Mass Spec Results In Seconds With Direct Sample …€¢ Insecticide on Mosquito Nets ... •...
Transcript of Mass Spec Results In Seconds With Direct Sample …€¢ Insecticide on Mosquito Nets ... •...
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MASS SPEC RESULTSIN SECONDS WITHDIRECT SAMPLE ANALYSIS
AxION DSA System A Reference Notebook of DSA Applications—Second Edition, 2013
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2www.perkinelmer.com/DSA
REVOLUTIONIZE YOUR MASS SPECWORKFLOW Going from sample to results can often be complex
and time-consuming. That is why PerkinElmer has introduced a unique solution: the AxION® DSA (Direct
Sample Analysis) system. Nothing simplifies workflows more than AxION DSA. Diminish cumbersome method development, eliminate chromatography and dramatically reduce sample preparation.
RESULTS IN SECONDSThe innovative AxION DSA technology was developed for the rapid direct analysis of solid, liquid or gaseous samples. It offers a novel alternative to standard chromatographically interfaced solutions. Laboratories can now screen, compare and confirm virtually any sample, by introducing it directly to a mass spectrometer in a matter of seconds.
• No chromatography required.
• Avoid time consuming method development.
• Minimal sample preparation.
This reference notebook of direct sample analyses, highlights the performance characteristics of the AxION DSA. It features a diverse selection of applications, sample types and results across a broad array of industries.
The AxION DSA system will change the way you work by providing results-driven decisions in seconds.
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Index of Applications
• Atrazine in Water ................................................................................................................................................................22
• Carbamates in River Water ..................................................................................................................................................23
• Insecticide on Mosquito Nets ..............................................................................................................................................24
• Personal Care Products in River Water .................................................................................................................................25
ENVIRONMENTAL
• Bisphenol A in plastic ..........................................................................................................................................................26
• Ferulic Acid in Skin Oil .........................................................................................................................................................27
• Fullerene C-60 .....................................................................................................................................................................28
• Limonene in Orange Peel ....................................................................................................................................................29
• Methylparaben in Hair Gel ..................................................................................................................................................30
• Paraben Screening in Texture Cream ...................................................................................................................................31
• Parabens in Lipstick .............................................................................................................................................................32
• Parabens in Lotions .............................................................................................................................................................33
• Salicylic Acid in Foundation .................................................................................................................................................34
CHEMICAL
FOOD AND BEVERAGE• Caffeine in Decaffeinated Coffee ..........................................................................................................................................5
• Caffeine in Green Teas ..........................................................................................................................................................6
• Capsaicin and Dihydrocapsaicin in Peppers ...........................................................................................................................7
• Curcumins in Turmeric Powder ..............................................................................................................................................8
• DEHP in Mango Juice ............................................................................................................................................................9
• Fungicide on Apple Peel ......................................................................................................................................................10
• Fungicide on Lemon Peel .................................................................................................................................................... 11
