo, M. G. Ferruzzi, P. Davies, and P. Marambaud. AMPK signaling

activation by resveratrol controls Abeta accumulation in vivo. Presented at

the 2nd Annual Meeting Symposium of the CERC NIH Grant, Mount Sinai

School of Medicine. New York, NY, September 28-29, 2009.

92. V. Vingtdeux, H. Zhao, P. Chandakkar, Q. Wu, J. E. Simon, E. M. Janle, J.

Lobo, M. G. Ferruzzi, P. Davies, and P. Marambaud. Resverptrol Controls

of Abeta levels, amyloid deposition, and activation of AMP-activated protein

kinase. Presented at the 2nd Annual Meeting Symposium of the CERC NIH

Grant, Mount Sinai School of Medicine. New York, NY, September 28-29,

2009.

93. J.K. Lobo, M.G. Ferruzzi, E.M. Janle, N. Whittaker, B.R. Cooper, C.M. Wea

ver, J.E. Simon, Q. Wu, C. Welch, L. Ho, G.M. Pasinetti. Bioavailability of

gallic acid and catechins from neuroprotective grape seed extract is

improved by repeated dosing in rats. Presented at Experimental Biology.

New Orleans, LA. 2009.

94. Cara R. Welch, Qing-Li Wu, Slavko Komarnytsky, Ilya Raskin and James E.

Simon. IDENTIFICATION OF THE BIOACTIVE CONSTITUENTS OF

SENEGAL’S BUSH TEA, KINKELIBA (COMBRETUM MICRANTHUM). The

50th Anniversary Meeting of the American Society of Pharmacognosy

(ASP). June 27, 2009. Honolulu, Hawaii, USA.

95. Qing-Li Wu, Cara R. Welch, Mario Ferruzzic, Lap Ho, Giulio Pasinetti and

James E. Simon. Chemical Profiling of Polyphenols in Grape Wine and

Grape Juice using LC/UV/MSD. The 50th Anniversary Meeting of the

American Society of Pharmacognosy (ASP). June 27, 2009. Honolulu,

Hawaii, USA.

96. Shen, D., Wu, Q. L. , Park, C. H. , Juliani, H. R. , Pan, M.H., Ho, C.T.,

Simon, J.E. .Investigation of Anti-inflammatory Compounds in Origanum

spp. 236th ACS National Meeting & Exposition. Philadelphia, PA, USA,

August 17-21, 2008.

97. Welch, C.R., Wu Q.L., Pan, M.H., Ho, C.T., Simon, J.E. Complete

Investigation into Kinkéliba (Combretum micranthum) for Bioactive

compounds. 236th ACS National Meeting & Exposition. Philadelphia, PA,

USA, August 17-21, 2008.

98. Xu, Y.P., Wu Q.L., Pan, M.H., Ho, C.T., Simon, J.E. Phytochemical

Screening and Bioactive Properties of the Medicinal Plant Eyebright,

Euphrasia officinalis. 236th ACS National Meeting & Exposition.

Philadelphia, PA, USA, August 17-21, 2008. 236th ACS National Meeting &

Exposition. Philadelphia, PA, USA, August 17-21, 2008.

99. Coppin, J.P., Xu, Y.P., Chen, H., Juliani, J., Wu Q.L., Simon, J.E.

Determination of flavonoids in Moringa Oleifera by LC/UV/MSD. 236th ACS

National Meeting & Exposition. Philadelphia, PA, USA, August 17-21, 2008.

236th ACS National Meeting & Exposition. Philadelphia, PA, USA, August

17-21, 2008.

100. Qing-Li Wu and James E. Simon. Development of Valuable

Natural Products and Botanicals-Case Studies on Polyphenol. Invited oral

presentation at Tea Research Institute, Chinese Academy of Agricultural

Sciences, Hangzhou, China. July 15, 2008.

101. Qing-Li Wu and James E. Simon. The Status of Dietary Supplements, The

Regulatory Environment and Phytomedicine Research in the USA. Invited

oral presentation at School of Pharmacy, Jiaotong University, Shanghai,

China. July 14, 2008.

