Luncheon Seminar 1 12:20-13:20 Room 1/ Kobe …...Medicine, University of Tokyo2, Department of...

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Luncheon Seminar 1 12:20-13:20 Room 1/ Kobe International Conference Center, Main Hall (1F)Commentary on liaison services

Chair: Hiroshi Hagino ( School of Health Science Tottori University Faculty of Medicine)

LS-1-1 Living with OsteoporosisEiko Dan(patient experienced fragility fracture)

LS-1-2 Clinical standards of fracture liaison services for secondary prevention in JapanNoriaki Yamamoto(Niigata Rehabilitation Hospital)

(Co-sponsored by UCB Japan Co.,Ltd.)

Luncheon Seminar 2 12:20-13:20 � Room 2/ Kobe International Conference Center, International Conference Room (3F)

Chair: Hiroaki Ohta ( Fujita Health University Hospital, International Medical Center / Sanno Medical Center, Women's Medical Center)

LS-2 Osteoporosis Liaison service; Present and Looking to the Future - Lecture & Discussion -

Part 1 : LectureKaoru Yamazaki(Department of Orthopaedic Surgery, Iwata City Hospital)

Part 2 : Panel DiscussionPanelist : Kaoru Yamazaki

(Department of Orthopaedic Surgery, Iwata City Hospital)

Toshiaki Kotani(Department of Orthopaedic Surgery, SEIREI SAKURA Citizen Hospital)

Osei Tsuji(Asahino General Hospital, Department of Orthopaedics)

Miwa Hoshino(Division of Regional cooperation, Niigata Rehabilitation Hospital)

Takehide Katogi(Department of Rehabilitation, SEIREI SAKURA Citizen Hospital)

(Co-sponsored by Pfizer Japan Inc.)

Luncheon Seminar 3 12:20-13:20 Room 4/ Kobe International Conference Center, 401･402 (4F)

Chair: Taku Saito ( Orthopaedic Surgery, The University of Tokyo Hospital) LS-3 The appropriate therapies for osteoporosis- Induction and sequential therapy -

Shinya Tanaka(Department of orthopaedic surgery, Saitama medical university)

(Co-sponsored by TEIJIN PHARMA LIMITED)

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Luncheon Seminar 4 12:20-13:20 Room 7/ Kobe International Conference Center, 502 (5F)

Chair: Naohisa Miyakoshi ( Akita University Graduate school of Medicine Department of Orthopedic Surgery)

LS-4 Interdisciplinary collaboration and community cooperation in the treatment of osteoporosis - Expectations for managers of osteoporosis liaison service -

Jun Iwamoto(Bone and Joint Disease Center, Keiyu Orthopaedic Hospital)

(Co-sponsored by Eisai Co., Ltd. )


Chair: Satoshi Asano ( Saitama Spine Center, Higashi Saitama General Hospital) LS-5 The Present Situations and Countermeasures of the Care Gap of Osteoporosis

Practice: Use of 5IQ for the Primary and Secondary Fracture PreventionShinichi Nakatoh(Department of Orthopedic Surgery, Asahi General Hospital)

(Co-sponsored by Asahi Kasei Pharma Corporation)

Luncheon Seminar 6 12:20-13:20 Room 9/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall A (2F)

Chair: Takeshi Miyamoto ( Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University)

LS-6 Why cannot we stop the treatment of osteoporosis?Mitsuru Saito(Department of Orthopaedic Surgery, Jikei University School of Medicine)

(Co-sponsored by Eli Lilly Japan K. K.)

Evening Seminar 1 18:00-19:00 Room 2/ Kobe International Conference Center, International Conference Room (3F)

Chair: Atsushi Suzuki ( Department of Endocrinology and Metabolism, Fujita Health University)

ES-1 AVOIDING RECURRENCE OF FRACTURES - AN INTERNATIONAL PERSPECTIVE OF SUCCESSFUL SECONDARY FRACTURE PREVENTION AND BEST PRACTICE STANDARDS

Kristina Åkesson(Lund University, Clinical Sciences Malmö, Clinical and Molecular Osteoporosis unit, Sweden / Department of Orthopedics, Skane University Hospital, Sweden)

(Co-sponsored by Chugai Pharmaceutical Co., Ltd)


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Evening Seminar 2 18:00-19:00 Room 6/ Kobe International Conference Center, 501 (5F)

Chair: Yasuhiro Takeuchi ( Toranomon Hospital Endocrine Center) ES-2 Pathophysiology and diagnosis of hypophosphatemic diseases -Importance of

FGF23 measurement-Takuo Kubota(Department of Pediatrics, Osaka University Graduate School of Medicine)

(Co-sponsored by Hitachi Chemical Diagnostics Systems Co.,Ltd.)

Day 1 Saturday, October 12

Future Planning Committee Highlights 8:00-9:00 Room 2/ Kobe International Conference Center, International Conference Room (3F)

Chairs: Sakae Tanaka ( Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo)

Yasuhiro Takeuchi (Toranomon Hospital Endocrine Center) Basic

Sakae Tanaka( Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo)

ClinicalYasuhiro Takeuchi(Toranomon Hospital Endocrine Center)

Symposium2 9:10-10:40�� Room 10/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall B (2F)New frontiers of conservation and regeneration of bone tissues

Chairs: Riko Nishimura ( Department of Molecular & Cellular Biochemistry, Osaka University Graduate School of Dentistry)

Yoshihide Ota ( Depaetment of Oral and Maxillofacial Surgery, Tokai University, School of Medicine)

SYB2-1 In vitro recapitulation of osteogenic differentiation and its applicationJunya Toguchida1, Shunsuke Kawai1, Junko Sunaga2, Taiji Adachi2

(Laboratory of Tissue Regeneration, Institute for Frontier Life and Medical Science, Kyoto University1, Laboratory of Biomechanics, Institute for Frontier Life and Medical Science, Kyoto University2)

SYB2-2 Development of a periodontal regeneration therapy by transplantation of autologous adipose tissue-derived multi-lineage progenitor cells

Masahide Takedachi(Department of Periodontics and Endodontics)

SYB2-3 An appropriate evaluation method of clinical gnathic bone regeneration and an effort to the social implementation of bone regenerative therapy with cultured autogenous periosteum

Masaki Nagata(Division of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Niigata University)


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SYB2-4 Treatment for anti-resorptive agents-related osteonecrosis of jawYoshihide Ota(Depaetment of Oral and Maxillofacial Surgery, Tokai University, School of Medicine, Japan)

SYB2-5 Necessity of the osteoporosis treatmentHiroshi Hagino(School of Health Sciences, Tottori University Faculty of Medicine)

Co-sponsored by Japanese Society of Oral and Maxillofacial Surgeons

Educational Lecture 09:40-10:40 Room 7/ Kobe International Conference Center, 502 (5F)

Chair: Hiroshi Takayanagi ( Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

EL The�role�of�cytokines�in�controlling�cortical�bone�developmentNatalie�A.�Sims

（St.�Vincent's�Institute,�Australia）

Alexion Sponsored Seminar 10:10-11:10 Room 1/ Kobe International Conference Center, Main Hall (1F)

Chair: Keiichi Ozono ( Department of Pediatrics, Osaka University) SS-1 The adult forms of Hypophosphatasia: clinical features, diagnosis and

managementFrancesco Conti(Department of Clinical and Molecular Medicine, Sapienza University, Sant’Andrea Hospital, Italy)

(Co-sponsored by Alexion Pharma GK)

Symposium1 10:50-12:20 � Room 7/ Kobe International Conference Center, 502 (5F)IFMRS symposium on Big Data analysis

Chairs: Shiro Ikegawa (Laboratory for Bone and Joint Diseases, IMS, RIKEN)Yuuki Imai (Proteo-Science Center, Ehime University)

SYB1-1 Using real-world big data to address challenges in osteoporosisAndrea M. Burden(ETH Zurich, Switzerland)

SYB1-2 Unravelling the Osteoclast Lysosomal ‘Transportome’Nathan J. Pavlos(Bone Biology & Disease Laboratory, School of Biomedical Sciences, The University of Western Australia, Australia)

SYB1-3 Building the Human Cell Atlas for MedicineChung-Chau Hon(RIKEN Center for Integrative Medical Science)

Co-sponsored by IFMRS


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Future Planning Committee Program Selection Outstanding Abstracts 10:50-12:20�� Room 8/ Kobe International Conference Center, 504・505 (5F)

Chairs: Riko Nishimura ( Department of Molecular & Cellular Biochemistry, Osaka University Graduate School of Dentistry)

Takeshi Miyamoto ( Department Orthopedic Surgery, Kumamoto University) JCA-1 Murine osteoclasts secrete serine protease HtrA1 capable of degrading

osteoprotegerin in the bone microenvironmentNagahiro Ochiai1,2, Yasuhiro Kobayashi3, Nobuyuki Udagawa3, Naoyuki Takahashi3, Tatsuo Suda 1

(Research Center for Genomic Medicine, Saitama Medical University1, Taisho Pharmaceutical Co., Ltd., 2, Institutes for Oral Science, Matsumoto Dental University3)

JCA-2 Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2Yoshifumi Takahata, KantaWakamori, Chika Fujiwara, Eriko Nakamura, Mitsuki Urushizaki, Ayaka Kimura, Kayon Yu, Kenji Hata, Tomohiko Murakami, Riko Nishimura(Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry)

JCA-3 Pmepa1 colocalizes with Nedd4 and LAMP2 in osteoclasts and regulates bone resorption

Hirohito Hirata1, Xianghe Xu2,3, Makoto Shiraki1, Asana Kamohara2, Toshio Kukita3, Masaaki Mawatari1, Akiko Kukita2

(2Department of Orthopedic Surgery, Faculty of Medicine, Saga University 1, Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 2, Department of Molecular Cell Biology & Oral Anatomy, Kyushu University3)

JCA-4 Merlot determines osteoclast lifespan by integrating termination of differentiation and induction of apoptosis

Tomoyuki Yamakawa1,2,3,4, Nobuaki Okamatsu1,2,3, Shuichi Kiyohara3,4,5, Kazuaki Handa1,2,3,4, Koji Ishikawa1,2,3,4, Nobuhiro Sakai3,4, Akiko Karakawa3,4, Masahiro Chatani3,4, Mayumi Tsuji1,4, Katsunori Inagaki2, Yuji Kiuchi1,4, Takako Koga3,4, Masamichi Takami3,4

(Department of Pharmacology, School of Medicine, Showa University1, Department of Orthopaedic Surgery, School of Medicine, Showa University2, Department of Pharmacology, School of Dentistry, Showa University3, Pharmacology Research Center, Showa University4, Department of Implant Dentistry, School of Dentistry, Showa University5)

JCA-5 Analysis of the mechanisms underlying differentiation into tenogenic/ligamentogenic and chondrogenic cells by a newly established in vitro differentiation system using ScxGFP iPS cells

Yuki Yoshimoto, Kazumasa Fujita, Chisa Shukunami(Department of Molecular Biology and Biochemistry, Biomedical Science Major, Graduate School of Biomedical and Heaith Sciences, Hiroshima University)

JCA-6 The association between plasma levels of pentosidine and change in bone mineral density: A 3-year follow-up of the ROAD Study

Toshiko Iidaka1, Shigeyuki Muraki1, Hiroyuki Oka2, Chiaki Horii3, Sakae Tanaka3, Kozo Nakamura4, Toru Akune4, NorikoYoshimura1

(Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, Faculty of Medicine, University of Tokyo1, Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical & Research Center, Faculty of Medicine, University of Tokyo2, Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo3, National Rehabilitation Center for Persons with Disabilities4)


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JCA-7 Simple and robust differentiation of human pluripotent stem cells into chondrocytes by two small-molecule compounds

Manabu Kawata 1,2, Taku Saito1,2, Fumiko Yano2, Sakae Tanaka1

(Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo1, Department of Bone and Cartilage Regenerative Medicine, Graduate School of Medicine, The University of Tokyo2)

JCA-8 Diagnostic performance of imaging tests and systemic venous sampling of FGF23 in 20 cases of tumor-induced osteomalacia

Minae Koga, Hajime Kato, Nobuaki Ito(Division of Nephrology and Endocrinology, The University of Tokyo Hospital)

JCA-9 GPRC5A facilitates cell proliferation and bone metastasis of prostate cancerYuichiro Sawada1, Tadahiko Kikugawa1, Hiroyuki Iio1,2, Iori Sakakibara3, Shuhei Yoshida2, Aoi Ikedo2, Yuta Yanagihara2,4, Noritaka Saeki2,4, Gyorffy Balazs5, Takeshi Kishida6, Yoichiro Okubo7, Yoshiyasu Nakamura8, Yohei Miyagi8, Takashi Saika1,4, Yuuki Imai2,4

(The Department of Urology, Ehime University1, Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University2, Research Center for Advanced Science and Technology, The University of Tokyo3, Division of Laboratory Animal Research, Advanced Research Support Center, Ehime University4, MTA TTK Lendulet Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of Sciences, Hungary.5, Department of Urology, Kanagawa Cancer Center6, Department of Pathology, Kanagawa Cancer Center7, Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute8)

Joint Symposium3 10:50-12:20 Room 10 / Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall B (2F)Considering the pathology and the treatment of osteoporosis from the viewpoint of bone metabolism and morphometry - including the new knowledge -

Chairs: Akinori Sakai ( Department of Orthopaedic Surgery, University of Occupational and Environmental Health)

Noriaki Yamamoto ( Department of Orthopedic Surgery, Niigata Rehabilitation Hospital)

JSY3-1 The forefront of the basic research in bone metabolism -Overview-Tomoki Nakashima(Department of Cell Signaling, Tokyo Medical and Dental University)

JSY3-2 Clinical topics on osteoporosis and bone metabolimDaisuke Inoue(Third Department of Medicine, Teikyo University Chiba Medical Center)

JSY3-3 Effects of once-weekly teriparatide treatment on trabecular bone microdamage accumulation and cortical structure in the lumbar vertebrae of ovariectomized cynomolgus monkeys

Tasuku Mashiba 1, Ryuji Fujihara 1, Shingo Yoshitake 1, Ken Iwata 1, Ryoko Takao2, Tetsuji Yamamoto1

(Department of Orthopedic Surgery, Faculty of Medicine, Kagawa University1, Pharmaceutical Research Center, Asahi Kasei Pharma Corporation2)

JSY3-4 Efficacy of osteoporosis drugs evaluated by high resolution peripheral quantitative CT

Ko Chiba, Narihiro Okazaki, Makoto Osaki(Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences)


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JSY3-5 The current therapy for osteoporosis including sequential therapyJunichi Takada1,2, Kousuke Iba2, Takashi Yoshizaki1, Toshihiko Yamashita2

(Kitago Orthopaedic Clinic1, Department of Orthopaedic Surgery, Sapporo Medical University2)

Co-sponsored by Japan Osteoporasis Society / The Japanese Society for of Bone Morphometry

Luncheon Seminar 7 12:30-13:30 Room 1/ Kobe International Conference Center, Main Hall (1F)

Chair: Yuho Kadono ( Department of Orthopaedic Surgery, Saitama Medical University) LS-7 Pathophysiology and treatment strategy for the ossification of the posterior

longitudinal ligament -Including the Involvement of Neuropathic painYasushi Oshima(Department of Orthopaedic Surgery, The University of Tokyo)

(Co-sponsored by DAIICHI SANKYO COMPANY, LIMITED.)

Luncheon Seminar 8 12:30-13:30 Room 2/ Kobe International Conference Center, International Conference Room (3F)

Chair: Masaru Ishii ( Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University)

LS-8 Clinical immunology of bone and joint - focusing on T cell targeted therapy for rheumatoid arthritis

Yoshiya Tanaka(The First Department of Internal Medicine, University of Occupational and Environmental Health)

(Co-sponsored by Bristol-Myers Squibb K.K./ ONO PHARMACEUTICAL CO., LTD)


Chair: Haruhiko Akiyama ( Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine)

LS-9 Baton passing for osteoporosis drugs with a focus on daily TeriparatideKeita Umehara(Hamamatsu South Hospital)



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Chair: Hiroaki Ohta ( International Medical Center, Fujita Health University Hospital FUJITA EXECUTIVE CLUB / Women’s Medical Center of Sanno Medical Center)

LS-10 The relationship between hand osteoarthritis and estrogen: efficacy of equol.Naoto Tsubokawa(Niigata Hand Surgery Foundation)

(Co-sponsored by Otsuka Pharmaceuticel Co., Ltd. Nutraceuticals Division)


Chair: Keishi Fujio ( Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo)

LS-11 The Role of Interleukin-6 in Bone and Cartilage MetabolismNatalie A. Sims(St. Vincent’s Institute of Medical Research, Australia / The University of Melbourne, Australia)



Chair: Daisuke Togawa ( Departments of Orthopaedic Surgery and Rheumatology, Kinki University Nara Hospital)

LS-12 Let's know vertebral augmentation -from basic knowledge to recent topics-Masatoshi Hoshino(Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine)

(Co-sponsored by Medtronic Sofamor Danek, Co., Ltd.)

