Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in...
-
Upload
sharon-robinson -
Category
Documents
-
view
219 -
download
0
Transcript of Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in...
![Page 1: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/1.jpg)
Lymphoma and Myeloma | Kristine Krafts, M.D.
![Page 2: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/2.jpg)
Leukemia• Malignancy of hematopoietic cells• Starts in bone marrow, can spread to blood, nodes• Myeloid or lymphoid• Acute or chronic
Lymphoma• Malignancy of hematopoietic cells• Starts in lymph nodes, can spread to blood, marrow• Lymphoid only• Hodgkin or non-Hodgkin
Hematologic Malignancies
![Page 3: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/3.jpg)
![Page 4: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/4.jpg)
Leukemias• Acute leukemias• Chronic leukemias
Lymphomas• Hodgkin lymphoma• Non-Hodgkin lymphoma
Plasma cell disorders• Multiple myeloma
Hematologic Malignancies
![Page 5: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/5.jpg)
Leukemias• Acute leukemias• Chronic leukemias
Lymphomas• Hodgkin lymphoma• Non-Hodgkin lymphoma
Hematologic Malignancies
![Page 6: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/6.jpg)
Lymphadenopathy
![Page 7: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/7.jpg)
Lymphadenopathy
![Page 8: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/8.jpg)
• Most common cause overall: benign reaction to infection
• Most common malignant cause: metastatic carcinoma
Causes of lymphadenopathy
![Page 9: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/9.jpg)
Lymph node anatomy
![Page 10: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/10.jpg)
Reactive lymph node
![Page 11: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/11.jpg)
Reactive lymph node
![Page 12: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/12.jpg)
Reactive lymph node
![Page 13: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/13.jpg)
Benign (L) vs. malignant (R)
![Page 14: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/14.jpg)
• Malignant proliferation of lymphoid cells (blasts or mature cells) in lymph nodes
• Skips around• Many subtypes• Most are B cell
Things you must know
Non-Hodgkin Lymphoma
![Page 15: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/15.jpg)
• Painless, firm lymphadenopathy• Extranodal manifestations• “B” symptoms: weight loss,
night sweats, fever
Symptoms of NHL
![Page 16: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/16.jpg)
NHL presenting as gingival lesion
![Page 17: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/17.jpg)
NHL involving gingiva
![Page 18: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/18.jpg)
NHL presenting as palatal lesion
![Page 19: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/19.jpg)
• Older patients• Indolent (incurable!)• Small, mature cells• Non-destructive
• Children, sometimes• Aggressive (curable?)• Big, ugly cells• Destructive
Low-grade High-grade
Features of Low-Grade vs. High-Grade NHL
![Page 20: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/20.jpg)
• Small lymphocytic lymphoma• Malt lymphoma• Follicular lymphoma• Mycosis fungoides
Low-grade High-grade
• Large cell lymphoma• Lymphoblastic lymphoma• Burkitt lymphoma
Types of NHL
![Page 21: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/21.jpg)
• Small mature lymphocytes• Same thing as CLL• CD5+• Long course; death from infection
Things you must know
Small Lymphocytic Lymphoma
![Page 22: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/22.jpg)
Small lymphocytic lymphoma
![Page 23: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/23.jpg)
Small lymphocytic lymphoma
![Page 24: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/24.jpg)
• Occurs in mucosa-associated lymphoid tissue• Associated with Helicobacter pylori• Early on, can be cured with antibiotics
Things you must know
MALT Lymphoma
![Page 25: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/25.jpg)
MALT lymphoma
![Page 26: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/26.jpg)
MALT lymphoma
![Page 27: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/27.jpg)
• Follicular pattern (later diffuse)• Small cleaved cell, mixed or large cell• Grade 1, 2, or3• t(14;18) - IgH and bcl-2
Follicular Lymphoma
Things you must know
![Page 28: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/28.jpg)
Follicular lymphoma
![Page 29: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/29.jpg)
Follicular lymphoma
I II III
![Page 30: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/30.jpg)
Follicular lymphoma