102. Qing-Li Wu and James E. Simon. The Regulatory Environment, the Status

of Dietary Supplements and Phytomedicines in the USA and Europe.

Invited oral presentation at Institute of Medicinal Plant Development, Peking

Union Medical College and Chinese Academy of Medical Sciences, Beijing,

China. June 26, 2008.

103. Qing-Li Wu and James E. Simon. Medicinal Plants of Africa. Invited oral

presentation at Institute of Medicinal Plant Development, Peking Union

Medical College and Chinese Academy of Medical Sciences, Beijing,

China. June 26, 2008.

104. Cara Welch, Qingli Wu, James E. Simon. Antioxidant Capacity and Anti-

inflammatory Activity of Kinkeliba Polyphenols. Presented at the 8th Meeting

of the Purdue/Alabama National Botanical Center. Birmingham, AL, March

2, 2008.

105. Yanping Xu, Qingli Wu, James E. Simon. Phytochemical investigation and

Biactive Study on Eyebright (Euphrasia officinalis). Presented at the 8th

Meeting of the Purdue/Alabama National Botanical Center. Birmingham,

AL, March 2, 2008.

106. Diandian Shen, QingLi Wu, Chung-Heon Park, Rodolfo Juliani and James

E. Simon. Development of Anti-inflammatory Agents from the Non-volatile

Component of Oregano. Presented at the 8th Meeting of the

Purdue/Alabama National Botanical Center. Birmingham, AL, March 2,

2008.

107. Simon, J.E., Q.L. Wu, R. Juliani, D. Acquaye, E. Jefthas. CHEMDRAWN

XII. Stellenbosch University, Stellenbosch, South Africa. Dec. 03-07, 2007.

The Role of Chemistry in Sustainable Agriculture and Human Wellbeing in

Africa. Invited presentation on: Role of Chemistry and Natural Products to

Improve Health and Nutrition in Africa.

108. Simon, J.E., Qing-Li Wu, Rodolfo Juliani. Future Role for Horticulture in

Medicinal and Aromatic Plants. Keynote Speaker for the International

Symposium on Medicinal and Nutraceutical Plants, Macon, Georgia. March

20, 2007.

109. Qing-Li Wu, and Jim Simon (2007), Chemical Analysis of Eyebright Using

LC/UV/MS. Presented at the 7th Meeting of the Purdue/Alabama National

Botanical Center. West Lafayette, IN, February 23, 2007.

110. Cara Welch, Qing-Li Wu, Rodolfo Juliani and Jim Simon (2007)

Polyphenols from Hibiscus: A New Promising Source of Anthocyanins.

Presented at the 7th Meeting of the Purdue/Alabama National Botanical

Center. West Lafayette, IN, February 23, 2007.

111. Simon, J.E., Q.L. Wu, R. Juliani, D. Acquaye, E. Jefthas. CHEMDRAWN

XII. 2007. Stellenbosch University, Stellenbosch, South Africa. Dec. 03-07,

2007. The Role of Chemistry in Sustainable Agriculture and Human

Wellbeing in Africa. Invited presentation on: Role of Chemistry and Natural

Products to Improve Health and Nutrition in Africa.

112. 2007. Simon, J.E., Qing-Li Wu, Rodolfo Juliani. Future Role for Horticulture

in Medicinal and Aromatic Plants. Keynote Speaker for the International

Symposium on Medicinal and Nutraceutical Plants, Macon, Georgia. March

20, 2007.

113. Simon, J.E., R. Juliani, M. Wang and Q.L. Wu. Botanicals for Energy in

Beverages: Long Distance Learning sponsored by IFT. Feb, 2007.

114. Simon, J.E. R. Juliani, Q. L. Wu and R. Govindasmay. Natural Products for

Health and Nutrition: Research Studies with Artemisia, Moringa and

Kombo. Inivted seminar, Departments of Food Science and Chemistry,

University of Ghana, East Legon, Accra, Ghana. February, 2007.

