Managing Type 2 Diabetes in Special Populations - · PDF fileManaging Type 2 Diabetes in...
Transcript of Managing Type 2 Diabetes in Special Populations - · PDF fileManaging Type 2 Diabetes in...
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ManagingType2DiabetesinSpecialPopulations
Patient‐CenteredTreatmenttoImproveOutcomes
DaleC.Moquist,MDTexasFamilyMedicineSymposiumJune5,2016
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ExpertPanelIldikoLingvay,MD,MPH,MSCSAssociateProfessor,DepartmentofInternalMedicine/DivisionofEndocrinologyDepartmentofClinicalSciencesUniversityofTexasSouthwesternMedicalCenterDallas,TX
JerryMcCauley,MD,MPH,FACPRobertCapizziProfessorofMedicine;Director,DivisionofNephrologySidneyKimmelMedicalCollageatThomasJeffersonUniversityPhiladelphia,PA
EverettSchlam,MDAssistantDirector,MountainsideFamilyPracticeResidencyProgramClinicalAssistantProfessor,DepartmentofFamilyMedicineUMDNJ– NewJerseyMedicalSchoolVerona,NJ
PennyTenzer,MD,FAAFPProfessor,ofClinicalFamilyMedicine;ViceChairofAcademicAffairs;DirectorofCMEandMedicalEducation;ChiefofService,FamilyMedicineUniversityofMiamiMillerSchoolofMedicineMiami,FL
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DisclosuresIldikoLingvay,MD,MPH,MSCS,hasreceivedconsultingfeesfromAstraZenecaandJanssenPharmaceuticals.JerryMcCauley,MD,MPH,FACP,reportsnofinancialrelationships.EverettSchlam,MD,hasreceivedconsultingfeesfromGalderma.PennyTenzer,MD,FAAFP,hasreceivedconsultingfeesfromAstraZenecaandExactScience.
TheresaBarrett,PhD,JackDouglass,CharlesGoldthwaite,PhD(Planners)andEverettSchlam,MD(reviewer)reportnofinancialrelationships.
ConflictshavebeenresolvedaccordingtoNJAFPpolicy.
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SpeakerDisclosure
Dr.Moquisthasdisclosedthathehasnoactualorpotentialconflictofinterestinrelationtothistopic.
Wewillusegenericnamesformedicationswithtradenamesinparentheses
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Support
Thisprogramissupportedbyaneducationalgrantfrom
JanssenPharmaceuticals,Inc.,administeredby
JanssenScientificAffairs,LLC.
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LearningObjectives• Employculturallycompetent,patient‐centeredtreatmentstrategiestomanagetype2diabetesinelderly,overweight/obese,orLatino/Latinapatients.
• Employstrategiestoovercomebarriersthattraditionallyinhibittheinitiationofcareinthesepopulations.
• Designsafeandeffectivetreatmentstrategiesthataretailoredtotheindividualneedsofpatientsinthesepopulations.
• Integrateemergingantihyperglycemicagentsintopatient‐centeredtype2diabetesmanagementplansforpersonsinthesepopulations.
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Housekeeping
• Completethepre‐testquestionsnow.• Thereisaspacetorecordyouranswersforthecasestudy.
• Completethepost‐testattheendofthesession.• Completetheevaluationformandclaimyourcredit.
• Returntheformtoastaffmemberorattheregistrationdesk.
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TheImpactofType2Diabetes
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TheDiabetesEpidemic• ~29millionindividualsntheUShavediabetes(8.1millionareundiagnosed).1
• 7th leadingcauseofdeathintheUS1
• InTexas2• Acrossallraces– 10.6%ofadultshavediabetes
• AmongHispanics– 11.6%havediabetes
Sources: 1CDC. National diabetes statistics report, 2014; 2 2012 Diabetes Fact Sheet—Texas, www.dshs.state.tx.us
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ComplicationsofType2Diabetes
HeartCoronaryarterydiseaseCardiovasculardisease
BloodVesselsPeripheralarterydiseaseIntermittentclaudication
KidneysMicroalbuminuriaNephropathy
NervesNeuropathyGastroparesis
HyperglycemiaHyperglycemia
EyesRetinopathyGlaucoma
Source: ADA.DiabetesCare.2010;33(Suppl1):S11‐S61.