Luncheon Seminar 13 12:30-13:30 Room 9/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall A (2F)

Chair: Sakae Tanaka ( Department of Orthopaedic Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

LS-13 osteoporosis treatment updateSatoshi Soen(Soen Orthopaedic Clinic)

(Co-sponsored by Astellas Pharma Inc. / Amgen Astellas BioPharma K. K.)


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Luncheon Seminar 14 12:30-13:30 Room 10/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall B (2F)

Chair: Toshitsugu Sugimoto ( Eikokai Ono Hospital) LS-14 Update of Hip Attack Prevention -The Role of Bisphosphonates and Vitamin D-

Hiroshi Hagino(School of Health Science, Tottori University Faculty of Medicine)

(Co-sponsored by Taisho Pharmaceutical Co., Ltd./ Chugai Pharmaceutical Co., Ltd)

Meet the Expert 1 13:40-14:40�� Room 6/ Kobe International Conference Center, 501 (5F)Onko-Chishin Project 1

Chair: Toshimi Michigami ( Department of Bone and Mineral Research, Research Institute, Osaka Prefectural Hospital Organization, Osaka Women’s and Children’s Hospital)

MTEB 1 Cancer cells abuse bone microenvironmentToshiyuki Yoneda(Department of Biochemistry, Osaka University Graduate School of Dentistry)

Meet the Expert 2 13:40-14:40�� Room 8/ Kobe International Conference Center, 504・505 (5F)Writing scientific papers and grant applications

MTEB 2-1 Points for writing scientific papers and grant applicationsSeiji Fukumoto(Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University)

MTEB 2-2 Toward the success in grant applicationMasaru Ishii(Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University)

Future Planning Committee Symposium1 14:50-16:20�� Room 2/ Kobe International Conference Center, International Conference Room (3F)Bone metabolism research related to biomaterials

Chairs: Noriyuki Tsumaki ( Center for iPS Cell Research and Application, Kyoto University)

Takayoshi Nakano ( Biomaterials & Structural Materials Design Area, Graduate School of Engineering, Osaka University)

JCS1-1 Biomaterial-based DDS technologies for regeneration imagingJun-ichiro Jo, Yasuhiko Tabata(Institute for Frontier Life and Medical Sciences, Kyoto University)

JCS1-2 Tissue engineering using biopinting approach for regenerative medicine and drug screening researches

Michiya Matsusaki(Graduate School of Engineering, Osaka University)


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JCS1-3 Optimized implantation of mesenchymal stem cells with a nanofiber-structured material and Epstein-Barr virus induced gene 3 regulation during chondrogenesis

Kaoru Yamagata1, Shingo Nakayamada1, Tong Zhang1, Masahiro Kondo2, Shigeru Iwata1, Yoshiya Tanaka1

(University of Occupational and Environmental Health, Japan, Kitakyushu1, Mitsubishi Tanabe pharma corporation2)

JCS1-4 Control of bone matrix anisotropy using biomaterialsAira Matsugaki, Takayoshi Nakano(Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University)

Joint Symposium2 : 14:50-16:20 Room 4/ Kobe International Conference Center, 401・402 (4F)State-of-the-art imaging of bone and joints

Chairs: Yoshiya Tanaka ( The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health)

Masaru Ishii ( Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University)

JSY2-1 Intravital observation of bone tissuesJunichi Kikuta, Masaru Ishii(Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University)

JSY2-2 X-rayShintaro Hirata(Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital)

JSY2-3 Evaluation of bone destruction in rheumatic diseases : role of ultrasoundShigeru Ohno(Yokohama City University Medical Center)

JSY2-4 Assessment of bone and joint using CT/MRIAoki Takatoshi(Department of Radiology, University of Occupational and Environmental Health)

Co-sponsored by Japan Osteoporasis Society / The Japan college of Rheumatology

Future Planning Committee Symposium2 : Industry-academic cooperation 14:50-16:20�� Room 6/ Kobe International Conference Center, 501 (5F)Innovation Road 4

Chairs: Takeshi Miyamoto ( Department Orthopedic Surgery, Kumamoto University)Naoto Kato ( Medical Affairs Department, Asahi Kasei Pharma Corporation)Ryoko Takao-Kawabata ( Pharmaceuticals Research Center, Asahi Kasei Pharma

Corporation) JCS2-1 Clinical trial of a single local administration of rhFGF-2 gelatin hydrogel for treatment

of osteonecrosis of the femoral headHaruhiko Akiyama(Department of Orthopaedics, Gifu University)


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JCS2-2 Research and Development of Basic Fibroblast Growth Factor (FGF-2) as Periodontal Tissue Regenerative Medicine.

Mitsuru Watanuki, Mikiko Kurihara(Keken Pharmaseucical CO., LTD.)

JCS2-3 Preparation of investigator initiated clinical trialsRyuta Asada(Gifu University Hospital)

Japan-Korea Joint Symposium1 14:50-16:20�� Room 7/ Kobe International Conference Center, 502 (5F)Topics in Clinical Research

Chairs: Daisuke Inoue [JOS] ( Third Department of Medicine, Teikyo University Chiba Medical Center)

Jung-Eun Kim [KSBMR] ( Department of Molecular Medicine, Kyungpook National University)

JS1-1 Age-related sarcopenia, frailty and their preventive approachesSumito Ogawa [JSBMR]

(Department of Geriatric Medicine Graduate School of Medicine, The University of Tokyo)

JS1-2 Bone and muscle evaluation in patients with distal radius fractureHyun Sik Gong [KSBMR]

(Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Korea)

JS1-3 Management of Diabetic Bone DiseaseIppei Kanazawa [JOS]

(Internal Medicine 1, Shimane University Faculty of Medicine)

JS1-4 Ca2+ allostery in PTH-receptor signalingSihoon Lee [KSO]

(Gachon University College of Medicine, Korea)

Joint Symposium4 14:50-16:20�� Room 10/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall B (2F)Combined Symposium of JSBMR37 and JOS21 Aiming at Best Practice for Fragility Fractures

Chairs: Takashi Matsushita ( Department of Traumatology, Fukushima Medical University)Satoshi Mori ( Bone and Joint Surgery, Seirei Hamamatsu General Hospital)

JSY4-1 Orthogeriatric co-management for geriatric hip fracturesKenji Shigemoto, Takeshi Sawaguchi(Department of Orthopaedic Surgery & Joint Reconstructive Surgery, Toyama Municipal Hospital)

JSY4-2 Thel way of treatment of fracture of the proximal femur from the viewpoint of a trauma doctor

Yoshiyuki Karasawa, Akira Yoshida, Tomoo Inukai, Hiroaki Miyake, Hideyuki Makino, Masateru Shinndou(Daiyukai general hospital)


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JSY4-3 Necessity of FFN-Japan National Hip Fracture DatabaseNarutaka Katoh1, Takashi Matsushita1, Takeshi Sawaguchi2, Noriaki Yamamoto3

(Department of Traumatology, Fukushima Medical University / Trauma & Reconstruction Center, Southern TOHOKU General Hospital1, Department of Orthopaedic Surgery and Joint Reconstructive Surgery, Toyama Municipal Hospital2, Department of Orthopaedic Surgery, Nigata Rehabilitation Hospital3)

JSY4-4 Global activities of Fragility Fracture Network for secondary fracture preventionNoriaki Yamamoto

(Department of Orthpedic Surgery, Niigata Rehabilitation Hospital)

Co-sponsored by Japan Osteoporasis Society /The Japan Fragility Fracture Network

Joint Symposium1 : 16:30-18:00�� Room 1/ Kobe International Conference Center, Main Hall (1F)Prevention and treatment of fragility fractures in elderly people

Chairs: Satoshi Soen ( Orthopaedic Surgery and Rheumatology, Soen Orthopaedics, Osteoporosis and Rheumatology Clinic)

Naoto Endo ( Niigata University Graduate School of Medical and Dental Sciences)

JSY1-1 Community based liaison is important for improving fragility fracture treatmentSatoshi Mori(Bone and Joint Surgery, Seirei Hamamatsu General Hospital)

JSY1-2 Treatment of the osteoporotic fractures of the upper extremity and our effort to prevent the subsequent fractures

Akinori Sakai1, Yukichi Zenke1, Yoshiaki Yamanaka1, Takafumi Tajima1, Yasuaki Okada1, Kenji Kosugi1, Satoshi Ikeda2

(Department of Orthopaedic Surgery, University of Occupational and Environmental Health1, Department of Orthopaedic Surgery, Ken-Ai Memorial Hospital2)

JSY1-3 Osteoporotic vertebral fractures: predictive factors for conservative treatment failure and indications for balloon kyphoplasty.

Shoichi Ichimura(Department of Orthopaedic Surgery, Kyorin University School of Medicine)

JSY1-4 Incidence of hip fracture in overseas countries and Japan: What should we do ?Norio Imai(Div. of Comprehensive Geriatrics in Community, Niigata University Graduate School of Medical and Dental Sciences)

JSY1-5 Improvement of locomotive syndrome by conservative and surgical interventionMorio Matsumoto(Department of Orthopedic Surgery, Keio University)

Co-sponsored by Japan Osteoporasis Society /The Japanese Orthopaedic Association


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Future Planning Committee Symposium3 16:30-18:00�� Room 6/ Kobe International Conference Center, 501 (5F)The cutting edge of Musculo & Skeletal Research

Chairs: Hiroshi Asahara ( Faculty of Medicine Department of Systems BioMedicine, Tokyo Medical and Dental University Graduate School)

Chisa Shukunami ( Graduate School of Biomedical and Health Sciences, Department of Molecular Biology and Biochemistry, Hiroshima University)

JCS3-1 Clinical development of nucleic acid medicine for spinal muscular atrophy and Duchenne muscular dystrophy

Hirofumi Komaki(Translational Medical Center, National Center of Neurology and Psychiatry)

JCS3-2 The novel polypeptide world revealed by analysis of long non-coding RNAsAkinobu Matsumoto(Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University)

JCS3-3 A novel induction method of tenocytes from human iPSCsMakoto Ikeya(Center for iPS Cell Research and Application (CiRA), Kyoto University)

Japan-Korea Joint Symposium2 16:30-18:00 　� Room 7/ Kobe International Conference Center, 502 (5F)Topics in Basic Research

Chairs: Seiji Fukumoto [JSBMR] ( Institute of Advanced Medical Sciences, Fujii Memorial Institute of Medical Sciences, Tokushima University)

Chang Suk Suh [KSO] ( Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Korea)

JS2-1 RANKL in bone, immunity and cancer Kazuo Okamoto [JSBMR]

(Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

JS2-2 Abnormal Cholesterol Metabolism Promotes the Development of OsteoarthritisJe-Huang Ryu [KSBMR]

(Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Korea)

JS2-3 Gravity change and muscle/bone relationshipHiroshi Kaji [JOS]

(Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine)

JS2-4 Engineering approaches of osteoporotic fracturesTaeyong Lee [KSO]

(Division of Mechanical and Biomedical Engineering, Ewha Womans University, Korea)


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Day 2 Sunday, October 13

Future Planning Committee Symposium4 : Basic 8:40-10:10�� Room 1/ Kobe International Conference Center, Main Hall (1F)Rising Stars in Skeletal Biology

Chairs: Yuuki Imai (Proteo-Science Center, Ehime University)Ritsuko Masuyama ( College of Gastronomy Management, Ritsumeikan

University) JCS4-1 RANK-RANKL signaling in the coupling regulation is a potential pharmacological

target.Yuki Ikebuchi(Department of Pharmacy, The University of Tokyo Hospital)

JCS4-2 Elucidation of a critical far-upstream enhancer complex for tissue-specific Sox9 expression

Yusuke Tabata1,2, Tomoki Chiba1, Kensuke Kataoka1, Satoshi Yamashita1, Tempei Sato1, Tomomi Kato1, Kenji Takahashi2, Takeshi Miyamoto3, Masashi Kitazawa4, Tomohisa Hatta4, Tohru Natsume4, Shinro Takai2, Hiroshi Asahara1

(Department of Systems BioMedicine, Tokyo Medical and Dental University1, Department of Orthopaedic Surgery, Nippon Medical School2, Department of Orthopaedic Surgery, Kumamoto University3, Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)4)

JCS4-3 Bone dynamics and inflammation: Lessons from rare diseasesYoshinori Matsumoto1,2, Ken-ei Sada1, Jun Wada1, Robert Rottapel2

(Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences1, Princess Margaret Cancer Center, University of Toronto, Canada2)

Joint Symposium5 8:40-10:10 　� Room 3/ Kobe International Conference Center, Reception Hall (3F)New information for the osteoporosis treatment of patients with chronic kidney disease

Chairs: Masaaki Inaba ( Department of Metabolism, Endocrinology and Molecular Medicine, and Department of Nephrology, Osaka City University Graduate School of Medicine)

Yoshifumi Ubara ( Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya)

JSY5-1 Updated treatment strategy for CKD-MBD based on KDIGO 2017 Clinical Practice Guideline

Masaaki Inaba(Department of Metabolism, Endocrinology and Molecular Medicine, and Department of Nephrology, Osaka City University Graduate School of Medicine)

JSY5-2 High rates of fracture and mechanisms of bone fragility in patients with chronic kidney disease and osteoporosis

Hirotaka Komaba(Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine)

JSY5-3 Bone mass independent fracture risk of osteoporosis complicated CKD (bone quality, sarcopenia, hypoglycemia, and fall)

Senji Okuno(Internal Medicine, Shirasagi Hospital)


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JSY5-4 A secondary effect of bone anti-resorptive agents -renoprotective/vasoprotective effects resulting from phosphorus load decrement from bone-

Daichi Miyaoka(Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine)

JSY5-5 Bone histomorphometrical analysis on patients with CKDYoshifumi Ubara(Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya)

Co-sponsored by Japan Osteoporasis Society / The Japanese Society of Nephrology

Women Researchers' Session 09:00-10:00 � Room 4/ Kobe International Conference Center, 401・402 (4F)

Chair: Masako Ito (Nagasaki University Center for Diversity and Inclusion ) WR Did the content that you conveyed reach the partner definitely?

Kazuyo Itaya1,2

(Tantaviva1, Faculty of Communication Studies, Tokyo Keizai University2)

JSBMR Promotional Committee of Clinical program Symposium1 10:20-11:50 � Room 1/ Kobe International Conference Center, Main Hall (1F)Epidemiology, pathogenesis and treatment of hypoparathyroidism

Chairs: Seiji Fukumoto ( Institute of Advanced Medical Sciences, Fujii Memorial Institute of Medical Sciences, Tokushima University)

Toshitsugu Sugimoto ( Research Institute for Metabolic Bone Diseases, Eikokai Ono Hospital)

JPC1-1 Questionnaire survey of patients with pseudohypoparathyroidism and hypoparathyroidism

Rieko Takatani1, Masanori Minagawa2, Takuo Kubota3, Daisuke Inoue4, Toshitsugu Sugimoto5, Seiji Fukumoto6, Keiichi Ozono3, Yoshikazu Nakamura7

(Center for Preventive Medical Science, Chiba University1, Department of endocrinology, Chiba children's hospital2, Department of Pediatrics, Osaka University Graduate School of Medicine3, Third Department of Medicine, Teikyo University Chiba Medical Center, 4, Ono hospital5, Fujii Memorial Institute of Medical Sciences, Tokushima University6, Department of Public Health, Jichi Medical University7)

JPC1-2 Molecular genetic etiology and treatment of chronic hypoparathyroidism Keisuke Nagasaki(Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences)

JPC1-3 Molecular mechanisms of pseudohypoparathyroidismTakeshi Usui1, Akiko Yuno2

(Department of Medical Genetics, Research Support Center, Shizuoka General Hospital1, Department of Endocrinology and Metabolism, Kin-i-kyo Chuo Hospital2)

JPC1-4 Patient registry of hypoparathyroidismTakuo Kubota(Department of Pediatrics, Osaka University Graduate School of Medicine)


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Chair: Hideki Nagashima ( Department of Orthopedic Surgery, Faculty of Medicine, Tottori University)

LS-15 Glucocorticoid-Induced Osteoporosis: Past, Present and FutureKenneth G. Saag (University of Alabama at Birmingham, USA)

(Co-sponsored by DAIICHI SANKYO CO.,LTD.)


