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March 10, 2012
How today is planned
Endocrine OverviewDiabetic Case StudyEndocrine JeopardyGlucagon hands onSimulation Practice
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The Endocrine SystemPCP – March 10, 2012
Adapted from EMS ProfessionsTemple College
Photos.. Credited in photos
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Endocrine Glands
• Controls many body functions– exerts control by releasing special chemical substances
into the blood called hormones– Hormones affect other endocrine glands or body
systems
• Ductless glands• Secrete hormones directly into bloodstream
– Hormones are quickly distributed by bloodstream throughout the body
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Hormones
• Chemicals produced by endocrine glands• Act on target organs elsewhere in body• Control/coordinate widespread processes:
– Homeostasis– Reproduction– Growth & Development– Metabolism– Response to stress
• Overlaps with the Sympathetic Nervous System
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Hormones
• Hormones are classified as:– Proteins– Polypeptides (amino acid derivatives)– Lipids (fatty acid derivatives or steroids)
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Hormones
• Amount of hormone reaching target tissue directly correlates with concentration of hormone in blood.– Constant level hormones
• Thyroid hormones
– Variable level hormones• Epinephrine (adrenaline) release
– Cyclic level hormones• Reproductive hormones
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The Endocrine System• Consists of several glands located in various parts of
the body
• Specific Glands – How many and What?• What is the Master Gland?
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The Endocrine System• Specific Glands
– Hypothalamus– Pituitary– Thyroid– Parathyroid– Adrenal– Pancreatic Islets– Ovaries– Testes
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Pituitary Gland
• Small gland located on stalk hanging from base of brain - AKA
• “The Master Gland” – Primary function is to control other glands.– Produces many hormones.– Secretion is controlled by hypothalamus in base of brain.
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Pituitary Gland• Two areas
– Anterior Pituitary– Posterior Pituitary
• Structurally, functionally different
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Pituitary Gland
• Anterior Pituitary– Thyroid-Stimulating Hormone (TSH)
• stimulates release of hormones from Thyroid– thyroxine (T4) and triiodothyronine (T3): stimulate
metabolism of all cells– calcitonin: lowers the amount of calcium in the blood by
inhibiting breakdown of bone
• released when stimulated by TSH or cold• abnormal conditions
– hyperthyroidism: too much TSH release– hypothyroidism: too little TSH release
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Pituitary Gland
• Anterior Pituitary– Growth Hormone (GH)
• stimulates growth of all organs and increases blood glucose concentration
– decreases glucose usage– increases consumption of fats as an energy source
– Adreno-Corticotrophic Hormone (ACTH)• stimulates the release of adrenal cortex hormones
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Pituitary Gland
• Anterior Pituitary– Follicle Stimulating Hormone (FSH)
• females - stimulates maturation of ova; release of estrogen
• males - stimulates testes to grow; produce sperm– Luteinizing Hormone (LH)
• females - stimulates ovulation; growth of corpus luteum
• males - stimulates testes to secrete testosterone
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Pituitary Gland
• Anterior Pituitary– Prolactin
• stimulates breast development during pregnancy; milk production after delivery
– Melanocyte Stimulating Hormone (MSH)• stimulates synthesis, dispersion of melanin pigment
in skin
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Pituitary Gland
• Posterior Pituitary– Stores, releases two hormones produced in
hypothalamus• Antidiuretic hormone (ADH)• Oxytocin
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Pituitary Gland
• Posterior Pituitary– Antidiuretic hormone (ADH)
• Stimulates water retention by kidneys– reabsorb sodium and water
• Abnormal conditions– Undersecretion: diabetes insipidus (“water diabetes”)– Oversecretion: Syndrome of Inappropriate Antidiuretic
Hormone (SIADH)
– Oxytocin• Stimulates contraction of uterus at end of pregnancy
(Pitocin®); release of milk from breast
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Hypothalamus• Produces several releasing and inhibiting factors
that stimulate or inhibit anterior pituitary’s secretion of hormones.
• Produces hormones that are stored in and released from posterior pituitary
What are these two hormones?
