Matthew P. Frosch, MD, PhDbradd/Harvard_Dementia_Course...Neuropathology of dementias Matthew P....
Transcript of Matthew P. Frosch, MD, PhDbradd/Harvard_Dementia_Course...Neuropathology of dementias Matthew P....
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Neuropathology of dementias
Matthew P. Frosch, MD, PhD
Lawrence J. Henderson Associate Professor of Pathology, Harvard Medical School
Director, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital
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DISCLOSURES
• Sponsored research agreement with Biogen (to perform autopsies on subject from clinical trials)
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Learning objectives
• Understand how neuropathologists render diagnoses
• Know how to read an autopsy report and interpret it for a family
• Appreciate clinico-neuropathological correlations associated with dementia
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Diseases to be discussed
• Alzheimer disease
• Lewy body diseases
• Frontotemporal lobar degenerations
• Cerebrovascular diseases
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Critical concept
• Neurodegenerative diseases are progressive disorders (from normal cognition to dementia)
• Pathologic lesions can be seen in advance of clinical end-point
• Therefore, can find lesions in subjects who are normal/mildly impaired
disease ≠ dementia
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Alzheimer disease
• Plaques – Extracellular deposits of Aβ (40-42 amino
acid peptide cleaved from a larger protein) – Genetic evidence links Aβ to AD
• Tangles – Intracellular (then extracellular) deposits of
hyperphosphorylated tau (microtubule binding protein)
– Genetic evidence links tau to FTLD
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Aβ
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Assessment of amyloid
• Where is it? – Distribution across anatomic structures – Thal scoring of amyloid
• What does it do to the surrounding brain? – Presence of neuritic plaques (abnormal
neuronal processes around the amyloid deposit)
– CERAD scoring of neuritic plaques
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Thal scoring of amyloid
• Distribution of parenchymal deposits
• Stages: 1 – Neocortical 2 – Allocortex (hippocampus) 3 – Thalamus, striatum, NbM 4 – Brainstem 5 – Cerebellum
[Thal et al. Neurology. 2002; 58(12):1791-800]
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Assessment of amyloid
• Where is it? – Distribution across anatomic structures – Thal scoring of amyloid
• What does it do to the surrounding brain? – Presence of neuritic plaques (abnormal
neuronal processes around the amyloid deposit)
– CERAD scoring of neuritic plaques
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Silver stain
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AD: CERAD
• Neuritic plaques • Frontal, temporal and parietal cortex • Assess on WORST area • Reporting:
Absent Sparse Moderate Frequent
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Alzheimer disease
• Plaques – Extracellular deposits of Aβ (40-42 amino
acid peptide cleaved from a larger protein) – Genetic evidence links Aβ to AD
• Tangles – Deposits of hyperphosphorylated tau
(microtubule binding protein) – Genetic evidence links tau to FTLD
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Silver stain
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tau
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AD: Braak & Braak
• Developed as a staging scheme
• Assumption: lesion develop in a stereotyped order across anatomic sites
[Braak & Braak 1991. Acta Neuropathol. 82:239]
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AD: Braak & Braak • Stages I-II: “transentorhinal” disease
– No cases had clinical diagnosis of dementia
• Stages III-IV: “limbic” disease – 5 of 10 Stage III cases and 5 of 10 Stage
IV cases had clinical diagnosis of dementia
• Stages V-VI: “isocortical” disease – All cases had clinical diagnosis of
dementia
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2012 NIA-Alzheimer Association
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2012 NIA-Alzheimer Association
• Any plaques (± tangles) implies “Alzheimer disease neuropathologic changes” [ADNC]
• Report an “ABC” score – A is for Amyloid (Thal) – B is for Braak – C is for CERAD
• Use population-based observations to suggest likelihood of cognitive impairment
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2012 NIA-Alzheimer Association
Based on Thal staging 0 - - - - - - 0 1 - - - - 1 or 2 2 - - - - - - 3 3 - - - - 4 or 5
Based on Braak staging 0 - - - - - 0 1 - - - - I or II 2 - - - III or IV 3 - - - V or VI
Based on CERAD score 0 - - - - None 1 - - - - Sparse 2 - - Moderate 3 - - - Frequent
A B C
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2012 NIA-Alzheimer Association
Low
A D N e u r o p a th o l o g i c C h a n g e B
A C 0 or 1 2 3 0 0 Not Not Not
1 0 or 1 Low Low Low
2 or 3 Low I n te r m e d i a te I n te r m e d i a te 2 An y C Low I n te r m e d i a te I n te r m e d i a te
3 0 or 1 Low I n te r m e d i a te I n te r m e d i a te 2 or 3 I n te r m e d i a te High
Low
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Alzheimer disease reporting