115. William J. Sciarappa, Laura K. Hunsberger , Diandian Shen, Qing-Li Wu,

Chung Park, Brian Hulme and Jim Simon. EVALUATION OF EDAMAME

VARIETIES IN THE MID-ATLANTIC. 2006 AAIC Annual Meeting and 6th

New Crops Symposium, San Diego, CA, October 14-18, 2006

116. J.E. Simon, C. Park, Q.L. Wu, M. Diatta, B. Diouf, B. Wilde, J. Asante-

Dartey, D. Acquaye, C. Quansah, R. Akromah, C. Giblain, G. Gbewonyo,

J. Ferreira, P. Melillo de Magalhães, D. Shen, N. Hitimani, A. Daka, H.

Malumo, J. Goliath, P. Langenhoven, R. Juliani and R. Govindasamy.

ARTEMISIA ANNUA: PRODUCTION IN SUB-SAHARAN AFRICA. 2006

AAIC Annual Meeting and 6th New Crops Symposium, San Diego, CA,

October 14-18, 2006.

117. James E. Simon, Chung Park, Qing-Li Wu, Pierre Tannous, William J.

Sciarappa, Mingfu Wang, Rick W. Van Vranken , Peter Nitzsche and Rodolfo

Juliani. CATMINT (NEPETA SPP.): AS A SOURCE OF ESSENTIAL OILS.

2006 AAIC Annual Meeting and 6th New Crops Symposium, San Diego, CA,

October 14-18, 2006.

118. Qing-Li Wu and James E. Simon. Development of valuable natural products

and botanicals-Case study of kudzu. Invited oral presentation on The 9th

International Congress on Ethnopharmacology. Nanning, China, August 22-

26, 2006.

119. Qing-Li Wu, Yong-hong Yang and James E. Simon. Chemical profiling and

quantification of isoflavone phytoestrogens in kudzu using LC/UV/MSD. 54th

ASMS Conference on Mass Spectrometry. Seattle, WA, may 28-June 1,

2006.

120. Qing-Li Wu, Yong-hong Yang and James E. Simon. Plant Sourcing of

Isoflavone Enriched Kudzu Species (Pueraria spp.). Presented at the 6th

Meeting of the Purdue/Alabama National Botanical Center. Birmingham,

AL, March 3, 2006.

121. Diandian Shen, Qing-Li Wu and Jim Simon. Determination of the

Predominant Catechins in Acacia catechu by LC/MS. Presented at the 6th

Meeting of the Purdue/Alabama National Botanical Center. Birmingham, AL,

March 3, 2006.

122. Diandian Shen, Qing-Li Wu and Jim Simon. An Analytical Survey of

Isoflavones in Tofu-type Soybeans Cultivated in North America. Presented at

the 6th Meeting of the Purdue/Alabama National Botanical Center.

Birmingham, AL, March 3, 2006.

123. Qing-Li Wu and James E. Simon. Development of Natural Products and

Botanicals for Health and medicine. Invited presentation at School of

Chinese Medicine, Hong Kong Babtist University, Kowloon, HK. December

1, 2005.

124. Qing-Li Wu and James E. Simon. Modern Analytical Methodologies in

Natural Products Chemistry, Case study on Phytoestrogens. Invited

presentation at Institute of Medicinal Plant Development, Peking Union

Medical College and Chinese Academy of Medical Sciences, Beijing, China.

December, 2005.

125. Qing-Li Wu and James E. Simon. Modern Analytical Methodologies in

Natural Products Chemistry, Purdue University-University of Alabama

Botanical Center for Age Related Diseases, 2005 Workshop: Botanical

Standardization of Medicinal Plants, Cook College, New Brunswick, NJ.

October 20- 21, 2005.

126. Jim Simon, Qing-Li Wu, Mingfu Wang and Rodolfo Juliani. The World of

Nutraceuticals- and Background of the New Use Agriculture & Natural Plant

Products Program, Purdue University-University of Alabama Botanical

Center for Age Related Diseases, 2005 Workshop: Botanical Standardization

of Medicinal Plants, Cook College, New Brunswick, NJ. October 20- 21,

2005.