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Hypothalamus• Also responsible for:
– Regulation of water balance– Esophageal swallowing– Body temperature regulation (shivering)– Food/water intake (appetite)– Sleep-wake cycle– Autonomic functions
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Pineal Gland• Located within the Diencephalon• Melatonin
– Inhibits ovarian hormones– May regulate the body’s internal clock
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Thyroid
• Located below larynx and low in neck– Not over the thyroid cartilage
• Thyroxine (T4) and Triiodothyronine (T3)– Stimulate metabolism of all cells
• Calcitonin– Decreases blood calcium
concentration by inhibiting breakdown of bone
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Parathyroids• Located on posterior surface of
thyroid• Frequently damaged during
thyroid surgery• Parathyroid hormone (PTH)
– Stimulates Ca2+ release from bone– Promotes intestinal absorption and
renal tubular reabsorption of calcium
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Parathyroids• Underactivity
– Decrease serum Ca2+
• Hypocalcemic tetany• Seizures • Laryngospasm
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Parathyroids
• Overactivity– Increased serum Ca2+
• Pathological fractures• Hypertension• Renal stones• Altered mental status
– “Bones, stones, hypertones, abdominal moans”
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Thymus Gland
• Located in anterior chest • Normally absent by ~ age 4• Promotes development of immune-system
cells (T-lymphocytes)
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Adrenal Glands
• Small glands located near (ad) the kidneys (renals)
• Consists of:– outer cortex– inner medulla
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Adrenal Glands
• Adrenal Medulla– the Adrenal Medulla secretes the catecholamine
hormones norepinephrine and epinephrine– Epinephrine and Norepinephrine
• Prolong and intensify the sympathetic nervous system response during stress
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Adrenal Glands• Adrenal Cortex
– Aldosterone (Mineralocorticoid)• Regulates electrolyte (potassium, sodium) and fluid
homeostasis
– Cortisol (Glucocorticoids)• Antiinflammatory, anti-immunity, and anti-allergy
effects.• Increases blood glucose concentrations
– Androgens (Sex Hormones)• Stimulate sexual drive in females
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Adrenal Glands
• Adrenal Cortex– Glucocorticoids
• accounts for 95% of adrenal cortex hormone production
• the level of glucose in the blood• Released in response to stress, injury, or serious
infection - like the hormones from the adrenal medulla
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Adrenal Glands
• Adrenal Cortex– Mineralcorticoids
• work to regulate the concentration of potassium and sodium in the body
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Ovaries• Located in the abdominal cavity adjacent to the
uterus• Under the control of LH and FSH from the
anterior pituitary• Produce eggs for reproduction• Produce hormones
– estrogen– progesterone– Functions include sexual development and preparation
of the uterus for implantation of the egg
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Ovaries
• Estrogen– Development of female secondary sexual characteristics– Development of endometrium
• Progesterone– Promotes conditions required for pregnancy– Stabilization of endometrium
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Testes
• Located in the scrotum• Controlled by anterior pituitary hormones FSH and
LH• Produce sperm for reproduction• Produce testosterone -
– promotes male growth and masculinization– promotes development and maintenance of male sexual
characteristics
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Pancreas
• Located in retroperitoneal space between duodenum and spleen
• Has both endocrine and exocrine functions– Exocrine Pancreas
• Secretes key digestive enzymes– Endocrine Pancreas
• Alpha Cells - glucagon production• Beta Cells - insulin production• Delta Cells - somatostatin production
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Pancreas
• Exocrine function– Secretes digestive enzymes
• Amylase• Lipase
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Pancreas
• Alpha Cells– Glucagon
• Raises blood glucose levels• Beta Cells
– Insulin• Lowers blood glucose levels
• Delta Cells– Somatostatin
• Suppresses release of growth hormone
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Disorders of the Endocrine System
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Abnormal Thyroid Function
• Hypothyroidism– Too little thyroid hormone
• Hyperthyroidism(Thyrotoxicosis / Thyroid Storm)– Too much thyroid hormone
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Hypothyroidism
• Thyroid hormone deficiency causing a decrease in the basal metabolic rate– Person is “slowed down”
• Causes of Hypothyroidism:– Radioactive iodine ablation– Non-compliance with levothyroxine– Hashimoto’s thyroiditis - autoimmune destruction
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Hypothyroidism• Confusion, drowsiness, coma• Cold intolerant• Hypotension, Bradycardia• Muscle weakness• Decreased respirations• Weight gain, Constipation• Non-pitting peripheral edema• Depression• Facial edema, loss of hair• Dry, coarse skin
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Hypothyroidism• Myxedema Coma
– Severe hypothyroidism that can be fatal • Management of Myxedema Coma
– Control airway– Support oxygenation, ventilation– IV fluids– Later
• Levothyroxine (Synthroid®)• Hydrocortisone
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Hyperthyroidism• Excessive levels of thyroid levels cause
hypermetabolic state– Person is “sped up”.
