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![Page 1: Making Sense of Sellar Region Pathology: Image-based Diagnostic Algorithm Ammar Chaudhry, MD Rajesh Gupta, MD Luboslav Woroch, DO Alexander Filatov, MD.](https://reader034.fdocuments.us/reader034/viewer/2022051516/56649d995503460f94a840c1/html5/thumbnails/1.jpg)
Making Sense of Sellar Region Pathology: Image-based
Diagnostic Algorithm
Ammar Chaudhry, MDRajesh Gupta, MDLuboslav Woroch, DOAlexander Filatov, MDRobert Peyster, MDLev Bangiyev, DO
eEdE-69SN: 960
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Disclosures
• No relevant disclosures
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Objective
• Review of anatomy of sellar and parasellar regions
• Review common indications for imaging of the pituitary gland
• Discuss imaging techniques of the pituitary gland
• Review common pathology of the pituitary gland and the adjacent structures
• Image-based diagnostic algorithm
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Sphenoid Bone Anatomy
• Pituitary fossa• Tuberculum sellae• Optic nerve canal• Chiasmatic sulcus• Superior orbital fissure• Anterior clinoid• Posterior clinoid• Greater wing of sphenoid• Lesser wing of sphenoid• Planum sphenoidale
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Pituitary Gland Anatomy• Lies within sella turcica• Composed of two major parts– Anterior lobe – Adenohypophysis• Pars distalis – bulk of the gland,
hormone secretion• Pars intermedia• Pars tuberalis• GH, TSH, ACTH, prolactin, LH, FSH
– Posterior lobe – Neurohypophysis• Vsopressin, oxytocin
• Laterally bounded by cavernous sinus• Optic chiasm superiorly• Diaphragma sella
http://mystatdx.com
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Embryology• Posterior lobe
– Neural primordia– Outpouching from the third
ventricle– Anatomic extension of the
CNS– Specialized glial cells
pituicytes• Anterior lobe
– Derives from the oral ectoderm Rathke’s pouch
– Gives rise to pars distalis and tuberalis
Blood Supply
• Posterior lobe supplied by inferior hypophysial arteries
• Anterior lobe – Little or no arterial supply– Portal venous system from the
pituitary stalk– Venous blood from posterior
pituitary– Humeral regulation from the
hypothalamus, posterior pituitary, and substances in the peripheral circulation
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Indications for Imaging
Imaging of the Pituitary Radiol Clin N Am 49 (2011) 549–571
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Imaging
• MR Protocol
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Imaging
• MR– Demonstrate relationship to chiasm
and cavernous sinus– Distinguishing solid, cystic, and
hemorrhagic components– Vascular structures– Anterior lobe is isointense to brain
on T1WI and T2WI– Posterior lobe is bright on T1WI and
lower intensity on T2WI
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Imaging
• Enhancement• Size
– children (<12 years) : 6mm (upper surface flat or slightly concave)
– puberty : 10mm (upper surface convex; more striking in females)
– young adult– male : 8mm– female : 9mm– pregnancy : 12mm– older adult ( > 50 years) : gradually
decreases in size
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Imaging
• CT– Calcifications– Bony septa assessment for transsphenoidal pre-
surgical planning– Involvement of the adjacent osseous structures– Contraindications to MRI
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Common Pathology• Macroadenoma• Microadenoma• Rathke’s cleft cyst• Craniopharyngioma• Langerhans Cell Histiocytosis• Germinoma• Apoplexy• Empty sella• Hypophysitis• Meningioma• Optic glioma• Hamartoma• Arachnoid cyst• Epidermoid• Lipoma• Ectopic posterior pituitary bright spot• Aneurysm• Sarcoid• Base of the skull tumors
Location Based AlgorhithmParasellar
Suprasellar Enhancing
Craniopharyngioma Germ Cell Tumors Menigioma Aneurysm
Non-enhancing Hamartoma
Pituitary Stalk Lymphocytic Hypophysitis Langherhans Histiocytosis Germ Cell Tumors Sarcoid Mets Ectopic Posterior Pituitary Lipoma
Clivus Chordoma Nasopharyngeal Carcinoma Mets
Chiasm Glioma
SellarExpanding Sella Turcica
Pituitary MacroadenomaNon-expansile
Intensity Hyperintense T1
Rathke’s Cleft Cyst (if protein)
Dermoid Cyst (children)
Hyperintense T2 Meningioma Rathke’s Cleft
Cyst Hypointense T1
Pituitary Microadenoma
Hypointense T2 Pituitary
Apoplexy
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Macroadenoma
• 55-year-old female with history of glaucoma patients was followed with serial visual field testing. The visual field deteriorated and began to show a bitemporal hemianopsia.
