MassTrak Solutions for Clinical and Forensic LaboratoriesMasstrak solutions for clinical and...

MassTrak Solutions for

Clinical and Forensic Laboratories

[ ]2

Masstrak solutions for clinical and forensic l aboratories

Waters Corporation has more than

50-years experience creating

business advantages for laboratory-

dependent organizations by delivering

practical and sustainable solutions in

areas such as healthcare delivery,

environmental management,

food safety, and water quality.

[ ]3

Working with clinical and forensic laboratories around the world, we have pioneered an integrated portfolio of MassTrak™

Solutions that include separations science, mass spectrometry, consumables, laboratory information management soft-

ware, services and support. This comprehensive approach helps optimize your laboratory processes and minimize the risks

associated with your assays.

MassTrak Solutions bring the power of Waters technologies, including tandem mass spectrometry, in easy-to-use cost-

effective packages addressing therapeutic drug monitoring, endocrinology, toxicology and many other applications.

Waters innovations and laboratory solutions provide better accuracy and precision for your assays ensuring the highest

quality results available, are backed by Waters application scientists and supported worldwide by field application experts.

We are committed to helping your laboratory deliver the highest quality results with new levels of sample throughput,

shortened turnaround times as well as increases in sensitivity, specificity and flexibility.

ForenSiC T oxiCoLogy neWBorn SCreeningAMino ACid AnALy SiS

T Her APeU TiC drUg MoniT oringendoCrinoLogy


[ ]4

Masstrak solutions for clinical and forensic l aboratoriesMasstrak solutions set new standards for diaGnostic and research applications

Many of the assays performed in diagnostic and research laboratories involve the

identification and quantification of chemical species in complex biological matrices.

Today’s chemists demand more accurate and cost-effective analytical tools that can

be easily integrated into current laboratory practices.

LC/MS/MS and other chromatographic detectors are ideally suited to many

applications as the selectivity of the technique enables individual analytes to be

quantified confidently. MassTrak Solutions integrate chromatography, consumables,

mass spectrometry, software and support services for diagnostic and research

laboratories worldwide. Single-vendor support is also available through the Waters

dedicated Clinical teams.

Wat ers Masst rak syst eMs

MassTrak Systems incorporating ACQUITY UPLC® coupled with the ACQUITY TQ

Detector or Xevo™ TQ mass spectrometers raise the performance bar for diagnostic

and research analysis. These innovative benchtop instruments optimize your laboratory

workflow from setup to on-going analytical performance, providing ultimate sensitivity

and speed of analysis while eliminating significant time and cost per sample.

T he new MassTrak Amino Acid Analysis Solution expands Waters solid history in

the field of amino acid analysis by providing to clinical research scientists a total

integrated solution for full profile amino acid analysis from urine and plasma.

Waters innovative technology and solutions provide your laboratory an enduring

platform for quality results and optimized laboratory operations.

Proven Methods

Reduce your development and validation effort with

proven methods developed and rigorously tested by

Waters application scientists.

Global Application Expertise and Support

W herever your laboratory is, we have application experts

ready to support your application and laboratory work.

Fast Speed of Analysis

Enables high sample throughput and rapid turnaround

of time sensitive samples.

For DIAGNoSTIC AND reSeArCh lAborATorIeS, MASSTrAk SySTeMS provIDe:

Improved Specificity

Eliminates cross reactivity problems, resulting in excellent

identification and quantification of target compounds.

Increased Sensitivity

Give reliable results at low ng/mL levels,

especially important for emerging drug

therapies and endocrine applications.

Enhanced Flexibility

Provides the capability to screen and

quantify a wide range of target analytes using

the same system.