• Causes of Hyperthyroidism– Overmedication with levothyroxine (Synthroid®) - Fad
diets– Goiter (enlarged, hyperactive thyroid gland)– Graves Disease
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Hyperthyroidism• Nervousness, irritable, tremors,
paranoid• Warm, flushed skin• Heat intolerant• Tachycardia - High output CHF• Hypertension• Tachypnea• Diarrhea• Weight loss• Exophthalmos
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Hyperthyroidism• Treatment
– Airway/Ventilation/Oxygen– ECG monitor– IV access - Cautious IV fluids– Acetaminophen for fever– Beta-blockers– Consider benzodiazepines for anxiety– PTU (propylthiouracil)
• Usually short-term use prior to more definitive treatment
– SSKI® (potassium iodide)
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Thyroid Storm/Thyrotoxicosis
• Severe form of hyperthyroidism that can be fatal– Acute life-threatening hyperthyroidism
• Cause– Increased physiological stress in hyperthyroid patients
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Thyroid Storm/Thyrotoxicosis
• Severe tachycardia• Heart Failure• Dysrhythmias• Shock• Hyperthermia• Abdominal pain• Restlessness, Agitation, Delirium, Coma
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Thyroid Storm/Thyrotoxicosis• Management
– Airway/Ventilation/Oxygen– ECG monitor– IV access - cautious IV fluids– Control hyperthermia
• Active cooling• Acetaminophen
– Inderal (beta blockers)– Consider benzodiazepines for anxiety– Potassium iodide (SSKI®)– Propylthiouracil (PTU)
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Abnormal Adrenal Function
• Hyperadrenalism– Excess activity of the adrenal gland– Cushing’s Syndrome & Disease– Pheochromocytoma
• Hypoadrenalism (adrenal insufficiency)– Inadequate activity of the adrenal gland– Addison’s disease
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Hyperadrenalism
• Primary Aldosteronism – Excessive secretion of aldosterone by adrenal cortex
• Increased Na+/H2O
– Presentation• headache• nocturia, polyuria• fatigue• hypertension, hypervolemia• potassium depletion
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Hyperadrenalism• Adrenogenital syndrome
– “Bearded Lady”– Group of disorders caused by adrenocortical hyperplasia
or malignant tumors– Excessive secretion of adrenocortical steroids especially
those with androgenic or estrogenic effects– Characterized by
• masculinization of women• feminization of men• premature sexual development of children
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Hyperadrenalism• Cushing’s Syndrome
– Results from increased adrenocortical secretion of cortisol
– Causes include:• ACTH-secreting tumor of the pituitary (Cushing’s
disease)• excess secretion of ACTH by a neoplasm within the
adrenal cortex• excess secretion of ACTH by a malignant growth
outside the adrenal gland• excessive or prolonged administration of steroids
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Hyperadrenalism• Cushing’s Syndrome
– Characterized by:• truncal obesity• moon face• buffalo hump• acne, hirsutism• abdominal striae• hypertension• psychiatric disturbances• osteoporosis• amenorrhea
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Hyperadrenalism• Cushing’s Disease
– Too much adrenal hormone• adrenal hyperplasia caused by an
ACTH secreting adenoma of the pituitary
– “Cushingoid features”• striae on extremities or abdomen• moon face• buffalo hump• weight gain with truncal obesity• personality changes, irritable
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Hyperadrenalism
• Cushing’s Syndrome– Management
• Airway/Ventilation/Oxygen• Supportive care• Assess for cardiovascular event requiring treatment
– severe hypertension– myocardial ischemia
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Hyperadrenalism
• Pheochromocytoma– Catecholamine secreting tumor of adrenal medulla– Presentation
• Anxiety• Pallor, diaphoresis• Hypertension• Tachycardia, Palpitations• Dyspnea• Hyperglycemia
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Hyperadrenalism
• Pheochromocytoma– Management
• Supportive care based upon presentation• Airway/Ventilation/Oxygen• Calm/Reassure• Assess blood glucose • Consider beta blocking agent - Labetalol• Consider benzodiazepines
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Hypoadrenalism
• Adrenal Insufficiency– decrease production of glucocorticoids,
mineralcorticoids and androgens• Causes
– Primary adrenal failure (Addison’s Disease)– Infection (TB, fungal, Meningococcal)– AIDS– Prolonged steroid use
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Addison’s Disease
• Primary hypoadrenalism, or Addison's disease, results from failure of the adrenal glands themselves. This is usually an 'autoimmune' disease, where the immune system produces antibodies that attack tissues of the body rather than a virus or bacteria.