Chair: Sakae Tanaka ( Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo)

LS-16 Vitamin D metabolites in bone metabolism and osteoporosisSeiji Fukumoto(Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University)

(Co-sponsored by Chugai Pharmaceutical Co., Ltd / Roche Diagnostics K.K.)


Chair: Naohisa Miyakoshi ( Department of Orthopedic Surgery Akita University Graduate School of Medicine)

LS-17 Real-world management of osteoporosis treatment: Clinical usefulness of bone turnover markers

Koji Ishikawa(Department of Orthopaedic Surgery, Showa University School of Medicine)

(Co-sponsored by YAMASA CORPORATION / Beckman Coulter K. K.)


Chair: Toshihisa Kojima ( Nagoya university Graduate School of Medicine Department of Orthopaedics/Rheumatology)

LS-18 Aiming for further improvement of rheumatoid arthritis medical treatment -Difficult cases, JAK inhibitors, and osteoporosis treatment-

Yuji Hirano(Toyohashi Municipal Hospital Department of Rheumatology)



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Chair: Toshio Matsumoto ( Fujii Memorial Institute of Medical Sciences, Univ. of Tokushima)

LS-19 Sclerostin Inhibition Promotes Modeling-Based Bone Formation to Reduce Fractures

Felicia Cosman(Columbia University, USA)



Chair: Akihiro Sudo ( Department of Orthopaedic Surgery, Mie University Graduate School of Medicine)

LS-20 New position of anabolic agent -Drug selection in clinical practice-Satoru Nakajo(Nakajo Orthopedic Clinic)

(Co-sponsored by MOCHIDA PHARMACEUTICAL CO., LTD)

Luncheon Seminar 21 12:10-13:10 Room 10/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall B (2F)

Chair: Toshitaka Nakamura ( Touto Sangenjaya rehabilitation Hospital) LS-21 Bone anabolic therapy for osteoporosis - Current and Future -

Toshitsugu Sugimoto(Eikokai Ono Hospital)


JSBMR General Meeting Award Lectures 14:20-15:50 Room 1/ Kobe International Conference Center, Main Hall (1F)

Chairs: Seiji Fukumoto ( Institute of Advanced Medical Sciences, Fujii Memorial Institute of Medical Sciences, Tokushima University)

Sakae Tanaka ( Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo)

Special Lecture 16:00-17:00 Room 1/ Kobe International Conference Center, Main Hall (1F)

Chair: Toshio Matsumoto ( Fujii Memorial Institute of Medical Sciences, University of Tokushima)

ISL Side effects of Bone TherapiesKenneth�G.�Saag

（The�University�of�Alabama�at�Birmingham,�USA）


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Evening Seminar 3 17:15-18:15 Room 4/ Kobe International Conference Center, 401･402 (4F)

Chair: Shinichi Nakatoh ( Department of Orthopedic Surgery, Asahi General Hospital) ES-3 The estimation of fracture risks based on the understanding with BMD and bone

qualityMitsuru Saito(Department of Orthopaedic Surgery, Jikei University School of Medicine)


Evening Seminar 4 17:15-18:15 Room 6/ Kobe International Conference Center, 501 (5F)

Chair: Hiroaki Ohta ( International Medical Center, Fujita Health University Hospital / Women's Medical Center, Sanno Medical Center)

ES-4 Theory and practice of nutrition and diet in the prevention and treatment of osteoporosis for medical staff

Kazuhiro Uenishi(Laboratory of Physiological Nutrition, Kagawa Nutrition University)

(Co-sponsored by Megmilk Snow Brand Co., Ltd.)

Evening Seminar 5 17:15-18:15 Room 8/ Kobe International Conference Center, 504･505 (5F)

Chair: Shigeki Momohara ( Hakkeikai Inc Medical Institution / Keio University) ES-5 Considering appropriate use of conventional synthetic disease-modifying anti-

rheumatic drugs (csDMARDs) from their pharmacological actionKosuke Ebina(Department of Musculoskeletal Regenerative Medicine, Osaka University, Graduate School of Medicine)

(Co-sponsored by Eisai Co., Ltd. )

Evening Seminar 6 17:15-18:15 Room 10/ Kobe International Exhibition Hall No.1 Bldg., Exhibition Hall B (2F)

Chair: Atsushi Suzuki ( Department of Endocrinology and Metabolism, Fujita Health University School of Medicine)

ES-6 The evidence for zoledronic acid, and its efficacy and problems in clinical practice.

Junichi Takada(Kitago Orthopaedic Clinic / Department of Orthopaedic Surgery, Sapporo Medical University)



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Day 3 Monday, October 14

Joint Symposium6 : 8:30-10:00�� Room 1/ Kobe International Conference Center, Main Hall (1F)Cancer and bone

Chairs: Yasuhiro Takeuchi (Endocrine Center, Toranomon Hospital)Keiichi Ozono ( Department of Pediatrics, Osaka University Graduate School of

Medicine) JSY6-1 Crosstalk between cancer bone metastasis and sensory neuron

Tatsuo Okui1, Masahiro Hiasa2, Toshiyuki Yoneda3

(Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences1, Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School2, Department of Biochemistry, Osaka University Graduate School of Dentistry3)

JSY6-2 Myeloma bone disease and tumor progressionMasahiro Abe(Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School)

JSY6-3 Skeletal complications of childhood cancer survivorsTakuo Kubota(Department of Pediatrics, Osaka University Graduate School of Medicine)

JSY6-4 Osteoporosis and fracture induced by cancer treatmentNoriko Kobayashi1, Takafumi Fujino2, Mahito Takeda1, Hidemichi Watari1

(Hokkaido University Hospital1, Teine Keijinkai Hospital2)

JSY6-5 Management of patients with cancer treatment-induced bone lossSeiji Fukumoto(Institute of Advanced Medical Sciences, Tokushima University)

Co-sponsored by Japan Osteoporasis Society / The Japan Endocrine Society

JSBMR Promotional Committee of Clinical program Symposium2 8:30-10:00�� Room 2/ Kobe International Conference Center, International Conference Room (3F)Exercise and bone

Chairs: Hiroshi Hagino ( School of Health Sciences, Tottori University Faculty of Medicine)

Jun Iwamoto ( Bone and Joint Disease Center, Keiyu Orthopaedic Hospital) JPC2-1 Exercise and Bone - Overview -

Jun Iwamoto(Bone and Joint Disease Center, Keiyu Orthopaedic Hospital)

JPC2-2 Alteration of bone volume and structure in association of skeletal loadingAkinori Sakai, Yoshiaki Yamanaka, Manabu Tsukamoto, Takafumi Tajima, Yasuaki Okada, Kenji Kosugi(Department of Orthopaedic Surgery, University of Occupational and Environmental Health)


－ 279 －

JPC2-3 Association of bone- and muscle-derived biomarkers with physical function in community-dwelling middle-aged and elderly adults

Kenta Moriwaki1, Hiromi Matsumoto2, Hiroshi Hagino3

(Department of Orthopedic Surgery, Misasa Onsen Hospital1, Department of Rehabilitation, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare2, School of Health Science, Faculty of Medicine, Tottori University3)

JPC2-4 Physical exercise and bone in the elderlyNaohisa Miyakoshi(Department of Orthopedic Surgery, Akita University Graduate School of Medicine)

JPC2-5 Skeletal modeling and remodeling induced by competitive athletic activity in athletes

Suguru Torii(Faculty of Sport Sciences, Waseda University)

Symposium5 : 8:30-10:00 � Room 4/ Kobe International Conference Center, 401・402 (4F)Basic and translational research on osteoimmunology

Chairs: Hiroshi Takayanagi ( Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

Atsushi Kumanogoh ( Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University)

SYB5-1 Investigation of abnormal ossification utilizing patients-specific iPS cellsJunya Toguchida1, Yonghui Jin1, Shunsuke Kawai1, Hirotsugu Maekawa2, Rena Kashimoto2

(Laboratory of Tissue Regeneration, Institute for Frontier Life and Medical Science, Kyoto University1, Laboratory of Differentiation Induction, Center for iPS Cell Research and Application, Kyoto University2)

SYB5-2 Bone marrow specific mesenchymal stem cells creating niches for hematopoietic stem cells and hematopoiesis

Takashi Nagasawa(Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University)

SYB5-3 Regeneration of articular cartilage damage by allogeneic iPSC-derived cartilageNoriyuki Tsumaki(Center for iPS Cell Research and Application, Kyoto University)

SYB5-4 Immuno-metabolic regulation by axon-guidance moleculeAtsushi Kumanogoh1,2, Yoshimitsu Nakanishi1,2

(Department of Respiratory medicine and Clinical Immunology, Graduate School of medicine, Osaka University1, Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University2)

Co-sponsored by Japan Society of Osteoimmunology / Japanese Society of Inflammation and Regeneration


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Meet the Expert 3 10:20-11:20�� Room 1/ Kobe International Conference Center, Main Hall (1F)Onko-chishin Project 2

Chair: Norio Amizuka ( Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University)

MTEB 3 Bone metabolism research focusing on Runx2Toshihisa Komori(Basic and Translational Research Center for Hard Tissue Disease, Nagasaki University)

Invited Lecture 11:30-12:30�� Room 1/ Kobe International Conference Center, Main Hall (1F)

Chair: Sakae Tanaka ( Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo)

IL Innovation of macrocyclic peptide therapeuticsHiroaki Suga(Graduate School of Science, The University of Tokyo)


Chair: Takashi Matsushita ( Department of Traumatology, Fukushima Medical University / Trauma & Reconstruction Center, Southern TOHOKU General Hospital)

LS-22 How to prevent secondary hip fracturesSerge Ferrari(Service and Laboratory of Bone Diseases, Geneva University and Faculty of medicine, Switzerland)


Chair: Naoki Ishiguro ( Department of Orthopaedic Surgery Nagoya University, Graduate School & Faculty of Medicine)

LS-23 Current and future perspectives for JAK inhibitors in RA treatmentAtsushi Kawakami(Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Science, Nagasaki University Graduate School of Biomedical Sciences)

(Co-sponsored by Gilead Sciences K.K. Medical Affairs)


－ 281 －


Chair: Yuko Kaneko ( Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine)

LS-24 Strategy of treatment for Rheumatoid Arthritis aimed at preventing joint destruction: Lessons from basic and clinical studies

Yoshinori Matsumoto(Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)

(Co-sponsored by AbbVie GK / Eisai Co., Ltd.)


Chair: Seiji Fukumoto ( Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University)

LS-25 X-Linked Hypophosphatemia and Tumor-Induced Osteomalacia: Clinical Windows into Phosphate Homeostasis with New Therapeutic Vistas

Karl Insogna(Yale Center for X-linked Hypophosphatemia, USA)

(Co-sponsored by Kyowa Kirin Co., Ltd.)


Chair: Kazuo Kawasugi (Teikyo University) LS-26 Pathology and treatment for hemophilic arthropathy

Hideyuki Takedani(Department of joint surgery, IMSUT Hospital)

(Co-sponsored by Bayer Yakuhin, Ltd.)


Chair: Sakae Tanaka ( Department of Orthopaedic Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

LS-27 Progress in skeletal muscle scienceHirotoshi Tanaka(Center for Antibody & Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, University of Tokyo)

(Co-sponsored by Mitsubishi Tanabe Pharma Corporation / Janssen Pharmaceutical K.K.)


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Symposium 3 13:50-15:20�� Room 1/ Kobe International Conference Center, Main Hall (1F)The coupling mechanism of bone resorption and bone formation

Chairs: Nobuyuki Udagawa ( Department of Biochemistry, Matsumoto Dental University)

Koji Okabe ( Section of Cellular Physiology, Department of Physiological Science and Molecular Biology, Fukuoka Dental College)

SYB3-1 An ENU-induced splice site mutation of mouse Collal causing recessive osteogenesis imperfecta and revealing a novel splicing rescue

Koichi Tabeta(Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences)

SYB3-2 Physiological roles of RANKL reverse signalingMasashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki(Department of Pharmacy, The University of Tokyo Hospital)

SYB3-3 Stimulation of bone formation via RANKL reverse signalingHisataka Yasuda(Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.)

SYB3-4 Speculation of the relationships between bone resorption and formation based on the 3-dimentional structure of osteoclasts

Masamichi Takami(Department of Dental Pharmacology, School of Dentistry, Showa University)

SYB3-5 Coupling of bone resorption and formation regulated by vitamin D: anti-resorptive and pro-resorptive actions of VDR in osteoblasts

Yuko Nakamichi(Institute for Oral Science, Matsumoto Dental University)

Co-sponsored by Japan association for Oral Biology

Symposium4 13:50-15:20�� Room 2/ Kobe International Conference Center, International Conference Room (3F)Osteoarthritis & Locomotive Syndrome

Chairs: Takuo Saito ( Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo)

Noriko Yoshimura ( Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, University of Tokyo)

SYB4-1 Mechanical loading in pathophysiology of osteoarthritisTaku Saito(Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo)

SYB4-2 Epidemiology of osteoarthritis in Japan. The ROAD studyNoriko Yoshimura(Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, University of Tokyo)


－ 283 －

SYB4-3 Influence of muscle weakness and effectiveness of muscle strengthening in osteoarthritis of knee and hip

Hideaki Ishibashi(The Department of Orthopedic surgery, Ina hospital)

SYB4-4 Age-related changes of musculoskeletal system leading to sarcopenia and locomotive syndrome

Sumito Ogawa(Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo)

SYB4-5 Pathophysiology of knee osteoarthritis associated with locomotive syndrome in elderlies

Muneaki Ishijima1,2, Kaneko Haruka1, Hitoshi Arita1, Yoshifumi Negishi1, Masahiro Momoeda1, Takako Aoki2, Lizu Liu1,2, Hui Huang1,2, Jun Shiozawa1,6, Adiri Aripati1, Masashi Nagao1,3, Masataka Nagayama1, Yoshitomo Saita1, Yuji Takazawa1,4, Hiroshi Ikeda1,5, Yosufumi Tamura2,6, Hirotaka Watada2,6, Ryuzo Kawamori2,6, Yasunori Okada7, Kazuo Kaneko1,2,7

(Department of Medicine for Orthopedics and Motor Organ, Juntendo University Graduate School of Medicine1, Sportology Center, Juntendo University Graduate School of Medicine2, Medical Technology Innovation Center, Juntendo University Faculty of Medicine3, Juntendo University Faculty of Health and Sports Science4, Juntendo University Faculty of Health Science5, Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine6, Department of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo University Graduate School of Medicine7)


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Oral Presentation01 16:30-17:20 Room 2/ Kobe International Conference Center, International Conference Room (3F)Bone resorption 1

Chairs: Eijiro Jimi ( OBT Research Center, Kyushu University, Faculty of Dental Science)Masahiro Shinohara ( Department of Rehabilitation for the Movement

Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities)

O-001 InvolvementofchemokineXCL1/lymphotactininthedevelopmentofinflammatoryosteolysis triggered by implants debris

Yuan Tian, Alaa Terkawi, Tomohiro Onotera, Hend Alhasan, Gen Matsumae, Daisuke Takahashi, Masanari Hamasaki, Taku Ebata, Norimasa Iwasaki (Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University)

O-002 Material chemical properties of bioresorbable OCP and beta-TCP ceramics alter the expression of coupling factors in osteoclasts

Yukari Shiwaku1,2, Osamu Suzuki1

(Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry1, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry2)

O-003 RegulatoryroleofannexinA1ininflammatoryosteolysisandosteoclastogenesistriggered by polyethylene wear debris of orthopedic implants

MohamadAlaa Terkawi, Alhasan Hend, Yuan Tian, Gen Matsumae, Masanari Hamasaki, Taku Ebata, Daisuke Takahashi, Norimasa Iwasaki (Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University)

O-004 Chimeric protein revSSDKA mimics Siglec-15-DAP12 complex and restores multinucleated osteoclast formation in DAP12 knockout RAW264 cells

Norihiro Ishida-Kitagawa (Graduated Shool of Sience and Technology)

