Malignant Breast Tumors Oke
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Transcript of Malignant Breast Tumors Oke
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SURGERY DEPARTMENT FACULTY OF MEDICINE YARSI UNIVERSITY JAKARTA 2011
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Risk FactorsMenarche , 11 years oldNulliparaNon breast feedingHormonal therapyHigh fat diet, alcoholPositive pedigreePrevious benign breast lesion Ovarium tumor Radiotherapy
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ANAMNESIS
The chief complain The risk factors The metastasis symptom and sign
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MASSFixedUnclear borderUn smooth surfacePeau de orangeDimplingUlcusSatellite nodule
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AXILLARY
Palpation of lymph nodes
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Mammography
Ultrasonography
MRI
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ClinicMammographyFNAB
Concordan benignaConcordan malignaInconcordan
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TNM system
TTxT0Tis, DCIS, LCIS
T1 T5cm
T4 a. chest wallb. skinc. bothd. mastitis carsinomatosa
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NxN0N1 axilla, mobileN2 axilla, fixedN3a. infraclaviculab. Axilla + mammaria internac. supraclavicula
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Mx M0no distance metastasesM1 distance metastases
Ro thoraxUSG abdomenOther clinical picture
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Grading
G1 Low gradeG2 IntermediateG3 High grade
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SURGERY
Breast Conserving TherapyModified Radical MastectomySimple Mastectomy
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RADIOTHERAPY
CHEMOTHERAPYCMFCEFCAFTaxol + DoxoCapecitabine
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AdditiveTamoxifen
AblativeBilateral oophorectomyOperativeRadiation
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GeneticBiomolecular
P53BRC A1BRC A2HER2/NEUC-erbB-2Cathepsin-D