LONG QT SYNDROME AND PREGNANCY - Rochester, NY · 2019. 10. 23. · LONG QT SYNDROME AND PREGNANCY...
Transcript of LONG QT SYNDROME AND PREGNANCY - Rochester, NY · 2019. 10. 23. · LONG QT SYNDROME AND PREGNANCY...
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LONG QT SYNDROME AND
PREGNANCY
Ilan Goldenberg MD
Director, Clinical Cardiovascular Research Center
The Cardiology Division of the Department of Medicine,
University of Rochester Medical Center, Rochester, N.Y
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Sex-Specific Risk in Congenital LQTS
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Clinical Course: Cardiac Events by Sex
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Cumulative Probability of a First ACA or SCD in LQT2
Patients by SexP
rob
ab
ilit
y o
f A
CA
/SC
D
for
LQ
T2 P
ati
en
ts
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
Age
0 10 20 30 40
Unadjusted P=0.001
Male
Female
Patients at RiskMale 490 411 (0.02) 300 (0.07) 235 (0.11) 171 (0.14)
Female 676 613 (0.01) 488 (0.08) 366 (0.18) 245 (0.26)
Migdalovich and Goldenberg, Heart Rhythm, 2011
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Effect of Sex Hormones on Congenital Long-QT Syndrome
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SEX HORMONES DURING THE MENSTRUAL
CYCLE
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HYPOTHETICAL EFFECT OF SEX HORMONES ON
QTc
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ORAL CONTRACEPTIVES AND QTc
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LONG QT SYNDROME AND PREGNANCY
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SEX HORMONES AND PREGNANCY
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Risk of cardiac events before and after
pregnancy
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Risk of cardiac events before and after
pregnancy
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Risk of cardiac events from conception
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Increased risk for Women with Ikr mutations:
LQT2 postpartum
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PROTECTIVE EFFECT OF BETA-BLOCKERS
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PROTECTIVE EFFECT OF BETA-BLOCKERS
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FUTURE DIRECTIONS
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Sex Hormones and Arrhythmias
1. What is the association
between female sex hormones
and arrhythmic risk?
1. Can sex-specific risk factors
improve risk stratification for
SCA in patients with LQTS?
2. Are there sex-differences in
response to medical and
defibrillator therapy in LQTS?
Understanding the relation between sex hormones, genetics,
and SCA risk may lead to novel, hormonal-based, therapeutic
interventions in inherited and acquired arrhythmic disorders
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Clinical Study: Congenital and
Drug-Induced LQTS
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CONCLUSIONS
Sex hormones affect the clinical course of LQTS patients from birth through adulthood
The effects are most pronounced in women with LQT1 and especially LQT2
The risk of cardiac events decreases during pregnancy and increases postpartum
Beta-blockers are protective during and after pregnancy
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THANK YOU