LMCC Review: Pediatric Neurology
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Transcript of LMCC Review: Pediatric Neurology
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LMCC Review:Pediatric Neurology
Asif Doja, MEd, MD, FRCP(C)
March 27th, 2012
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Outline
• Seizures
• Febrile Seizures
• Status Epilepticus
• Headache
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Seizures
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Question 1
Someone can be diagnosed with epilepsy if they have:
A. More than one febrile seizure
B. More than one afebrile seizure
C. Seizures in the context of hypoglycemia
D. One seizure and a history of brain injury
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Question 2
All of the following seizure types are classified as “generalized” seizures EXCEPT:
A. Complex partial seizuresB. Absence seizuresC. Tonic-clonic seizuresD. Atonic seizures
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Question 3
All of the following are features of Absence seizures EXCEPT:
A. Lack of an aura or warning
B. Impairment in consciousness
C. Post-ictal drowsiness/lethargy
D. 3 Hz spike and wave on EEG
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Question 4
Which of the following is an appropriate first line treatment for an 8 year old child with epilepsy?
A. Bromide therapyB. Ketogenic DietC. CarbemazepineD. Phenobarbital
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Question 5
A 9 year old child presents with recurrent episodes of waking in the morning with facial twitching, dysarthria and normal level of consciousness. The most likely diagnosis is:
A. Transient Ischemic AttacksB. Benign Epilepsy of Childhood with Rolandic
SpikesC. Juvenile Myoclonic EpilepsyD. Facial tics
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Definitions
• Seizure: Paroxysmal discharge of neurons resulting in behaviour change, motor or sensory dysfunction
• Epilepsy: > 1 unprovoked seizure
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Was it a Seizure?
• Differential Diagnosis– Syncope– Breath Holding– Night Terrors– Tics– GERD– etc
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Syncope vs Seizure
• Vasovagal reflex
• Usually happens when standing up
• Lightheaded feeling
• Pale, cold, clammy
• Loss of consciousness and fall
• Tremble but no tonic-clonic movements
• No post-ictal lethargy
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Focal vs. Generalized Seizures
Focal• Simple Partial• Complex Partial• Partial Seizure with 2O
Generalization
Generalized• Generalized Tonic-
Clonic• Tonic• Clonic• Absence• Atonic• Myoclonic
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How to differentiate “Staring Spells”
Complex Partial• Aura• ~ 30 sec or more• Decr LOC• Automatisms• Post-ictal period• EEG: focal epileptiform
abnormality• Hyperventialtion has no
effect
Absence• No aura• Lasts few seconds• Decr LOC• May have automatisms• No post-ictal period• EEG: 3 HZ spike and
wave• Provoked by
hyperventialtion
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Investigations and Treatment
• Neuroimaging if focal findings present• May do EEG after first seizure• Treatment if patient has 2 or more seizures
– Commonly used: Carbemazepine, Valproic Acid, Phenobarbital
– Many other newer anticonvulsants ie Topiramate, Levotiracetam
– (For refractory patients: Ketogenic Diet, Epilepsy surgery)
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Epilepsy Syndromes
West Syndrome• Infantile Spasms• Onset in 1st year• Symmetrical
contractions of trunk/extremities
• EEG: hypsarrythmia• Poor prognosis
Lennox Gastault• Onset age 3-5• Multiple seizure types• Developmental delay• EEG: slow spike and
wave• Many have history of
infantile spasms
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Epilepsy Syndromes
Benign Epilepsy of Childhood with Rolandic Spikes
(BECRS)• 5-10 years• Simple partial seizures
involving face• Remits spontaneously,
no treatment
Juvenile Myoclonic Epilepsy
• 12-16 years• Myoclonus and GTC
seizures• Good prognosis, but
requires lifelong treatment with Valproic Acid
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Question 1
Someone can be diagnosed with epilepsy if they have:
A. More than one febrile seizure
B. More than one afebrile seizure
C. Seizures in the context of hypoglycemia
D. One seizure and a history of brain injury
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Question 2
All of the following seizure types are classified as “generalized” seizures EXCEPT:
A. Complex partial seizuresB. Absence seizuresC. Tonic-clonic seizuresD. Atonic seizures
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Question 3
All of the following are features of Absence seizures EXCEPT:
A. Lack of an aura or warning
B. Impairment in consciousness
C. Post-ictal drowsiness/lethargy
D. 3 Hz spike and wave on EEG
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Question 4
Which of the following is an appropriate first line treatment for an 8 year old child with epilepsy?