[ ]5

Masstrak solutions set new standards for diaGnostic and research applications

Tacrolimus

Sirolimus

Everolimus

Cyclosporin A

Clinical Biomarkers

Homocysteine

Methylmalonic Acid

25 OH Vitamin D

Steroid Analysis

Catecholamines and Metanephrines

Amphetamines

Opiates

Benzodiazepines

Cannabis and Metabolites

Psychotherapeutics

Inborn Errors of Metabolism

ap plicat ions include:

[ WAT erS ISN’T JUST

My INST rUMeNT

provIDer. They’re My

SCIeNTIFIC pArTNer. ]

ACQUITY UPLC TQD SYSTEM

John Engen, Ph.D.Associate Professor,

Chemistry & Chemical Biology,Northeastern University

Masstrak solutions for clinical and forensic l aboratoriesMasstrak solutions for therapeutic druG MonitorinG (tdM)

Precision

Linearity

Method Comparison

Recovery

Interference

Dilution

Accuracy

Reagent Stability

Patient Specimen Stability

Column Robustness

The Waters method for Tacrolimus has been in routine use worldwide

for several years and has proven to be very robust and reproducible.

An immunosuppressants reagent kit is available to further facilitate

laboratory implementation and ensure reliable results. The MassTrak

Immunosuppressants Reagent Kit is 510(k) cleared and CE marked to

the IVD Directive for the quantification of Tacrolimus in whole blood for

kidney and liver transplant patients as an aid in the management of

Tacrolimus therapy. The reagent kit has been extensively tested against

key criteria in three different laboratories, this degree of testing means

that you can rely on reproducible and accurate results in your laboratory.

These criteria include:

0.6 0.7 0.8 0.9 1 1.1 1.2 1.3 1.4 1.5 min

%

0

100Ascomycin

%

0

100Tacrolimus

Chromatogram illustrating the a 3 ng/mL tacrolimus concentration acquired on an Alliance/Quattro micro system.

LC/MS/MS is now widely used for the therapeutic drug monitoring of

immunosuppressive drugs in routine clinical laboratories around the

world. The increased specificity of LC/MS/MS enables the measurement

of immunosuppressive drugs with much improved precision and accuracy

when compared with the traditional immunoassay methods. This is of

particular benefit when the concentration of immunosuppressive

drugs is in the low ng/ml range, for example when they are used in

combination therapy. In high throughput laboratories LC/MS/MS

has also proved to be a cost effective alternative to immunoassay

based methods.

The challenges facing laboratories wishing to implement LC/MS/MS

for therapeutic drug monitoring can include a lack of laboratory staff

to develop, support or implement LC/MS methods, access to reliable

calibrators, QCs and Internal Standards, application and services

support. Waters has addressed these key challenges by supplying the

total system, methodology and consumables such as LC columns and

reagents for the quantification of Tacrolimus.

adVantaGes oF Masstrak clinical solutions For tHerapeutic druG MonitorinG

Cost Effective — low consumable and operating costs

Fast Analysis — less than two minute run times for high through put capability.

Excellent Specificity of LC/MS/MS — offers good accuracy and precision.

Small Instrument Footprint — requires minimal bench space allowing you to optimize expensive lab bench space.

Unmatched Sensitivity — enables reliable measurement at low nanogram/mL levels

ADvANTAGeS oF MASSTrAk ClINICAl SolUTIoNS For TherApeUTIC DrUG MoNITorING:

[ ]6

[ ]7


Masst rak iMMunosup pressant X e ruo kit proVides:

Consistent quality of calibration materials and internal standards enabling

repeatable, accurate results.

Total system including LC/MS/MS, methodology and reagents

are supplied and supported by Waters.

Savings on Immunoassay reagent costs can lead to instrument payback in less than 2 years.

Fast analysis < 2 minutes using ACQUITY UPLC TQD enables 30 samples to be analyzed per hour.

The results below were obtained using the MassTrak Immunosuppressants XE RUO Kit (part number 176001673).

The MassTrak Immunosuppressant XE RUO Kit eliminates your worries about sourcing reliable quality control (QC) materials, calibrators and

internal standards. The Kit includes a column, QC standards and calibrators specifically designed for use with ACQUITY UPLC TQD to ensure

reliable analyses. The results below were obtained using the MassTrak Immunosuppressants XE RUO Kit (part number 176001673). This is the

first commercially available kit from Waters to contain isotopically labelled internal standards for Everolimus and Cyclosporin A.

