BioMedical Engineering Master’s Degree Program

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BioMedical Engineering Master’s Degree Program

The BME-Paris Master’s Degree Program offers two years of academic and professional trai-ning in bioengineering, a bur-geoning field at the crossroads of the biomedical and engineering sciences. This program results from a partnership established between Paris-Descartes Univer-sity and the Paris Institute of Technology (ParisTech), a mem-ber of the IDEA League of Euro-pean science and technology uni-versities. Firmly based on an interdiscipli-nary approach, the BME-Paris Master’s relies on international collaboration and features strong student initiative. These prin-ciples are strengthened by the complementary competencies of the program’s two outstanding academic partners: Paris-Descartes in the biomedical and health sciences and ParisTech in the engineering sciences.

This jointly sponsored program offers a high-quality curriculum to students arriving from a broad range of academic backgrounds: biology and biochemistry, medi-cine, chemistry, physics, enginee-ring, mathematics and computer science, etc… The aim of the BME Paris Master’s is to provide students with the tools and capa-cities that will enable them to function in a broad range of biomedical engineering applica-tions that today rank among the most scientifically innovative and rapidly developing areas of academic research, industrial R&D, and the clinical environ-ment.

Chairpersons Professor Sébastien LAPORTE, PhD Arts & Métiers ParisTech Professor Robert Barouki, MD, PhD Université Paris Descartes

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Assets available High-profile teaching staff: research specialists

of international stature

Interdisciplinary research projects and seminars

Unique student environment at Paris-Descartes and ParisTech

Individual, tailor-made support for students Students can take advantage of the international partnerships of Paris-Descartes and ParisTech, including the Idea League program, a Europe-wide network of leading science and technology univer-sities and engineering schools (Imperial College London, Technische Universiteit Delft, Eidgenö-ssische Technische Hochschule Zürich, Rheinisch-Westfälische Technische Hochschule Aachen, as well as ParisTech).

Skills taught Use of interdisciplinary approaches in develop-ing innovative research projects in bioengineering fields

Planning and conducting scientific / technologi-cal projects; analysis, diagnosis, modeling, experi-mental protocols, result interpretation

Oral and written scientific communications for international conferences and peer-reviewed jour-nals

Adapting to professional environments; team-work, adjusting to new or different contexts and corporate cultures

Scientific and medical ethics

Professionnal opportunities The BME-Paris Master’s program provides high-quality graduate education in scientific research, including lecture courses, seminars, and laborato-ry training by internationally recognized scientists. The program prepares students for positions in academia (teaching and research), industry (R&D), and the clinical environment (healthcare). Other opportunities are available through the close partnership that exists between Paris-Descartes and ParisTech. At the end of the first year, BME students may apply to continue for a second year at other ParisTech schools. At the end of the second year, students from a nonmedi-cal background may apply for entry into the third year of medical studies at Paris-Descartes.

Admission Applications for admission to the BME-Master’s Degree program are reviewed by an admission committee con-sisting of members of the program’s international teaching staff. The application form may be downloaded from the following web site: http://www.bme-paris.org

Entrance requirements This BME-Paris Master program is open to highly moti-vated students of all nationalities, with life and health science curriculum. Admission can be considered at either M1 or M2 level (see details on www.bme-paris.org).

Language requirements All courses and examinations are in English. Applicants must read, speak, and write English fluently.

Location All teaching sites are located in the heart of Paris.

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Biomechanics & Biomaterials (BM²)

Molecular & Cellular Biotherapies (MCB)

Systems & Synthetic Biology, Information & Interaction (S2I2)

Bioengineering and Innovation in Neurosciences (BIN)

Impact & Injury Mechanisms (I2M) Biomaterials & Biological Materials (B2M) MusculoSkeletic System(MS2) Biofluid & the Cardiovascular System (BCS) Clinical BioMechanics (CBM)

Bioimaging (BIM) Imaging from Molecule to Human (IMH) Imaging Modalities & Processing (IMP)

MASTER 2 (semesters 3 & 4)

MASTER 1 (semesters 1 & 2)