A. Bromide therapyB. Ketogenic DietC. CarbemazepineD. Phenobarbital
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Question 5
A 9 year old child presents with recurrent episodes of waking in the morning with facial twitching, dysarthria and normal level of consciousness. The most likely diagnosis is:
A. Transient Ischemic AttacksB. Benign Epilepsy of Childhood with Rolandic
SpikesC. Juvenile Myoclonic EpilepsyD. Facial tics
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Febrile Seizures
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Question 1
Which of the following is NOT a feature of a typical febrile seizure?
A. Onset between ages 6 months – 6 yearsB. Duration of < 15 minutesC. Only one seizure in 24 hour spanD. Patients usually have pre-existing
developmental delay
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Question 2
Which of the following is FALSE regarding atypical febrile seizures?
A. They may show clonic jerking on only one side of the body
B. The patient is at no increased risk for further febrile seizures.
C. The patient can present in status epilepticusD. The patient can show focal abnormalities on
neurologic exam.
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Question 3
A 8 month old female has one typical febrile seizure, then 2 months later has another. With respect to anticonvulsants, you would prescribe:
A. Phenobarbital
B. Carbemazepine
C. Valproic Acid
D. None, as the patient does not require treatment
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Question 4
A 7 month old male has a typical febrile seizure. With respect to doing a lumbar puncture, the AAP guidelines state that you should:
A. Not do an LP
B. Do an LP if the temperature is > 39 degrees
C. Do an LP only if there are meningeal signs
D. Do an LP irregardless of the physical exam findings
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Question 5
What is the risk of developing epilepsy in a child with a typical febrile seizure?
A. 1%, the same as the general population
B. 2-3%
C. 10-15%
D. 33%
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Febrile Seizures
• 3-5% of all children
• Ages 6 months to 6 years
• Usually GTC
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Typical vs Atypical Febrile Seizures
Typical• Duration < 15 min• No focality• Does not recur in 24-
hour period• No hx of
developmental delay
Atypical• Duration > 15 min• Focal findings during
seizure or after exam• > 1 in 24 hours• Previous History of
Developmental Delay
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Risk of Recurrence
• 33% chance of recurrence (75% occur within 1 year)
• Risk Factors:– Family history of feb. con. or epilepsy– Short duration of fever prior to seizure– Developmental / Neurological problems– Atypical febrile seizure
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Investigations
• History and Physical – determine source of fever
• EEG and Neuroimaging only needed in atypical cases
• LP:– If < 12 months: Do LP– If 12-18 months: Consider LP– If > 18 months: Only if meningeal signs present
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Management
• Reassurance
• Risk of developing epilepsy is 2-3% (1% in general population)
• Antipyretics and fluids for comfort (neither prevent seizures)
• No need for anticonvulsants
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Question 1
Which of the following is NOT a feature of a typical febrile seizure?
A. Onset between ages 6 months – 6 yearsB. Duration of < 15 minutesC. Only one seizure in 24 hour spanD. Patients usually have pre-existing
developmental delay
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Question 2
Which of the following is FALSE regarding atypical febrile seizures?
A. They may show clonic jerking on only one side of the body
B. The patient is at no increased risk for further febrile seizures.
C. The patient can present in status epilepticusD. The patient can show focal abnormalities on
neurologic exam.