• In Addison's disease, antibodies attack the adrenal cortex, causing damage and scarring. Antibodies to the adrenal cortex can be detected in the blood of some patients.
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Hypoadrenalism• Presentation –
– Hypotension, Shock– Hyponatremia, Hyperkalemia– Progressive Muscle weakness– Progressive weight loss and anorexia– Skin hyperpigmentation
• areas exposed to sun, pressure points, joints and creases– Arrhythmias– Hypoglycemia– N/V/D
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Hypoadrenalism
• Management– Airway/Ventilation/Oxygen– ECG monitor– IV fluids– Assess blood glucose – D10W if hypoglycemic– Steroids
• hydrocortisone or dexamethasone• florinef (mineralcorticoid)
– Vasopressors if unresponsive to IV fluids
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Diabetes Mellitus• Chronic metabolic disease• One of the most common diseases in North
America– One million Canadians live with diabetes
• Results in– insulin secretion by the Beta () cells of the islets of
Langerhans in the pancreas, AND/OR– Defects in insulin receptors on cell membranes leading
to cellular resistance to insulin• Leads to an risk for significant cardiovascular,
renal and ophthalmic disease
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Break.
• End of this portion of lecture – More information is on North Island Paramedic Web Site
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Diabetes Mellitus
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Regulation of Glucose
• Dietary Intake– Components of food:
• Carbohydrates• Fats• Proteins• Vitamins• Minerals
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Regulation of Glucose• The other 3 major food sources for glucose are
– carbohydrates– proteins– fats
• Most sugars in the human diet are complex and must be broken down into simple sugars: glucose, galactose and fructose - before use
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Regulation of Glucose
• Carbohydrates– Found in sugary, starchy foods– Ready source of near-instant energy– If not “burned” immediately by body, stored in
liver and skeletal muscle as glycogen (short-term energy) or as fat (long-term energy needs)
– After normal meal, approximately 60% of the glucose is stored in liver as glycogen
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Regulation of Glucose
• Fats– Broken down into fatty acids and glycerol by
enzymes– Excess fat stored in liver or in fat cells (under the
skin)
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Regulation of Glucose
• Pancreatic hormones are required to regulate blood glucose level– glucagon released by Alpha () cells– insulin released by Beta Cells ()– somatostatin released by Delta Cells ()
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Regulation of Glucose• Alpha () cells release glucagon to control blood
glucose level– When blood glucose levels fall, cells the amount of
glucagon in the blood– The surge of glucagon stimulates liver to release
glucose stores by the breakdown of glycogen into glucose (glycogenolysis)
– Also, glucagon stimulates the liver to produce glucose (gluconeogenesis)
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Regulation of Glucose• Beta Cells () release insulin (antagonistic to
glucagon) to control blood glucose level– Insulin the rate at which various body cells take up
glucose insulin lowers the blood glucose level – Promotes glycogenesis - storage of glycogen in the
liver– Insulin is rapidly broken down by the liver and must be
secreted constantly
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Regulation of Glucose• Delta Cells () produce somatostatin, which
inhibits both glucagon and insulin– inhibits insulin and glucagon secretion by the pancreas– inhibits digestion by inhibiting secretion of digestive
enzymes– inhibits gastric motility– inhibits absorption of glucose in the intestine
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Regulation of Glucose• Breakdown of sugars carried out by enzymes in
the GI system– As simple sugars, they are absorbed from the GI
system into the body
• To be converted into energy, glucose must first be transmitted through the cell membrane– Glucose molecule is too large and does not readily
diffuse
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Regulation of Glucose• Glucose must pass into the cell by binding to a
special carrier protein on the cell’s surface. – Facilitated diffusion - carrier protein binds with the
glucose and carries it into the cell.