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Type2DiabetesisLinkedwithCVDRiskFactors
• Obesity• Insulinresistance• Hypertension• Dyslipidemias
Sources: AmericanDiabetesAssociation.DiabetesCare2016;39(Suppl1):S23‐S35;NationalCholesterolEducationProgram(NCEP)AdultTreatmentPanel(ATP)III.Circulation 2002;106:3143‐3421.
IdentificationofoneCVDriskfactorshouldpromptthesearchforothersandpromptthehealthcareprovidertobeginproactive,aggressivetreatmenttoreduceCVDrisk.
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EstablishingGlycemicControlisEssentialtoManageDisease
• Microvascularandmacrovascularbenefitsareassociatedwithglycemiccontrol.1‐8
• Targetglucoselevelsshouldbeindividualized.
• Hypoglycemiashouldbeavoided.
Sources: 2000;321:405‐12;4DiabetesControlandComplicationsResearchGroup.NEnglJMed1993;329:977‐86;5DCCT/EpidemiologyofDiabetesInterventionsandComplicationsResearchGroup.NEnglJMed2000;342:381‐89;6GaedeP,etal.NEnglJMed2003;348:383‐93;7LawsonML,et.al.DiabetesCare1999;22(suppl2):B35‐B39;8NathanDM,etal.NEnglJMed2005;353:2643‐53.
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AmericanDiabetesAssociationGlycemicRecommendations
Source: AmericanDiabetesAssociation.DiabetesCare2016;39(Suppl1):S39‐S46.
A1c <7.0%
Preprandialplasmaglucose 80‐130mg/dL
Peakpostprandialplasmaglucose <180mg/dL
Individualizebasedonage/lifeexpectancy,durationofdiabetes,comorbidities,knownCVDoradvancedmicrovascularcomplications,hypoglycemiaunawareness,andpatientpreferences.Moreorlessstringentgoalsmaybeappropriateforsomepatients.
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EstimatedAverageGlucose(eAG)
• HemoglobinA1C:MaySeemArbitrarytoPatients
• AmericanDiabetesAssociationRecommendstheuseofeAG:Expressedasmg/dl.
• Formula:– 28.7XA1C—46.7=eAG
DiabetesCare2008;31:1473‐1478
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A1C &CorrespondingeAGHemoglobinA1C % eAG(mg/dl)
6 1266.5 1407 1547.5 1698 1838.5 1979 2129.5 22610 240
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DesigninganEffectiveInterventionforType2Diabetes
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LookingBeyondA1c
• Cardiovascularriskmanagement(e.g.,hypertension,dyslipidemia,microalbuminuria)
• Normalizingbloodglucoselevel• Patientpreferencesandindividualizedgoals
• Lifestyleinterventions(diet,activity)foroverweight/obeseindividualsgearedtowardaninitiallossof5‐10%ofbaselinebodyweight
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ComponentsofaDiabetesManagementProgram
MedicalNutritionTherapy
DiabetesSelf‐ManagementEducation
Pharmacotherapy
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WhatisDiabetesSelf‐ManagementEducation(DSME)?
• Aninteractive,ongoingeducationalprocesstohelppatientsmakeinformedself‐managementdecisions
• Patientreceivesindividualassessmentandidentifiespersonalself‐managementgoals
• Patientandeducatordevelopplanwithinterventionsandperiodicreassessment
• Providermustconsiderpatient’sattitudeandbeliefsaboutdiabeteswhentailoringastrategy
Source: ADA.DiabetesCare2016;39(Suppl1):S23‐S35.