• Fungicides on Oranges ........................................................................................................................................................ 12
• Malathion on Peaches ......................................................................................................................................................... 13
• Melatonin in Lazy Cake® .....................................................................................................................................................14
• Natural Vanilla Extract ......................................................................................................................................................... 15
• Olive Oil Adulteration ..........................................................................................................................................................16
• Pomegranate Juice Adulteration ......................................................................................................................................... 17
• Propanethiol S-oxide in Onions ...........................................................................................................................................18
• Resveratrol in Red Wine ......................................................................................................................................................19
• Sterols in Olive Oil ...............................................................................................................................................................20
• Sweeteners in Diet Cola ......................................................................................................................................................21
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Index of Applications
• Components of Multivitamin Powder .................................................................................................................................. 41
• Aerosols/Inalers ...................................................................................................................................................... 42
• Components of Panadol® Extra ............................................................................................................................... 43
• Components of Panadol® Sinus Max ........................................................................................................................44
• Paracetamol Tablets ................................................................................................................................................ 45
NUTRACEUTICAL
PHARMACEUTICAL
FORENSICS• Cathinones in Bath Salts .....................................................................................................................................................35
• CID of Cathinone Standards ................................................................................................................................................36
• Date Rape Drug in Cola .......................................................................................................................................................37
• Ethyl Centralite ....................................................................................................................................................................38
• Nitroglycerin .......................................................................................................................................................................39
• Testosterone in Steroid Powder ...........................................................................................................................................40
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TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Product integrity
No chromatography
• Caffeineisanaturalstimulantinteaandcoffee
• Decaffeinatedcoffeeofferspeoplethechoicetoavoidcaffeineorreducetheircaffeineintake
• DSA/TOFanalysisofdecaffeinatedcoffeeconfirmedcaffeinewasstillpresentwithhighaccuratemass
• Analysiswasperformedin15seconds;confirmedproductcontaminationwithnosamplepreparationandexternalcalibration
Food and Beverage: Caffeine in Decaffeinated Coffee
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TOF MS
DIRECT SAMPLE ANALYSIS
Rapid analysis
Comparison of products
No method development
Food and Beverage: Caffeine in Green Teas
• Caffeineisanaturalstimulantenjoyedbymanyinteaandcoffee
• RapidscreeningofdifferentgreenteasbyDSA/TOFenableseasyproductcomparisons
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Easy to use
Semi-quantitative
• Capsaicinanddihydrocapsaicinarethecompoundsresponsibleforpepperhotness
• 1cm3piecesofcubanelle,chilli,andjalapeñopeppersweredirectlyanalyzed
• Thesignalintensitiesprovidedtherelativeamountsofcapsaicinanddihydrocapsaicininthepeppers
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Capsaicin and Dihydrocapsaicin in Peppers
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TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Easy to use