• The rate at which glucose can enter the cell is dependent upon insulin levels– Insulin serves as the messenger - travels via blood to
target tissues– Combines with specific insulin receptors on the surface
of the cell membrane
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Regulation of Glucose
• Body strives to maintain blood glucose between 4 mmol/L and 7 mmol/L
• Glucose– brain is the biggest user of glucose in the body– sole energy source for brain– brain does not require insulin to utilize glucose
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Regulation of Glucose
Insulin Glucagon
Glucagon and Insulin are opposites (antagonists) of each other.
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Regulation of Glucose• Glucagon
– Released in response to:• Sympathetic stimulation• Decreasing blood glucose concentration
– Acts primarily on liver to increase rate of glycogen breakdown
– Increasing blood glucose levels have inhibitory effect on glucagon secretion
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Regulation of Glucose
• Insulin– Released in response to:
• Increasing blood glucose concentration• Parasympathetic innervation
– Acts on cell membranes to increase glucose uptake from blood stream
– Promotes facilitated diffusion of glucose into cells
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Diabetes Mellitus• 2 Types historically based on age of onset (NOT
insulin vs. non-insulin)– Type I
• juvenile onset• insulin dependent
– Type II• historically adult onset
– now some morbidly obese children are developing Type II diabetes
• non-insulin dependent– may progress to insulin dependency
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Types of Diabetes Mellitus
• Type I• Type II• Secondary• Gestational
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Pathophysiology of Type I Diabetes Mellitus
• Characterized by inadequate or absent production of insulin by pancreas
• Usually presents by age 25• Strong genetic component• Autoimmune features
– body destroys own insulin-producing cells in pancreas– may follow severe viral illness or injury
• Requires lifelong treatment with insulin replacement
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Pathophysiology of Type II Diabetes Mellitus
• Pancreas continues to produce some insulin however disease results from combination of:– Relative insulin deficiency – Decreased sensitivity of insulin receptors
• Onset usually after age 25 in overweight adults– Some morbidly obese children develop Type II diabetes
• Familial component• Usually controlled with diet, weight loss, oral
hypoglycemic agents– Insulin may be needed at some point in life
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Secondary Diabetes Mellitus
• Pre-existing condition affects pancreas– Pancreatitis– Trauma
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Gestational Diabetes Mellitus
• Occurs during pregnancy– Usually resolves after delivery
• Occurs rarely in non-pregnant women on BCPs• Increased estrogen, progesterone antagonize insulin
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Presentation of New Onset Diabetes Mellitus
• 3 Ps– Polyuria– Polydipsia– Polyphagia
• Blurred vision, dizziness, altered mental status• Rapid weight loss• Warm dry skin, • Weakness, Tachycardia, Dehydration
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Long Term Treatment of Diabetes Mellitus
• Diet regulation– e.g. 1400 calorie ADA diet
• Exercise– increase patient’s glucose metabolism
• Oral hypoglycemic agents– Sulfonylureas
• Insulin– Historically produced from pigs (porcine insulin)– Currently genetic engineering has lead to human insulin
(Humulin)
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Long Term Treatment ofDiabetes Mellitus
• Insulin– Available in various forms distinguished on onset and
duration of action• Onset
– rapid (Regular, Semilente, Novolin 70/30)– intermediate (Novolin N, Lente)– slow (Ultralente)
• Duration– short, 5-7 hrs (Regular)– intermediate, 18-24 hrs (Semilente, Novolin N, Lente, NPH)– long-acting, 24 - 36+ hrs (Novolin 70/30, Ultralente)
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Long Term Treatment ofDiabetes Mellitus
• Insulin– Must be given by injection as insulin is protein which
would be digested if given orally• extremely compliant patients may use an insulin
pump which provides a continuous dose• current research studying inhaled insulin form
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Long Term Treatment of Diabetes Mellitus
• Oral Hypoglycemic Agents– Stimulate the release of insulin from the pancreas,
thus patient must still have intact beta cells in the pancreas.