O-005 Siglec-15-targeting therapy is a therapeutic strategy for glucocorticoid induced osteoporosis in growing rats

Dai Sato1,2, Masahiko Takahata1, Masahiro Ota1, Tomohiro Shimizu1, Ryo Fujita1, Hideyuki Kobayashi1, Tie Fukuda3, Eisuke Tsuda3, Tomoka Hasegawa4, Norio Amizuka4, Norimasa Iwasaki1

(Hokkaido University, Department of Orthopedic Surgery, Graduate School of Medicine1, NTT Higashi-Nihon2, Specialty Medicine Research Laboratories I.3, Hokkaido University, Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine4)

Oral Presentation02 14:50-15:50 Room 8/ Kobe International Conference Center, 504・505 (5F)Primary osteoporosis 1

Chairs: Akira Itabashi (Kubojima Clinic, Saitama Center for Bone Research)Taro Mawatari ( Department of Orthopaedic Surgery, Hamanomachi Hospital)

O-006 Whether or not different drugs for osteoporosis affect non-weight bearing bones differently

Shozo Sasaki, Tetsushi Osada (Orthopedic Department, Ushioda General Hospital)

骨代謝_14_p284_312_英語02一般プログラム.indd 284 2019/09/04 8:19

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O-007 The effects of teriparatide on acceleration of bone healing following atypical femoral fracture: comparison between daily and weekly administration

Hiroyuki Tsuchie1, Naohisa Miyakoshi1, Kosuke Iba2, Takayuki Dohke2, Yuji Kasukawa1, Toyohito Segawa3, Hayato Kinoshita4, Masazumi Suzuki5, Toshihiko Yamashita2, Yoichi Shimada1

(Department of Orthopedic Surgery, Akita University Graduate School of Medicine1, Department of Orthopedic Surgery, Sapporo Medical University School of Medicine2, Joto Orthopedic Clinic3, Department of Orthopedic Surgery, Akita Kousei Medical Center4, Department of Orthopedic Surgery, Yuri Kumiai General Hospital5)

O-008 Relationship between serum-creatinine-to-cystatin C ratio and bone mineral density of Japanese osteoporotic women

Ichiro Yoshii (Department of Rheumatology and Musculoskeletal Medicine)

O-009 Age-related changes in bone mineral density and bone turnover markers in menKo Chiba, Shuta Yamada, Narihiro Okazaki, Makoto Era, Kounosuke Watanabe, Shingo Ota, Makoto Osaki (Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences)

O-010 Predictive factors of mortality of patients with fragility hip fractures at 1 year after discharge: a multicenter, retrospective study in the northern Kyushu district of Japan

Atsushi Kimura1, Yoshihiro Matsumoto1, Yoshifumi Wakata2, Akiko Oyamada3, Masanobu Ohisi4, Toshifumi Fujiwara1, Kuniyoshi Tsuchiya5, Shinji Tomari6, Hisaaki Miyahara7, Taichi Saito8, Kozo Kaji9, Toshihiko Hara10, Taro Mawatari11, Riku Sakimura12, Kunichika Shin13, Masami Fujiwara14, Shoji Tokunaga15, Naoki Nakachima16, Yukihide Iwamoto9, Yasuharu Nakashima1

(Department of Orthopedics Surgery, Graduate School of Medical Science, Kyushu University1, Department of Medical Informatics, Institute of Biomedical Sciences, Tokushima University Graduate School2, Department of Orthopaedic Surgery, Saga Handicapped Children's Hospital3, Department of Orthopaedic Surgery, Chihaya Hospital4, Department of Orthopaedic Surgery, JCHO Kyushu Hospital5, Department of Orthopaedic Surgery, Fukuoka Red Cross Hospital6, Department of Orthopaedic Surgery, National Kyushu Medical Center7, Department of Orthopaedic Surgery, Fukuoka City Hospital8, Department of Orthopaedic Surgery, Kyushu Rosai Hospital9, Department of Orthopaedic Surgery, Aso Iizuka Hospital10, Department of Orthopaedic Surgery, Hamanomachi Hospital11, Department of Orthopaedic Surgery, Harasanshin Hospital12, Department of Orthopaedic Surgery, Saiseikai Yahata General Hospital13, Department of Orthopaedic Surgery, Sada Hospital14, Clinical Research Support Center Kyushu15, Medical Information Center, Kyushu University Hospital16)

O-011 Long term effects of inhabitants organaizing circles for preventing osteoporosis and falls

Osamu Fujinawa1, Toyo Kikumoto2, Yasuyo Sunaga2, Kennji Murata2, Mariko Zensho3, Mari Uchiyama4, Kazunori Kayaba5, Keiko Hirose6, Tomoko Araki7,8, Naoto Endo9

(Department of Rehabilitation, Fukui Health Science University1, Saitama Prefectural University 2, Saitama Prefectural University3, Saitama Prefectural University4, Saitama Prefectural University5, Japan Lutheran College6, WiTHs7, Kio University8, Niigata University9)


－ 286 －

Oral Presentation03 16:00-17:10 Room 8/ Kobe International Conference Center, 504・505 (5F)Primary osteoporosis 2

Chairs: Satoshi Inoue (Tokyo Metropolitan Institute of Gerontology )Masahiro Yamamoto (Internal Medicine 1, Shimane University Faculty of Medicine)

O-012 Flavanone derived from Chamaecrista nomame prevents bone loss in ovariectomized mice by promoting osteogenic differentiation

Tatsuo Takahashi1,2, Hirokazu Suzuki1,2, Yukio Kawata1, Syoko Kitade1, Mako Takenaka1, Fumiha Abe1, Hanae Nakanishi1, Asuka Mukai1, Masanori Ohmoto1, Yuki Satoh1, Takashi Kamei1,2, Yasuhiro Tezuka1, Yuri Matsuo1, Masaaki Nomura1, Masakazu Miura1,2

(Faculty of Pharmaceutical Sciences, Hokuriku University1, Healthy Aging Research Group, Hokuriku University2)

O-013 Disruption of the Aldehyde Dehydrogenase 2 Gene Increases Bone Anabolic Response to Intermittent PTH Treatment in Ovariectomized Mice Model

Kenji Kosugi1, Takafumi Tajima1, Kayoko Okuma1, Yasuaki Okada1, Manabu Tsukamoto1, Yoshiaki Yamanaka1, Kunitaka Meniki2, Akinori Sakai1

(The Department of Orthopaedic Surgery, University of Occupational and Environmental Health1, The Department of Orthopaedic Surgery, Kitakyushu Municipal Yahata Hospital2)

O-014 High intensity pulsed ultrasound improves ovariectomy-induced osteoporosis in rats

Shota Inoue1, Masato Nomura1, Yoshio Wakimoto1, Hideki Moriyama2

(Department of Rehabilitation Science, Graduate School of Health Sciences, Kobe University1, Life and Medical Sciences Area, Health Sciences Discipline, Kobe University2)

O-015 Effects of teriparatide and low intensity aerobic exercise on body composition and bone in rats

Chiaki Sato, Naohisa Miyakoshi, Yuji Kasukawa, Koji Nozaka, Tsutie Hiroyuki, Itsuki Nagahata, Yusuke Yuasa, Kazunobu Abe, Hikaru Saito, Yoichi Simada (Department of Orthopedic Surgery, University of Akita)

O-016 Abnormal changes of collagen/apatite orientation and bone mechanical property in osteoporotic bones

Ryosuke Ozasa1, Takuya Ishimoto1, Jun Hashimoto2, Makoto Hirao3, Hideki Yoshikawa3, Takayoshi Nakano1

(Biomaterials & Structural Materials Design Area, Graduate School of Engineering, Osaka University1, Osaka Minami Medical Center2, Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka University3)

O-017 Bone remodeling measurement by quantifying new bone formation and resorbed bonemassincalcifiedbonesusingquantitativecomputedtomography

Nobuhito Nango1, Shogo Kubota1, Kazutaka Nomura1, Yusuke Horiguchi1, Ko Chiba2, Masafumi Machida3

(Ratoc System Engineering Co., LTD.,1, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences2, City of Yokohama, Medical Care Bureau Hospital Administration Headquarters Stroke, Nerve Backbone Center General Affairs Division3)


－ 287 －

O-018 In silico analysis of bone quality with drug treatment for osteoporosis using a mathematical model of bone metabolism

Young Kwan Kim1, Yoshitaka Kameo2, Taiji Adachi2, Sakae Tanaka3

(Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo1, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University2, Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo3)

Day 2 Sunday, October 13

Oral Presentation04 8:40-9:40 Room 6/ Kobe International Conference Center, 501 (5F)Cancer / Bone diseases

Chairs: Masaki Inada ( Department of Biotechnology and Life science, Tokyo University of Agriculture and Science)

Hiroshi Kobayashi ( Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo)

O-019 The importance of soluble RANKL in bone metastasisKazuo Okamoto1, Tatsuo Asano2, Yuta Nakai2, Hiroshi Takayanagi2

(Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo1, Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo2)

O-020 Efficacyofanorallyactivesmall-moleculeinhibitorofRANKLinbonemetastasisYuta Nakai1,2, Kazuo Okamoto3, Asuka Terashima3, Takashi Ono2, Hiroshi Takayanagi1

(Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo1, Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University2, Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo3)

O-021 Development of a C57BL/6 Mouse Model of Bone Metastasis of Breast CancerToru Hiraga1, Tadashi Ninomiya2,3

(Department of Histology and Cell Biology, Matsumoto Dental University School of Dentistry1, Institute for Oral Science, Matsumoto Dental University2, Department of Anatomy, Nihon University School of Dentistry3)

O-022 Breast cancer cell-derived extracellular vesicle-mediating transfer of miRNAs regulates osteoclast function

Norihisa Uehara1, Yukari Kyumoto1, Akiko Kukita2, Toshio Kukita1

(Department of Molecular Cell Biology & Oral Anatomy, Kyushu University1, Microbiology, Faculty of Medicine, Saga University2)

O-023 Elucidation of the mechanisms for bone destruction in chordomaKatsuhiro Kawaai1, Yumiko Oishi2, Yukiko Kuroda1, Koichi Matsuo1

(Laboratory of Cell and Tissue Biology, Keio University School of Medicine1, Department of Neurosurgery, Keio University School of Medicine2)


－ 288 －

O-024 Immobilization aggravates myeloma tumor expansion in bone through enhanced bone resorption

Kotaro Tanimoto1,2, Masahiro Hiasa1,2, Hirofumi Tenshin1,2, Jumpei Teramachi2,3, Mohannad Mohannad1,2, Masami Iwasa2, Asuka Oda2, Kimiko Sogabe2, Masahiro Oura2, Takeshi Harada2, Shingen Nakamura2, Kazuhiro Miki4, Itsuro Endo5, Eiji Tanaka1, Toshio Matsumoto6, Masahiro Abe2

(Department of Orthodontics and Dentofacial Orthopedic, Tokushima University1, Department of Hematology, Endocrinology and Metabolism, Tokushima University2, Department of Tissue Regeneration, Tokushima University3, Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital4, Department of Biomaterials and Bioengineering, Tokushima University5, Fujii Memorial Institute of Medical Sciences, Tokushima University6)

Oral Presentation05 9:50-10:50 Room 6/ Kobe International Conference Center, 501 (5F)Rheumatoid arthritis / Osteoarthritis 1

Chairs: Jun Hirose (Department of Orthopaedic Surgery, The University of Tokyo)Noriko Komatsu ( Department of Immunology, Graduate School of Medicine

and Faculty of Medicine, The University of Tokyo) O-025 Runx3 protects articular cartilage through Prg4 induction ?

Kosei Nagata, Song-Ho Chan, Fumiko Yano, Ryota Chijimatsu, Yuma Makii, Manabu Kawata, Daisuke Mori, Sakae Tanaka, Taku Saito (Sensory & Motor System Medicine, Faculty of Medicine, The University of Tokyo)

O-026 Effect of angiotensin II on cartilage degradation and the regulatory mechanism by CCN2

Takashi Nishida1, Masaharu Takigawa2, Satoshi Kubota1,2

(Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences1, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School2)

O-027 An attempt to clarify the pathological mechanisms of osteoarthritis development using a chondroitin sulfate synthase 1 knockout mice

Toshihiro Inubushi1, Kazu Matsumoto2, Fumitoshi Irie3, Takashi Yamashiro1, Yu Yamaguchi3

(Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University1, Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine2, Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, USA3)

O-028 GRK5 Inhibition Attenuates Cartilage Degradation via Decreased IkBa Phosphorylation

Takuya Sueishi, Yukio Akasaki, Ichirou Kurakazu, Masakazu Toya, Masanari Kuwahara, Hidetoshi Tsushima, Yasuharu Nakashima (Department of Orthopaedic Surgery, Kyushu University)

O-029 Epigenetic regulator Uhrf1 orchestrates genes expression of aggravating factors in rheumatoid arthritis

Noritaka Saeki1,2, Kazuki Inoue2, Kunihiko Watamori3, Shinichi Mizuki4, Katsuto Takenaka5, Hiromasa Miura3, Yuuki Imai1,2

(Division of Integrative Pathophysiology, Proteo-Science Center (PROS), Ehime University1, Division of Laboratory Animal Research, Advanced Research Support Center (ADRES), Ehime University2, Department of Orthopaedic Surgery, Graduate School of Medicine, Ehime University3, The Centre for Rheumatic Diseases, Matsuyama Red Cross Hospital4, Department of Hematology, Clinical Immunology and Infectious Diseases, Graduate School of Medicine, Ehime University5)


－ 289 －

O-030 TAK1inhibitioneffectivelysuppressesNLRP3inflammasomemediatedjointinflammationaswellasbonedestructioninrheumatoidarthritis

Hirofumi Tenshin1,2, Jumpei Teramachi2,3, Masahiro Hiasa1,2, Kotaro Tanimoto1,2, Mohannad Ashtar1,2, Bat Erdene Ariunzaya2, Masami Iwasa2, Takeshi Harada2, Shingen Nakamura2, Hirokazu Miki4, Itsuro Endo5, Eiji Tanaka1, Toshio Matsumoto6, Masahiro Abe2

(Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School1, Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School2, Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School3, Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital4, Department of Chronomedicine, Institute of Biomedical Sciences, Tokushima University Graduate School5, Fujii Memorial Institute of Medical Sciences, Tokushima University6)

Oral Presentation06 11:00-12:00 Room 6/ Kobe International Conference Center, 501 (5F)Rheumatoid arthritis / Osteoarthritis 2

Chairs: Jun Hashimoto ( Director of Medical Divisions, National Hospital Organization, Osaka Minami Medical Center)

Yuho Kadono ( Deparment of Orthopaedic Surgery, Saitama Medical University) O-031 Anti-Fractalkine Monoclonal Antibody Suppress Joint Destruction and synovitis in

Collagen-induced Arthritis ModelKana Hoshino-Negishi (KAN Research Institute, Inc.,)

O-032 Measurement of CT value on distal tibia and its comparison between end-stage ankle osteoarthritis and rheumatoid arthritis

Ryutaro Takeda, Takumi Matsumoto, Zyunya Higuchi, Yuji Maenohara, Taro Kasai, Yasunori Omata, Jyun Hirose, Sakae Tanaka (Department of Orthopaedic Surgery, University of Tokyo)

O-033 EfficacyofdailyteriparatideonbonemicrostructureinrheumatoidarthritiswithprogressivehandjointdestructionusingHR-pQCT

Ikuko Tanaka1, Takashi Kato2, Hisaji Oshima3, Shigenori Tamaki1

(Nagoya Rheumatology Clinic1, National Center for Geriatrics and Gerontology Department of Radiology2, Tokyo Medical Center Department Of Connective Tissue Disease3)

O-034 Quantitativeanalysisofjuxta-articularosteoporosisbyHR-pQCTinpatientswithrheumatoid arthritis

Kounosuke Watanabe1, Ko Chiba1, Naomi Iwamoto2, Nozomi Loki3, Masataka Uetani3, Atsushi Kawakami2, Makoto Osaki1

(Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences1, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences2, Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences3)

O-035 The natural course of postoperative bone metabolic changes after total knee arthroplasty

Shinya Nakamura1, Masakazu Kanetaka1, Yorito Anamizu2, Fumiaki Tokimura1, Tsuyoshi Miyazaki1

(Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology1, Department of Spine Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology2)


－ 290 －

O-036 PredictedbonestrengthevaluationbyquantitativeCT-basedfiniteelementmethodinasymptomaticsubjectswithossificationoftheposteriorlongitudinalligament