RECONSTRUCTION BASSIN S007

COURSES SUBJECT TO FURTHER CHANGES

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Master 1st year

UE 1.0 - Seminars, projects, language, culture

UE 1.1 - Anatomy & Physiology

UE 1.2 - Life chemistry & biocompatibility

UE 1.3 - Molecular, cell & tissue biology

UE 1.4 - Medicine & science

UE 1.5 - Statistics for systems biology

UE 1.6 - Fluid & solid mechanics

UE 1.7 - Computational biology

UE 1.8 - Physics for biomedical imaging

UE 1.9 - Advanced organic chemistry

UE 1.10 - Mathematics & informatics

UE 1.11 - Applied mathematics for signal processing

Core courses

UE 2.1 - Scientific communication

UE 2.2 - Economy & management

UE 2.3 - Physics for biology

UE 2.4 - Pre-specialization : BIM, S2I2, MCB, BM², IBE

UE 2.5 - Lab training, research intern-ship, tutored projects

The first year of the BME-Paris Master’s (M1) is intended to strengthen and broaden stu-dents’ capacities in specific engi-neering and biomedical subjects. Considering the wide variety of academic origins and back-grounds of the students, five 6-credit (ECTS) courses (UE) cho-sen from among the eight offered must be taken during the first semester of the M1 year in order to fill-in gaps in individu-al students’ capacities in a wide spectrum of fundamental sci-ence subjects. For example, an engineering graduate would be required to take Anatomy & Physiology and a life-science or medical school graduate would have to follow courses in signal-processing and solid or fluid me-chanics.

In preparation for their 2nd year of studies (M2), students must select one or several pre-specialization courses (a total of five are proposed) during the second semester.

Chairpersons S. Bernard, PhD Université Paris Descartes M. Pietri, PhD Université Paris Descartes master1@bme-paris.org

Third semester

Fourth semester

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The BIM track offers high-level interdisciplinary education and training supported by the com-plementary skills of Paris-Descartes and ParisTech. A large network of research laboratories provides students access to in-dustrial and experimental imaging systems that utilize innovative technologies.

Chairpersons Pr. F. Cloppet, PhD Université Paris Descartes Pr. C. Oppenheim, MD, PhD Université Paris Descartes Pr. E. Angelini, PhD Telecom ParisTech BIM@bme-paris.org

BioImaging (BIM)

Bioimaging is an exciting and growing field at the interfaces between engineering, mathe-matics and computer sciences, as well as chemistry, physics, life sciences, and medicine. Bioimag-ing focuses on the development and usage of imaging modalities to advance diagnosis, under-standing, treatment, and preven-tion of human diseases.

The BIM track is accessible to Engineering, science and life-science students (medicine, phar-macology, biology, chemistry, biochemistry, physics, mathe-matics) preparing for career paths in academic research or industrial R&D environments. It relies on close collaborations between Paris-Descartes and several ParisTech engineering schools (Telecom, ESPCI, Mines, Chimie, Arts et Métiers, IOGS, ENSTA, Polytechnique). The BIM curriculum offers 15 courses (UE) that cover medical and biological imaging technologies, image pro-cessing, contrast agent principles and clinical applications such as functional or molecular imaging.

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Core courses

UE 3.0 – Seminars & conferences

UE 3.1 – Interdisciplinary week

UE 3.2 – Optical imaging – level 1

UE 3.3 – Medical image analysis – level 1

UE 3.4 – Diagnostic imaging

UE 3.5 – Chemistry for imaging

UE 3.6 – Physics and Technology of medi-cal imaging

UE 4.0 – Ethics in bioengineering

UE 4.1 – Bioengineering Economy and Industry

UE 4.2 – Research Internship

During the M2 year, students select two 6-ECTS courses (UE) from a core syllabus, two 3-ECTS UE to specialize in one of the two subtracks (IMH and IMP), and one 6-ECTS or two 3-ECTS addi-tional UE(s) in one of the sub-tracks, or in the common-core, or in another track. Students’ elective courses are determined according to their professional objectives and approval by the BIM pedagogical committee.