Cor T2WI Sag Pre T1WI Cor Pre T1WI Cor Post T1WI
• Similar imaging characteristics as microadenoma• Normal pituitary tissue often not identified• Expands the sella• “Snowman” appearance where the waist is the imprint from rigid
dura• May extend into the suprasellar region and compress the chiasm• May invade the cavernous sinus
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Microadenoma
• 19 yo female with hyperprolactinemia
Dyn Cor Pre T1WI Dyn Cor Post T1WI • Approximately 10% to 15 % of all intracranial neoplasms• Most common sellar tumor• Benign• Classified based on size
– Microadenomas <10mm – Macroadenomas >10mm
• Clinically classified based on endocrinological activity or lack– Functional pituitary adenomas usually secrete single hormone– Prolactin most common followed by GH and ACTH
• Microadenomas are hypovascular compare to normal pituitary tissue
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Invasive Pituitary Adenoma• Clival invasion is rare but potentially significant complication of pituitary adenoma• Difficult to detect on MR imaging, easily seen on CT• Risk factor for clival invasion:
• female sex • large tumor volume • null-cell subtype • Larger tumor volume correlated with null-cell subtype (Mann-Whitney U test, P = .006), incidence of clival invasion (P < .001), and
extent of clival invasion
• Clival invasion was associated with a significantly higher ratio of operative complications and recurrence
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Pituitary Apoplexy
• 40 yo male with progressive visual decline in the right eye over several weeks, presents with rapid visual loss, slight droopiness of the right eye, and severe headache. Pituitary adenoma with hemorrhage.
Sag Pre T1WI Ax T2WI Cor Post T1WI
Lack of direct arterial supply to anterior pituitary lobe makes it susceptible to ischemia with or without hemorrhage
Clinical syndrome
HeadacheVisual changesOphthalmoplegiaMental status change
Underlying adenoma is often present
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Empty Sella• Patulous diaphragma
sellae• Aging• Pseudotumor cerebri• Infarction• Surgery• Radiation therapy• Hypopituitarism is rare
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Rathke’s Cleft Cyst
25 yo female with headaches
Sag Pre T1WI Sag Post T1WI Cor T2WI Cor Post T1WI
• Derive from Rathke’s pouch (primitive oral ectoderm)• Lined by single layer of columnar or cuboidal epithelium• Frequently asymptomatic• May present with bitemporal hemianopsia or pituitary
dysfunction• Intrasellar and non-invasive• May contain serous or mucoid material
– Serous – hypodense on CT, T1 hypointense and T2 hyperinstense– Mucoid – hyperdense on CT, T1 hyperintense
• Rarely calcify• May demonstrate mild enhancement of the wall
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• 8 yo female presented with progressive double vision and papilledema• Left CN VI palsy
• Adamantinomatous type craniopharyngioma
• 73 yo female with headache and visual disturbance
• Papillary craniopharyngioma
Ax Pre T1WI
Cor Post T1WI
Sag Post T1WI
Ax Post T1WI
Ax T2WI
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Craniopharyngioma• Benign neoplasm arising from
squamous epithelial remnants of Rathke’s pouch
• Tend to recur and invade adjacent structures
• Commonly present with – Headaches – Endocrine dysfunction – Visual disturbance
• Bimodal age at presentation – 5 to 14 years in children – 65 to 74 years in adults
• Usually suprasellar, but may extend into the sella– Preachasmatic – visual disturbance– Retrochiasmatic – increased ICP,
compression of the hypothalamus and protrusion into the third ventricle