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ADADSMECriteria• Describingthediabetesdiseaseprocessandtreatmentoptions• Incorporatingnutritionalmanagementandphysicalactivityintolifestyle
• Usingmedicationssafelyand formaximumtherapeuticeffectiveness
•Monitoringbloodglucose andotherparametersandinterpretingtheresultsforself‐managementdecision‐making
• Preventing,detecting,andtreatingacuteandchroniccomplications
• Developingpersonalstrategiestoaddresspsychosocialissues/concernsandtopromotehealthandbehaviorchange.
Source: HaasL,et.al.DiabetesCare2014;37(Suppl1):S144‐S153.
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MedicalNutritionTherapy
• OptimizeBGcontrol• Improvebloodlipids• Controlbloodpressure
Achieveconsistentcarbohydrateintake
Monitorbloodglucoseto
adjusttherapy
Achievemodestweightloss
Increasephysicalactivity
Mealtiming/portioncontrol
Modifyfatandcaloriecontent
Source: HaasL,et.al.DiabetesCare2014;37(Suppl1):S144‐S153. 21
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LifestyleModifications• Modestweightloss(5‐10%ofbodyweight)lowersriskforCVDandtype2diabetes1‐2
• Lossmaybeachievedandmaintainedsafelybycombiningdietaryadjustmentsandregularphysicalactivity
• Mustbetailoredtothepatient’sneeds• Oftenrequireadjustmentsforoptimization• Theprovidermusttakeanactiveroleindesign
Sources: 1RatnerR,et.al.DiabetesCare 2005;28:888‐894;2DiabetesPreventionProgramResearchGroup.NEnglJMed 2002;346:393‐403. 22
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CaloricIntakeandBalancedDiet
• Caloricbalanceisthemajordeterminantofweightloss
• Caloricintakemustbereducedmoderatelyandgradually
• Vitaminsupplementsmaybenecessary• Nutritionalbalanceandweightmanagementarecomplementarygoalstoweightloss
Source: RosenbaumM,et.al.NEnglJMed1997;337:396‐407. 23
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PromotingHealthyWeightLoss
3,500caloriesOnepoundofadiposetissue
Deficitof500‐1,000cal/day
Lossof1‐2lbs/week
Sources: RosenbaumM,et.al.NEnglJMed1997;337:396‐407;NHLBI.NationalHeartLungandBloodInstitute.ManagingOverweightandObesityinAdults:SystematicEvidenceReviewfromtheObesityExpertPanel;2013.
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Take‐HomeIdeasforthePatient• Drinkaproteinshakeforbreakfastratherthansodasorjuice
• Plan/preparemealsathomevstake‐out• Payattentiontoportion/servingsizes• Selecthigh‐fiberfoodswhenpossible• Choosebroiled,boiled,orsteamedfoodinsteadoffried
• Considercalorie‐controlledmealsaspartofanoveralldiet.
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BenefitsofPhysicalActivity
• DecreasesriskforCVD,type2diabetes,dyslipidemiaofoverweightandobesity
• Gradedlipoproteinresponse(triglycerides,LDL,HDL)• Increasesmetabolicrate• Increasesmusclemass
Sources: RatnerR,et.al.DiabetesCare 2005;28:888‐94;WeiM,et.al.JAMA1999;282:1483‐492;TuomilehtoJ,et.al.NEnglJMed 2001;344:1343‐50;KrausWE,et.al.NEnglJMed 2002;347:1483‐92. 26
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PhysicalActivityRecommendations
• Evaluatepatientforcardiovascularfitnesspriortocommencement
• Stressthatactivitymustbebalancedwithdiet• Targetregimentopatient’sbaselinefitnessandactivitylevel
• Suggest30minutesofmoderatelyvigorousphysicalactivity,performeddaily
• Stressthatactivityaccumulates duringday
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IncorporatingActivityIntoDailyRoutines
• Usestairsinsteadofelevator• Parkfartherawayfromworkorshopping• Walkatlunchtime• Exitpublictransportationonestopaheadofusual• Useapedometertocountsteps• Limittelevisionviewingto1hour/day• WhenwatchingTV,standorwalkduringcommercials
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SpecialConsiderationsfortheElderly
• Tailoredexerciseprescriptionsarehighlyeffectivefortheelderly– Improvedglycemiccontrol– Improvedindependence,self‐esteemandqualityoflife
• Forfrailandvulnerablefocusonresistiveactivities– Lightweights(cannedgoodsorwaterbottles)
• Moderatetohighintensityexerciseisgenerallyconsideredsafe• Balanceexercisesmayprovebeneficial• Caution– beawareof:
– Higherpossibilityofhypoglycemia(especiallywithinsulin)– Orthostatichypotensionthatmayworsenbydehydration– Contraindicationsforthepracticeofeachexercise– Interactionsandlimitationsimposedbymedications– Geriatricsyndromesandchroniccomorbidities
Source: Ferriollietal.2014.DiabetesandExerciseintheElderly.InJ.H.Goedecke&E.O.Ojuka(Eds.),DiabetesandPhysicalActivity.Basel:Karger.