127. Jim Simon and Qing-Li Wu. Traceability and Botanical Standardization:

Challenges and Approaches, Purdue University-University of Alabama

Botanical Center for Age Related Diseases, 2005 Workshop: Botanical

Standardization of Medicinal Plants, Cook College, New Brunswick, NJ.

October 20- 21, 2005.

128. Qing-Li Wu and James E. Simon. Development of Valuable Natural

Products and Botanicals. Presented at Institute of Medicinal Plant

Development, Peking Union Medical College and Chinese Academy of

Medical Sciences, Beijing, China. August 24, 2005.

129. James E. Simon, Qing-Li Wu, Mingfu Wang and Rodolfo Juliani. Research,

Discovery and Application of Natural Products for Health and Medicine.

Gordon Conference, NH, July 10, 2005.

130. Qing-Li Wu, Yong-Hong Yang, MingFu Wang and James E. Simon.

Determination of isoflavones in kudzu by LC/UV/MSD. Presented at the 5th

Meeting of the Purdue/Alabama National Botanical Center. February 25-26,

2005.

131. Simon, J.E., Q.L. Wu, M. Wang and R. Juliani. Research, Discovery and

Application of Natural Products for Health and Medicine. Invited openning

speaker in Plant Chemistry and EthnoBotany, Plant Metabolic Engineering.

Gordon Conference, Tilton, New Hampshire, July 10, 2005.

132. Simon, J.E., R. Govindasamy, R. Juliani, D. Acquaye, E. Jefthas, N.

Hitimana, J. Goliath, P. Langenhoven, A.E. Daka, M. Diatta, J.Astante-

Dartey, D.Alipoe, Q.L. Wu and C. Quansah. Sustainable Development:

Natural Products and Medicinal Plants Sector Using a Science and Market-

Driven Approach to Strengthen Demand. Building New Partnerships in the

Global Food Chain. Experiences from North Africa, the Near East and Asia.

A USAID and Univ. of Illinois Post-IAMA Workshop, June 29-30, 2005.

Chicago, Ill. Simon also served as a co-Moderator with Scott Christiansen,

USAID for the natural products session. (a special symposia paper has

been requested for all presenters for publication).

133. Simon, J.E., E. Jefthas, D. Acquaye, R. Juliani, H. Moharram, P.

Langenhoven, P. Tannous & M. Wang, Q.L Wu, E. Renaud, B. Neimark, D.

Alipoe, K. Chin, J. Dartey-Asante, C. Quansah, M. Diatta, N. Hitimana and

A. Daka. Natural Products: From Bush to Processed Product: Natural

Products and Medicinal Plants Sector Developing the Market for Natural

Products Using a Sustainable Approach. A Model for International

Development. Invited presentation for the session on Sustainable

Development. Trading morsels, Growing Hunger, Decimating Nature:

Linking Food and Trade Development and the Environment. Princeton

Institute for International and Regional Studies, Princeton University,

Princeton, New Jersey, February 24-26, 2005. (all invited papers now

invited to submit a special symposia paper on the ASNAPP model for J.

Food, People, Culture and Society).

134. Simon, J.E., R. Juliani, Q.L. Wu and M. Wang. Processing Technologies

and Packaging Systems – From the Simple to Complex. Making Quality

Matter Workshop, ASNAPP, Accra, Ghana, June, 2005.

135. Simon, J.E., C.h. Park, Q.L. Wu and M. Wang. The anti-malarial Artemisia

annua: From Botany and Biology, through Chemistry and Pharmacology to

Production, Processing and Post-harvest handling. Making Quality Matter

Workshop, ASNAPP, Accra, Ghana, June, 2005.