The bioimaging track places strong emphasis on the basic sci-ences (mathematics, physics, chemistry) and applied mathe-matics (image-processing, numer-ical analysis).

A. Subtrack IMP : Imaging Modalities & Processing

B. Subtrack IMH : Imaging from Molecule to Human

Third semester

Fourth semester

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Subtrack « Imaging Modalities & Processing (IMP) »

Contact Pr. Elsa ANGELINI Telecom ParisTech Pr. Catherine OPPENHEIM Université Paris Descartes IMP@bme-paris.org

Subtrack courses

UE 3.7b – Optical imaging – level 2

UE 3.8b – Acoustics & electromagnetics for Imaging

UE 3.9b – Medical Image Analysis – Level 2

UE 3.10b – Tissue optics and laser interactions

UE 3.11 – Core courses

UE 3.12 – Elective courses of IMH or IMP tracks

The Imaging Modalities and Processing (IMP) track pro-vides in depth multidisciplinary training to engineers and sci-entists (mathematics, physics) in medical and biological imag-ing modalities and image pro-cessing. Emphasis is placed on methods used for image data extraction dedicated to interpretation, diagnosis, therapeutic follow up and modeling. Novel appli-cations are introduced, such as image-guided treatment, elas-tography or molecular and functional imaging. IMP cours-es provide students with solid technical training in the phys-ics of medical imaging modali-ties, technologies involved in acquisition systems, and image processing methods for the extraction of anatomical and biological information. There is a strong emphasis put on the quantification of image-based information for specific diagnosis (e.g. brain tumors, stroke,…) and image-based modeling of biological and anatomical structures.

The training offered in the IMP track will qualify students for employment in the broad sec-tor of biomedical imaging, which includes industrial man-ufacturers (whole-body scan-ners and microscopic systems), image-processing software editors, and hospital or R&D departments that use biomedi-cal image processing tools (e.g. pharmaceutical and cosmetic groups). Students can also pur-sue their studies toward a Ph.D. degree in biomedical engineering, applied mathe-matics, computer science, physics or medical science. Medical students will acquire Medical students will acquire Medical students will acquire

training in biomedical training in biomedical training in biomedical imaging that will enable imaging that will enable imaging that will enable them to manipulate a them to manipulate a them to manipulate a wide variety of screening wide variety of screening wide variety of screening modalities and to master modalities and to master modalities and to master image processing tools image processing tools image processing tools for clinical researchfor clinical researchfor clinical research...

Teaching is mainly provided by engineering faculty, research-ers, and radiologists who are highly familiar with technical innovations related to compu-tational methods, imaging sys-tems, and innovative thera-pies. A wide network of re-search and clinical laboratories at ParisTech and Paris-Descartes provide students an access to industrial and experi-mental imaging systems. Sev-eral courses even provide the opportunity to manipulate such systems.

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Subtrack « Imaging from Molecule to Human (IMH) »

Contact Pr. Florence CLOPPET Université Paris Descartes Pr. Catherine OPPENHEIM Université Paris Descartes IMH@bme-paris.org

Subtrack courses

UE 3.7a - Chemistry level 2 : Molecular Tools for Imaging

UE 3.8a - Advanced Biology for Imaging

UE 3.9a - Medicine: Molecular Imaging

UE 3.10a - Medicine: Functional and Metabolic Imaging

UE 3.11 – Core courses

UE 3.12 – Elective courses of IMH or IMP tracks

The Imaging from Molecule to Human (IMH) track provides in depth multidisciplinary training to clinicians and material or life-scientists (biophysics, phar-macology, chemistry, biology, medicine), in medical and bio-logical imaging modalities, analysis and use in the clinic. Students are provided with a broad prospective of the do-main and the high-level-technical skills needed to work on novel and innovative-imaging- solutions.