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SharedDecision‐MakinginDiabetesManagement
• Personalizedmanagementplan• Self‐managementeducation• Adherencetotreatment• Appropriatefollow‐upandmonitoring
Source: InzucchiSE,etal.DiabetesCare2015;38:140‐49.
TheADA/EASDrecommendationssupportashareddecision‐makingapproachthatappliestoprimarycarepractices.
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ManagementRequiresActivePatientParticipation
• Maintaindailydiet/exercisediary• Identify/avoidcompromisingsituations
• Establishaself‐managementplanbasedonwhatthepatientfeelscanbeconfidentlyachieved
• Recognizesuccessatfollow‐upvisits
• Setrealisticgoalsbasedonpatientinput
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PharmacotherapyConsiderations
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Pharmacotherapy
• Sulfonylureas(SUs)• Metformin• Thiazolidinediones(TZDs)• Dipeptidylpeptidase‐4(DPP‐4)inhibitors
• Sodium‐glucosecotransporter‐2(SGLT2)inhibitors
• Glucagon‐likepeptide(GLP‐1)receptoragonists
• Insulin•Rapid‐acting•Short‐acting•Intermediate‐acting•Long‐acting(basal)
OralAntihyperglycemics
ParenteralAgents
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AvoidingHypoglycemia• Mayoccursuddenly• Symptomsincludehunger,dizziness,confusion,palpitations
• Severehypoglycemiacanleadtoseizuresorcoma• Maycausefalls,motorvehicleaccidents,orinjury• Treatedbyingestingglucose‐ orcarbohydrate‐containingfoods
“Severeorfrequenthypoglycemiaisanabsoluteindicationforthemodificationoftreatmentregimens,includingsettinghigherglycemicgoals.”1
Source: 1ADA.DiabetesCare2016;39(Suppl1):S39‐S46. 34
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HypoglycemiaandtheElderly• Hypoglycemiacanprofoundlyimpactelderlypatients,whomaybeparticularlyvulnerabletoitsconsequences:• Limitedcapacitytorecognizesymptoms• Clinicalcomplicationsandcomorbiditiesthatcanbeexacerbatedbyhypoglycemia.
• Elderlypatientswhoexperiencehypoglycemicepisodesmayriskpotentiallyseriousphysicalinjuryfromfallsorotheraccidents.
Source: ADA.DiabetesCare2016;39(Suppl1):S81‐S85. 35
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CommonAgents:WeightandHypoglycemiaRisk
Source: ADA.DiabetesCare2016;39(Suppl1):S52‐S59.