Complete characterization
• Curcuminsaretheactiveingredientinturmericpowderusedforfoodflavoring,dyeing,andpossiblemedicalbenefits
• Turmericpowderwasdirectlyanalyzedinaglasscapillary
• DSA/TOFanalysisofturmericpowderdetectsall3curcuminoidswithhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Curcumins in Turmeric Powder
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TOF MS
DIRECT SAMPLE ANALYSIS
Food and Beverage: DEHP in Mango Juice
Results in seconds
No method development
Assures food safety
• Bis-(2-Ethylhexyl)Phthalate(DEHP),bannedbytheEU,hasbeenusedasacheaperalternativecloudingagenttoimprovetheappearanceoffruitjuice
• DEHPhasbeenaddedillegallytoexoticfruitjuices,suchasmangoandpassionfruit.Themaximumallowablelimitforphthalatesinfruitjuiceis1ppm
• PresenceofDEHPat1ppmwasconfirmedin15secondswithnosamplepreparation,chromatographyorexternalcalibration
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10www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Fast accurate mass
Assures food safety
• Thiabendazoleisacommoningredientinthewaxesappliedtotheskinsofcitrusfruitsandisalsoafungicideusedtoprotectharvestyields
• ResidualthiabendazolewasconfirmedusingDSA/TOFwithhighmassaccuracy
• Analysisperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Fungicide on Apple Peel
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11www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Outstanding sensitivity
Fast accurate mass
Assures food safety
• Pesticidessuchasimazalilareoftenusedtoprotectfruitsandvegetablesfrominsects
• Awashed1cm3pieceoflemonpeelwasextractedwithmethanolandanalyzed
• Residualimazalilwasconfirmedwithhighmassaccuracy
• Analysiswasperformedin15secondswithminimalsamplepreparationandexternalcalibration
Food and Beverage: Fungicide on Lemon Peel
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TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Easy to use
Assures food safety
• Tracesoffungicidesonourfoodposeapotentialrisktohumanhealth
• Swabbingwithmethanolfromanorangeboughtatagrocerystorewasanalyzed
• DSA/TOFanalysisdetectedthepresenceoftwofungicidesontheorangeskin
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Fungicides on Oranges
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TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Low detection limits
Fast, accurate mass
• Malathionisacommonlyusedinsecticide.TheEPAtolerancelevelformalathiononpeachesis8000ng/g
• Apeachsurfacewasspikedwith10ng/gmalathion,thenswabbedwithmethanolandanalyzed
• DSA/TOFanalysisoftheswabsampleconfirmedmalathion,withhighmassaccuracy,at800timeslowerthantheEPAtolerancelevel
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Malathion on Peaches
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TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Confirms active ingredient
Rapid analysis
• LazyCakes®,marketedas“relaxationbrownies”arelacedwiththesleepaidmelatonin
• Packagingiskid-friendlyandchildrenhaveeatenthemandfallenasleep
• Apieceofcakewasanalyzedtodeterminetheingredientthatwascausingsleepiness
• Directanalysisconfirmstheactiveingredientmelatoninwithhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Melatonin in Lazy Cake®
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DIRECT SAMPLE ANALYSISTOF MS
DIRECT SAMPLE ANALYSIS
Results in seconds
Easy to use
Assures product authenticity
Food and Beverage: Natural Vanilla Extract
• Thepriceofnaturalvanillaextractisupto5timesmoreexpensivethanartificialvanillaflavoring
• 4-hydroxbenzaldehydecanbeusedasamarkerionasitispresentinnaturalvanillaextractbutnotinartificialvanillaflavorings
• DSA/TOFanalysis,performedin15seconds,rapidlyconfirmsproductauthenticitywithnosamplepreparationandexternalcalibration
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16www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Results in seconds
No chromatography
Assures product authenticity
Food and Beverage: Olive Oil Adulteration
• Oliveoilisonethemostadulteratedfoodproductsinworld.Itis4-5timesmoreexpensivethansoybasedvegetableoil
• Ratiooflinoleicacidtooleicacidresponsecanbeusedasawaytodetectadulterationofoliveoil
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Adulterated Olive Oil with Soy Based Oil.
Olive Oil
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17www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Results in seconds
Low detection limits
Assures product authenticity
Food and Beverage: Pomegranate Juice Adulteration
• Pomegranatejuiceisapproximately5timesmoreexpensivethangrapejuice,acommonadulterant.
• Tartaricacid,presentingrapejuiceandabsentinpomegranatejuicecanbeusedasamarkertodetectadulterationofpomegranatejuice
• Successfulmeasurementoflevelsaslowas1%grapejuiceinpomegranatejuice
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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18www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Easy to use
Fast, accurate mass
• PropanethiolS-oxideinonionsisknowntocausetheeye’stotear(whencuttingtheonion)
• 1cm3pieceofonionwasdirectlyanalyzed
• Withnosamplepreparation,DSA/TOFanalysisoftheonionsampledetectedPropanethiolS-oxidewithhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Propanethiol S-oxide in Onions