![Page 31: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/31.jpg)
Stage I
Stage II
Stage III
Stage IV
Single node
Two or more nodes onsame side of diaphragm
Lymph nodes on both sidesof the diaphragm
Diffuse extranodalinvolvement
90% 5ys
A = no additional symptomsB = weight loss, night sweats, fever
40% 5ys
Staging and Prognosis of Follicular Lymphoma
![Page 32: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/32.jpg)
• Skin lesions• Blood involvement• Cerebriform lymphocytes• T-cell immunophenotype
Things you must know
Mycosis Fungoides/Sézary Syndrome
![Page 33: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/33.jpg)
Mycosis fungoides/Sézary syndrome
![Page 34: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/34.jpg)
Mycosis fungoides/Sézary syndrome
![Page 35: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/35.jpg)
Mycosis fungoides/Sézary syndrome
![Page 36: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/36.jpg)
Mycosis fungoides/Sézary syndrome
![Page 37: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/37.jpg)
Mycosis fungoides/Sézary syndrome
![Page 38: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/38.jpg)
Mycosis fungoides/Sézary syndrome
![Page 39: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/39.jpg)
• Large B cells• Extranodal involvement• Grows rapidly• Bad prognosis
Things you must know
Diffuse Large-Cell Lymphoma
![Page 40: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/40.jpg)
Diffuse large-cell lymphoma
![Page 41: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/41.jpg)
Diffuse large-cell lymphoma
![Page 42: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/42.jpg)
• Typical patient: teenage male with mediastinal mass
• Lymphoblasts in diffuse pattern• Same as ALL*
* Which kinds of ALL?
Things you must know
Lymphoblastic Lymphoma
![Page 43: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/43.jpg)
T-Lymphoblastic lymphoma
![Page 44: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/44.jpg)
T-cell lymphoblastic lymphoma/T-cell ALL
![Page 45: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/45.jpg)
• Children, young adults• Fast-growing• Extranodal mass• Starry-sky pattern
Things you must know
Burkitt Lymphoma
![Page 46: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/46.jpg)
Burkitt lymphoma
![Page 47: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/47.jpg)
Burkitt lymphoma
![Page 48: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/48.jpg)
Burkitt lymphoma
![Page 49: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/49.jpg)
• Younger patients, good prognosis• Contiguous spread• Five subtypes• Reed-Sternberg cell
Things you must know
Hodgkin Lymphoma
![Page 50: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/50.jpg)
Hodgkin lymphoma
![Page 51: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/51.jpg)
Reed-Sternberg cell
![Page 52: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/52.jpg)
Hodgkin lymphoma
![Page 53: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/53.jpg)
• Younger patients• Disease often localized• Prognosis generally good• Danger: second malignancies
Clinical Features of Hodgkin Lymphoma
![Page 54: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/54.jpg)
• Malignant proliferation of plasma cells• Monoclonal gammopathy• Decreased normal immunoglobulins• Osteolytic lesions
Multiple Myeloma
Things you must know
![Page 55: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/55.jpg)
• Weakness• Infections• Renal failure• Bone pain• Hypercalcemia
Clinical Features of Multiple Myeloma
![Page 56: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/56.jpg)
Multiple Myeloma
![Page 57: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/57.jpg)
Multiple Myeloma
![Page 58: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/58.jpg)
Multiple Myeloma
![Page 59: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/59.jpg)
Multiple Myeloma
![Page 60: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/60.jpg)
Multiple Myeloma
![Page 61: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/61.jpg)
Serum protein electrophoresis
![Page 62: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/62.jpg)
Serum protein electrophoresis
![Page 63: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/63.jpg)
Serum protein electrophoresis
![Page 64: Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.](https://reader036.fdocuments.us/reader036/viewer/2022062314/56649e8f5503460f94b937ee/html5/thumbnails/64.jpg)
• Chemo and radiation• Bone marrow transplant• 5 year survival with chemo only: 20%
Treatment of Multiple Myeloma