• Imaging characteristics– Vary in size and composition– Cystic and/or solid
• CT– Enhancing solid/cystic mass– Calcifications +/-
• MRI– T1WI – vary intensity depending on
contents (proteinaceous debris, cholesterol, and hemoglobin)
– Enhancement of the solid component
– T2WI – predominantly hyperintense– Calcifications are hypointense on all
pulse sequences
Histopathologic Types of Craniopharyngiomas
Adamatinous Squamous-Papillary
Location Suprasellar Intrasellar/suprasellar or suprasellar
Age Children, occasionally adults Adults
Tissue structure Predominantly cystic Predominantly solid
T1 without contrast Hyperintense cysts typical If ever, hypointense cysts
Shape Lobulated Spherical
Encase vessel Yes No
Tumor recurrence +++ +
Calcifications +++ +
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Meningioma
25 yo female with history of meningioma
Sag Pre T1WI
Ax Post T1WI
Cor Post T1WISag Post T1WI
Ax T2WI
• May arise from the tuberculum sellae, anterior clinoid, diaphragma sellae, planum sphenoidale, cavernous sinus, and upper clivus
• Commonly present with progressive visual symptoms• CT – hyperdense mass with homogenious enhancement• MRI – T1 isointense, T2 iso-hyperintense, avid
enhancement• Distinguished from pituitary adenoma by
– Normal size of the sella turcica– Identification of the normal pituitary tissue – Can invade cavernous sinus with narrowing and/or occlusion of ICA – Hyperostosis
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Optic Glioma
6 yo male with progressive left eye vision loss over a year
Ax Pre T1WI Cor Pre T1WI Cor Post T1WI Cor Post T1WI
Cor T2WI
• Tumor of childhood• Majority benign and slow growing• Often associated with NF1• Separate from pituitary gland• T1 isointense and T2 hyperintense with
variable enhancement• Presence of cystic component suggests JPA
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Germ Cell Tumor• Lesion of childhood and young adults• Germinoma is the most common type• 20 % in sellar/suprasellar region and remainder in
pineal region• Commonly present with DI, hypopituitarism, and
optic chiasm compression• CT – hyperdense and homogeneously enhancing
• MR Findings– T1WI – Iso-/hyperintense to gray matter– T2WI – Iso-/hyperintense to gray matter– Calcification, hemorrhage (rare)– DWI: Restricted diffusion due to high
cellularity– Strong, homogeneous enhancement, ± CSF
seeding, ± brain invasion
Sag T2WI Sag Pre T1WI Sag Post T1WI Cor Post T1WI
• 21 yo male presented with progressive vomiting, polyuria and polydipsia for months, progressive loss of his peripheral vision in both eyes bitemporal inferior quadrantsanopsia, panhypopituitarism and diabetes insipidus
• HCG serum ↑, BhCG CSF ↑ ↑ ↑
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Lymphocytic Hypophysitis
23 yo female with hypopituitarism
Sag Post T1WI Cor Post T1WICor T2WI Sag Pre T1WI
• Inflammatory disease of the pituitary• Can involve infundibulum• Young women during late pregnancy or postpartum• Imaging shows enlarged enhancing pituitary gland and thickened
infundibulum• May regress spontaneously or with steroids
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Hamartoma of the Tuber Cinereum
2 yo female with gelastic sezures consisted of laughing, turning her head to left side and tonic motor activity of the extremities
Sag Pre T1WI Sag Post T1WI Ax FLAIR Ax T2WI
• Congenital non-neoplastic heterotopias• Known cause of
– Precaucious puberty due to secretion of LH-releasing hormone– Gelastic seizures may be related to connection of the lesion with limbic system or possibly presence
of other abnormalities (callosal agenesis, heterotopias, and microgiria)• Just anterior to mamillary bodies• T1 isointense and T2 hyperintense to gray matter• Do not enhance, calcify, or contain cysts