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Question 3
• A 8 month old female has one typical febrile seizure, then 2 months later has another. With respect to anticonvulsants, you would prescribe:
• A. Phenobarbital• B. Carbemazepine• C. Valproic Acid• D. None, as the patient does not require treatment
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Question 4
A 7 month old male has a typical febrile seizure. With respect to doing a lumbar puncture, the AAP guidelines state that you should:
A. Not do an LP
B. Do an LP if the temperature is > 39 degrees
C. Do an LP only if there are meningeal signs
D. Do an LP irregardless of the physical exam findings
![Page 37: LMCC Review: Pediatric Neurology](https://reader035.fdocuments.us/reader035/viewer/2022062217/56814e6f550346895dbc0a2d/html5/thumbnails/37.jpg)
Question 5
What is the risk of developing epilepsy in a child with a typical febrile seizure?
A. 1%, the same as the general population
B. 2-3%
C. 10-15%
D. 33%
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Status Epilepticus
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Question 1
Status Epilepticus is defined as:
A. 30 minutes or > of continuous seizure activity
B. Recurrent seizures with no intervening normal level of consciousness for > 30 min
C. A and BD. None of the above
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Question 2
A 5 year old boy presents to the ER with a 45 minute GTC seizure. What is your initial management?
A. ABC’sB. Stat CT headC. Lorazepam 0.1mg IV pushD. Tox screen
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Question 3
Which of the following metabolic disturbances is MOST likely to cause seizures?
A. High Potassium
B. High Chloride
C. Low urea
D. Low glucose
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Question 4
First line anticonvulsant treatment in status epilepticus should be:
A. Lorazepam
B. Phenytoin
C. Phenobarbital
D. Thiopentol coma
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Status Epilepticus
• 30 minutes or > of continuous seizure activity
• Recurrent seizures with no intervening normal level of consciousness for > 30 min
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Status Epilepticus
• ABC’s– Oxygen / pulse oximetry– Bag-valve support or intubation if req’d– IV access
• Check blood sugar -- give dextrose if low (2-4 ml/kg of 25% solution)
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Status Epilepticus
• Anticonvulsants:– Benzodiazepines ie Lorazepam (0.1 mg/kg IV),
can repeat X1– If fails, Phenytoin 20mg/kg (no faster than 1
mg/min)– If fails, Phenobarbital 20 mg/kg (no faster than
1 mg/min)– If fails, will need to go to ICU for barbituate
coma (ie thipentol) or midazolam infusion
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Question 1
Status Epilepticus is defined as:
A. 30 minutes or > of continuous seizure activity
B. Recurrent seizures with no intervening normal level of consciousness for > 30 min
C. A and BD. None of the above
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Question 2
A 5 year old boy presents to the ER with a 45 minute GTC seizure. What is your initial management?
A. ABC’sB. Stat CT headC. Lorazepam 0.1mg IV pushD. Tox screen
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Question 3
Which of the following metabolic disturbances is MOST likely to cause seizures?
A. High Potassium
B. High Chloride
C. Low urea
D. Low glucose
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Question 4
First line anticonvulsant treatment in status epilepticus should be:
A. Lorazepam
B. Phenytoin
C. phenobarbital
D. Thiopentol coma
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Headache
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Question 1
• A 7 year old male presents with headache. Which of the following would NOT be a “red flag” on history?
A. Early morning vomiting
B. Headache worse after certain foods
C. Vomiting without nausea
D. Focal neurologic symptoms
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Question 2
• Which is the following is FALSE regarding migraine in children
A. The headache can last as little as 1 hour in children
B. Children do not need to have nausea AND vomiting to be diagnosed with migraine
C. There is often a family history of migraineD. MRI is often needed to rule ot other serious
causes of headache.
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Question 3
• Which of the following medications has the best evidence for aborting migraine in children?
A. Acetaminophen
B. Demerol
C. Sumatripan
D. Ibuprofen
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Question 4
• Which of the following is NOT a migraine variant in childhood?