137. Simon, J.E., M. Wang, R. Juliani, Q.L. Wu, H. Moharram and M. Rafi.

Research, Discovery and Application of Natural Products for Health and

Medicine. Campinas, Brazil, 2004. 138. Simon, J.E., M. Wang and Q-L. Wu. New Trends in the Research, Discovery

and Application of Natural Products for Health and Medicine. Prestented at the Laboratorio de Fitofármacos. Hospital de Especialidades Centro Médico Nacional Siglo XXI, IMSS. April 28, 2004, Mexico City, Mexico.

139. Simon, J.E., M. Wang, Q-L. Wu, R. Juliani, H. Moharram and P. Tannous. Quality Control Issues Facing Botanicals and Dietary Supplements. Prestented at the Laboratorio de Fitofármacos. Hospital de Especialidades Centro Médico Nacional Siglo XXI, IMSS. April 28, 2004, Mexico City, Mexico.

140. Simon, J.E., H. Moharram, M. Wang, Q.L. Wu, P. Tannous, and R. Juliani. Strategies for Commercializing Plants Targeted for Natural Products. April 01, 2004. Dupont Chemical Science and Engineering Division. Dupont Central Research and Development Experiment Station, Wilmington, Delaware (industry invitation).

143. 2004. Simon, J.E., M. Wang, Q.-L. Wu, C.K. Chin, S. Garrison, B. Sciarappa, P. Nitzsche, T.C. Lee, W. Kline and R. VanVranken. New Products from Asparagus, Artichokes, Edamame Soy and Herbs Presentation for the Annual Meeting of the New Jersey Vegetable Growers, New Jersey Farm Bureau. Atlantic City, NJ. January 12, 2004.

144. Qing-Li Wu, MingFu Wang and James E. Simon. LC/MS Determination of

proanthocyanidins in fresh grape and grape products. Presented at the 4th

Meeting of the Purdue/Alabama National Botanical Center. February 25-26,

2004.

145. Qing-Li Wu, MingFu Wang and James E. Simon. LC/MS Determination of

proanthocyanidins in areca nuts by high-performance liquid

chromatography combined with electrospray ionization ion trap mass

spectrometry. Presented at the 4th Meeting of the Purdue/Alabama National

Botanical Center. February 25-26, 2004.

146. Qing-Li Wu, MingFu Wang and James E. Simon. Determination of

Isoflavones in Red Clover and Related Species by LC/UV/ESI-MS, American

Chemical Society Annual Meetings, New York, NY, Sept. 8-11, 2003 (invited

oral presentation).

147. Qing-Li Wu, M. Wang, J. Kapteyn, R. Juliani, and J.E. Simon. Quality Control

in Botanicals & Herbal Drugs and Issues Facing Botanicals Used in the

Natural Products/Nutraceuticals Industry. Invited Lecture and Workshop.

Sept 25-26, 2003, Purdue University, West Lafayette, IN.

148. William J. Sciarappa, Peter Nitzsche, Qing-Li Wu, Ming-Fu Wang, Jim Simon

and Tung-Ching Lee, Phytochemistry and Horticultural properties of 16

Edamame Soybean Varieties. Annual Meeting of the American Society for

Horticultural Science, Providence, Rhode Island. October 06, 2003.

149. MingFu Wang, Rodolfo Juliani, Qing-Li Wu and James E. Simon. Analysis of

flavonoids and rosmarinic acid contents in different varieties of mint by HPLC

and LC-MS Methods. American Chemical Society Annual Meetings, New

York, NY, Sept. 8-11, 2003 (invited oral presentation).

150. Ming-Fu Wang, Qing-Li Wu, Jerimy Kapteyn, Rodolfo Juliani and J.E.Simon.

Health Promoting Components in Asparagus, Artichokes and Other Foods.

Foods for Health: A Look To the Future. For Health Care Professionals,

Nurses, Dieticians and Health Care and Extension Specialists. Rutgers

University, New Brunswick, NJ. September 10, 2003.

151. Qing-Li Wu, Ming-Fu Wang, James E. Simon. Determination of Isoflavones

in Red Clover and Related Species by LC/UV/MSD. Presented at the 3rd

Meeting of the Purdue/Alabama National Botanical Center. February 25-26,

2003.

