Malaria pan-R Malaria cassette. Agenda Disease overview Infectious agents Diagnosis pan-R Malaria...
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Transcript of Malaria pan-R Malaria cassette. Agenda Disease overview Infectious agents Diagnosis pan-R Malaria...
Malariapan-R Malaria cassette
Agenda• Disease overview
• Infectious agents
• Diagnosis
• pan-R Malaria cassette: specifications
• Conclusion
Malaria Overview• One of the most common & serious tropical diseases
– 300-500 million clinical cases worldwide– 1-2 million deaths– 41% of the world's population live in areas where
malaria is transmitted – rising each year as drug resistance increases and
health systems deteriorate
• Transmitted via the female Anopheles mosquito
• No vaccine
Global distribution
Infectious agents• Caused by 4 species of protozoal parasites from the
Plasmodium genus
– Plasmodium falciparum– Plasmodium vivax– Plasmodium ovale– Plasmodium malariae
• P. falciparum causes the most severe form of the disease
• If P. falciparum infection is not treated or the parasites are resistant to the drug-therapy, the disease can become life-threatening
Infectious agents• P.falciparum infection is most prevalent throughout Africa
• Increasing P.falciparum infections throughout Latin America, the Western Pacific and the Asia-Pacific regions
• Rapidly developing resistance to many of the drugs commonly used to treat malarial infections
• Expensive drug combination therapies now needed
• Accurate and rapid diagnosis of infection is more crucial than ever
Diagnosis• Accurate, Rapid & Confident diagnosis of infection is
crucial to providing effective treatment to manage the disease
• Misdiagnosis improper & unnecessary treatment
– Increased therapy costs
– Increased risk of drug resistance
Diagnosis• Accurate, Rapid & Confident diagnosis:
– Appropriate & effective drug treatment– Greater control over spread of infection
• Great advantage for health workers to be able to differentiate a P. falciparum malarial infection
• Increasing importance on the accurate diagnosis of parasitaemia prior to treatment
• P. falciparum drug resistance– expensive multi-drug regimes
Diagnosis• The pan-R Malaria Cassette can:
– Detect all pathogenic malaria antigens, in whole blood – Differentiate a P.falciparum infection
• Provides qualitative detection of:
– Plasmodium falciparum– Plasmodium vivax– Plasmodium ovale– Plasmodium malariae
Diagnosis• Provides patients and health-workers with a useful
diagnosis
– Rapid implementation of therapy
– Correct therapy
– Prioritise precious (& expensive) resources
– Save lives
SpecificationsName: pan-R Malaria CassetteCat. No. R-MAL01DExpiry: 18 monthsStorage: 4 – 28°C (room temperature, below 30°C)Antigen: HRP2, P. aldolaseSample: Whole bloodTest time: 15 minutesKit size: 25 tests & Collection devices, 1 bottle of
bufferProcedure: 2 well cassette, 5uL serum, 5 drops of
buffer
Procedure
Interpretation
Performance CharacteristicsTable 1: Sensitivity and Specificity of the Panbio pan-R Malaria Cassette P. falciparum versus non-P. falciparum Characterised Specimens
Specimen characterisation (Microscopy & PCR)
Panbio pan-R Malaria Cassette
Positive Negative Total
P.falciparum 262 11 273
Non P.falciparum 32 3 35
Negative 1 316 317
Total 295 330 625
Performance Characteristics95% CI*
Serological Sensitivity(P. falciparum)
= 262/273 96.0% 92.9 - 98.0%
Serological Sensitivity(non-P. falciparum)
= 32/35 91.4% 76.9 - 98.2%
Serological Specificity (Negative)
= 316/317 99.7% 98.3 - 100.0%
Relative Serological Agreement
= 610/625 97.6% 96.1 - 98.7%
*Confidence Interval
pan-R Malaria Cassette
Product brochure
Summary Card
Competitors• DiaMed OptiMAL
• Binax NOW
• Standard Diagnostics
• Core Diagnostics
Binax NOW OptiMAL
Panbio
Conclusion
www.panbio.com