This track offers a unique com-bination of courses, involving instructors from various fields, including particle and molecu-lar imaging, biology, medicine, image acquisition systems and physics principles, as well as image processing for computer aided diagnosis. Courses are taught by engineers, research-ers, university faculty, and phy-sicians specialized in radiology, from ParisTech and the Univer-sities Paris Descartes and Paris Diderot. This diversity enables students to gain specific train-ing in innovative technologies within the biological and medi-cal imaging domain. This high-level interdisciplinary education program qualifies students to seek jobs in indus-try (R&D departments) or to pursue their education to-wards a Ph.D. degree.

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Bioengineering and Innovation

Chairpersons A. Klarsfeld, PhD ESPCI ParisTech P-P. Vidal, MD, PhD Université Paris Descartes bein@bme-paris.org

This specialty, hosted by ESPCI ParisTech, ENSAM ParisTech and Paris Des-cartes, is designed both for engineering school students and for university students having a robust initial training in basic sciences or medicine. Courses will mesh engineering, mathematics, and computer concepts with molecular, cellular and systems neuroscience. BIN students will contribute to bridge the gap between basic, clinical, and engineering neuroscience. This is a key issue for both industry and medicine in the 21st century, because of: 1. aging of the world population, which will considerably increase the pre-valence of neurodegenerative diseases, and more generally of sensory and motor handicaps. These will require the development of new biomedical devices and molecular tools to better (i) diagnose neurological diseases, (ii) evaluate their progression or treatment, and (iii) remediate disease- or age-associated handicaps. 2. strong demands from a broadening range of industries, way beyond the biomedical ones. There is an increasing need to understand how humans interact with their environments in general and with the new complex working environments of today in particular (human factor). Many industries will thus require engineers with both good engineering skills and basic knowledge of neurophysiology. 3. the requirement of integrative methods and concepts, from the behavio-ral to the molecular level, to understand how the central nervous system functions, and can be repaired and enhanced. The neurosciences strongly illustrate the interdisciplinarity that lies at the heart of biomedical enginee-ring, requiring the collaboration of doctors and engineers.

in Neurosciences (BIN)

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UE 3.0 – Seminars and conferences (common to all specialties)

UE 3.1 – Interdisciplinary week (common to all specialties)

UE 3.2 – Tutored project and Methodol-ogies (common to all specialties)

UE 3.3 – Refresher courses

UE 3.4 – A window into the mind : new technologies to explore and stimulate the brain

UE 3.5 – Miniaturisation for neurosci-ence

UE 3.6 – Drug design for neurological diseases

UE 3.7 – Advanced modelling: from molecule to behavior

UE 3.8 – Neural bases and engineering of brain/machine and brain/computer interfaces

Core courses

UE 4.0 – Ethical aspects of bioengineer-ing (common to all specialties)

UE 4.1 – From research to innovation: Business plan workshop

UE 4.2 – Research internship (5 months minimum)

The BIN specialty has also an industrial orientation, by :

1. relying on many lecturers from research and development (R&D) departments of major compa-nies, as well as start-ups. Techni-cal and industrial aspects will be emphasized.

2. offering a practical initiation to innovative entrepreneurship through a Business plan work-shop.

3. encouraging students to apply for their 2nd semester internship in an industrial R&D laboratory or a hospital department.

Courses cover human-machine, brain-machine and brain-computer interfaces, the imaging and manipulation of neuronal and brain activity, predictive che-mistry for neuroscience, micro-fluidics and other innovative mi-niaturized biotechnologies for the nervous system, statistics, computer modeling of neuronal networks and their applications...

Employment opportunities co-ver numerous professional fields, such as the medical de-vice industry (for medical bioimaging, or advanced sensory and motor remediation), or the pharmaceutical, cosmetics and chemical industries (drug design, biosensors), as well as robotics, or the defense, sports, automo-bile or videogame industries. The BIN specialty can also lead to a PhD thesis in an academic or industrial research laboratory, and subsequently to an academic career in medical or scientific fields.

