Lorenzo’s Oil Obectives: To demonstrate understanding of….. 1. How Lorenzo inherited the disease...
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Transcript of Lorenzo’s Oil Obectives: To demonstrate understanding of….. 1. How Lorenzo inherited the disease...
![Page 1: Lorenzo’s Oil Obectives: To demonstrate understanding of….. 1. How Lorenzo inherited the disease through genetic inheritance. 2. How a disease is the result.](https://reader031.fdocuments.us/reader031/viewer/2022020117/56649f4c5503460f94c6cb2d/html5/thumbnails/1.jpg)
Lorenzo’s OilObectives: To demonstrate understanding of…..1. How Lorenzo inherited the disease through genetic inheritance.2. How a disease is the result of a malfunctioning system, organ, and cell. 3.The importance of proteins to the normal breakdown of fatty acids.4.The implications of abnormal metabolic functioning in ALD patients.5.Fatty acid manipulation as a therapeutic treatment in ALD patients using Lorenzo’s oil.6.Ethical implications demonstrated by the Lorenzo Odone story.
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Lorenzo’s Oil
Obectives: To demonstrate understanding of…..
1. How Lorenzo inherited the disease through genetic inheritance.-What is a sex-linked gene? -Why do sex linked disorders affect males more often?-Which parent passed the defective gene to Lorenzo? -Why don’t Lorenzo’s parents suffer ALD?-What was the defective gene responsible for? (What was it suppose to code for?)-Illustrate how Lorenzo inherited ALD using a punnett square.
-See 9.21 & 9.22 in text for additional help.
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Lorenzo’s Oil
2. How is ALD the result of a malfunctioning system, organ, and cellular level?Organ System Level:What organ system is failing? Why is it failing?
Organ Level:What organ is failing? Why is it failing?
Cellular Level:What is happening at a cellular level that causes cell destruction? Why is this happening?
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Lorenzo’s Oil
3. The importance of proteins to the normal breakdown of fatty acids.-What type of proteins are involved in ALD? -How are enzymes involved in ALD?-How does competitive inhibition in enzyme activity help reduce the biosynthesis of VLCFA?
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Lorenzo’s Oil
4. The implications of abnormal metabolic functioning in ALD patients.
Metabolic Pathway: A series of chemical rxns that either builds a complex molecule or breaks down a complex molecule into smaller units.
• Describe ALD in terms of a malfunctioning metabolic pathway.
• Explain why diet alone cannot help ALD patients in terms of biosynthesis?
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Lorenzo’s Oil
5. Fatty acid manipulation as a therapeutic treatment in ALD patients using Lorenzo’s oil.
Lorenzo’s oil is a mixture of oleic acid (from olive oil) and erucic acid (extracted from rapeseeds).
• How are these oils used as a treatment? Discuss answer in terms of competitive inhibition in enzyme activity and biosynthesis.
• Why don’t these oils harm ALD patients?• How do these oils differ structurally from the fatty acids
that build up in ALD patients?
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Lorenzo’s Oil
6. Ethical implications demonstrated by the Lorenzo Odone story.
The process of finding medical treatments for people (clinical trials) often puts sound scientific processes (repeating trials; having control groups; taking time for peer review) against human morales (helping those who suffer). How is this highlighted in Lorenzo’s story? Be able to give specific examples.
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Long Chain Fatty Acids & ALDVISIT this site•http://clasfaculty.ucdenver.edu/bstith/loren.htm
The Myelin Project Play slide show•http://www.myelin.org/resources/toolsforteachers.html•http://www.myelin.org/ - Link to Lorenzo’s Oil