Marginal zone (IgM + memory) B cells and IgA antibodies respond to gut microbial products
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Transcript of Marginal zone (IgM + memory) B cells and IgA antibodies respond to gut microbial products
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Antibody and B cell responses may control circulating lipopolysaccharide in
patients with HIV infection
Lim A1, Amini A1, D’Orsogna L2, Rajasuriar R3, Lewin S3,4, Purcell D5, Price P1, French MA1,2
1. School of Pathology and Laboratory Medicine, University of Western Australia 2. Department of Clinical Immunology, Royal Perth Hospital, Perth 3. Alfred Hospital, Melbourne 4. Monash University, Melbourne 5. Department of Microbiology and Immunology, University of Melbourne
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Marginal zone (IgM+
memory) B cells and IgA antibodies respond to gut microbial products
Cerutti A, Rescigno M. Immunity 2008; 28:740-50
Kraal G. Nature Immunol 2008; 9:11-12
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Plasma levels of LPS are inversely correlated with serum levels of antibodies to LPS in
ART-naïve HIV patients
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LPS-specific IgG antibodies correlate with IgM+
memory B cell counts in ART-naïve patients
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Better immune reconstitution on ART is associated with lower plasma LPS and serum
anti-LPS
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Summary• In ART-naïve patients:• Serum levels of IgG and IgA antibodies to LPS are
negatively correlated with plasma LPS levels• Serum levels of IgG anti-LPS are positively correlated
with circulating IgM+ memory B cell counts• Serum IgA levels are strongly correlated with serum
levels of IgA antibodies to LPS
• In ART-treated patients:• Better immune reconstitution (higher CD4+ T cell
and switched memory B cell counts) is associated with lower levels of LPS and antibodies to LPS
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Conclusions• Plasma LPS levels in ART-naive HIV patients
may be determined by immune responses against LPS, as well as by increased gut permeability
• High serum IgA levels in untreated HIV infection may reflect an IgA antibody response against LPS