Toru Doi, Koji Nakajima, Shima Hirai, Fumihiko Oguchi, So Kato, Yuki Taniguchi, Yoshitaka Matsubayashi, Sakae Tanaka, Yasushi Oshima (Department of Orthopaedic Surgery, University of Tokyo)

Oral Presentation07 8:40-9:40 Room 8/ Kobe International Conference Center, 504・505 (5F)Stem cell / Tissue regeneration

Chairs: Toru Ogasawara ( Department of Oral and Maxillofacial Surgery, The University of Tokyo Hospital )

Toshihide Mizoguchi (Oral Health Science Center, Tokyo Dental College) O-037 BroadapplicationofmTORinhibitorstofibrodysplasiaossificansprogressiva

Hirotsugu Maekawa1,2, Hiroyuki Yoshitomi1,2,3, Shunsuke Kawai1,3, Yonghui Jin3,4, Shuichi Matsuda2, Junya Toguchida1,2,3,4

(Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University1, Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University2, Department of Tissue Regeneration, Institute for Frontier Life and Medical Sciences, Kyoto University3, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital4)

O-038 A new therapeutic strategy for Perthes disease by targeting interleukin 6 and osteoimmunology

Nobuhiro Kamiya (Sports Medicine, Tenri University Graduate School)

O-039 PAI-1 is involved in the delayed bone repair induced by glucocorticoidKiyotaka Okada1,2, Naoyuki Kawao2, Takeshi Shimoide2, Masayoshi Ishida2, Yoshimasa Takafuji2, Osamu Matsuo3, Hiroshi Kaji2

(Arts and Science, Kindai University Faculty of Medicine1, Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine2, Kindai University Faculty of Medicine3)

O-040 Pericytes possess multilineage differentiation capacity and contribute to bone fracture healing as a cellular source of osteogenic cells

Shingo Sato1,2,3, Supakul Sopak2, Kenta Yao2, Hiroki Ochi1,2, Kyoko Hashimoto2, Satoko Sunamura1,2, Shu Takeda4, Atsushi Okawa1

(Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Graduate School1, Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Graduate School2, Tokyo Medical and Dental University, Cancer Center3, Division of Endocrinology, Toranomon Hospital Endocrine Center4)

O-041 Visualization of osteogenesis in vitro from human iPSCShunsuke Kawai1,2,3, Hiroyuki Yoshitomi1,2,3, Junko Sunaga2, Shuichi Matsuda3, Taiji Adachi2, Junya Toguchida1,2,3

(Center for iPS Cell Research and Application, Kyoto University1, Institute for Frontier Life and Medical Sciences, Kyoto University2, Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University3)


－ 291 －

O-042 Development of novel auricular reconstruction for microtia with cartilage regeneration

Sakura Uto1, Atsuhiko Hikita1, Taku Saito2, Shinsuke Ohba4, Kazuto Hoshi1,3

(Division of Tissue Engineering, The University of Tokyo1, Division of Orthopedic Surgery, The University of Tokyo2, Division of Oral and Maxillofacial Surgery and Orthodontics, The University of Tokyo3, Center for Disease Biology and Integrative Medicine, The University of Tokyo4)

Oral Presentation08 9:40-10:40 Room 8/ Kobe International Conference Center, 504・505 (5F)Muscle / Tendon / Ligament 1

Chairs: Chisa Shukunami (Hiroshima University)Masashi Naito ( Department of Rheumatology, Tokyo Metropolitan Tama

Medical Center) O-043 Modulators of Fam210a and effects of Fam210a on myoblastic differentiation and

degradationKen-ichiro Tanaka, Ippei Kanazawa, Toshitsugu Sugimoto (Internal Medicine 1, Shimane University Faculty of Medicine)

O-044 Satb2 and Zfp423 cooperatively integrate Wnt and Bmp Signaling to regulate myogenesis

William Addison, Takuma Matsubara, Shoichiro Kokabu (Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University)

O-045 Rolesofexosomeintheinfluencesofmechanicalstressonthemuscle/bonerelationship

Yoshimasa Takafuji, Kohei Tatsumi, Masayoshi Ishida, Naoyuki Kawao, Kiyotaka Okada, Hiroshi Kaji (Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine)

O-046 RoleofDKK2intheinfluencesofdecreasedmechanicalstressonthemuscle/bone relationships

Naoyuki Kawao1, Hironobu Morita2, Masayoshi Ishida1, Yoshimasa Takafuji1, Hiroshi Kaji1

(Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine1, Department of Physiology, Gifu University Graduate School of Medicine2)

O-047 Insulin-like growth factor-I protects against apoptosis and suppression of differentiation by advanced glycation end products and high glucose in myoblastic C2C12 cells

Ippei Kanazawa, Kenichiro Tanaka, Masakazu Notsu, Toshitsugu Sugimoto (Internal Medicine 1, Shimane University Faculty of Medicine)

O-048 Fluorescent imaging of Scx+/Sox9+ cells contributing to enthesis formationKazumasa Fujita1, Yuki Yoshimoto1, Haruhiko Akiyama2, Takeshi Imamura3, Chisa Shukunami1

(Department of Molecular Biology and Biochemistry, Division of Biomedical Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University1, Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine2, Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine3)


－ 292 －

Oral Presentation09 10:50-12:00 Room 8/ Kobe International Conference Center, 504・505 (5F)Muscle / Tendon / Ligament 2

Chairs: Takeshi Nikawa (Tokushima University, Institute of Space Nutrition)Hiroshi Asahara ( Department of Systems Bio Medicine, Tokyo Medical and

Dental University) O-049 Fragility of intervertebral disc in Marfan syndrome

Yuki Taniguchi, Yoshitaka Matsubayashi, So Kato, Toru Doi, Takeshi Oichi, Yasushi Oshima, Taku Saito, Sakae Tanaka (Department of Orthopedics, the University of Tokyo)

O-050 Artificialbonegraftinthetreatmentformono-andpolyostoticfibrousdysplasiaToshihide Hirai1, Hiroshi Kobayashi1, Masachika Ikegami1, Yusuke Shinoda2, Ryoko Sawada2, Sakae Tanaka1

(Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo1, Department of Rehabilitation Medicine, The University of Tokyo Hospital2)

O-051 AdenosineandOxidativeStressInducesOssificationofTendonCellsTomomi Sakuma1,2, Chantida Pawaputanon Na Mahasarakham2,3, Chin Lyn2, Yutaka Kobayashi4, Shuhei Kajikawa2, Hiroyuki Inose4, Masaki Noda4,5, Jyunn Okawa4, Yoiti Edura2

(Dept. Maxillofacial Surgery, Tokyo Medical and Dental University1, Frontier Research Unit: Skeletal Molecular Pharmacology, Med. Res. Inst., Tokyo Medical and Dental University2, Faculty of Dentistry, KhonKaen University, Thailand 3, Dept. Orthopedics, Tokyo Medical and Dental University4, Yokohama City Minato Red Cross Hospital5)

O-052 Collagen 12a1 gene as a maintenance factor for anterior cruciate ligamentShin Fukusato1, Masashi Nagao1, Yayoi Izu 2

(The Department of Orthopedics, University of Juntendo1, Department of Veterinary Okayama Science University2)

O-053 Adipose-DerivedStemCellspreventEctopicOssificationinTendonInjurybyRegulatingEarlyinflammatoryResponse:AnalysisUsinganInVivoCollagenase-induced Tendinopathy Mouse Model

Saeko Kokubu1, Ryoko Inaki2, Kazuto Hoshi1,2, Atsuhiko Hikita2

(Department of Sensory and Motor System Medicine, Department of Oral and Maxillofacial Surgery, Dentistry and Orthodontics, The University of Tokyo Graduate School of Medicine1, Division of Tissue Engineering, The University of Tokyo Hospital2)

O-054 Functionalanalysisofacandidatecausalgeneofossificationoftheposteriorlongitudinal ligament, CDC5L

Go Jokoji1,2, Shingo Maeda2, Hiroyuki Tominaga1, Yuuhei Yahiro1, Ichiro Kawamura1, Masahiro Nakajima3, Shiro Ikegawa3, Noboru Taniguchi1

(Department of Orthopaedics, Kagoshima University1, Department of Medical Joint Materials, Kagoshima University2, Laboratory of Bone and Joint Diseases, Center for Integrative Medical Sciences, RIKEN3)

O-055 Phenotypic analysis of mice lacking the CXCL7 protein responsible for ossificationoftheposteriorlongitudinalligament

Michiyo Tsuru1,2, Hiroyuki Matsumoto1,2,3, Kensei Nagata1,2,4

(Clinical Proteomics and Gene Therapy Laboratory, Kurume University1, Research Center for Innovative Cancer Therapy, Kurume University2, University of Oklahoma Health Sciences Center, Department of Biochemistry & Molecular Biology3, Department of Orthopaedic Surgery, Kurume University School of Medicine4)


－ 293 －


Oral Presentation10 10:30-11:30 Room 2/ Kobe International Conference Center, International Conference Room (3F)Vitamin D

Chairs: Takehisa Yamamoto (Department of Pediatrics, Minoh City Hospital)Naoko Tsugawa ( Department of Health and Nutrition, Osaka Shoin Women’s

University) O-056 EffectofVitaminDtreatmenttothe25-hydoroxyvitaminDdeficientpatientswith

elevated intact PTH levelsKazuhiko Takabe1, Takamichi Yuhara1, Hisanori Kameda2

(The Department of Internal Medicine, Namegata District Medical Center1, The Department of Orthpedics, Namegata District Medical Center2)

O-057 The relationship between low bone mineral density and serum 1,25-dihydroxyvitanmin D

Kazuhiko Takabe1, Takamichi Yuhara1, Hisanori Kameda2

(The Department of Internal Medicine, Namegata District Medical Center,1, The Department of Orthopedics, Namegata District Medical Center2)

O-058 TheprevalenceofvitaminDsufficiency:age-relatedchangeandrelationshiptobone mineral density

Narihiro Okazaki, Ko Chiba, Kazuaki Yokota, Shuta Yamada, Mitsuru Doi, Choko Kondo, Makoto Osaki (Department of Orthopaedic Surgery, Nagasaki University Hospital)

O-059 Vitamin D status and its associated factors in Japanese pregnant womenYuko Sakamoto1, Yuka Honda2, Hideaki Nakajima3, Daiki Ogishima4, Shozo Matsuoka4, Mitsuyoshi Suzuki5, Akifumi Tokita6, Toshiaki Shimizu5, Kazuo Kaneko7, Sung-Gon Kim1

(Department of Orthopaedics, Juntendo University Nerima Hospital1, Graduate School of Media and Governance, Keio University2, Center for Global Environmental Research, National Institute for Environmental Studies3, Department of Obstetrics-gynecology, Juntendo University Nerima Hospital4, Department of Pediatrics, Juntendo University Graduate School of Medicine,5, Clinic Bambini6, Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine7)

O-060 Vitamin D and 25-hydroxyvitamin D concentrations in breast milk; Longitudinal comparison and regional and seasonal effects

Naoko Tsugawa1,2, Mayu Nishino2, Akiko Kuwabara3, Honami Ogasawara1, Maya Kamao4, Shyunjiro Kobayashi5, Junichi Yamamura5

(Department of Health and Nutrition, Faculty of Health and Nutrition, Osaka Shoin Women's University1, Division of Human Dietics, Graduate School of Human Sciences, Osaka Shoin Women's University2, Department of Clinical Nutrition, Faculty of Comprehensive Rehabilitation, Osaka Prefecture University3, Extension Center, Kobe Pharmaceutical University4, Research & Development Department, Bean Stalk Snow Co., Ltd5)

O-061 The factors associated with the degree of genu varum in patients with vitamin D insufficiencyordeficiency

Masashi Mukai1, Takehisa Yamamoto1, Shinji Takeyari2, Yasuhisa Ohata2, Yasuhiro Hasegawa2, Taichi Kitaoka2, Takuo Kubota2, Katsusuke Yamamoto3, Toshimi Michigami3, Keiichi Ozono2

(Minoh City Hospital1, Department of Pediatrics, Osaka University Hospital2, Osaka Maternal and Child Medical Center3)


－ 294 －

Oral Presentation11 10:30-11:30 Room 4/ Kobe International Conference Center, 401・402 (4F)Osteocyte

Chairs: Hiroshi Kamioka ( Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University)

Tadahiro Iimura ( Department of Pharmacology, Graduate School of Dental Medicine, Hokkaido University)

O-062 Regulatory mechanism of bone formation via Wnt/beta-catenin signaling by long non-coding RNA in osteocytes

Makoto Arai1,2, Hiroki Ochi1, Satoko Sunamura1, Shu Takeda3, Shingo Sato1,4

(Department of Physiology and Cell Biology, Tokyo Medical and Dental University 1, Division of Nephrology and Endocrinology, Department of Internal Medicine, University of Tokyo2, Division of Endocrinology, Toranomon Hospital Endocrine Center3, Department of Orthopedic Surgery, Tokyo Medical and Dental University4)

O-063 Osteocyte Sirt6 has crucial roles in bone and phosphate metabolismYoshinori Asou1, Alkebaier Aobulikasimu1, Hiroki Ochi1, Shingo Sato1, Jinying Piao1, Daisuke Koga1, Kunikazu Tsuji2, Atsushi Okawa1

(Dept. of Orthop. and Spinal Surg, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental Univ.1, Dept of Joint Sung and Sports Medicine, Tokyo Medical and Dental Univ.2)

O-064 Analysis of bone metabolism in antiparkinsonian drugsKazuaki Handa1,2,3, Shuichi Kiyohara2, Tomoyuki Yamakawa1,2,3, Koji Ishikawa1,2,3, Nobuhiro Sakai2, Akiko Karakawa2, Takashi Nagai1, Yuji Kiuchi3, Takako Koga2, Masamichi Takami2, Katsunori Inagaki1

(School of Medicine Department of Orthopedic Surgery, University of Showa1, Dental Faculty Dental Pharmacology Course, University of Showa2, School of Medicine Pharmacology Course Medical Pharmacology Department, Univ Ersity of Showa3)

O-065 Alignment of differentiated osteocytes depending on mechanical boundary conditions of collagen gel culture

Taiji Adachi, Junko Sunaga (Laboratory of Biomechanics, Institute for Frontier Life and Medical Sciences, Kyoto University)

O-066 The importance of biologically active vitamin D administration for mineralization by osteocytes after parathyroidectomy for renal hyperparathyroidism

Aiji Yajima1, Yoshihiro Tominaga2, Masaaki Inaba3, Akemi Ito4

(IU School of Medicine, USA1, Nagoya Second Red Cross Hosital2, Osaka City University Graduate School of Medicine3, Ito Bone Histomorphometry Institute4)

O-067 Treatment of synthetic carbonated apatite plate with culture medium increases osteoblast adhesion and proliferation in vitro

Nagomi Tabuchi, Toshiya Suzuki, Yusuke Shigemitsu, Shinichi Kato, Katsuyuki Yamanaka, Tomohiro Kumagai (GC Corporation)


－ 295 －

Oral Presentation12 13:50-14:40 Room 4/ Kobe International Conference Center, 401・402 (4F)Bone formation 1

Chairs: Takenobu Katagiri ( Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University)

Asuka Terashima ( Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

O-068 The Wnt antagonist Sfrp5 inhibits osteoclast formation and promotes osteoblast differentiation

Kohei Murakami1,2, Nobuyuki Udagawa2, Shunsuke Uehara2, Masanori Koide3, Teruhito Yamashita3, Yasuhiro Kobayashi3

(Laboratory of Immunology, Faculty of Veterinary Medicine, Okayama University of Science1, Department of Biochemistry, Matsumoto Dental University2, Institute for Oral Science, Matsumoto Dental University3)

O-069 Wnt7b expressed by hypertrophic chondrocytes is a critical inducer of bone formationduringendoochondralossification

Sho Tsukamoto1, Mai Kuratani1, Shinya Tanaka2, Eijiro Jimi3, Takenobu Katagiri1

(Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University1, Department of Orthopedic Surgery, Saitama Medical University2, Faculty of Dental Science, Oral Health Brain Health Total Health Research Center, Kyushu University3)

O-070 Hypermineralizing osteoblasts produce type II collagen-containing high BMD boneYukiko Kuroda, Katsuhiro Kawaai, Koichi Matsuo (Laboratory of Cell and Tissue Biology, Keio University School of Medicine)