Semester 3 (two subtracks may be offered)

UE 3.9 – Neuroengineering: motricity and sensory supplementation

UE 3.10 – Neuroengineering: Human-machine interface

UE 3.11 – Detection of vigilance states and communication with the environ-ment

UE 3.12 – Movement analysis and loco-motion (common with BM²)

Semester 4

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The "Systems & Synthetic biology, Information and Interactions" track (S2I2) offers an interdiscipli-nary curriculum in integrative biology, focusing on the emerging fields of systems biology and syn-thetic biology, as well as on the interface between the web sci-ences (Information and Commu-nication Technologies, ICT) track and medicine, health, and life sciences. It applies quantitative experimental and modeling tools to the study of fundamental as-pects of systems that are larger than their parts (e.g., genetic and social networks and the web).

Chairpersons A. Lindner, PhD Université Paris Descartes P. Hersen, PhD Université Paris Diderot S2I2@bme-paris.org

Systems & Synthetic biology, Information & Interactions (S2I2)

The often-quoted credo of the Nobel Prize-winning physicist, Richard Feynmann, "What I can-not create, I do not understand," represents another pillar of the master -- learning to apply knowledge to create new sys-tems. This is represented by the synthetic biology or the TIC op-tions of this track. Within S2I2, students can choose between “systems and synthetic biology” and “web science interface” op-tions, for which appropriate S2I2 courses are offered. The importance of these emerg-ing themes is evident from the growing number of high-profile scientific publications, dedicated research institutes, and start-ups. The link between the life-sciences and ICT is manifested in the growing interest in personal-ized medicine, web-based detec-tion of epidemics, e-health, etc.

This track is shared with the 'Interdisciplinary Ap-proaches to Life Sciences' - cursus Liliane Bettencourt master program of Paris Descartes & Paris Diderot Universities (aiv-paris.org).

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UE 3.0 – Seminars & conferences

UE 3.1 – Interdisciplinary week

UE 3.2 – Analysis of articles concerning S2I2

UE 3.3 – Bibliographic review of an inter-face subject

UE 3.4 – Networks & dynamics

UE 3.5 – Synthetic biology

UE 3.6 – Rotating internship 1 (3 mo.)

Core courses

UE 4.0 – Ethical aspects of bioenginee-ring

UE 4.1 – Analysis of scientific books

UE 4.2 – ICT and health

UE 4.3 – Rotating internship 2 (3 mo.)

UE 4.4 – Rotating internship 3 (3 mo.)

The originality of S2I2 is its inter-disciplinary approach, based on active collaboration among stu-dents from different back-grounds (engineering, biology, medicine, physics, mathematics, chemistry, computer science, humanities...). S2I2 amounts to training for research through research. This track consists of three 14-week internship rota-tions (at least one experimental and one theoretical), as is the case in leading life-science grad-uate programs around the world. We strongly encourage students to do one internship in the pri-vate sector. Another internship may be in a laboratory outside France. The internship rotations enable students to acquire a wide spectrum of state-of-the-art concepts and technical com-petence. They also encourage students’ initiatives in creating their own research projects (which are often too compart-mentalized,) including cross-disciplinary collaboration. In parallel, students take courses that cover a wide-range of themes and participate in semi-nars and web 2.0 interactions aimed at developing critical thinking, scientific questioning, and project design.

Environment: Students in the S2I2 track benefit not only from the rich interactions available in the BME-Paris master’s program, but also from the wealth of activ-ities hosted by the Center for Research and Interdisciplinarity (CRI; cri-paris.org), which hosts both AIV master’s program and the Liliane Bettencourt Frontiers of Life Sciences (FdV) PhD pro-gram. Elements of preparation for pro-fessional life and research: S2I2 is designed to provide sci-entists, physicians, and engi-neers with an excellent educa-tion in emerging life-science disciplines. S2I2-track students are trained in a broad range of the life sciences, learn to be au-tonomous, and acquire the ca-pacity to be innovative. They are provided opportunities to explore links in medicine, engi-neering, physics, chemistry, mathematics and computer sci-ence, the aim of taking leadersip roles in public and private re-search establishments. Job op-portunities for S2I2 graduates are available in academia and in innovative biotechnology enter-prises, as well as in information science and the web-sector.