[ ]7

MassTrak Immunosuppressants XE RUO Kit

compound Mean (ng/ml) combined sd combined cV

Cyclosporin A48.0 1.76 3.7

392.9 23.10 5.9

713.9 27.94 3.9

Everolimus2.1 0.15 7.5

12.0 0.73 6.1

20.1 1.27 6.3

Sirolimus2.6 0.20 8.0

12.3 1.11 9.0

20.6 1.61 7.8

Tacrolimus2.8 0.16 6.0

11.8 0.35 3.0

21.5 0.46 2.2

Compound name: TacrolimusCorrelation coefficient: r = 0.998680, r2 = 0.997361Calibration curve: 0.0612355 * x + 0.00363735Response type: Internal Std ( Ref 1 ), Area * ( IS Conc. / IS Area )Curve type: Linear, Origin: Exclude, Weighting: 1/x, Axis trans: None

0 5 10 15 20 min

Resp

onse

0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

0.0 5.0 10.0 15.0 20.0 25.0 30.0 ng/mL

Resp

onse

0

0.25

0.50

0.75

1.00

1.25

1.50

1.75

2.00

Compound name: EverolimusCorrelation coefficient: r = 0.999706, r2 = 0.999413Calibration curve: 0.064383 * x + 0.0203155Response type: Internal Std ( Ref 1 ), Area * ( IS Conc. / IS Area )Curve type: Linear, Origin: Exclude, Weighting: 1/x, Axis trans: None

Chromatograms representing Everolimus (upper trace) signal responses for the lowest calibrator (1.4 ng/mL) and the corresponding internal standard (lower trace).

Calibration curve for Tacrolimus (X) overlaid with the Tacrolimus QC (◊) results.

Calibration curve for Everolimus (X) overlaid with the Everolimus (◊) results.

0.6 0.7 0.8 0.9 1.0 1.1 1.2 1.3 1.4 min0

3.0e4

0

2.5e3

Internal Standard

Quanti�er

Masstrak solutions for research applications

T he following results were obtained using the MassTrak Immunosuppressant XE RUO Kit

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

Intra-day and Inter-day imprecision results from the analysis of external control materials.

Masstrak aMino acid analysis (aaa) solutions

[ ]8

ensures the highest quality of data is obtained in your laboratory with both ease and consistency. High resolution separations are achieved

using pre-qualified MassTrak AAA UPLC columns and mobile phases that lead to dependable chromatography for both quantitative and

qualitative facets of amino acid analysis.

By offering the highest level of control over the common variables in amino acid analysis, optimized methods and quality controlled

chemistries functioning in combination with preeminent ACQUITY UPLC technology, the MassTrak AAA

Solution provides a detailed approach to the successful analysis of every sample.

total analyt ical solut ion

T he MassTrak Amino Acid Analysis Solution represents

seamless integration of the ACQUITY UPLC technology

with innovative derivatization chemistry, consumables

and software. This total system approach to amino acid

analysis ensures that all of the necessary instrumentation,

chemistries and pre-optimized methods are delivered

simultaneously to provide an easy to use system with a

rapid start-up in your laboratory.

Amino acid analysis (AAA) from urine and plasma samples presents some unique challenges in the clinical research laboratory. Faced with the

need to report accurate results for 40 or more analytes with absolute clarity and confidence in a timely manner, amino acid analysis places

weighty demands upon any laboratory.

The need for a comprehensive AAA methodology that overcomes many of the limitations of conventional ion-exchange methods, such as long

run times, is clear. By design, the MassTrak AAA Solution encompasses each stage of the implementation providing a revolutionary approach to

amino acid analysis and the reporting of first-class quality data backed by consummate support - all from Waters. Placing a strong emphasis on

traditionally labor-intensive areas of amino acid analysis such as data processing, the MassTrak AAA Solution provides a comprehensive approach

to dependable amino acid profiles faster than ever before.

