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![Page 1: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/1.jpg)
Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic
Peripheral Neuropathy
Featured Article:
Dinesh Selvarajah, Iain D. Wilkinson, Michael Maxwell, Jennifer Davies, Adhithya Sankar, Elaine Boland, Rajiv Gandhi, Irene Tracey, and Solomon Tesfaye
Diabetes Care Volume 37: 1681-1688
June, 2014
![Page 2: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/2.jpg)
STUDY OBJECTIVE
• To investigate any differences in brain structure in subjects with diabetic peripheral neuropathy (DPN)
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688
![Page 3: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/3.jpg)
STUDY DESIGN AND METHODS
• 36 subjects with type 1 diabetes underwent neurophysiological assessment to quantify the severity of DPN:
• No DPN, n = 18• Painful DPN, n = 9• Painless DPN, n = 9
• All subjects underwent volumetric brain magnetic resonance imaging at 3 Tesla
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688
![Page 4: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/4.jpg)
RESULTS
• Adjusted peripheral gray matter volume was statistically significantly lower in subjects with painless and painful DPN than in subjects with no DPN and healthy volunteers (HVs)
• Difference was not statistically significant in adjusted peripheral gray matter volume between subjects with no DPN and HVs and those with painful DPN and painless DPN
• Voxel-based morphometry analyses revealed greater localized volume loss in the primary somatosensory cortex, supramarginal gyrus, and cingulate cortex in DPN subjects
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688
![Page 5: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/5.jpg)
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688
![Page 6: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/6.jpg)
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688
![Page 7: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/7.jpg)
CONCLUSIONS
• There is increased peripheral gray matter volume loss localized to regions involved with somatosensory perception in subjects with DPN
• This finding may have important implications for the long-term prognosis of DPN
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688
![Page 8: Magnetic Resonance Neuroimaging Study of Brain Structural Differences in Diabetic Peripheral Neuropathy Featured Article: Dinesh Selvarajah, Iain D. Wilkinson,](https://reader036.fdocuments.us/reader036/viewer/2022081603/56649f2b5503460f94c45398/html5/thumbnails/8.jpg)
Selvarajah D. et. al. Diabetes Care 2014;37:1681-1688