Matt Wiener

24 November 2014

(a small part of) Analytics & Modeling at MSD

We are here for one reason…

Prescription Pharmaceuticals & Vaccines Animal Health

To discover, develop and provide innovative products and services that save

and improve lives around the world.

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Our History of Innovation

• Antibiotics

• Cardio-vascular

• Vaccines • Diabetes

• HIV

• Oncology

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New Facility in Smíchov – Riverview(moving in February 2015)

• 10 people in January 2014• 170 people today (November 2014)• Expected ~450 by December 2015

Modeling and Simulation

Exploration of Knowledge

Gaps

Portable, integrated form of knowledge

EnhancedUnderstanding

Ideas & Scientific Knowledge

Clearly Defined Assumptions

Data

Predictions vs. Observations

Enhanced Decision Making

MODELING

Integrated, mathematical representation of all inputs

INPUTSOUTPUTS

Internal, Regulators, Payers, Physicians, and Patients

Mathematics & statistics, modeling & data analysis contribute at all phases of drug discovery & development

• Research & Development

• Manufacturing

• Demonstrating value to patients & payers

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Modeling based on data from small experiments shows: No dose provides safety and efficacy

Based on 5000 simulations at each concentration

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1.0

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EfficacySafety

Re

lativ

e R

isk

to S

OC

Median Drug Concentrations NME Cmin (ng/mL)

Displacement

Computational estimate of

bone strength

High resolution

image

Using Validated FEA

procedure

p < 0.01p < 0.05

Finite Element Analysis of Radius Images Demonstrates Increased Bone Strength based on a treatment

FE-Estimated Peak Load increased 27% for new treatment, 7% for SOC, and unchanged for VEH after 18 months of treatment

Cabal et al. 2011, 3rd Joint ECTS-IBMR Meeting

0 12 18Month

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Est

imat

ed fa

ilure

load

(N

)

(HR-pQCT ultradistal radius) FEA estimated compression failure loadModel means and relative standard errors

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5

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perc

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chan

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rom

est

imat

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Validation of FEA strength estimates with ex vivo

mechanical testing

y = 1.20x - 5.24

R2 = 0.90

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Peak Stress (MPa) - Ex-Vivo FEA

Pea

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tres

s (M

Pa

) -

Exp

eri

me

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Optimization Models

Modeling & Optimization of Filling for a vaccine

Maximize! Extra doses

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Potency

BSA

pH

Dilution

Can usage

Bulk blend

Cans/fill

Batch size

Mixed Integer LP

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Enabled >3.6 Million additional men & women to be vaccinated (mid-2013)

Enabled >1.2 Million additional children to be vaccinated (mid-2013)

Additional Revenue generated: $561.3 MM

(mid-2013)

What we’d love to have.......

... What we usually experience!

Using a model, we can estimate the effectiveness (& cost-effectiveness) of vaccination programs

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Based on a differential equations model of transmission and disease

Automated image analysis can substantially reduce variability(compared to manual analysis)

Manual Segmentation Automated Segmentation

Recruitment process

• Link msd.cz/kariera – list of currect positions, you can choose the position and submit your CV there

(There is also a folder graduates – submit CV)

Process:

1. Phone prescreen – 15 minutes• Co studujete, kdy ukončíte, od kdy můžete začít• O co máte zájem• Jaké projekty máte za sebou, případná praxe• Test úrovně angličtiny - rozhovor v průběhu přejde do angličtiny

2. Assesment centrum

3. Technical interviews