Masst rak aaa solut ion k its

MassTrak AAA Solution delivers a complete package of consumables, reagents and standards required for amino acid analysis. Providing sufficient

supplies for the analysis of more than 250 samples, each MassTrak AAA Solution Kit has been designed to deliver consistent performance with

unmatched convenience and ease of use.

Integrating pre-defined analytical methodologies with a fully-tested set of reagents, columns, vials and eluents, the MassTrak AAA Solution

MassTrak Amino Acid Analysis Solutions for the analysis of amino acids in physiological fluids.


ap plicat ion speciF ic installat ion, t raininG and QualiF icat ion

T he implementation of new equipment or analyses has often been

a time-consuming and frustrating process. Understanding the

needs of your laboratory to begin generating data of the highest

quality in as short a time as possible, the MassTrak AAA Solution

incorporates dedicated installation and training services from

Waters-certified MassTrak AAA Solution experts - but the support

doesn’t stop there. Continued highly skilled technical support

from Waters combined with application specific performance tests

guarantee optimized application and instrument performance for

the lifetime of your equipment.

[ ]9

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-0.02

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0.06

0.08

0.10

0.12

0.14

0.16

0.18

0.20

4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 min

Full panel amino acid analysis complete inless than 35 minutes

Full panel amino acidanalysis complete inless than 35 minutes

Near baseline resolution ofisoleucine & allo-isoleucineNear baseline resolution ofisoleucine & allo-isoleucine

Derivatization by-productsare baseline resolved

Derivatization by-productsare baseline resolved

The combination of Waters award winning ACQUITY UPLC technology and market leading AccQ•Tag™ pre-column derivatization chemistry provides the robustness, reliability and ease of use required for trouble-free operation in your research laboratory.


Fast er tHan eV er BeFore

The MassTrak AAA Solution provides full profile amino acid analysis

faster than conventional methods. Separation of the 42 commonly

encountered physiological amino acids is provided in a little under

32 minutes with an inject-to-inject time of just over 45 minutes. As

well as making obvious contributions to throughput in your laboratory,

the MassTrak AAA Solution offers swift analyses even from a standing

start for those urgent samples.


Over the last few years, there has been a significant increase in

interest using LC/MS/MS analysis of small molecules associated with

endocrine disorders. LC/MS/MS systems have been adopted in many

clinical laboratories world-wide for the routine analysis of endocrine

related compounds such as:

25OH Vitamin D

Testosterone

Cortisol

Plasma Free Metanephrines

Aldosterone

Steroid Panels

For many of these analyses LC/MS/MS has been able to demonstrate

improved precision and accuracy when compared to commercially

available immunoassay methods, leading to improved clinical

decisions and consistent diagnosis.

0.25 0.5 0.75 1 1.25 1.5 1.75 2

%

0

100

MRM of 3 channels, ES+294.1 > 100.1

1.320e+006

Internal Standard0.05 ng/mL testosterone

Testosterone_d51.03

34944.20

%

0

100

MRM of 3 channels, ES+289.1 > 97.051.060e+004

Qualifier0.05 ng/mL testosterone

Testosterone1.04

279.06

%

0

100

MRM of 3 channels,ES+289.1 > 109.18.583e+003

Quantifier0.05 ng/mL testosterone

Testosterone1.04

227.37

Chromatogram illustrating a liquid-liquid extracted serum calibrator at 50 pg/mL (0.17 nM) on an ACQUITY UPLC and TQ detector system.

endocrinoloGy

[ ]10

0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 2.2 2.4 2.6 2.8 3 3.2 3.4 min

%

0

%

0

Cortisol

Androstenedione

17-OHP

100

100

Control

CAH Patient

Cortisol

Chromatograms to show the differences in the steroid profiles for a CAH patient and a control sample.


Scatter plot and Passing and Bablok fit.

neW Born sc reeninG

Tandem Mass Spectrometry is now established as the technique of

choice used for high throughput screening of inherited metabolic

disorders and as an aid to diagnosis of metabolic disorders in children

and adults. Over 5 million babies are currently being screened using

Waters LC/MS/MS systems.