• Alzheimer disease neuropathologic changes [ADNC] – Thal score for amyloid – Braak & Braak stage of tangles – CERAD score for neuritic plaques – ABC score, with interpretation of likelihood
of cognitive impairment
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Dementia with Lewy Bodies (DLB) • Pathologic features:
– Lewy bodies (absolute requirement) – Lewy neurites – Appropriate neuronal loss in brain stem
(SN, LC) – Spongiform changes, especially in upper
layers of entorhinal cortex [common not required]
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Braak staging of LB pathology
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Dementia with Lewy Bodies (DLB) Newcastle criteria
Score LB per gyrus0 01 1-52 >5
Ent Cin Tem Fr Pa TotalBrainstem 0-1 0-1 0 0 0 0-2Limbic 1-2 1-2 0-1 0-1 0 3-6Neocortical 2 2 1-2 1-2 1-2 7-10
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2012 NIA-Alzheimer Association Reporting LB changes
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Frontotemporal lobar degenerations (FTLD)
• Degenerations not dementias • Basis for classification:
– Distribution of lobar atrophy – Type of inclusions – Pattern of clinical symptoms
• bvFTD vs PPA (including subtypes)
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FTLD
• Severe cortical neuronal loss and gliosis (basis for gross atrophy)
• Microscopic changes mirror the grossly evident atrophy
But… • Microscopic changes commonly exceed
the gross changes
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FTLD -- inclusions
• Basis for neuropathologic classification • Least specific marker: ubiquitin • Two dominant more specific markers:
– Tau – TDP-43
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FTLD-tau
• Mutations in MAPT gene for tau (chromosome 17) are causative – BUT many cases are sporadic
• Mutations can be coding region or change in splicing
• Most inclusions are mixtures of 3R & 4R tau, except for Pick bodies (just 3R tau)
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FTLD-tau
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FTLD-tau/Pick Disease
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FTLD-TDP (TDP-43)
• RNA-binding protein (many RNA targets) • Normal: Nuclear localization • Disease: Aggregates and relocates to
cytoplasm (Neuronal cytoplasmic inclusions); intra-nuclear aggregates (Neuronal intra-nuclear inclusions)
• Aggregates can also occur in neurites (dystrophic neurites)
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FTLD-TDP
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FTLD-TDP
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FTLD-TDP
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TDP-43 associated diseases • Sporadic and genetic FTLD-TDP exist
– TDP-43 gene – C9orf72 – Progranulin – Valosin-Containing Protein (VCP)
• Relationship with ALS: – Clinical and familial (C9orf72>>TDP-43) – Shared patterns of inclusions (distinct from
ALS with SOD1 mutations)
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Patterns of FTLD-TPD Type Inclusions Phenotype Genetics
A Many NCI Short DN Layer 2 burden
bvFTD PNFA
GRN mutations
B Some NCI Rare DN All layers
bvFTD FTD with MND
C Rare NCI Many long DN Layer 2 burden
SD bvFTD
D Many NII Short DN All layers
IBMPFTD VCP mutations
NCI: Neuronal cytoplasmic inclusions; DN: dystrophic neurites; NII: Neuronal intra-nuclear inclusions
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FTLD Reporting
• If tau containing inclusions: – FTLD-tau
• Pick disease (3R tau, round inclusions) – Specify mutation status, if known
(MAPT)
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FTLD Reporting
• If TDP-43 containing inclusions: – FTLD-TDP
• Specify subtype • Specify mutation status, if known
– TDP-43 – Progranulin – C9ORF72 hexanucleotide repeat expansion
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FTLD Reporting
• If ubiquitin-positive, tau-negative, TDP-43-negative containing inclusions: – FTLD-other – Specify mutation status, if known
• Range of rarer loci
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Cerebrovascular disease
• Large vessel diseases – Atherosclerosis – “Strategic” infarction
• Small vessel diseases – Arteriolar sclerosis (hypertension) – Leukoariosis (white matter changes) – Microinfarcts – Cerebral amyloid angiopathy
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Clinicopathologic correlation • Presence of one neuropathologic
disease is not ‘protective’ for other diseases
• Dementia is commonly associated with evidence of multiple neuropathologic processes
• Impossible to assign “blame”
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Interaction of infarct and AD
Snowdon, et al. (1997) JAMA 277:813-817
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Adjusted for age-at-death, sex, education, large infarcts, AD and LB
Arvanitakis, et al (2001) Stroke 42: 722–727
Impact of microinfarcts
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[Courtesy of Dennis Dickson, Mayo Clinic Jacksonville]
1242 cases with neuropathologically diagnosed AD
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Diseases to be discussed
• Alzheimer disease
• Lewy body diseases
• Frontotemporal lobar degenerations
• Cerebrovascular diseases