– Common agents include:• Glucotrol® (glipizide)• Micronase® or Diabeta® (glyburide)• Glucophage® (metformin) [Not a
sulfonylurea]
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Emergencies Associated Blood Glucose Level
• Hyperglycemia– Diabetic Ketoacidosis (DKA)– Hyperglycemic Hyperosmolar Nonketotic Coma
(HHNC)
• Hypoglycemia – “Insulin Shock”
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Hyperglycemia• Defined as blood glucose > 7 mmol/L• Causes
– Failure to take medication (insulin)– Increased dietary intake– Stress (surgery, MI, CVA, trauma)– Fever– Infection– Pregnancy (gestational diabetes)
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Hyperglycemia• Two hyperglycemic diabetic states may
occur– Diabetic Ketoacidosis (DKA)– Hyperglycemic Hyperosmolar Non-ketotic
Coma (HHNC)
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Diabetic Ketoacidosis (DKA)• Occurs in Type I diabetics (insulin dependency)• Usually associated with blood glucose level in the
range of 11 – 33 mmol/L• No insulin availability results in ketoacidosis
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Diabetic Ketoacidosis (DKA)• Pathophysiology
– Results from absence of insulin• prevents glucose from entering the cells• leads to glucose accumulation in the blood
– Cells become starved for glucose and begin to use other energy sources (primarily fats)
• Fat metabolism generates fatty acids• Further metabolized into ketoacids (ketone bodies)
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Diabetic Ketoacidosis (DKA)• Pathophysiology (cont)
– Blood sugar rises above renal threshold for reabsorption (blood glucose > 10 mmol/L)
• glucose “spills” into the urine• Loss of glucose in urine causes osmotic diuresis
– Results in• dehydration• acidosis• electrolyte imbalances (especially K+)
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Diabetic Ketoacidosis (DKA)• Presentation
– Gradual onset with progression– Warm, pink, dry skin – Dry mucous membranes (dehydrated)– Tachycardia, weak peripheral pulses– Weight loss– Polyuria, polydipsia– Abdominal pain with nausea/vomiting– Altered mental status– Kussmaul respirations with acetone (fruity) odor
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Diabetic Ketoacidosis
Increased Blood Sugar
Osmotic Diuresis
Polyuria
PolydipsiaVolume DepletionShock
Cells Can’t Burn Glucose
Cells Burn FatPolyphagia
Ketone Bodies
Metabolic Acidosis
FruityBreath
Kussmaul Breathing
Inadequate insulin
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Management of DKA
• Airway/Ventilation/Oxygen NRB mask• Assess blood glucose level & ECG• IV access, large bore NS
– normal saline bolus for hypotension– often requires several liters
• Assess for underlying cause of DKA• Transport
How does fluid treat DKA?
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Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC)
• Usually occurs in type II diabetics• Typically very high blood sugar (>33 mol/L)• Some insulin available• Higher mortality than DKA
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Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC)
• Pathophysiology– Some minimal insulin production
• enough insulin available to allow glucose to enter the cells and prevent ketogenesis
• not enough to decrease gluconeogenesis by liver• no ketosis
– Extreme hyperglycemia produces hyperosmolar state causing
• diuresis• severe dehydration• electrolyte disturbances
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Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC)
Increased Blood Sugar
Osmotic Diuresis
Polyuria
PolydipsiaVolume DepletionShock
Inadequate insulin
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Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC)
• Presentation– Same as DKA but with greater severity
• Higher blood glucose level• Non-insulin dependent diabetes• Greater degree of dehydration
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Management of HHNC
• Secure airway and assess ventilation– Consider need to assist ventilation– Consider need to intubate
• High concentration oxygen• Assess blood glucose level & ECG• IV access, large bore NS
– normal saline bolus and reassess– often requires several liters
• Assess for underlying cause of HHNC• Transport
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Further Management of Hyperglycemia
• Insulin (regular)– Correct hyperglycemia
• Correction of acid/base imbalances– Bicarbonate (severe cases documented by ABG)
• Normalization of electrolyte balance– DKA may result in hyperkalemia 2o to acidosis
• H+ shifts intracellularly, K+ moves to extracellular space
– Urinary K+ losses may lead to hypokalemia once therapy is started
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Hypoglycemia• True hypoglycemia defined as blood sugar
< 60 mg/dl• ALL hypoglycemia is NOT caused by diabetes