152. Zhong-zhe Ma, David Y. W. Lee, Qing-Li Wu, SE Lukas, Determination of

Puerarin in Human Plasma and Urine. American Chemical Society Annual

Meetings, New York, NY, Sept. 8-11, 2003.

153. Qing-Li Wu, Ming-Fu Wang, James E. Simon. LC/UV/ESI-MS Analysis of

Isoflavones in Immature Fresh Soy Seeds. Presented at the 3rd Meeting of

the Purdue/Alabama National Botanical Center. February 25-26, 2003.

154. Qing-Li Wu, Mingfu Wang, and James E. Simon, The Botanical Core,

Method Development, and Determination of Isoflavones by LC/MSD.

Presented as a distance-learning seminar to the Botanical Center Seminar

Series, Purdue/Alabama/Rutgers. November 14, 2002.

155. Qing-Li Wu, Ming-Fu Wang, Rodolfo Juliani, Adolfina Koroch, Jeremy

Kapteyn, ChungHeon Park, David Rotter, Cicero Dechamps, Insong Han,

Kobi Tadmor, Erica Renaud, Kathleen Shimomura and James E. Simon:

New Use Agriculture and Natural Plant Products Program. 43rd Annual

Meeting of the American Society of Pharmacognosy and 3rd Monroe Wall

Symposium, New Brunswick, NJ. July 27-31, 2002.

156. Qing-Li Wu, Ming-Fu Wang and James E. Simon. Determination of

Proanthocynidins in grape products by LC/MSD. 43rd Annual Meeting of the

American Society of Pharmacognosy and 3rd Monroe Wall Symposium,

New Brunswick, NJ. July 27-31, 2002.

157. Qing-Li Wu, MingFu Wang and James E. Simon. LC/MS Determination of

proanthocyanidins in grape products by LC/MSD. Presented at the 2nd

Meeting of the Purdue/Alabama National Botanical Center. February 25-26,

2002.

158. Qing-Li Wu, Mingfu Wang, and James E. Simon. The Botanical Core and

Quantitative Determination of Monoproanthocyanidins and Estimation of

Oligoproanthacyanidins in Grape Products by LC/MSD. Presented as a

distance-learning seminar to the Botanical Center Seminar Series,

Purdue/Alabama/Rutgers. December 20, 2001.

159. Qing-Li Wu, Ming-Fu Wang, Rodolfo Juliani, Adolfina Koroch, Jeremy

Kapteyn, Wudeneh Letchamo and James E. Simon. (2001): New Use

Agriculture and Natural Plant Products Program. 5th National Symosium

New Crops and New Uses: Strenght in Diversity, Altlanta, Georgia. Nov. 10-

12. 2001.

160. David Zaurov, James E. Simon, Qing-Li Wu and Ming-Fu Wang. Medicinal

Plant from Central and Western Asia. 5th National Symosium New Crops

and New Uses: Strenght in Diversity, Altlanta, Georgia. Nov. 10-12. 2001.

161. Qing-Li Wu, J.E. Simon, R. Juliani, A. Koroch, J. Kapteyn, K. Shawe, K.

Shimomura, and C.Santerre. Botanical Center and Age-Related Diseases.

Core B. Botanical and Educational Outreach. Presented at the 1st Meeting

of the Purdue/Alabama National Botanical Center. February 25-26, 2001.

162. J. L. Neumeyer, J. Bergman, N. S. Kula, Qing-Li Wu, G. Leclerc, P. Nguyen

and R. J. R. J. Baldessarini. Characterization of Novel D1 Partial-Agonists

for the Treatment of Psychostimulant Addiction. 2000 Annual Meeting of

Society for Neuroscience, P2153, 809.2, New Orleans, LA. November 4,

2000.

163. Qing-Li Wu, Yu-xiu Feng, Shao-mei Shun and yu-Mei Shong, (1994):

Pharmcognostic Study on Piper Species. The 3rd International Congress on

Ethnopharmcology, Beijing, China, Sept. 6, 1994, C-28.