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19www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Increased sensitivity
Rapid analysis
• Resveratrolisnaturallyoccurringpolyphenolpresentingrapeskinandseeds
• Itisanantioxidantthoughttobepresentinhigherlevelsinredwineandlinkedtomanyhealthbenefits
• DSA/TOFanalysisinTrapPulse™modeof1µLofredwine(onamesh)providestherequiredsensitivityfordetectionandconfirmationofresveratrol
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Resveratrol in Red Wine
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TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Comparison of products
Rapid analysis
• Somesterolsinoliveoilarethoughttodecreasebloodcholesterol
• Saponifiedoliveoilwasdirectlyanalyzedforsterols
• DSA/TOFanalysisdetectsthebeneficialsterolsinoliveoilwithminimalsamplepreparation
• Oliveoilscanrapidlybecomparedfordetectionofbeneficialsterols
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Sterols in Olive Oil
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21www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Component analysis
No sample preparation
• Artificialsweetenersareoftenusedindietcola
• Sweetenersindietcolawasdirectlyanalyzedwithoutanysamplepreparation
• DSA/TOFanalysisconfirmssweetenersusedindietcolaaswellasotheradditiveswithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Food and Beverage: Sweeteners in Diet Cola
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22www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Environmental: Atrazine in Water
Results in seconds
Increased sensitivity
Confirms water safety
• Thepesticideatrazineisacontaminantofsurfaceanddrinkingwater
• Themaximumlevelofatrazineinwaterhasbeensetas0.003mg/L
• UseofTrapPulse™modeincreasessensitivity8foldandgivesgreatermassaccuracy
• DSA/TOFanalysisof2µLofwateronameshconfirmspresenceofatrazinewithamassaccuracy<1ppm
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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23www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Environmental: Carbamates in River Water
No complex method development
Fast, accurate mass
Ensures water quality
• Carbamatesareknowncontaminantsofriverwater,EPAmaximumconcentrationof10ug/L
• ExistingprotocolsrequirelengthySPEworkupfollowedbyLC,LC/MSorGC/MSanalysis
• 10ppbspikedriversamplessimplyfilteredandpipettedontoamesh
• DSA/TOFanalysisconfirmspresenceofcarbamates,withhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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24www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Environmental: Insecticide on Mosquito Nets
Results in seconds
Assures product authenticity
Protects consumers
• DeltamethrinisaWHOapprovedinsecticidefortreatmentofmosquitonets
• Treatednetscommandahigherpricebutsomesuppliersomittheinsecticide
• ExistingprotocolsrequireextractionfollowedbyHPLCorGC/MSanalysis
• DSA/TOFanalysisofanetsectionconfirmspresenceofdeltamethrinattherequiredleveltobeeffective
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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25www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
No complex method development
Comprehensive analysis
Ensures water quality
• Personalcareproductsposearisingconcernasacontaminantinpostwatertreatmentriverwaters
• ExistingprotocolsrequirelengthySPEworkupfollowedbyLC,LC/MSorGC/MSanalysis
• 10ppbspikedriversamplessimplyfiltered,10mMammoniumformateadded,andpipettedontoamesh
• DSA/TOFanalysisconfirmspresenceofpersonalcareproductsandpesticides,withhighmassaccuracy
• Analysiswasperformedin15secondswithminimalsamplepreparationandexternalcalibration
Environmental: Personal Care Products in River Water
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26www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Chemical: Bisphenol A in Plastic
Easy-to-use
No sample prep or chromatography
Protects consumers
• BisphenolA(BPA)isusedalongwithothermaterialstomakeplastics.Itischaracterizedasanendocrinedisruptormimickingnaturalhormoneswhichhaselevatedsafetyconcernsaboutitleachingintoourfoodfromthepackagingandnegativelyimpactinghumanhealth.
• In2010,theFDAwarnedofthepossiblehazardtoyoungchildrenandBPAwasbannedfrombabybottles.
• DSA/TOFdirectanalysisofasectionofplasticbottleconfirmspresenceofBPAwithaccuratemass.
• Analysiswasperformedin30secondswithnosamplepreparationandexternalcalibration
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27www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Chemical: Ferulic Acid in Skin Oil
Rapid analysis
Protects customers
No sample prep or chromatography
• Ferulicacidisanantioxidantoftenaddedtoanti-agingskinproducts
• Cosmeticskinoilwasanalyzedtodetermineifferulicacidwaspresent
• DSA/TOFdirectanalysisofcosmeticskinoilconfirmsthepresenceofferulicacidwithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparation
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28www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
No chromatography
Fast accurate mass
Chemical: Fullerene C-60
• Buckminsterfullerenesareresearchedfortheirtechnologicalapplicationsinmaterialsscienceandnanotechnology.