O-071 Col1a1-Cre targets the ovary and testisTadayoshi Hayata1, Yoichi Ezura2, Masaki Noda2,3

(Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Science, Tokyo University of Science1, Frontier Research Unit, Skeletal Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University2, Yokohama City Minato Red Cross Hospital3)

O-072 A long noncoding RNA regulatory mechanism of osteoblast proliferationHiroyuki Inose, Yutaka Kobayashi (Department of Orthopedics, Graduate School, Tokyo Medical and Dental University)

Oral Presentation13 15:00-15:50 Room 4/ Kobe International Conference Center, 401・402 (4F)Bone formation 2

Chairs: Akira Nifuji ( Department of Pharmacology, School of Dental Medicine, Tsurumi University)

Tomohiko Murakami ( Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry)

O-073 Local administration of soluble Frizzled2 accelerates bony callus formation during bone fracture repair process in a mouse model

Kenta Nakajima1, Yoshiaki Kitaura2, Hisashi Hasegawa1, Yuji Yamazaki1, Kenji Nagao1, Ung-il Chung3, Shinsuke Ohba3

(Nephrology Research Labs., Nephrology R&D Unit, R&D Division, Kyowa Kirin Co., Ltd,1, Department of Bioengineering, The University of Tokyo Graduate School of Engineering2, Division of Clinical Biotechnology, The University of Tokyo Graduate School of Medicine3)


－ 296 －

O-074 Acceleration of bone formation and suppression of bone resorption by soluble Frizzled2 receptor in mice

Hisashi Hasegawa, Kenta Nakajima, Yuji Yamazaki, Kenji Nagao (Kyowa Kirin Co., Ltd,)

O-075 Sex difference in the repair of mouse femoral cortical bone after drill holingHokuto Fukuda1, Masato Tsutsui2, Eiichiro Nakamura1, Ken Sabanai1, Manabu Tsukamoto1, Mayuko Sakanashi2, Yasuaki Okada1, Akinori Sakai1

(Department of Orthopaedic Surgery, University of Occupational and Environmental Health 1, Department of Pharmacology, Graduate School of Medicine, University of The Ryukyus2)

O-077 Endochondralossificationproducessmallerauditoryossiclesthantheprimordialcartilages

Shuting Ji1, Yukiko Kuroda1, Katsuhiro Kawaai1, Atsushi Momose2, Koichi Matsuo1

(Laboratory of Cell and Tissue Biology, Keio University School of Medicine1, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University2)

O-078 Analyses of Tmem161a function in bone metabolism using the exchangeable gene trap mutagenesis

Takuya Ngai, Tomohisa Sekimoto, Youichirou Yamaguchi, Syuji Kurogi, Taro Funamoto, Tomomi Oota, Shihoko Miyazaki, Takuya Tajima, Etsuo Chosa (The Department of Orthopaedic Surgery, University of Miyazaki)

Oral Presentation14 8:30-9:30 Room 6/ Kobe International Conference Center, 501 (5F)Bone resorption 2

Chairs: Masamichi Takami (Department of Dental Pharmacology, Showa University)Yasuhiro Kobayashi (Institute for Oral Science, Matsumoto Dental University)

O-079 In vitro observation of bone remodeling in the presence of bone resorption inhibitors with different mechanism

Shuya Oguchi, Atsuhiko Hikita, Kazuto Hosi (Graduate School of Medicine, The University of Tokyo)

O-080 Overexpression of miR-125b in osteoblasts inhibits bone resorption without affecting skeletal development and improves age-related changes in bone mass and quality

Shota Ito1, Tomoko Minamizaki2, Yoshiaki Kitaura3, Shinsuke Ohba4, Ung-il Chung4, Yuji Yoshiko2

(Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical and Health Sciences1, Department of Calcified Tissue Biology, Hiroshima University Graduate School of Biomedical and Health Sciences2, Department of Bioengineering, The University of Tokyo3, Center for Disease Biology and Integrative Medicine, The University of Tokyo4)

O-081 The important role of cytolinker protein Plectin1 in osteoclastic bone resorptionTakuma Matsubara, William Addison, Shoichiro Kokabu (Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University)


－ 297 －

O-082 Oxygen imaging of osteoclast using intravital two-photon microscopyKeizo Nishikawa1, Masaru Ishii1,2

(Laboratory of Immunology and Cell Biology, Immunology Frontier Research Center, Osaka University1, Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University2)

O-083 DynamicanalysisofosteoclasticboneresorptionusingpH-sensitivefluorescenceprobes

Junichi Kikuta, Masaru Ishii (Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University)

O-084 Distribution and function of Yolk-sac derived osteoclasts in the postnatal bone Yasuhito Yahara1,2

(Departments of Orthopaedic Surgery, Faculty of Medicine, University of Toyama1, Duke University School of Medicine, Department of Orthopaedic Surgery and Regeneration Next Initiative2)

Oral Presentation15 10:30-11:20 Room 6/ Kobe International Conference Center, 501 (5F)Bone resorption 3

Chairs: Keizo Nishikawa (IFReC, Osaka University)Masahiro Chatani (Showa University)

O-085 Fine tuning of calcium oscillations under ITAM receptors regulated RANKL-induced osteoclast differentiation

Hiroyuki Okada1, Hiroshi Kajiya2, Yasunori Omata1, Masashi Shin2, Fujio Okamoto2, Taku Saito1, Koji Okabe2, Takeshi Miyamoto3,4, Sakae Tanaka1

(Department of Orthopaedic Surgery, The University of Tokyo1, Department of Physiological Science and Molecular Biology, Fukuoka Dental College2, Department of Orthopaedics, Keio University School of Medicine3, Department of Orthopaedic Surgery, Kumamoto University4)

O-086 Three-dimensional ultrastructural analysis of resorbing osteoclasts by Correlative Light Electron Microscopy (CLEM) and Focused Ion Beam Scanning Electron Microscope (FIB-SEM)

Masahiro Hosonuma1,2,3,7, Nobuhiro Sakai1,7, Yutaro Kurotaki1,7,8, Takashi Takaki4, Hideki Matushima5, Akira Takebe6, Akiko Karakawa1,7, Masahiro Chatani1,7, Takako Koga1,7, Yuji Kiuchi2,7, Masamichi Takami1,7

(Department of Pharmacology, School of Dentistry, Showa University1, Department of Pharmacology, School of Medicine, Showa University2, Division of Rheumatology, Department of Medicine, Showa University School of Medicine3, Section of Electron Microscopy, Showa University4, Japan Electron Optics Laboratory5, NIKON INSTECH CO., LTD.6, Pharmacological Research Center, Showa University7, Depatment of Dental Pharmacology, School of Dentistry, Showa University8)

O-087 Suppression of osteoclastogenesis by adenoviral expression of exogenous proteins

Kazuhisa Nakashima1, Koichiro Komatsu1, Hisashi Ideno1, Teruhito Yamashita2, Nobuyuki Udagawa3, Akira Nifuji1

(Department of Pharmacology, Tsurumi University School of Dental Medicine1, Institute for Oral Science, Matsumoto Dental University2, Department of Biochemistry, Matsumoto Dental University3)


－ 298 －

O-088 RolesofTLR3signalingininflammatoryboneresorptionTsukasa Tominari1, Ryota Ichimaru2, Chiho Matsumoto1, Michiko Hirata1, Chisato Miyaura1,2, Masaki Inada1,2

(Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology1, Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology2)

O-089 Identificationofnephroblastomaoverexpressed(NOV)asanewplayerininflammatoryosteolysisandboneresorption

Gen Matsumae, Terkawi Alaa, Norimasa Iwasaki (Dept. of Orthop. Surg, Faculty of Medicine and Graduate School of Medicine, Hokkaido Univ.)

Oral Presentation16 13:50-14:50 Room 6/ Kobe International Conference Center, 501 (5F)Mechanical stress

Chairs: Koichi Matsuo ( Laboratory of Cell and Tissue Biology, Keio University School of Medicine)

Hiroshi Kaji ( Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine)

O-090 Mechanosensitive ion channel Trpv2 protects articular cartilage by inducing Lubricin

Hideki Nakamoto1, Ryota Chijimatsu1, Yasutaka Muarahashi1, Fumiko Yano2, Yuji Maenohara1, Kosei Nagata1, Sakae Tanaka1, Taku Saito1

(Orthop. Surg, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The Univ. of Tokyo1, Division of Tissue Engineering, The University of Tokyo Hospital2)

O-091 In silico modeling of bone remodeling dynamics in bone mechanical adaptation to cyclic loading

Yoshitaka Kameo, Taiji Adachi (Institute for Frontier Life and Medical Sciences, Kyoto University)

O-092 Systemic Effect of LIPUS, low intensity pulsed ultrasound, on subcutaneously implanted beta-TCP-(tri-calcium-phosphate) ceramic discs

Yuko Mikuni-Takagaki1, Kouki Hidaka1, Maiko Fujita-Otani2, Azusa Seki3, Akira Kawata1, Ken Kumagai4, Ryohei Takeuchi1,5

(Department of Oral Science, Kanagawa Dental University Graduate School of Dentistry1, Department of Oral Interdiciplinary Medicine, Kanagawa Dental University Graduate School of Dentistry2, Hamri Co. Ltd.3, Department of Orthopaedic Surgery and Musculoskeletal Science, Graduate School of Medicine, Yokohama City University4, Kawasaki Saiwai Hospital Joint Surgery Center5)

O-093 Mechanical load-regulated expression of periosteal Osteocrin promotes bone growth

Haruko Takano (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute)

O-094 Role of leptin in the recovery from mechanical unloading-induced muscle wasting and bone loss in high fat diet-fed mice

Naoyuki Kawao, Masayoshi Ishida, Yoshimasa Takafuji, Hiroshi Kaji (Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine)


－ 299 －

O-095 Hypergravity and microgravity oppositely controlled the bone and muscle mass in mice

Ryota Ichimaru1, Tsukasa Tominari2, Chiho Matsumoto2, Michiko Hirata2, Dai Shiba3, Chisato Miyaura1,2, Masaki Inada1,2

(Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology1, Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology2, JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA3)

Oral Presentation17 15:00-16:00 Room 6/ Kobe International Conference Center, 501 (5F)Hormone / Cytokines

Chairs: Shigeaki Kato ( Graduate School of Science and Engineering, Iryo Sosei University)

Kotaro Azuma ( Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology)

O-096 Analysis of the roles of glucocorticoids in bone metabolism using in-vivo-imaging system of medakafish

Yuki Azetsu1,2, Masahiro Chatani1,2, Takako Negishi-Koga1,2, Nobuhiro Sakai1,2, Akiko Karakawa1,2, Masamichi Takami1,2

(Department of Dental Pharmacology, School of Dentistry, Showa University1, Pharmacological Research Center, Showa University2)

O-097 RolesofirisinintheeffectsofandrogendeficiencyonmuscleandboneinmiceShunki Iemura1,2, Naoyuki Kawao2, Katsumi Okumoto3, Masayoshi Ishida2, Yoshimasa Takafuji2, Masao Akagi1, Hiroshi Kaji2

(Department of Orthopedic Surgery, Kindai University Faculty of Medicine1, Department of Physiology and Regenerative Medicine, Kindai University Faculty of Medicine2, Life Science Research Institute, Kindai University3)

O-098 RanBP3Lisresponsibleforsex-specificactionsofPAI-1inosteoblastsfromfemale mice

Masayoshi Ishida1, Naoyuki Kawao1, Kiyotaka Okada2, Kohei Tatsumi1, Yoshimasa Takafuji1, Yoshihiro Mine3, Osamu Matsuo1, Hiroshi Kaji1

(Department of Physiology & Regenerative Medicine, Kindai University Faculty of Medicine1, Department of Arts and Sciences2, Kindai University Life Science Research Institute3)

O-099 Circadianproductionofmelatoninincartilageinfluenceschondrocyterhythmicgene expression

Shanqi Fu1, Miho Kuwahara1, Yoko Uchida2, Sei Kondo1, Takashi Nishida1, Mika Ikegame3, Satoshi Kubota1, Takako Hattori1

(Department of Biochemistry & Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences1, Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences2, Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences3)

O-100 FGFR1 is the phosphate sensing receptor regulating blood FGF23 levelYuichi Takashi1, Shun Sawatsubashi2, Itsuro Endo3, Masahiro Abe3, Munehide Matsuhisa1, Toshio Matsumoto2, Seiji Fukumoto2

(Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University1, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Scineces, Tokushima University2, Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences3)


－ 300 －

O-101 Vitamin D reduces skeletal muscle atrophy following immobilization via vitamin D receptor in Schwann cells

Satoshi Nakamura, Akihito Oya, Arihiko Kanaji, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura (Department of Orthopedic Surgery, Keio University School of Medicine)

Oral Presentation18 8:30-9:30 Room 7/ Kobe International Conference Center, 502 (5F)Secondary osteoporosis 1

Chairs: Osamu Chaki (Yokohama Rosai Hospital)Reiko Watanabe ( Third Department of Medicine， Teikyo University Chiba

Medical Center) O-102 Effect of treatment of biologic agents for 10 years on bone mineral density in

rheumatoid arthritis patientsIchiro Nakamura1,2, Sakae Tanaka3

(Faculty of Health and Medical Science, Teikyo Heisei University1, Department of Rheumatology, JCHO Yugawara Hospital2, Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo3)

O-103 EfficacyofdailyteriparatideonbonemicrostructureinrheumatoidarthritiswithmarkedlyreductionofcancellousboneusingHR-pQCT

Ikuko Tanaka1, Takashi Kato2, Hisaji Oshima3, Shigenori Tamaki1

(Nagoya Rhuematology Clinic1, National Center for Geriatrics and Gerontology Department of Radiology2, Tokyo Medical Center Department of Connective Tissue Disease3)

O-104 Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritisTakuya Tomizawa1, Hiromu Ito1,2, Koichi Murata1,2, Motomu Hashimoto2,3, Masao Tanaka2,3, Kohei Nishitani1,2, Syuichi Matsuda1

(Dept. of Orthop. Surg, Graduate School of Medicine, Kyoto Univ1, Dept of Adv Med for Rheumatic Diseases, Graduate School of Medicine, Kyoto Univ2, Dept of Rheumatology and Clin Immunol, Graduate School of Medicine, Kyoto Univ3)

O-105 Systemicboneloss,impairedosteogenicactivityandtypeImusclefiberatrophyin mice with elastase-induced pulmonary emphysema: Establishment of a COPD-related osteoporosis/sarcopenia mouse model

Manabu Tsukamoto1, Toshiharu Mori2, Ke-Yong Wang3, Yasuaki Okada1, Hokuto Fukuda1, Keisuke Naito4, Yoshiaki Yamanaka1, Ken Sabanai1, Eiichiro Nakamura1, Kazuhiro Yatera4, Akinori Sakai1

(Department of Orthopaedic Surgery, University of Occupational and Environmental Health1, Department of Orthopaedic Surgery, Shin-Kokura Hospital2, Shared-Use Research Center, University of Occupational and Environmental Health3, Department of Respiratory Medicine, University of Occupational and Environmental Health4)

O-106 The effects of Graves' disease on vertebral fractures: a study of postmenopausal women

Kai Takedani1, Masakazu Notsu1, Ayumu Takeno1, Kennichiro Tanaka1, Ippei Kanazawa1, Masahiro Yamamoto1, Kiyoko Nawada2, Mika Yamauchi1, Toshitugu Sugimoto1,3

(Internal Medicine 1, Shimane University Faculty of Medicine1, Department of Health and Nutrition, The University of Shimane2, Eikokai Ono Hospital3)


－ 301 －

O-107 Is there the interaction between Collagen-induced arthritis and dysbiosis, as the risk factor for secondary osteoporosis?