Using tandem mass spectrometers, more than 30 metabolic disorders

can be detected from a single blood sample (taken within a week after

birth). Screening by LC/MS/MS can mean the difference between a

healthy life and one of severe disabilities or even death. In addition

to the obvious health benefits, system solutions can provide cost

benefits as early diagnosis can prevent costly health care in the

future. Prior to the use of LC/MS/MS, routine screening of newborns

was limited to three or five metabolic disorders – each requiring

a different test.

Waters has been involved in newborn screening since the mid

1990s. T he current ACQUITY UPLC TQD combination builds on

nearly 20 years of proven field experience and sets new standards

for performance, reliability and ease of use. T his solution is offered

in collaboration with Perkin Elmer.

NeoLynx browser enables easy interpretation of data.

Robust Analytical Methodology developed and validated by Waters Clinical Application Scientists.

Implementation and Support of LC/MS/MS assays on your site by Clinical Application Specialists.

Automated Sample pre-treatment protocols.

Fast Throughput without multiplexing.

Selectivity and Sensitivity enabling reliable measurement at low levels.

autoMat ed saMple preparat ion

To ensure accurate and reliable measurement, LC/MS/MS, assays for

endogenous compounds such as steroids, metanephrines and 25OH

Vitamin D, usually require sample pre-treatment steps prior to analysis.

To overcome laborious manual sample pre-treatment and potential er-

rors due to operator variablity, Waters has developed automated off-line

sample pre-treatment solutions to enable the successful implementation

in clinical laboratories optimizing work effectiveness.

[ ]11

Waters adVantaGe For endocrinoloGy applications:

Compound name: 25OHD3Correlation coefficient: r = 0.9996, r2 = 0.9993Calibration curve: 0.0286787 * x + 0.0166297Curve type: Linear, Origin: Exclude, Weighting: 1/x, Axis trans: None

0 20 40 60 80 100 120 140 160 180 200 220 ng/mL

Resp

onse

0

1

2

3

4

5

6

BRI [Total 25OHD] ng/mL

Wat

ers [

Tota

l 25O

HD] n

g/m

L

0

5

10

15

20

25

30

35

40

45

50

0 10 20 30 40 50

Identity

Passing & Bablok (I) fit(1.47 + 0.98x)

95% CI bands

Horse serum calibration curve for 25OHD3.

[ ]12


Traditionally, confirmation analysis of drugs of abuse was carried out by gas chromatography/mass spectrometry (GC/MS). However this can be

a time consuming and labor intensive procedure, as many drugs require derivatization and complex sample pre-treatment before they can be

analyzed by GC/MS. In addition, long GC run times limit sample throughput.

To address these challenges many laboratories are now employing LC/MS/MS systems to conduct their confirmatory analysis. At Waters, the

MassTrak Solutions approach minimizes your sample pre-treatment requirements and optimizes your laboratory throughput. The technique is

particularly useful for polar, non-volatile, thermally labile compounds which are difficult to analyze by gas chromatography-based techniques.

The introduction of UltraPerformance LC® has resulted in significant improvements for routine laboratory analysis. Methods are now faster, more

efficient in respect to resolution and ultimately more sensitive.

Some recent examples of our customer’s success with the implementation and routine use of UPLC, as highlighted by peer-reviewed

publication, include:

Sixty percent reduction in the analytical process for 8 drugs of abuse in a high throughput laboratory.

[ Ref: AACC Meeting Abstract, Washington, 2008; AIT Laboratories Inc.]

Identification of 130 analytes in a Doping Control Laboratory in less than 9 minutes.

[ Ref: J.Mass. Spectrom, 2008; 43: 980-992, John-Olof T hörngren et al.]