AgentClass EffectonWeight HypoglycemiaRiskMetformin Neutral/loss LowSulfonylurea Gain ModerateThiazolidinedione Gain LowDPP‐4Inhibitor Neutral LowSGLT2Inhibitor Loss LowGLP‐1 agonist Loss LowInsulin Gain High
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Metformin
• ExtensiveExperience• NoHypoglycemia• GISideEffects:Cramping&Diarrhea• VitaminB12 Deficiency• LacticAcidosisRiskisRare
– UseeGFRtoEstimateRenalFunction– DoNotUseSerumCreatininetoEstimateRenalFN– SafeLevelisGFR>30ml/min
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MetformininCKD
CKDStage eGFR Maximum TotalDailyDose
1and2 60 2550mgm
3A 45‐60 2000mgm
3B 30‐45 1000mgm
4 15‐30 DoNotUse
5 <15 DoNotUse
38Source:InzucchiS.MetformininPatientsWithType2DiabetesandKidneyDisease:ASystematicReview.JAMA2014;312(24):2668‐2675.
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Thiazolidinediones• Maycauseedema1
• Associatedwithhigherriskofheartfailureinadultswithoratriskfortype2diabetes1
• IncreaseRiskofBoneFracturesinWomen• PioglitazoneassociatedwithreductioninCVevents(MI,stroke,mortality)inPROActivestudy(n=5,238)2
• NoEvidenceofBladderCancer
Sources:1HernandezAV,et.al.AmJCardiovascDrugs2011;11:115‐128;2DormandyJA,etal.Lancet2005;366:1279‐1289.
UseclinicaljudgementwhenconsideringTZDsforpatientswithtype2diabetes,especiallyinthesettingofpreexistent
congestiveheartfailure.
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SGLT2Inhibitors• BlocksGlucoseReabsorptioninNephron• IncreaseinUTIsandGenitalMycoticInfections• EMPA‐REGOUTCOMEtrial(n=7,020)ofindividualswithtype2diabetesatriskforCVevents
• Comparedtoplacebo,empagliflozinwasassociatedwithlowerratesof:• PrimarycompositeCVoutcome• Deathfromanycause
• ThisrelationshipcurrentlyunderinvestigationforotherSGLT2inhibitors
Source:ZinmanB,et.al.NEnglJ Med2015;373:2117‐2128. 40
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SGLT‐2Inhibitors• DiureticEffect:WatchforDehydration
– EspeciallyinElderly• DecreaseWeightandBloodPressure• IncreaseHDLCholesterol• CurrentMeds:
– Canagliflozin:IncreasedFractures– Dapagliflozin– Empagliflozin:DecreasedRiskofCVDeath
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SGLT2Inhibitors:SafetyWarning
• OnMay15,2015,theUSFDAissuedasafetywarningstatingthatSGLT2inhibitorsmayleadtoketoacidosis.
• OnDecember4,2015,thiswarningwasextendedtoincludeseriousurinarytractinfections(UTIs).
Sources: USFDA.http://www.fda.gov/Drugs/DrugSafety/ucm446845.htm(May15,2015); http://www.fda.gov/Drugs/DrugSafety/ucm475463.htm(December4,2015).
• Nochangestotheprescribinginformationweremadewiththeseannouncements.
• FDArecommendsthatcliniciansevaluatepatientsforacidosisorseriousUTIsanddiscontinueSGLT2inhibitorsifconfirmed.