Go Okumura, Naoki Kondo, Naoto Endo (Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences)

Oral Presentation19 10:30-11:30 Room 7/ Kobe International Conference Center, 502 (5F)Secondary osteoporosis 2

Chairs: Kunihiro Yamaoka ( Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine)

Mika Yamauchi (Internal Medicine 1, Shimane University Faculty of Medicine) O-108 Eldecalcitol for glucocorticoid-induced osteoporosis versus alfacalcidol:

e-GLORIA trialToshio Matsumoto1, Kazuhiko Yamamoto2, Tsutomu Takeuchi3, Yoshiya Tanaka4, Sakae Tanaka5, Masako Ito6,7, Tetsuo Nakano8, Akihiro Hirakawa9, Satoshi Soen10

(Fujii Memorial Institute of Medical Sciences, University of Tokushima1, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences2, Division of Rheumatology, Department of Internal Medicine , School of Medicine, Keio University3, First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health4, Department of Orthopaedic Surgery, The University of Tokyo5, The Open University of Japan6, Nagasaki University7, Tamana Central Hospital8, Department of Biostatistics and Bioinformatics, The University of Tokyo, Graduate school of Medicine9, Department of Orthopaedic Surgery and Rheumatology, Kindai University Nara Hospital10)

O-109 TheEfficacyofOnceWeeklyTeriparatideforGlucocorticoid-inducedOsteoporosis:-72Weeks The TOWER-GO study-

Ikuko Tanaka1, Yoshiya Tanaka2, Satoshi Soen3, Hisaji Oshima4

(Nagoya Rheumatology Clinic, Initiative for Rheumatology & Osteoporosis1, The first Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health2, Department of Orthopedic Surgery, Kindai University Nara Hospital3, Department of Connective Tissue Disease, Tokyo Medical Center4)

O-110 Combination therapy of teriparatide and anti-RANKL monoclonal antibody increases bone mass and promotes bone regeneration of glucocorticoid-induced osteoporosis in mice

Yuki Etani1, Kosuke Ebina1, Makoto Hirao1, Kazuma Kitaguchi2, Akira Miyama1, Gensuke Okamura1, Kenji Takami1, Hideki Yoshikawa1

(Department of Orthopedic Surgery, Osaka University Graduate School of Medicine1, Department of Orthopedic Surgery, Toyonaka Municipal Hospital2)

O-111 Bone formation occurred in the primary trabecular bone, and in the endosteal and periosteal portions of cortical bone in femurs of rats with glucocorticoid-induced osteoporosis; however, cortical bone thickness and secondary trabecular bone were reduced

Fumiya Nakamura1, Ryota Oseto2, Yuya Kanehira1, Dai Sato3, Ryo Fujita3, Hideyo Horiuti2, Tomomi Masuya2, Shota Furukawa2, Masahiko Takahata3, Hiromi Kimura-Suda1,2

(Graduate School of Photonics, Chitose Institute of Science and Technology1, Faculty of Science and Technology, Chitose Institute of Science and Technology2, Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine3)


－ 302 －

O-112 Evaluation of bone metabolism markers in patients with severe motor and intellectual disabilities

Nagahisa Takahashi (National Rehabilitation Center for Children with Disabilities)

O-113 Serum Sclerostin levels depend on long-term glycemic control in male patients with type 2 diabetes

Reiko Watanabe, Nobuyuki Tai, Junko Hirano, Yoshiyuki Ban, Daisuke Inoue (Third Department of Medicine, Teikyo University Chiba Medical Center)

Oral Presentation20 13:50-15:00 Room 7/ Kobe International Conference Center, 502 (5F)CKD / Rickets / Osteomalacia 1

Chairs: Masafumi Fukagawa ( Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine)

Yuichi Takashi ( Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital)

O-114 Factors that correlate with serum creatinine to cystitis C ratioYoshii Ichiro (Department of Rheumatology and Musculoskeletal Medicine, Yoshii Hospital)

O-115 Reversal of serum cystatin C-based eGFR decline by decreased phosphate release from bone by denosumab in osteoporotic patients even at non-CKD stage

Daichi Miyaoka, Masaaki Inaba, Yasuo Imanishi, Noriyuki Hayashi, Masaya Ohara, Yuki Nagata, Shinsuke Yamada, Katsuhito Mori, Masanori Emoto (Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine)

O-116 Effect of denosumab in patients undergoing dialysis therapyShozo Yano1, Yukihiro Wada2, Yasutoshi Himeno2, Atsushi Nagai1

(Department of Laboratory Medicine, Shimane University Faculty of Medicine1, Himeno Clinic2)

O-117 Efficacyandsafetyofevocalcetforhypercalcemiainpatientswithparathyroidcarcinoma and intractable primary hyperparathyroidism

Yasuhiro Takeuchi1, Seiji Fukumoto2, Yasuo Imanishi3, Yuichi Nishida4, Yuichiro Kondo4

(Toranomon Hospital Endocrine Center1, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University2, Osaka City University Graduate School of Medicine, Department of Metabolism, Endocrinology and Molecular Medicine3, Kyowa Hakko Kirin Co., Ltd.,4)

O-118 Prevalence of Idiopathic Hypoparathyroidism and Pseudohypoparathyroidism in Japan

Rieko Takatani1, Masanori Minagawa2, Takuo Kubota3, Daisuke Inoue4, Toshitugu Sugimoto5, Seiji Fukumoto6, Keiichi Ozono3, Yoshikazu Nakamura7

(Center for Preventive Medical Science, Chiba University1, Department of Endocrinology, Chiba Children's Hospital2, Department of Pediatrics, Osaka University Graduate School of Medicine3, Third Department of Medicine, Teikyo University Chiba Medical Center4, Ono Hospital5, Fujii Memorial Institute of Medical Sciences, Tokushima University6, Department of Public Health, Jichi Medical University7)


－ 303 －

O-119 Etelcalcetide reduces PTH-calcium setpoint, but does not change maximal PTH secretion

Noriyuki Hayashi1, Yasuo Imanishi1, Tomoe Hirakawa1, Atsuto Inoue1,2, Kazutsune Harada1,2, Daichi Miyaoka1, Katsuhito Mori1, Masanori Emoto1, Masaaki Inaba1

(Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine1, ONO PHARMACEUTICAL CO., LTD.,2)

O-120 Regulation of osteoblast metabolism by type III sodium/phosphate co-transportersMiwa Yamazaki1, Masanobu Kawai1, Keiichi Ozono2, Toshimi Michigami1

(Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital1, Department of Pediatrics, Osaka University Graduate School of Medicine2)

Oral Presentation21 15:00-16:00 Room 7/ Kobe International Conference Center, 502 (5F)CKD / Rickets / Osteomalacia 2

Chairs: Noriyuki Namba ( Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University)

Nobuaki Ito ( Division of Nephrology and Endocrinology, The University of Tokyo Hospital)

O-121 Clinical and genetic features in 98 Japanese patients with hypophosphatasia; frequency of mutant alleles and genotype-phenotype correlation

Toshimi Michigami1, Kanako Tachikawa1, Miwa Yamazaki1, Masanobu Kawai1, Takuo Kubota2, Keiichi Ozono2

(Department of Bone and Mineral Research, Osaka Women's and Children's Hospital1, Department of Pediatrics, Osaka University Graduate School of Medicine2)

O-122 A childhood type hypophosphatasia case with delayed fracture healingDaisuke Harada1, Hiroko Kashiwagi1, Shinji Takeyari2, Yasuhisa Ohata2, Yasunori Ishihara2, Takuo Kubota2, Yoshiki Seino1, Noriyuki Namba1

(Osaka Hospital Community of Healthcare Organization1, Department of Pediatrics, Osaka University Graduated School of Medicine 2)

O-123 AcaseofadulthypophosphatasiawithprominentperiarticularcalcificationHajime Kato, Minae Koga, Nobuaki Ito (Division of Nephrology and Endocrinology, The University of Tokyo)

O-124 Mutational analysis of the PHEX gene and genotype-phenotype correlation in 37 Japanese patients with X-linked hypophosphatemic rickets

Yasuhisa Ohata1, Yasuki Ishihara2, Takuo Kubota1, Shinji Takeyari1, Taichi Kitaoka1, Hirofumi Nakayama1,3, Yukako Nakano1, Kenichi Yamamoto1,4, Makoto Fujiwara1,2, Toshimi Michigami5, Noriyuki Namba1,6, Keiichi Ozono1

(Department of Pediatrics, Osaka University Graduate School of Medicine1, The 1st. Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry2, The Japan Environment and Children's Study, Osaka Unit Center3, Department of Statistical Genetics Osaka University Graduate School of Medicine4, Department of Bone and Mineral Research, Osaka Women's and Children's Hospital5, Department of Pediatrics, Osaka Hospital, Japan Community Healthcare Organization (JCHO)6)


－ 304 －

O-125 Burosumab Showed Greater Improvement in Rickets, Phosphate Metabolism, Growth, and Mobility than Conventional Therapy in Children with X-linked Hypophosphatemia (XLH)

Noriyuki Namba1, Hiroyuki Tanaka2, Takuo Kubota3, Hironori Kanda4

(Department of Pediatrics, Osaka Hospital Community Healthcare Organization1, Department of Pediatrics, Okayama Saiseikai General Hospital2, Department of Pediatrics, Osaka University Graduate School of Medicine3, Kyowa Hakko Kirin Co., Ltd.,4)

O-126 Infiltrativenatureoftumor-inducedosteomalacialesionsinbone:correlationbetween radiological and histopathological features

Hiroshi Kobayashi1, Naohiro Makise2, Tetsuo Ushiku2, Nobuaki Ito3, Minae Koga3, Yusuke Shinoda1, Sakae Tanaka1

(Orthopaedic Department, University of Tokyo Hospital1, Department of Pathology, University of Tokyo2, Department of Nephrology and Endocrinology, University of Tokyo3)

Oral Presentation22 8:30-9:20 Room 8/ Kobe International Conference Center, 504・505 (5F)Tooth / Oral / Maxillofacial diseases

Chairs: Kazuto Hoshi (The University of Tokyo)Tomohiko Murakami ( Department of Molecular and Cellular Biochemistry,

Osaka University Graduate School of Dentistry) O-127 Distinctimmunopathologicalfindingsinbisphosphonate/chemotherapeutic-and

anti-RANKLantibody/chemotherapeutic-inducedosteonecrosisofthejaw-likelesions in mice

Hiroki Hayano1, Shinichiro Kuroshima2, Saki Tamaki1, Maaya Inoue1, Takashi Sawase2

(Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University1, Department of Applied Prosthodontics, Institute of Biomedical Sciences, Nagasaki University2)

O-128 Anxa5protectsjawboneovergrowth,excessivetoothattritionandwideningofperiodontal ligament space, induced by mechanical loading

Hisashi Ideno1, Koichiro Komatsu1, Kazuhisa Nakashima1, Yasuo Imanishi2, Toshihiko Amemiya3, Yoshinori Arai3, Yoichi Ezura4, Akira Nifuji1

(Department of Pharmacology, Tsurumi University School of Dental Medicine1, Osaka City University, Graduate School of Medicine and Faculty of Medicine2, Nihon University School of Dentistry3, Tokyo Medical and Dental University, Medical Research Institute4)

O-129 The role of Fam20C in dentin formation Katsutoshi Hirose1, Yu Usami1, Kaori Oya1, Toshihisa Komori2, Satoru Toyosawa1

(Department of Oral Pathology, Osaka University Graduate School of Dentistry1, Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences2)

O-130 Biochemical and genetic analysis in patients with odontohypophosphatasiaTakuo Kubota1, Yasuhisa Ohata1, Yasuki Ishihara1,2, Makoto Fujiwara1,2, Shinji Takeyari1, Kenichi Yamamoto1, Yukako Nakano1, Hirofumi Nakayama1, Taichi Kitaoka1, Keiichi Ozono1

(Department of Pediatrics, Osaka University Graduate School of Medicine1, First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry2)


－ 305 －

O-131 Acceleratory phenomenon of bone metabolic activity after orthognathic surgeryYoko Abe1, Sanicha Yaklai1,2, Roan Solis Pechayco1,2, Mirei Chiba2

(Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University1, Division of Oral Physiology, Department of Oral Function and Morphology, Graduate School of Dentistry, Tohoku University2)

Oral Presentation23 10:30-11:30 Room 8/ Kobe International Conference Center, 504・505 (5F)Signal transduction / Transcription factor

Chairs: Masato Tamura ( Department of Oral Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University)

Hironori Hojo ( Center for Disease Biology and Integrative Medicine, The University of Tokyo)

O-132 Cell-type-specificregulatoryactionofRunx2onthegenomeunderliesitsdistinctroles in osteoblasts and chondrocytes

Hironori Hojo1,2, Akira Yamakawa2, Taku Saito3, Shoko Onodera4, Toshifumi Azuma4, Yuichi Tei1,2, Shinsuke Ohba1,2

(Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo1, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo2, Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo3, Department of Biochemistry, Tokyo Dental College4)

O-133 AnalysisofpostnatalroleofRunx2usingtime-specificRunx2knockoutmiceIkue Tosa1,2, Kenji Kawabe1, Mitsuaki Ono3, Takuo Kuboki2, Takeshi Takarada1

(Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences1, Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences2, Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences3)

O-134 Identificationofthreenon-codingRNAsasvitaminDtargetgenesKouichi Nishimura1,2, Yoshiaki Kanemoto2, Jinichi Mori1,2,3, Shigeaki Kato1,2

(Graduate School of Science and Engineering 1, Research Insitute of Innovative Medicine, Tokiwakai Group2, Jyoban Hospital3)

O-135 Elucidation of bone metabolism regulation mechanism of AKAP13Akiko Ishida1, Akitoshi Nakayama2, Hidekazu Nagano2, Hisashi Koide1, Ichiro Tatsuno3, Tomoaki Tanaka2, Koutaro Yokote1

(Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine1, Department of Molecular Diagnosis, Chiba University Graduate School of Medicine2, Center for Diabetes, Metabolism and Endocrinology, Toho University Sakura Medical Center3)

O-136 IdentificationofacriticalaminoacidresidueinALK2forthebindingandinhibitionby the anti-ALK2 blocking antibody

Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani (Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University)

O-137 Smurf2 suppresses osteoblast differentiation and ectopic bone formation via the BMP/SMAD pathway

Junichi Kushioka1, Takashi Kaito1, Hideki Yoshikawa1, Takeshi Imamura2

(Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine1, Department of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine2)


－ 306 －

Oral Presentation24 13:50-14:40 Room 8/ Kobe International Conference Center, 504・505 (5F)Cartilage development / Metabolism

Chairs: Yuki Taniguchi ( Department of Orthopaedics, The University of Tokyo Hospital)

Fumiko Yano ( Bone and Cartilage Regenerative Medicine, Department of Orthopaedic Surgery, The University of Tokyo Hospital)

O-138 Examination of the cartilage tissue repair effect of human synovial mesenchymal stemcells(MSC)causedbytheadditionofbasicfibroblastgrowthfactor(bFGF)

Gensuke Okamura, Kosuke Ebina, Yuki Etani, Akira Miyama, Kenji Takami, Makoto Hirao, Hideki Yosikawa (Dept. of Orthop. Surg, Graduate School of Medicine, Osaka Univ)

O-139 Effects of implantation of a scaffold free 3D mesenchymal cell structure layered by a bio 3D printer for knee full thickness defects

Yosuke Kaneko, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura (Department of Orthopedic Surgery, Keio University School of Medicine)

O-140 A tumor suppresser gene, platelet-derived growth factor receptor-like (PDGFRL) controls chondrocyte proliferation and differentiation by binding to CCN2and CCN3

Kazumi Kawata1, Satoshi Kubota1,2, Masaharu Takigawa1,2

(Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences1, Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School2)

O-141 Channel-kinase TRPM7 regulates chondrogenesis in bone developmentMasashi Shin1, Shihomi Mori1,2, Toshihide Mizoguchi3, Fujio Okamoto1, Hiroshi Kajiya1, Atsushi Arai4, Nobuyuki Udagawa5, Koji Okabe1

(Cellular Physiology, Fukuoka Dental College1, Oral Surgery, Fukuoka Dental College2, Oral Health Science Center, Tokyo Dental College3, Department of Orthodontics, Matsumoto Dental University4, Department of Biochemistry, Matsumoto Dental University5)

O-142 The role of microRNA in cartilage homeostasisYoshiaki Ito1,2, Hiroshi Asahara2

(Research Core, Tokyo Medical and Dental University1, Department of Systems BioMedicine, Tokyo Medical and Dental University2)


Poster Presentation01 13:40-14:40 Poster and Exhibition / Kobe International Exhibition Hall No.1 Bldg., ExhibitionBasic 1

Chairs: Shinsuke Ohba ( Department of Biology, Nagasaki University)Ryota Chijimatsu ( Bone and Cartilage Regenerative Medicine, Graduate School

of Medicine, The University of Tokyo) P1-1 Itpr1-deficientmiceshowreducedviabilityandbirthratewithboneloss