Masstrak systeMs for druGs of abuse analysis

[ ]13


adVantaGes oF Masstrak solutions For druG VeriFication and QuantiFication

[ ]13

1 1.5 2 2.5 3 3.5 4 4.5 5 min

%0

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%0

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%0

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%0

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%0

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%0

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%0

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%0

100 3 .51

3 .2 7

3 .2 6

3 .0 0

2.5 9

2 .4 4

1 .9 2

1 .89

1 1.5 2 2.5 3 3.5 4 4.5 5 min

%0

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%0

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%0

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%0

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1004 .8 1

4 .6 9

4 .5 7

4 .4 0

4 .2 2

4 .0 3

3 .8 9

3 .6 5

3 .5 6

IMIPRAMINE

PROTRIPTYLINE

DESIPRAMINE

PAROXETINE

DOXEPIN

CITALOPRAM

TRAZODONE

VENLAFAXINE

CLOMIPRAMINE

NORCLOMIPRAMINE

SERTRALINE

FLUOXETINE

TRIMIPRAMINE

NORFLUOXETINE

AMITRIPTYLINE

NORTRIPTYLINE

FLUVOXAMINE

Analyses without prior derivatization or complex sample

pre-treatment of Amphetamines, opiates, benzodiazepines,

GHB and many other drugs of abuse.

Higher sensitivity enabling volumne limited samples to

be used in addition to blood and urine. For example, using

UPLC/MS/MS, accurate quantification can be achieved from

as little as 50 microliters of oral fluid, benefitting the types

of analysis you can achieve.

Achieve quantification and verification of drugs of abuse in

a single LC run with a high degree of confidence.

Completed Application Notes that save you the time of

developing complex methods from basic principles, are

available for your review and immediate implementation at

www.waters.com/forensics

TargetLynx automatically flags out-of-range analytes.

TargetLynx™ allows you to monitor several qualifier transitions to confirm the presence of a specific drug. This application manager also includes a wide range of automatic validity checks, such as calculation of ion ratios and LC retention time tolerances, to provide confidence in reported results.

MRM chromatograms for 17 psychotherapeutic drugs in serum.

Analysis performed simultaneously by UPLC/MS/MS in 8 minutes.

ACQUITY Xevo TQ MS

Ref: Waters Application Note: 720002463

1 1.5 2 2.5 3 3.5 4 4.5 5 min

%0

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%0

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%0

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%0

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%0

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%0

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%0

100 3 .51

3 .2 7

3 .2 6

3 .0 0

2.5 9

2 .4 4

1 .9 2

1 .89

1 1.5 2 2.5 3 3.5 4 4.5 5 min

%0

100

%0

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%0

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%0

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%0

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%0

1004 .8 1

4 .6 9

4 .5 7

4 .4 0

4 .2 2

4 .0 3

3 .8 9

3 .6 5

3 .5 6

IMIPRAMINE

PROTRIPTYLINE

DESIPRAMINE

PAROXETINE

DOXEPIN

CITALOPRAM

TRAZODONE

VENLAFAXINE

CLOMIPRAMINE

NORCLOMIPRAMINE

SERTRALINE

FLUOXETINE

TRIMIPRAMINE

NORFLUOXETINE

AMITRIPTYLINE

NORTRIPTYLINE

FLUVOXAMINE

[ ]14

Masstrak serVice solutions for clinical and forensic laboratories

syst eMatic toXicoloGical analysis [sta] and tarGet ed MrM sc reeninG.

Waters has developed two separate and complementary approaches to accurately identify unknown compounds, leveraging LC/MS/MS technologies:

For Systematic Toxicological Analysis: ChromaLynx™, for forensic toxicology is a unique data processing software tool ensures you routinely perform

faster analysis and data interpretation. ChromaLynx automates the process of extracting mass spectra from complex chromatograms and searching

against library spectra. When combined with UPLC, this results in rapid chromatography (e.g., run times reduced from 30 minutes to 15 minutes).

A chromatogram that would usually require hours of manual data analysis can now be processed in minutes using ChromaLynx.

The ChromaLynx™ browser shows; (i) the total ion chromatogram (TIC); (ii) the list of proposed candidates; (iii) the spectral match for function 5 (cone voltage 65 V), of one of the proposed compound candidates (EDDP). The spectrum view window allows a direct visual comparison of the acquired spectral data with the library data. In this example an excellent average Match Factor was observed i.e., 924 out of a possible max. 1000.