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DipeptidylPeptidase4Inhibitors• NoHypoglycemia&WeightNeutral• NoOverallCardiovascularRiskorBenefit• WellTolerated:PossibleBenefitinElderly• UseCautiouslyinPatientsWithHXofHF• SideEffects:URI,SoreThroat,Diarrhea,Pancreatitis
• Meds:– Sitagliptin– Saxagliptin– Linagliptin– Alogliptin
Source:FDAIssuedWarningonSaxagliptin&AlogliptinCausingHeartFailureinCertainPatients.April5,2016. 43
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GLP‐1ReceptorAgonists• ActivatesGLP‐1Receptors&IncreasesInsulin
• SlowsGastricEmptying• LessHypoglycemiaRiskThanInsulin• WeightLoss• DecreaseinPostprandialGlucose• SideEffects:Nausea,Vomiting,Diarrhea,Hypoglycemia,Pancreatitis,ThyroidTumor
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GLP‐1Agonists• Injectable:AdjustForRenalClearance• Expensive• DifferentProducts
– Exenatide:GivenBID– Liraglutide:LicensedforWeightLoss– Albiglutide:WeeklySC– Dulaglutide:WeeklySC
• LowerHgbA1CButnoChangeinVascularOutcomes
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PossibleOptionsWithMetformin• DoNOTUseLASulfonylureas:Hypoglycemia• AddDPP‐4
– NoHypoglycemicRisk– UseCautiouslyinPatientsWithHF
• AddSGLT2Inhibitors– DemonstratedEfficacy– ClinicalExperience:WeightLoss– DoNotUseWithGLP‐1
• MayTryThiazolidinedione– HighEfficacy,LowHypoglycemicRisk,&Generic– WatchforEdema,HF,&Fractures
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Source:InzucchiSEetal.DiaCare2015;38:140‐149
©2015byAmericanDiabetesAssociation47
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DeliveringCulturally‐InformedCare:TheProvider‐PatientPartnership
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TheCulturally‐InformedOffice• Language‐ andtopic‐appropriatematerials• Stafftomatchpopulationserved• Bilingualorlanguage‐appropriatewallpostersandsigns• Writtentextgearedforcomprehension• Atrainedmedicalinterpreteroraccesstointerpretationservices
• Stafftrainedtoovercomeculturalmisconceptions• Recognitionofculturally‐observedholidays
Establishingaculturally‐informedofficeisthefirststeptowardprovidingculturally‐appropriatecare.
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EffectofRegularPrimaryCare• 2138DiabeticPatients• FollowedFrom1995thru2010• SouthcentralFoundation:NonprofitHealthCorporation• GivePrepaidPrimaryCareto60,000AlaskanNatives• 60%Female&AverageAgeof52atFirstEncounter• RegularPrimaryCare:AtLeast1VisitQ6MonthsFor2Consecutive6‐MonthIntervals
• 89%IncreasedLikelihoodofBPControl• 177%IncreasedLikelihoodofGlycemicControl• IncreasingtheDistanceby10MilestoRPCReducedLikelihoodofRegularPrimaryCare
50Source:SmithH.TheEffectofRegularPrimaryCareUtilizationonLong‐TermGlycemicandBloodPressureControlinAdultsWithDiabetes.JABFMJanuary‐February2015;28:28‐37
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ConsiderationsforProvidingCulturally‐AppropriateCare(1)
• Educationlevelandhealthliteracy(e.g.,abilitytounderstandconcepts)
• Familyintegrationandsupportsystems(church,community)
• Culturaljudgmentsaboutdiseaseandnormsregardingbodyimage
• Knowledgeaboutdiabetes• Learningstylesandmotivationalstrategies
Source: JuckettG.AmFamPhysician 2013;87:48‐54.
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ConsiderationsforProvidingCulturally‐AppropriateCare(2)
• Spiritualbeliefs(e.g.,beliefthateventsarepredeterminedbyfate)
• Nutritionalpreferences• Alternative/herbalpracticesandfolkremedies• Languageissues
Source: JuckettG.AmFamPhysician 2013;87:48‐54.
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PartneringwithMinorityPatients
Culturally‐informedcareisbasedonapartnership betweenthepatientandthe
healthcareprovider.
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PartneringwithMinorityPatients• Appreciatevaluesystemassociatedwithpatient’sculturalheritage
• Emphasizeholisticcarebyrecognizingbiologic,psychologic,andfaith‐basedcomponents
• Provideframeworktounderstandlevelofdiseaseseverityandrealistictreatmentoptions
• Promotetrustthroughengagedattitude• Avoidpaternalisticstance
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Cross‐CulturalInterviewing• Establishtrustthrough“smalltalk”• Useopenbodylanguage• Speakslowlyanddirectlytothepatient(ratherthantotheinterpreter)
• Useshortsentencesandanormaltoneofvoice• Avoiduseofidioms• Askpatientswhatillnessmeanstothemandabouttheircurrenttreatments
• Providetreatmentinstructionsinwriting• Havepatientrepeatinstructionsinhis/herownwords
Source: JuckettG.AmFamPhysician 2005;72:2267‐2274. 55
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Cross‐CulturalInterviewQuestions
• Whatisyournativecountry?• Howlonghaveyoubeenhere?• Whatdoyouthinkiswrong?• Whatdoyoucalltheillness?• Whatdoyouthinkhascausedtheillness?• Whydoyouthinkthattheillnessbeganwhenitdid?• Whatproblemsdoyouthinkthattheillnesscauses?
