LPPD University of Illinois Chicago, LPPP. Summer 2008 Magnetically-Guided Nanoparticles for...

LPPD LPPD University of Illinois Chicago, LPPP. Summer 2008

Magnetically-Guided Nanoparticles Magnetically-Guided Nanoparticles for Targeted Drug Deliveryfor Targeted Drug Delivery

Magnetically-Guided Nanoparticles Magnetically-Guided Nanoparticles for Targeted Drug Deliveryfor Targeted Drug Delivery

Presentation for RET program

June 30, 2011

Seth Baker

Advisors: Dr. Andreas Linninger

Eric Lueshen, Madhawa Hettiarachchi

Laboratory for Product and Process DesignLaboratory for Product and Process Design

University of Illinois- Chicago

Department of Chemical Engineering

University of Illinois Chicago, LPPD, Summer 2011


Motivations for ResearchMotivations for Research

• Over 7 million Americans suffer from neurological conditions such as Alzheimer’s, Parkinson’s, Brain Cancer, and Stroke.

• These conditions have direct and indirect costs of over $200 billion dollars annually in the United States.

• Magnetically-guided nanoparticle drug delivery allows treatment for

– Neurological diseases such as Alzheimer’s and Parkinson’s

– Abnormal vascular structures (tumors)

– Stroke conditions

– Effective methods of blocking angiogenesis of tumors



Materials for ResearchMaterials for Research

Magnetite core (Fe3O4) nanoparticles from 8 – 30 nm in diameter. Nanoparticles are defined as less than 100 nm diameter and can pass through endothelial barriers.

Prussian blue stain for imaging the movement of the magnetic (iron) nanoparticles.

Agarose gel brain phantoms with similar properties to brain tissue.



Benefits of Magnetic Nanoparticles Benefits of Magnetic Nanoparticles

• Allows for more targeted drug delivery resulting in lower dosage and systemic toxicity.

• Magnetite core nanoparticles are biocompatible and biodegradable.

• Nanoparticles can be coated or loaded with various therapeutics.

Magnetically-guided nanoparticles for targeted drug delivery can provide a wide range of applications for the detection, diagnosis and treatment of neurological conditions.



Experimental Design Experimental Design

• Agarose Gel Experiments


Investigating 35 and 173 pound magnetic pull force on magnetite nanoparticles in 5% agarose

gel. Infusion flow rate is 0.5 µl/min.

• Rat Brain Staining • Agarose Gel Experiments

Investigating the movement of Prussian Blue stain in rat brain samples to determine

permeability of brain tissue.


Future WorkFuture Work

• Measure magnetic nanoparticle movement in different concentrations of agarose gel and magnetic force.

• Determine best method for visualizing the nanoparticle movement (Prussian blue stain, angiogram)

• Determine the most effective protocol for administrating and measuring magnetically-guided nanoparticles in rat brain samples.

• Investigate methods to manufacture nanoparticles



Acknowledgements

• NSF EEC-0502272 Grant, Chicago Science Teacher Research

• Dr. Andreas Linninger

• Eric Lueshen

• Sukhi Basati

• Joe Kanikunnel – REU Summer Fellow


LPPD University of Illinois Chicago, LPPP. Summer 2008 Magnetically-Guided Nanoparticles for...

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