Alternatively, if your analysis requires a more targeted screening approach, you can use MRM [Multiple Reaction Monitoring] to increase the

selectivity and sensitivity for unknown compound identification. The ACQUITY TQD system uses the same 15 minute chromatography as with

the STA method, and in combination with a dedicated library containing the most frequently encountered toxicological compounds, ensures rapid

and reliable results from sample injection to injection. The TargetLynx software ensures that comprehensive reports are generated instantly after

samples are analyzed. The capability to then confirm and quantify any identified compounds using the same UPLC/MS/MS System ensures you

maintain the optimal laboratory efficiency.*

Both MassTrak screening solutions, including their respective compound libraries, are available without requiring additional method development.

*A separate validated method is necessary for any drug confirmation and quantification.

[ AT The eND oF The DAy, The

TeChNoloGy hAve leD To IMproveD TUrN

For oUr ClIeNTS, AND ThAT IS WhAT

(i) Chromatogram TIC

(ii) Candidatelisting

(iii) Spectrum view

[ ]15

Masst rak serV ice solut ions For clinical and Forensic laBoratories

achieve Maximum uptime

A MassTrak Clinical Service Plan is a comprehensive system package designed

for the clinical laboratory where instrument uptime is critical. It is the highest

priority service plan offered by Waters. All services and support are delivered

by Waters worldwide Field Service Engineers and dedicated teams of Clinical

Specialists. Their job is to ensure your success.

The plan delivers performance maintenance and the reassurance of fast on-site support:

Ensure reliable operation and minimize unscheduled downtime

Get applications and system support from dedicated Waters Clinical Solutions Experts

Fix the cost of ownership for your mission critical instruments

Save up to 30% over time and material repair costs

Eliminate the administrative costs of processing future multiple purchase orders.

service when you need it

Guaranteed priority two-hour call back, seven days a week

Guaranteed on-site response time of two business days (48 hours)

Annual Performance Maintenance on-site visit

Waters certified field service engineers

Labor and travel for on-site repair

Genuine Waters Quality Parts®

Remote monitoring and diagnostics

Discount on hardware upgrades

Firmware updates

Discounts on customer training.

service plan

An annual Performance Maintenance

visit keeps your Waters MassTrak System

running at optimal performance. During the

visit, your Waters certified field service

engineer replaces normal wear-and-tear

maintenance parts based upon a proven

protocol developed specifically for your

system. The engineer also looks for signs

of wear, corrosion, and damage to key

parts so we can correct problems before

they impact your productivity.

[ AT The eND oF The DAy, The

TeChNoloGy hAve leD To IMproveD TUrN

For oUr ClIeNTS, AND ThAT IS WhAT Michael A. Evans, Ph.D.

CEO, AIT Laboratories

beNeFITS oF WATerS

AroUND TIMeS

MATTerS MoST. ]

© 2009 Waters Corporation. Waters, ChromaLynx, Quattro micro, Alliance,

MassTrak, MassLynx, Xevo TQ, TargetLynx, Waters Quality Parts, ACQUITY, ACQUITY

TQ, ACQUITY TQD, UPLC, AccQ•Tag, UltraPerformance LC, Empower, NeoLynx and

The Science of What’s Possible, are trademarks of Waters Corporation.

All other trademarks are the property of their respective owners

720001139EN NOVEMBER 2009 VW-FP

sales offices

Select MassTrak systems and kits are in vitro diagnostic devices compliant with EU directive 98/79/EC and the

United States Food and Drug Administrative Quality System Regulations and current Good Manufacturing Practices.

Waters Corporation is ISO 13485:2003 certified.

Photographs on Pages 4-5 (top) and Page 15 (left) reproduced with permission of AIT Laboratories.

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Australia 61 2 9933 1777

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MassTrak Solutions for Clinical and Forensic LaboratoriesMasstrak solutions for clinical and...

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