Source: JuckettG.AmFamPhysician 2005;72:2267‐2274. 56
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Cross‐CulturalInterviewQuestions
• Howsevereisyourillness?• Whatkindoftreatmentdoyouthinkisnecessary?• Whatarethemostimportantresultsyouhopetoreceivefromthistreatment?
• Whatdoyoufearmostabouttheillness?• Howdoyoucopewithyourfeelings?• Whatcanyouchange?• Whattypesofsupportdoyouhavetohelpyoudealwiththisillness?
Source: JuckettG.AmFamPhysician 2005;72:2267‐2274. 57
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The“Teach‐Back”Approach
“Teachingback”Havethepatientrepeatyourstatementsintheirownwords.
• Assessespatient’shealthliteracyandlanguageproficiency
• Promotesunderstandingofculturalissues
• Mayfacilitateadherencetoanintervention.
Source: JuckettG.AmFamPhysician 2013;87:48‐54. 58
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DeliveringCulturally‐InformedCaretoLatinoPatients
• Listenforsomaticpresentationofcomplaints• Recognizethatdiseasemaybeperceivedasinternal/externalimbalance(e.g.,bodyandsoul)
• Beawareoffolk‐healingtraditions• Incorporatesupportsystemsintotreatment(family,clergy,socialworkers,counselors)
• Recognizecentralroleofmalefamilymembers• Providetrainedmedicalinterpreterwhenneeded
Source: JuckettG.AmFamPhysician 2013;87:48‐54. 59
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CommonLatinoSomaticComplaints• Nervios (nerves;nervous,tense,irritable)• Débil (fearofbecomingweak)• Sofocada/sofocado (shortnessofbreath;outofbreath;chestpressure)
• Nerviosa /nervioso(tense,nervous)• Dolordecerebro(headache)• Empacho (stomachache;bellypain)• Malaire(“badair”;abnormalcirculationofairinthebodyasacauseofdisease)
• Susto (“soulloss”;fright;changesinappetite;difficultysleeping;headache)
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OnlineResourcesOrganization URL
AmericanDiabetesAssociation www.diabetes.org
AmericanAcademyofFamilyPhysicians www.aafp.org
AmericanAssociationofDiabetesEducators www.diabeteseducator.org
AmericanAssociation ofClinicalEndocrinologists www.aace.com
AcademyofNutritionandDietetics www.eatright.org
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CaseStudyMartin
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CaseStudy:Martin• 65‐year‐oldHispanicnotdiagnosedwithdiabetes(BMI=35.0kg/m2)
• CurrentlytakesACEinhibitorandcalcium‐channelblocker
• Frequentlywakesatnighttourinate• Recentlylostthreepounds• Doesnotwantmedicationthatcausesweightgain
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CaseStudy:Martin
Martin’slaboratoryworkupvaluesinclude:• A1c:9.2%• Randomplasmaglucose:229mg/dL• Bloodpressure:130/80mmHg• eGFR:79mL/min/1.73m2
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CaseStudy:Martin
1.AccordingtoADAguidelines,whichofthefollowingisareasonableA1c goalforMartin?
1. 5.8%2. 6.0%3. 6.5%4. 7.0%5. 8.0%
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CaseStudy:Martin2.HowshouldyouinitiallycounselMartinatthispoint?