– Can occur in non-diabetic patients• thin young females• alcoholics with liver disease• alcohol consumption on empty stomach will block
glucose synthesis in liver (gluconeogenesis)
• Hypoglycemia causes impaired functioning of brain which relies on constant supply of glucose
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Hypoglycemia
• Causes of hypoglycemia in diabetics– Too much insulin– Too much oral hypoglycemic agent
• Long half-life requires hospitalization– Decreased dietary intake (took insulin and missed meal)– Vigorous physical activity
• Pathophysiology– Inadequate blood glucose available to brain and other cells
resulting from one of the above causes
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Hypoglycemia
• Presentation– Hunger (initially), Headache– Weakness, Incoordination (mimics a stroke)– Confusion, Unusual behavior
• may appear intoxicated– Seizures– Coma– Weak, rapid pulse– Cold, clammy skin– Nervousness, trembling, irritability
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Hypoglycemia: PathophysiologyBlood Glucose Falls
Brain Lacks Glucose SNSResponse
Altered LOCSeizures
HeadacheDizziness
Bizarre BehaviorWeakness
AnxietyPallor
TachycardiaDiaphoresis
NauseaDilated Pupils
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Hypoglycemia
Beta Blockers may mask symptoms by
inhibiting sympathetic
response
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Management of Hypoglycemia • Secure airway manually
– suction prn– Ventilate prn
• High concentration oxygen• Vascular access
– Large bore IV catheter– Saline lock, D5W or NS
– Large proximal vein preferred
• Assess blood glucose level
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Management of Hypoglycemia
• Oral glucose– ONLY if intact gag reflex, awake & able to sit up– 15gm-30gm of packaged glucose, or– Oral route often slower
• Intravenous glucose– Patient > 12 years old: 100 ml D10W IV bolus in patent,
free-flowing vein, followed by 50 mg Thiamine. May repeat second bolus once
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Management of Hypoglycemia
• Glucagon– Used if unable to obtain IV access– 1 mg SC > 20 kg or 0.5 mg SC < 20 kg– Requires glycogen stores– slower onset of action than IV route
What persons are likely to have inadequate glycogen stores?
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Management of Hypoglycemia
• Have patient eat high-carbohydrate meal• Transport?
– Patient Refusal Policy• Contact medical control• Leave only with responsible family/friend for 6 hours• Must educate family/friend to hypoglycemic signs/symptoms• Advise to contact personal physician
– Transport• Hypoglycemic patients on oral agents (long half life)• Unknown, atypical or untreated cause of hypoglycemia
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Long-term Complications of Diabetes Mellitus
• Blindness– Retinal hemorrhages
• Renal Disease• Peripheral Neuropathy
– Numbness in “stocking glove” distribution (hands and feet)
• Heart Disease and Stroke– Chronic state of Hyperglycemia leads to early
atherosclerosis• Complications in Pregnancy
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Long-term Complications of Diabetes Mellitus
• Diffuse Atherosclerois– AMI– CVA– PVD
• Hypertension– Renal failure– Diabetic
retinopathy/blindness– Gangrene
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10% of all diabetics develop renal disease usually resulting in dialysis
Diabetics are up to 4 times more likely to have heart
disease and up to 6 times more likely to have a stroke than a
non-diabetic
Long-term Complications of Diabetes Mellitus
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Long-term Complications of Diabetes Mellitus
• Peripheral Neuropathy– Silent MI
• Vague, poorly-defined symptom complex– Weakness– Dizziness– Malaise– Confusion
• Suspect MI in any diabetic with MI signs/symptoms with or without CP
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Diabetes in Pregnancy
• Early pregnancy (<24 weeks)– Rapid embryo growth– Decrease in maternal blood glucose– Episodes of hypoglycemia
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Diabetes in Pregnancy• Late pregnancy (>24 weeks)
– Increased resistance to insulin effects– Increased blood glucose– Ketoacidosis
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Diabetes in Pregnancy
• Increased maternal risk for:– Pregnancy-induced hypertension– Infections
• Vaginal• Urinary tract
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Diabetes in Pregnancy• Increased fetal risk for:
– High birth weight– Hypoglycemia– Liver dysfunction-hyperbilirubinemia– Hypocalcemia
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Assessment of the Diabetic Patient
• Maintain high-degree of suspicion• Assess blood glucose level in all patients with
– seizure, neurologic S/S, altered mental status– vague history or chief complaint
• Blood glucose assessment IS NOT necessary in all patients with diabetes mellitus!!
