May 2015ECFA meeting1 Spin-off technologies for cancer diagnosis J. Varela, LIP Lisbon ECFA meeting,...

May 2015 ECFA meeting 1

Spin-off technologies for cancer diagnosis

J. Varela, LIP Lisbon

ECFA meeting, Coimbra, 15 May, 2015


Since ≈10 years there is an active program in Lisbon developing spin-off from HE physics in medical imaging, mainly PET.

Main activities are- ClearPEM- EndotofPET- Dedicated readout electronics for TOF-PET- New ClearPEM


The ClearPEM project

A dedicated PET scanner for breast imaging


Why?

- breast cancer is 3rd most frequent cancer in humans

- one in 10 women eventually develops breast cancer

- good survival rate if detected at an early stage


Hamamatsu APD arrayS8850How?

- take advantage of the (at that time) newAPD photodetectors

- Use our expertise in using APDs acquired in CMS

The ClearPEM scanners

6

ClearPEM-II in Monza (Italy)ClearPEM (prototype) in Coimbra

3.0 mm

2.5 mm 2.0 mm

1.5 mm

1.2 mm

Spatial resolution : 1.3 mmObtained with Derenzo phantom (Na22 rods)

Sensitivity: 2 to 5%, depending on the configuration

May 2015 ECFA meeting

Breast tumor with FDG activity is concentrated in the periphery

Clinical studies

Tumour heterogeneity is recognised as an important challenge in modern oncology.

Tumours consist of different populations of both benign and malignant cells with a specific impact on patient prognosis and outcome of neo-adjuvant treatments.

Tumor

Lymph Node

PET Whole Body

Clinical case: multifocal breast cancerClinical case: multifocal breast cancer

PET/CT exam Resolution is insufficient to identify multiple focus

PEM: Multifocal Lesions

ClearPEM


In Monza, after one year of upgrade work on the image reconstruction software and user interface, the patient studies with ClearPEM have resumed very recently.

A clinical study (200 patients) will evaluate if FLT(3-deoxy-3-[18F]fluorothymidine) can be used to monitor the stage of the disease reducing the need to perform a biopsies. The performance of ClearPEM will be compared the one of the standard whole-body PET.


In Coimbra, the team has mainly been using the ClearPEM as a small animal PET, and evaluating the possibility to use it as a brainPET.


But we have been overtaken by technological progress

APD SiPM


But we have been overtaken by technological progress

APD SiPMs allow for a dramatic improvement in time resolution


The EndoTOFPET-US project

EU FP7 project


Our role in the EndoTOFPET-US project is to develop the PET Detectors and the readout electronics based on SiPM readout of the scintillation light.

The challenge is to have a highly integrated electronics with low power consumption and the best possible time resolution (≈ 200 ps).


Our new, SiPM based, front end PET detector based onthe TOF PET ASIC allows building the most compactPET detector ever.


And allows building a PET scannerwith many 10'000 channels


Should we revisit ClearPEM?

Make sure to keep the physician involved from the design phase

I didn’t know I had a problem

Hey, I’ve solved your clinical problem

Physicist Physician

Thesis• Design and Evaluation of a Positron Emission Tomograph for Breast Cancer Imaging, PhD

• Study and Development of the Clear–PEM Trigger and Data Acquisition System, PhD

• Development and Experimental Study of a Detector Module for Positron Emission Mammography, PhD

• The ClearPEM detector in breast cancer: correction methods for improved imaging, PhD

• Tecnologia de medicina molecular em oncologia. Avaliação da PET Mamografia , PhD

• Integrated Circuit Design for Time-of-Flight PET, PhD

• Controlo de Qualidade de matrizes de Fotodíodos de Avalanche, Master

• Development and Study of the Detector Control System and Calibration Software for the Clear-PEM Scanner, Master

• Development of an Intelligent Front End Board for a High Performance PET, Master

• Performance evaluation of new upgrades on ClearPEM detector modules, Master

• Evaluation of the Clear-PEM scanner in Clinical Environment, Master

• Development and Implementation of the ClearPEM-Sonic Detector Control System, Master

• Amplicador CMOS de baixo rudo para imagiologia medica, Master

• Investigação da detecção do cancro da mama com tomógrafo ClearPEM utilizando fantomas de gelatina, Master

• Development of an innovative LSO-SiPM detector module for high-performance Positron Emission Tomography, Master

• Development and Evaluation of Combined PET-MRI Imaging, PhD (on-going)

• Development of new high-performance Positron Emission Mammography based on silicon photomultipliers and optimized detector geometry, PhD (on-going)


8 PhD, 9 Master


Thank you for your attention


Backup slides


Time Of Flight > TOFWhat if we could measure the time difference very accurately ∆t =1 ns >>> ∆x=15 cm => !

If ∆t ≈10 ps events would be space points !

Detector 1 Detector 2


Simulation: object D=35 cm, TOF=600 ps, Sensitivity gain factor 3.9

Karp JS, Surti S, Daube-Witherspoon ME, Muehllehner G. Benefit of time-of-flight in PET, experimental and clinical results: . J Nucl Med 2008; 49(3):462-70.


Colon cancer, left upper quadrant peritoneal node114 kg; BMI=32.2 ; 13.4 mCi; 2 hr post-inj

Images J. Karp, University of Pennsylvania


And the internal probe ..

May 2015ECFA meeting1 Spin-off technologies for cancer diagnosis J. Varela, LIP Lisbon ECFA meeting,...

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