1. HelphimlocateaCertifiedDiabetesEducatorandadietitian
2. Discussimportanceofmaintainingahealthylifestyle
3. Tellhimthathewilllikelyneedtoincorporatepharmacotherapytomanagehisdisease
4. Askaboutsymptomsofdiabeticketoacidosis5. Alloftheabove
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CaseStudy:Martin
Martinreportsthatheismotivatedtomanagehisweightandgetintoshape,ashehasrecentlybegundatingayoungerwoman.Healsostatesthathe“coulddobetter”withregardtohisdiet,andhedrinkssixsodasperdaywhileatwork.Youaskhimaboutthetypesofactivitythatheenjoys.
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CaseStudy:Martin
1. Takingthestairsratherthantheelevatoratwork2. Parkingfartherawayfromthebuildingatwork3. Considerjoiningalocalsportsleague4. Wearingapedometerorfitnesstrackertomeasure
stepsperday5. Alloftheabove
3.Whatcouldyourecommendforhimtoincorporatephysicalactivityintohisdailyroutine?
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CaseStudy:Martin
AlthoughyouwillconnectMartinwithaCDEforacomprehensivenutritionevaluation,youalsorecommendseveralsmalladjustmentstohisdiet,suchasswitchingfromsodatocoffeeortea,limitingfast‐foodintakeandsnacks,andcontrollingportionsizeswheneatingatrestaurants.Thisisalsoagreattimetodiscussoptionsformedications.
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CaseStudy:Martin4.WhichofthefollowingclassesofantihyperglycemicagentsareNOT associatedwithweightgain?
1. Sulfonylurea2. SLGT2inhibitor3. Thiazolidinedione4. Metformin5. 2 and4only
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CaseStudy:Martin5.BasedonMartin’sstatus,whichofthefollowingisasuitableinitialinterventiontohelpMartinmanagehisdiabetesandlowerhisCVDrisk?
1. Nochangesatpresent2. Lifestylechangesonly3. Lifestylechangesplusmetformin4. Lifestylechangesplusmetforminandasecond
agent5. Lifestylechangesplusbasalinsulin
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CaseStudy:Martin
Yourecommenddualtherapy,butMartinoptsinitiallyformetforminonly.YouscheduleaconsultwithaCDEinoneweekandfollowupwithMartininthreemonthstoassesshisprogress.
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CaseStudy:MartinAthisfollow‐upvisit,Martinhaslostfivepounds,andhisA1c isnow8.3%.Hereportsnoadditionalpolyuriaornocturia.Goingforward,youshouldconsiderthefollowingwithMartin:• Initiateasecondagenttosustainhismomentum,offeringseveraloptions,dependinguponwhetherhewishestouseanoralorparenteralagent.
• Scheduleafollow‐upvisitinthreemonths
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Conclusions• Achievingglycemiccontrolisessentialtomanagediabetesanditscomplications.
• Managementismulti‐facetedandinvolvesbehavioralmodificationsandinterdisciplinarycare.
• TreatmentmustbeindividualizedandaimedatadditionalfactorsthataffectCVhealth(e.g.,bloodpressure,lipidprofiles,weight).
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Conclusions
• Hypoglycemicepisodesshouldbeminimized.• Patientsshouldbeinvolvedinthediseasemanagementprocessasearlyaspossible,informedwithculturally‐appropriateconsiderations.
• Attentivenesstospecificpatientcharacteristicswillhelptheproviderdesigneffectiveinterventions
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MedicationsGeneric TradeName
Canagliflozin InvokanaDapagliflozin FarxigaEmpagliflozin JardianceSitagliptin JanuviaLinagliptin TradjentaAlogliptin NesinaExenatide ByettaLiraglutide VictozaAlbiglutide TanzeumDulaglutide Trulicity
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Questions
TolearnmoreaboutdiabetesmanagementinspecialpopulationsandearnadditionalCME
credit,visit
www.njafp.org/education
Don’tforgottocompleteyourevaluationandclaimcredit.Returnthecompletedformtoastaffmember.
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