Third semester

Fourth semester

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Molecular & Cellular Biotherapies (MCB)*

Chairperson Pr. S. Hacein-Bey-Abina, PharmD, PhD Université Paris Descartes MCB@bme-paris.org

The MCB track concerns two major categories of biotherapeu-tics applications: cell and gene therapy, and biopharmaceuti-cals. Cell and gene therapy differs from drug therapy in that it con-cerns the use of "custom" or "à la carte" therapeutic agents cre-ated for a individual patients, a domain in which few manufac-turers operate. Biopharmaceuti-cals are complex macromole-cules created by biotechnology, and involve genetic manipula-tion of living organisms, which differ from conventional chemi-cally synthesized small mole-cules.

The specific pharmacological and immunological features of biotherapy products, consid-ered to constitute a new gen-eration of drugs, are studied in conjunction with the charac-teristics of target populations, clinical follow-up, and biologi-cal monitoring.

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UE 3.0 – Seminars & conferences

UE 3.1 – Interdisciplinary week

UE 3.2 – Fundamentals of biotherapy, level 1

UE 3.3 – Fundamentals of biotherapy, level 2

UE 3.4 – Biological tools for biotherapy

UE 3.5 – Cell & tissue biotherapy, level 1

UE 3.6 – Industrial, biothechnological & pharmaceutical strategies

Core courses

UE 4.0 - Ethical aspects of bioenginee-ring

UE 4.1 - Clinical & regulatory aspects

UE 4.2 - Cell & tissue biotherapy, level 2

UE 4.3 - Lab training, research internship

The MCB program is divided into several course units. The first one covers the back-ground and fundamental bio-logical concepts needed to understand the various bio-therapeutic approaches. It also provides an introduction to biological considerations involved in the use of thera-peutic tools. The second unit addresses each biological sys-tem individually. The remain-ing two units deal with the study of specific examples, industrial aspects, and regula-tory issues involved in the use of various types of biothera-peutic tools, as well as to clini-cal applications.

The aim of this track is to train students of advanced scientific level in the field of biotherapy in order to prepare for careers in academia. These students may also find opportunities in indus-try at the national, European, and international level, particu-larly in biotechnology and medi-cal research laboratories in teaching hospitals) , as well as in cell and gene therapy firms.

* Opening september 2011

Third semester

Fourth semester

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Chairpersons H. Pillet, PhD Arts et Métiers ParisTech L. Corté, PhD Mines ParisTech Pr. F. Rannou, MD, PhD Université Paris Descartes BMBM@bme-paris.org

BioMechanics & BioMaterials (BM)²

The BioMechanics & BioMaterials track (BM)2 provides fundamental tools and in-depth knowledge on the biomedical applications of mechanics, materials science and related fields. (BM)2 education and training fo-cus on recent and anticipated developments in biomechanics and biomaterials that hold prom-ise for innovative solutions to major health problems and that respond to industrial challenges.

The lectures, team projects, case studies, and engineering and medical invited conferences by academic and industrial experts enable students to benefit from a stimulating and multidiscipli-nary environment. This program provides scientists, engineers, and medical students with the wherewithal to face the numerous challenges of biome-chanics and biomaterials R&D; how to apply their skills in order to solve specific biomedical prob-lems, how to carry out innova-tive and fruitful research with the appropriate methods and ethical considerations, how to collaborate and interact in pro-jects at the interfaces among mechanics, materials, and bio-medical science.

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Impact & Injury Mechanisms (I2M)

Biomaterials & Biological Materials (B2M)

MusculoSkeletal System (MS2)

Clinical BioMechanics (CBM)

Biofluid & the Cardiovascular System (BCS)

UE 3.0 – Seminars & conferences

UE 3.1 – Interdisciplinary week

UE 3.2 – Methodology & tutorial project

UE 3.3 – Modeling & simulation for bio-mechanics

UE 3.4 – Basics in cell and tissue biology

UE 3.5 – Basics in biomaterial science

UE 3.6 – Anatomy

Core courses (except subtrack CBM: U.E. 3.0, 3.1 and 3.2)

A set of core teaching units pro-vides a broad overview of basic and state-of-the-art knowledge of biomechanics and its meth-ods, as well as of biomaterials. In-depth focus on major biome-chanics issues and biomaterials research is developed in a series of five sub-tracks.