Yoichiroh Yamaguchi, Tomohisa Skimoto, Syuji Kurogi, Taro Funamoto, Tomomi Oota, Shihoko Miyazaki, Takuya Nagai, Takuya Tajima, Etsuo Chosa (The Department of Orthopaedic Surgery, University of Miyazaki)


－ 307 －

P1-2 InvestigationofdiseasemechanismofOPLLusingpatient-specificiPSCsRena Kashimoto1,2,3, Shunsuke Kawai2,3, Junya Toguchida2,3, Hiroyuki Yoshitomi2,3

(Department of Medical Science, Graduate School of Medicine, Kyoto University1, Center for iPS Cell Research and Application, Kyoto University2, Institute for Frontier Life and Medical Sciences, Kyoto University3)

P1-3 The role of Hedgehog signal modulator gene, Hhip, in bone formationRyuma Haraguchi1, Yukihiro Kohara1, Yuuki Imai2, Riko Kitazawa3, Sohei Kitazawa1

(Dept. Mol. Pathol., Ehime Univ., Grad. Sch. Med.1, PROS, Ehime Univ.2, Dept. Diagn. Pathol., Ehime Univ. Hosp.3)

P1-4 Slitrk1, an integral membrane protein, promotes osteoblast differentiationTomohiko Shirakawa1,2, Takuma Matsubara1, Addison William1, Kayoko Kuroishi2, Kaori Gunjigake2, Tsuyoshi Satou3, Tatsuo Kawamoto2, Shoichiro Kokabu1

(Division of Molecular Signaling and Biochemistry, Kyushu Dental University1, Division of Orofacial and Functional Orthodontics, Kyushu Dental University2, Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University3)

P1-5 Fate mapping of fetal osteoclast inducer cellsEriko Sumiya, Shinichiro Sawa (Division of Mucosal Immunology, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University)

P1-6 Establishment of hMSC reporter cell lines to monitor osteogenic differentiation in living state

Takashi Narai (Division of Oral and Maxillofacial Biopathological Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine)

P1-7 Examination of optimal culture condition of bone marrow cells loaded on b-TCP / RCP hybrid scaffold

Ryo Umeyama1,2, Takanori Yamawaki2, Kazuto Hoshi1,2, Atshuhiko Hikita2

(Department of Sensory and Motor System Medicine, Department of Oral and Maxillofacial Surgery, Dentistry and Orthodontics, The University of Tokyo Graduate School of Medicine1, Division of Tissue Engineering, The University of Tokyo Hospital2)

P1-8 Effects of NMDA receptor antagonists on bone healing and the differentiation of bone-related cells

Shuichi Kiyohara1, Kazuaki Handa2,3, Tomoyuki Yamakawa2,3, Koji Ishikawa2,3, Nobuhiro Sakai2, Masahiko Ozeki1, Takako Koga2, Masamichi Takami2

(The Department of Implant Dentistry, Showa University School of Dentistry1, The Department of Dental Pharmachology, Showa University School of Dentistry2, The Department of Orthopaedic Surgery, Showa University School of Medicine3)

P1-9 ComprehensivegeneexpressionprofileofosteoblastsafteranabolicPTHtreatment

Akito Morimoto, Junichi Kikuta, Masaru Ishii (Immunology and Cell Biology, University of Osaka)


－ 308 －

P1-10 Ellagic acid increases osteoblast differentiation of bone marrow mesenchymal stem cells

Yasuhiro Horimoto, Sachie Nakatani, Kenji Kobata (Department of Pharmaceutical and Health Sciences, Josai Univercity)

Poster Presentation02 13:40-14:40 Poster and Exhibition / Kobe International Exhibition Hall No.1 Bldg., ExhibitionClinical

Chairs: Akihiro Sudo ( Department of Orthopaedic Surgery, Mie University Graduate School of Medicine)

Yukio Nakamura ( Department of Orthopaedic Surgery, Shinshu University School of Medicine)

P2-1 Establishment of a New Technique for the Fabrication of Regenerative Cartilage with a Microslicer Device to Prepare Three Dimensional Diced Cartilage

Erika Aoki, Yukiyo Asawa, Atsuhiko Hikita, Kazuto Hoshi (Graduate School of Medicine, The University of Tokyo)

P2-2 Effects of high bone turnover state on skeletal pain induction of osteoarthritis - a study using knee OA model mouse -

Kenta Kiyomoto1,2, Kousuke Iba1, Megumi Hanaka1, Hikaru Hayakawa1, Toshihiko Yamashita1

(Department of Orthopedic Surgery School of Medicine, Sapporo Medical University1, Department of Rehabilitation, Japan Health Care College2)

P2-3 Effects of anti-RANKL monoclonal antibody on high-prevalence model of osteonecrosisofthejaw-likelesionsinmice

Shinichiro Kuroshima1, Saki Tamaki2, Hiroki Hayano2, Maaya Inoue2, Takashi Sawase1

(Department of Applied Prosthodontics, Institute of Biomedical Sciences, Nagasaki University1, Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University2)

P2-4 Questionnaireresearchontumor-inducedosteomalaciainassociationwithJSBMR and JMOG

Minae Koga, Nobuaki Ito (Division of Nephrology and Endocrinology, The University of Tokyo Hospital)

P2-5 ChangesinbonedensityofsurroundingjointsinCompleteFreund'sadjuvant(CFA) -induced arthritis

Norihiro Mayumi, Hiroki Wakabayashi, Gaku Miyamura, Akihiro Sudou (Department of Orthopaedic Surgery, Mie University Graduate School of Medicine)

P2-6 High-fat diet feeding mice exhibit abnormities of incisor and bone metabolismYutaro Kurotaki1,2,4, Nobuhiro Sakai2,4, Masahiro Hosonuma3,4, Takako Koga2,4, Akiko Karakawa2,4, Masahiro Chatani2,4, Masamichi Takami2,4

(Division of Community-Based Comprehensive Dentistry, Department of Special Needs Dentistry, School of Dentistry, Showa University1, Depatment of Dental Pharmacology, School of Dentistry, Showa University2, Division of Rheumatology, Department of Medicine, Showa University School of Medicine3, Pharmacological Research Center, Showa University4)


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P2-7 Denosumabsignificantlyimproveslumbarspinebonemineraldensitymoreintreatment-naive than in long-term bisphosphonate-treated patients

Takako Suzuki1,2, Yukio Nakamura1

(Department of Orthopaedic Surgery, Shinshu University School of Medicine1, Department of Health and Nutrition, Tokyo Kasei Gakuin University2)

P2-8 Decrease in Bone Density and Kidney Function in Japanese High School Long-Distance Track and Field Female Athletes

Kimiko Miyahara1, Yukari Iwasaki2, Nobuyuki Miyatake3

(Faculty of Health Care, Department of Nutrition1, Department of Food and Nutrition, Sanyo Gakuen College2, Department of Hygiene, Faculty of Medicine, Kagawa University3)

P2-9 A case of Bone Paget's diseaseSahoko Ueda, Yasumasa Yoshino, Megumi Shibata, Takeshi Takayanagi, Atsushi Suzuki (Department of Endocrinology and Metabolism, Fujita Health University)

P2-10 18F-NaFPET/CTinForty-fourPatientswithFibrodysplasiaOssificansProgressivaUncovers Highly-prevalent, Multifocal, Metabolically-Active Heterotopic Ossification,LargelyDisassociatedfromFlare-ups

Esmée Botman1, Eduardo Forleo Neto2, Pieter G.H.M. Raijmakers3, Maqsood Yaqub3, Gary Herman2, Aris N. Economides2, Scott J. Mellis2, Melissa Simek-Lemos2, J. Coen Netelenbos1, Adriaan A. Lammertsma3, Andrew J. Rankin2, E. Marelise W. Eekhoff1 and Dinko González Trotter2

(Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine section Endocrinology, Amsterdam Bone Center, Amsterdam Movement Sciences, the Netherlands1, Regeneron Pharmaceuticals, Inc., United States of America2, Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, the Netherlands3)



Chairs: Shingo Maeda ( Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences, Kagoshima University)

Atsuhiko Hikita (The University of Tokyo) P3-1 Augmented mechano-induced Ca2+oscillationsinperiodontalligamentfibroblast

control bone remodeling via Rankl/Opg and canonical Wnt/Beta-catenin signalingEi Ei Hsu Hlaing1, Yoshihito Ishihara2, Ziyi Wang1, Naoya Odagaki2, Hiroshi Kamioka1

(Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University1, Department of Orthodontics, Okayama University Hospital2)

P3-2 MENK suppresses osteocyte apoptosis induced by compressive force loadingChisumi Sogi1,2, Nobuo Takeshita2, Arata Ito2, Michiko Yoshida2, Toshihito Oyanagi2, Ikuma Fujiwara1, Teruko Yamamoto2

(Department of Pediatrics, Graduate School of Medicine, Tohoku University1, Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University2)

P3-3 Deletion of ferroportin in osteoclast precursors increases iron accumulation and stimulates osteoclastogenesis

Toshifumi Fujiwara1,2, Lei Wang2, Bin Fang2, Yasuharu Nakashima1, Zhao Haibo2

(The Department of Orthopaedic Surgery, Kyushu University1, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences2)


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P3-4 Downregulation of receptor activator NF-kB (RANK) expression by methylation of its gene promoter

Riko Kitazawa1,2, Yuki Murata1, Yukihiro Kohara1, Ryuma Haraguchi1, Sohei Kitazawa1

(Ehime University Graduate School of Medicine, Department of Molecular Pathology1, Ehime University Hospital, Division of Diagnostic Pathology2)

P3-5 Vibration enhances osteoclastogenesis by inducing RANKL expression via NF-kB signaling in osteocytes

Mayuri Sakamoto1, Tomohiro Fukunaga1, Kiyo Sasaki1, Nobuo Takeshita1, Teruko Yamamoto1,2

(Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry1, Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University2)

P3-6 Evaluation of the wound model mice pain like behavior and bone metabolism after use of bisphosphonate, COX inhibitor

Hikaru Hayakawa, Kousuke Iba, Megumi Hanaka, Kenta Kiyomoto, Toshihiko Yamashita (Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine)

P3-7 Hedgehog signaling Inhibitor Cyclopamine suppresses osteoclast formationYukihiro Kohara1, Ryuma Haraguchi1, Riko Kitazawa2, Sohei Kitazawa1

(Department of Molecular Pathology, Ehime University Graduate School of Medicine1, Department of Diagnostic Pathology, Ehime University Hospital2)

P3-8 Analysis of bone destruction in hemophilic arthropatyAsuka Terashima1, Kazuo Okamoto1, Jun Hirose2, Hiroshi Takayanagi3

(Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo1, Faculty of Medicine, Department of Orthopaedic Surgery, The University of Tokyo2, Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo3)


Chairs: Shigeru Kotake (Saitama Medical Center, Jichi Medical University)Yasunori Omata ( Department of Orthopaedic Surgery, Faculty of Medicine,

The University of Tokyo) P4-1 p21deficiencyissusceptibletoTMJ-Osteoarthritiswithmechanicalstress

Tsendsuren Khurel-Ochir1, Takashi Izawa2, Takuma Sakamaki1, Hiroki Mori2, Akihiko Iwasa2, Eiji Tanaka2

(Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Oral Sciences1, Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School2)

P4-2 Tace negatively regulates osteoarthritisTaizo Kaneko1, Ryota Chijimatsu2, Fumiko Yano2, Keisuke Horiuchi3, Sakae Tanaka1, Taku Saito1

(Department of Orthopaedic Surgery, The University of Tokyo1, Bone and Cartilage Regenerative Medicine, The University of Tokyo Hospital2, Department of Orthopaedic Surgery, National Defense Medical College3)


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P4-3 BMP-3b controls the regeneration of skeletal muscleAki Miyawaki1,2, William Addison1, Takuma Matsubara1, Kazuhiro Tominaga2, Shoichiro Kokabu1

(Division of Molecular Signaling and Biochemistry, Kyushu Dental University1, Division of Maxillofacial Surgery, Department of Science of Physical Functions, Kyushu Dental University2)

P4-4 Lubricinregulatesarticularcartilagehomeostasisviasuppressionofsuperficialzone cells differentiation

Yuji Maenohara, Ryota Chijimatsu, Hideki Nakamoto, Yasutaka Murahashi, Fumiko Yano, Sakae Tanaka, Taku Saito (Orthop. Surg, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The Univ. of Tokyo)

P4-5 Histological scoring system for subchondral bone changes in mouse models of jointagingandosteoarthritis

Keita Nagira1,2, Yohei Sanada3, Masahiro Shinohara5, Hiroshi Hagino4, Shigeru Miyaki3

(Department of Orthopaedic Surgery, University of Tottori1, Scripps Research Institute, United State2, Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University3, School of Health Science, Faculty of Medicine, Tottori University4, National Rehabiritaion Center for Persons with Disabilities5)

P4-6 Generation of engineered-tendon-like-tissue using Mkx and mechanical-stressKensuke Kataoka1, Hiroshi Asahara1,2

(Department of Systems Biomedicine, Tokyo Medical and Dental University1, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, USA2)

P4-7 TheeffectofnicotineonendochondralossificationShigeki Yamanaka, Kazumasa Nakao, Noriaki Koyama, Marina Kashiwagi, Kazuhisa Bessho (Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine)

P4-8 Modulation of arthritis by type 2 innate lymphoid cell (ILC2)Yasunori Omata1,2, Georg Schett2, Mario Zaiss2

(Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo1, Friedrich Alexander University Erlangen-Nuremberg, Germany2)

P4-9 Inhibition of Activin A does not ameliorate the formation of trauma-induced HeterotopicOssification.

Aris N. Economides1, 2, Nanditha Das1, Liqin Xie1, Lily Huang1, Lili Wang1, Xialing Wen1, Kalyan Nannuru1, Andrew J. Murphy1, and Sarah Hatsell1

(Regeneron Pharmaceuticals Inc., USA1, Regeneron Genetics Center, USA2)

P4-10 Thefibrodysplasiaossificansprogressiva-causingACVR1[R206H]andACVR1[R258G]mutationsexhibitdistinctskeletalphenotypesinneonatalmice.

Lily Huang1, John B. Lees-Shepard1, Lili Wang1, Xialing Wen1, Qian Zhang1, Vincent Idone1, Kalyan Nannuru1, Christopher Schoenherr1, Andrew J. Murphy1 and Aris N. Economides1,2 and Sarah Hatsell1

(Regeneron Pharmaceuticals Inc., USA1, Regeneron Genetics Center, USA2)


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Student-Resident Poster 9:30-10:30 Poster and Exhibition / Kobe International Exhibition Hall No.1 Bldg., Exhibition

Chair: Sumito Ogawa ( Department of Geriatric Medicine Graduate School of Medicine, The University of Tokyo)

SRP-1 Primarycultureofmousefibrousandadiposesynovialfibroblastsundernormoxicand hypoxic conditions

Hikaru Sugimoto (Tokyo Metropolitan Geriatric Hospital)

SRP-2 The Relationship between ALDH2/ADH Gene Mutation and Osteoblastic Differentiational Factor Gene Expression in Human Hair Root Cell

Mimu Mochizuki ( Laboratory of Neuropathology, Faculty of Medical Science, Teikyo University of Science)

SRP-3 Cartilage regeneration by mouse synovial cells in a mouse knee cartilage defect model

Satoshi Miwa (Faculty of Medicine, The University of Tokyo)

SRP-4 Morphological assessment for different histology between long bones and vertebrates in db/db mice

Taiji Yoshida (Hokkaido University School of Dentistry)

SRP-5 Bone metastatic breast cancer cell-derived extracellular vesicles regulate osteoblast function

Hidenobu Shibusawa (Kyushu University Faculty of Dental Science)

SRP-6 Nuclear receptor Nrli2 regulates osteoblastic gene expressionsSayuri Tatsuta (Osaka University school of dentistry)

SRP-7 Identificationofmechano-signalinginosteoclast-likecellsJunna Tanaka (Department of Pharmacology, Osaka Dental University)

SRP-8 Lipoteichoicacidfromgram-positivebacteriacellwallinducedinflammatoryboneresorption

Yuki Tanaka ( Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology)

SRP-9 Roles of HB-EGF-EGFR signaling in melanoma bone metastasis and bone destruction

Kento Karouji ( Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology)


Luncheon Seminar 1 12:20-13:20 Room 1/ Kobe …...Medicine, University of Tokyo2, Department of...

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