A. Alice in Wonderland syndromeB. Paroxysmal TorticollisC. Cyclic Vomiting SyndromeD. Benign Paroxysmal VertigoE. All of the above are migraine variants in
childhood
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Key Questions to ask on H/A Hx
• Duration• Constant or Intermittent• Quality of Pain (ie throbbing, pressure)• Scale 1-10• Location of pain +/- radiation• Nausea or vomitting• Photo or Phonophobia• Aggravating and Alleviating factors
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Key Questions to ask on H/A Hx
• Early am waking
• Weight loss, fever etc
• Aura / Visual changes
• Focal neuro symptoms
• Change with position / Valsalva
• Family Hx of H/A
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Key items on Physical
• Temperature
• Blood pressure and CVS exam
• Cranial Bruits
• Scalp tenderness
• Fundi
• Focal neurological signs
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H/A in increased ICP
• Nocturnal or early morning H/A in 15%
• Nx and Vx in 50%
• May be precipitated by change in position / Valsalva
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Other features of Brain Tumours/ H/A in increased ICP
• Personality change, memory problems, poor concentration
• Seizures in 1/3• Vomiting NOT preceded by nausea• Focal neuro findings• Papilledema – formally seen in 60-70%
– Now seen in ~ 10-20%– Likely due to better neuroimaging techniques
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Migraine
• Epidemiology– 75% of H/A’s referred for pediatric neurologic
consultation– prevalence 1.2 – 11% depending on age
• +ve family hx in 70 – 90%
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Key Features
• May have previous history of motion sickness
• Headache is dull then becomes pulsating/throbbing (NOT maximal at onset)
• Unilateral (2/3) or bilateral (1/3)
• Can be associated with cutaneous allodynia
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Key Features
• Ask re: nausea, vomiting, anorexia, relief with sleep, “Do they look sick”?
• Triggers: exercise, anxiety, fatigue, head trauma, menses, foods (chocolate, nitrites, MSG)
• Auras: visual changes, dysesthesias of limbs and perioral region – For auras, ask re: sudden onset vs gradual onset
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Diagnostic Criteria
• A. At least 5 attacks • B. Headache lasting 30 min to 48 hrs• C. Headache has at least 2 of the following
1. Bilateral (fronto-temporal) or unilateral location2. Pulsating quality3. Moderate to severe intensity4. Aggravation by routine physical activity
• D. During headache, at least 1 of:– 1. Nausea or vomiting – 2 . Photophobia or phonophobia
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Migraine TreatmentAbortive
• Reference: Neurology, 2004• Best Evidence (Level A)
– Ibuprofen (10mg/kg)
• Level B– Acetaminophen (15 mg/kg)
(Often need to tell parents correct dose)• Intranasal Sumatriptan effective in adolescents
– (5-20 mg at onset of H/A, can repeat X 1)
• Insufficient evidence for oral triptans
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Migraine Variants:With Headache
• Hemiplegic Migraine
• Confusional Migraine
• Basilar Migraine
• Ophthalmoplegic Migraine
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Migraine Variants:No Headache
• Alice in wonderland syndrome
• Benign Paroxysmal Vertigo
• Paroxysmal Torticollis• Cyclic Vomitting
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Question 1
• A 7 year old male presents with headache. Which of the following would NOT be a “red flag” on history?
A. Early morning vomiting
B. Headache worse after certain foods
C. Vomiting without nausea
D. Focal neurologic symptoms
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Question 2
• Which is the following is FALSE regarding migraine in children
A. The headache can last as little as 1 hour in children
B. Children do not need to have nausea AND vomiting to be diagnosed with migraine
C. There is often a family history of migraineD. MRI is often needed to rule ot other serious
causes of headache.
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Question 3
• Which of the following medications has the best evidence for aborting migraine in children?
A. Acetaminophen
B. Demerol
C. Sumatripan
D. Ibuprofen
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Question 4
• Which of the following is NOT a migraine variant in childhood?
A. Alice in Wonderland syndromeB. Paroxysmal TorticollisC. Cyclic Vomiting SyndromeD. Benign Paroxysmal VertigoE. All of the above are migraine variants in
childhood
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Questions?