• DSA/TOFanalysis,innegativemode,ofa1mg/mLfullereneC-60intoluene
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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29www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Compound confirmation
No sample preparation
• Limoneneisamoleculethatgivesorangestheirstrongsmellandisoftenusedincleaningproductsandaprecursorforchemicalsynthesis
• Samplepreparationandmethoddevelopmentforanalysisoflimoneneislengthyandtimeconsuming
• Limoneneismeasuredinorangepeelwithdirectanalysisandaccuratemassconfirmation
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Chemical: Limonene in Orange Peel
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TOF MS
DIRECT SAMPLE ANALYSIS
Chemical: Methylparaben in Hair Gel
Rapid, accurate results
Protects consumers
No sample prep or method development
• Parabensareaclassofchemicalsusedinpreservationofpersonalcareproductsandareimplicatedtonegativelyimpacthumanhealth
• Traditionalsamplepreparationandmethoddevelopmentofparabensistimeconsuming
• DSA/TOFdirectanalysisofpersonalcareproductsconfirmsthepresenceofmethylparabenwithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparation
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31www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Chemical: Paraben Screening in Texture Cream
Easy to use
Ensures product safety
No sample prep
• Parabensareaclassofchemicalsusedinpreservationofpersonalcareproductsandareimplicatedtonegativelyimpacthumanhealth
• Traditionalsamplepreparationandmethoddevelopmentofparabensistimeconsuming,approximately25minpersample
• DSA/TOFallowedforfastscreeningofparaben-freetexturecreamandconfirmedtheabsenceofparabenswithhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparation
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32www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
No chromatography
Protects consumers
• Parabensarewidelyusedinlipstickstoimproveshelflifebutlinkstobreasttumourshavebeenfound
• DSA/TOFdirectanalysisoflipstickinaglasscapillaryconfirmspresenceofparabenswithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Chemical: Parabens in Lipstick
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33www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Complete characterization
No sample preparation
• Parabensareaclassofchemicalsusedinpreservationofcosmetics
• Samplepreparationandmethoddevelopmentofparabensislengthyandtimeconsuming
• DSA/TOFdirectanalysisoflotionconfirmsparabensinlotionwithaccuratemass
• Analysiswasperformedin15secondswithminimalsamplepreparationandexternalcalibration
Chemical: Parabens in Lotions
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34www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Chemical: Salicylic Acid in Foundation
Results in seconds
Product integrity
No sample prep or chromatography
• Salicylicacidisacommoningredientinacnefightingpersonalcareproductsusedtohelpclearandpreventskinblemishes
• Liquidfoundationwasdirectlyanalyzedtodetermineifsalicylicacidwaspresent
• DSA/TOFdirectanalysisoffoundationconfirmsthepresenceofsalicylicacidwithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparation
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35www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Forensics: Cathinones in Bath Salts
Rapid analysis
Complete characterization
No sample prep
• Cathinonesarecommonlyfoundinstreetdrugs,suchasbathsalts
• Currently,nostandardmethodofanalysisexistsforcathinonesinbathsaltsamples
• DSA/TOFanalysisofbathsaltsconfirmedthepresenceofbutylone,α-PVP,α-MPPP,andMDPBPwithaccuratemassofparentandfragmentions
• Analysiswasperformedin15secondswithnosamplepreparation
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36www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Rapid analysis
Complete characterization
No method development or sample preparation
• Cathinonesarecommonlyfoundinstreetdrugs,suchasbathsalts
• Currently,nostandardmethodofanalysisisavailableforcathinones
• DSA/TOFanalysisofcathinonestandards,butylone,2-MDPV,mephedrone,andMDPBPresultedinexcellentmassaccuracyofparentandfragmentions
• Analysiswasperformedin15secondswithnosamplepreparation
Forensics: CID of Cathinone Standards
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37www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Low detection limits
Fast, accurate mass
• Theminimumlevelofthedaterapedrug,Gamma-HydroxyButyricAcid,whichaffectshumansis1mg/mL
• Acolasamplewasspikedwiththedrugat0.1mg/mL,10-foldlessthantheminimumdetectionlimit
• Withnosamplepreparation,DSA/TOFanalysisofthecolasampledetectedthedrugwithhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Forensics: Date Rape Drug in Cola
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38www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Results in seconds
No sample preparation
Non destructive
Forensics: Ethyl Centralite
• Residueanalysisonfabricisimportantforforensicanalysisofcrimescenes.Moderngunpowdersusenitrocelluloseandnitroglyercinasbasicingredients
• 2%Dichloromethyleneinmethanolwasinfusedat10µL/minandDSA/TOFwasruninpositivemode
• DSA/TOFanalysisonfabricidentifiedgunshotresiduebyconfirmationofethylcentralitewithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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39www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Forensics: Nitroglycerin
Results in seconds
No sample preparation
Non-destructive
• Gunshotresidueanalysisonfabricisimportantforforensicanalysisofcrimescenes.Moderngunpowdersusenitrocelluloseandnitroglyercinasbasicingredients.