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Assessment of the Diabetic Patient
• History and Physical Exam includes– Look for insulin syringes, medical alert tag, glucometer,
or insulin (usually kept in refrigerator)– Last meal and last insulin dose – Missed med or missed meal?– Signs of infection
• Foot cellulitis / ulcers– Recent illness or physiologic stressors
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Blood Glucose Assessment• Capillary vs. venous blood sample
– Depends on glucometer model– Usually capillary preferred
• Dextrostick vs Glucometer– Dextrostick - colorimetric assessment of blood
provides glucose estimate– Glucometer - quantitative glucose measurement
• Neonatal blood– Many glucometers are not accurate for neonates
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Case Study #1
• You are dispatched to a college residence hall to see a 20-year-old female complaining of fever and a fluttering in her chest. You find her awake but she appears very anxious. – Airway - Open without assistance– Breathing - Slightly increased ventilatory rate; No obvious
abnormal sounds of breathing– Circulation - Rapid, strong, regular radial pulse; Skin warm and
pink
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Case Study #1• You direct your partner to assess vital signs while you
place the patient on Oxygen 15 lpm by NRB mask. Your physical exam findings are:– trembling, nervous – warm, flushed skin– clear and equal lung sounds
• Your partner relays the following vital signs to you:– Pulse - 120, regular, strong– BP - 144/88– Ventilatory rate - 20, regular with adequate TV– Glucose – 6.2 mmol/l– ECG - Sinus tachycardia with occasional PACs
What additional information regarding her history would you like to know?
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Case Study #1
• The patient states this has occurred before but never lasted this long. She has not been ill lately other than some recurrent diarrhea and weight loss. She has attributed these to worrying about finals. She has no significant medical history and takes no meds. She denies use of any drugs. She has no family history of pulmonary disease, diabetes or heart disease. Her mother, however, does have a problem with something in her neck for which she takes medication.
What are the two most probable diagnosis for this patient?
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Case Study #2• You are dispatched to a residence to see a 44-year-old
man who has fainted. You arrive to find him semi-reclined in bed. He is awake and very wide-eyed but appears very tired.– Airway - Maintained without assistance– Breathing - No obvious distress; No obvious, unusual sounds– Circulation - Rapid, weak, irregular radial pulse
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Case Study #2
– Your partner assesses vital signs while you obtain the following history:
• Hx of Present Illness: For the past month, he has felt very weak and dizzy; He has not felt like eating and has been losing weight. He has also experienced N/V/D on a few days this month.
• Past Medical Hx: Has been fairly healthy all of his life; Three months ago he became ill with bacterial meningitis for which he was successfully treated.
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Case Study #2
– Vital signs are:• Pulse: 110-126, irregular• BP: 92/62• Ventilatory rate: 20, regular• Skin: cool, clammy• ECG: Atrial fibrillation• Blood glucose: 4.2 mmol/l
What should you include in your differential diagnosis?
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Case Study #2– Your partner is a brand new, naïve paramedic. He
comments to the patient, “That is a great tan you have. Have you been on a tropical vacation lately?”
Now, what do you believe is the most likely diagnosis for this patient?
What is your treatment plan for this patient?
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Case Study #3
• Your last call (you hope) of the shift is to a manufacturing plant for a possible drug overdose. Your patient is a 24-year-old female. The patient’s supervisor states the woman seems very jittery and “out of it”. You find the patient to be a very thin female who is acting unusual.– Airway - Maintained without assistance– Breathing - No distress or unusual sounds– Circulation - Rapid, strong, regular radial pulse with clammy skin– LOC - Confused and answers questions slowly
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Case Study #3• Your partner quickly assesses the patient’s vital signs and
relays the following:– Pulse - 110, regular, strong– BP - 108/76– Ventilatory rate - 16 with clear and equal lung sounds– Skin - pale, cool, clammy– Pupils - dilated, equal and reactive to light– ECG - Sinus tachycardia without ectopy
• History– No significant medical history; No recent illness; No meds
What would you like to include in your differential diagnosis for this patient?
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Case Study #3
• A coworker now tells you that the patient is going through a difficult divorce and has not been eating well lately
• Your partner now tells you the patient’s blood glucose is 2 mmol/l
Would this patient be a good candidate for Glucagon therapy if an IV can not be established quickly?
What is your specific diagnosis now?