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Langerhans Cell Histiocytosis
13 yo male presented with diabetes insipidus
Sag Post T1WI Cor Post T1WI
• Proliferation of Langerhans cell histiocytes forming granulomas within any organ system
• Etiology: Uncertain: Inflammatory ↔ neoplastic• Peak age at onset 1 year (isolated), 2-5 years (multifocal disease)• Common presentation – DI, ± visual disturbance, ± hypothalamic
dysfunction• On imaging thick enhancing infundibulum, absent posterior pituitary
bright spot
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Lymphocytic Hypophysitis
23 yo female with hypopituitarism
Sag Post T1WI Cor Post T1WICor T2WI Sag Pre T1WI
• Inflammatory disease of the pituitary• Can involve infundibulum• Young women during late pregnancy or postpartum• Imaging shows enlarged enhancing pituitary gland
and thickened infundibulum• May regress spontaneously or with steroids
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Granulomatous Disease
• Sarcoid, TB, Wegener etc.• Cranial nerve involvement• Cannot be differentiated by imaging• Sarcoid may present with sellar or suprasellar mass
and masquerade as pituitary adenoma or meningioma
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Epidermoid
• Cystic lesion filled with keratin• Signal characteristics are similar to CSF on T1 and T2, however
not FLAIR• Show restricted diffusion• Usually do not enhance• Insinuate throughout the suprasellar region
Ax T2WI Ax FLAIR Sag Pre T1WI Ax DWI
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Lipoma
• Incidentally found lipoma. Patient was imaged for headache.
Sag Pre T1WI
• Characterized by T1 hyperintensity due to fat
• Lipomas are usually circumscribed
• Teratomas and dermoids can grow large and compress adjacent structures
• Teratomas may contain calcification or ossification
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Chordoma
58 yo male with jerking motions during sleep and progressive memory loss. No visual changes or endocrine symptoms
Ax NECT Sag Pre T1WI Sag Post T1WI
Cor T2WI
• Imaging– CT
• Soft tissue mass with bone destruction and calcifications
– MRI• T1WI – isointense to brain parenchyma with
hypointense calcifications • T2WI – hyperintensity is a rule• Enhance
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Metastasis
• 53 yo female with history of breast CA
Ax Pre T1WI Ax T2WI Sag Post T1WI
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Aneurysm
• 51 yo male with acute onset of headache and left CN III palsy
NECT Ax T2WI Ax Pre T1WI Cor Post T1WI
AP Lt CCALat Lt CCA
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CONCLUSION Location
Sellar
Intensity
Isointense T1
Hypo T2
Pit apoplexy-subacute
(hyper T1/T2)-comp of adenoma
Hyperintense T2
Gender
Both
Pituitary Macroadenoma
- >10 mm-mild
enhancement
Female
Enhancement
Intense
Meningioma
-Calcify
-can be
supras ellar
Rare
Rathke’s Cleft cyst
Hypointense T1
Pituitary Micr oadenoma- <10 mm
-hypoenhancement
Hyperintense T1
Gender
Male
Dermoid Cyst
-Children-Calcify
Female
Rathke’s cleft cyst
-if protein content-Adults
Eccentric mass (cavernous carotid
aneurysm)
Suprasellar
Heterogeneous
Craniopharyngioma-cystic – high T1/T2-solid – enhances
-bimodal age-calcify
Homogeneous
Germ Cell Tumors-iso T1/T2-uniform
enhancement
Pituitary Stalk
Young age
Histiocytosis (Eosinophilic Granuloma)
Intensity
Hypo
T1/hyper T2
Mets-enhances
Iso T1/T2
Sar co i d-en h an ces
-femal e
Lymphocytic Hypophysitis
Chiasm/Hypothalamus
Enhancement
Yes
Glioma-iso T1/hyper T2
-young age-hyperintense FLAIR
No
Hamartoma-iso T1/T2
-floor of 3rd vent