• 2%Dichloromethyleneinmethanol(asadopant)wasinfusedat10µL/mintoionizenitroglycerinasachlorideadduct
• DSA/TOFanalysisonfabricidentifiedgunshotresiduebyconfirmationofnitroglyercinwithaccuratemass
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
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40www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Easy to use
Confirms compound identity
Fast, accurate mass
• Testosteroneisananabolicsteroidthatcanbeusedtoenhancephysicalperformanceinathletes
• Testosteronepowderwasdirectlyanalyzedinaglasscapillary
• Confirmationoftestosteronewasachievedinsecondswithhighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Forensics: Testosterone in Steroid Powder
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41www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
No sample preparation
Complete component analysis
Confirms product authenticity
• Emergen-C®isadietarysupplementdesignedtosupporthealthymetabolicfunction
• Analysisinbothpositiveandnegativemodesensurescompleteproductcharacterization
• DSA/TOFanalysisofEmergen-C®powderinaglasscapillarydetectscomponentswithahighmassaccuracy
Nutraceuticals: Components of Multivitamin Powder
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42www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
No method development
Fast accurate mass
Assures product safety
• Albuterolsulfateinhalationaerosolisintendedfororalinhalationasatreatmentforbronchospasm.Itcontainsamicrocrystallinesuspensionofalbuterolsulfateinapropellant,andnootherexcipients.
• TheactivecompoundwasmeasuredusingDSA/TOFwhichprovidedaccuratemassconfirmation
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Pharmaceutical: Aerosols/Inhalers
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43www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Results in seconds
No chromatography
Confirms product authenticity
• Panadol®Extratabletsaresolubletabletswithtwoactiveingredients,paracetamolandcaffeine,designedformildtomoderatepainrelief
• DSA/TOFanalysisofatabletdirectlydetectscomponentswithahighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Pharmaceutical: Components of Panadol® Extra
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44www.perkinelmer.com/DSA
Results in seconds
Complete component analysis
Confirms product authenticity
TOF MS
DIRECT SAMPLE ANALYSIS
• Panadol®SinusMaxisdesignedforfastandeffectivereliefofsinuscongestionandpressure
• DSA/TOFanalysisofatabletdirectlydetectscomponentswithahighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Pharmaceutical: Components of Panadol® Sinus Max
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45www.perkinelmer.com/DSA
TOF MS
DIRECT SAMPLE ANALYSIS
Results in seconds
No method development
Confirms product authenticity
• Paracetamolisawidelyusedoverthecounteranalgesicandantipyretic,commonlyusedforthereliefofminorachesandpains
• DSA/TOFanalysisofatabletdirectlydetectscomponentswithahighmassaccuracy
• Analysiswasperformedin15secondswithnosamplepreparationandexternalcalibration
Pharmaceutical: Paracetamol Tablets
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