Each student chooses a sub-track and selects a set of at least four teaching units: three specific to the particular sub-track and one from the general master’s pro-gram. A pedagogical commission of lecturers and researchers as-sists students and helps them to devise a personalized program consistent with their individual backgrounds and professional objectives.

UE 4.0 – Ethical aspects of bioengineering

UE 4.1 – Economical & industrial aspects

UE 4.2 – Lab training, research internship

Third semester

Fourth semester

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The aim of the I2M track is to widen and deepen the scientific bases of road safety, as well as its clinical considerations. I2M training is mainly directed to-ward human modeling of high-velocity loading, but also in-cludes a broad range of multidis-ciplinary domains, leaning heavi-ly on experimental and clinical data. I2M training is designed to confer a wide range of compe-tencies, from fundamental scien-tific analysis to concrete knowledge of various aspects of the field, such as accidentology data, regulation, and ethics con-siderations. The presence among the teach-ing staff of representatives from IFSTTAR (French National Insti-tute of Research on Transport and Safety), as well as from French automobile manufactur-ers (LAB-GIE Renault-Peugeot), provides concrete approaches to problems related to this theme.

Subtrack « Impact & Injury Mechanisms (I2M) »

Contact Baptiste SANDOZ Arts & Métiers ParisTech Jean-Yves Le COZ Arts & Métiers ParisTech Renault I2M@bme-paris.org

Road safety is a major socioeco-nomic issue. The World Health Organization predicts that road accidents will be the third big-gest killer worldwide by 2020. The objective of the BME-Paris Master’s track is to validate the dialogue and complementarity related to road safety by award-ing an original diploma in this field at both the national and international level.

Subtrack courses

UE 3.7a - Mechanical behavior of biologi-cal tissues

UE 3.8a - Accidentology & regulations

UE 3.9a - Impact mechanics & high ve-locities

UE 3.10a - Experimental methods for impact biomechanics

UE 3.11a - Traumatology, injury me-chanisms & therapies

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Subtrack « Biomaterials & Biological Materials (B2M) »

Contact Pr. François RANNOU Université Paris Descartes Laurent CORTE Mines ParisTech Rachele ALLENA Arts & Métiers ParisTech B2M@bme-paris.org

Recent progress in the under-standing, characterization, and manipulation of biological ma-terials has led to remarkable opportunities in the biomedi-cal field, as well as in the bio-materials industry. Biomateri-als research and development currently not only encom-passes, but extends beyond the field of prosthetics design. Modelling and control of bio-logical, bio-sourced, biocom-patible, and biomimetic mate-rials are central to the devel-opment of numerous biomedi-cal applications.

The Biomaterials and Biological Materials track provides stu-dents in-depth knowledge of the understanding and use of biomaterials, from nanoscale biomolecules, such as proteins, lipids, and bio-source polymers to macroscale prostheses and implants. B2M focuses on health-related applications ranging from implant and tis-sue engineering through the modelling and characterization of biological materials to mate-rial design for therapeutics.

UE 3.7b - Tissue engineering and implant design

UE 3.8b - Development, growth and repair of living tissues

UE 3.9b – Handling of proteins & bio-membranes

UE 3.10b - Biointerfaces

UE 3.11b - Cellular Mechanics

UE 3.12b - Cardiovascular system resto-ration

UE 3.13b - Biomaterials for dental re-construction

Subtrack courses

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Subtrack « MusculoSkeletal System (MS2) »

Contact Pr. Philippe ROUCH Arts & Métiers ParisTech Dominique SALETTI Arts & Métiers ParisTech MS2@bme-paris.org

Biomechanical modeling is used in the analysis of muscu-loskeletal pathologies. The frequency and healthcare im-pact of these diseases are such that 2000-2010 has been named the “Bones and Joints Decade” by the UN and the WHO. Articular diseases ac-count for half of all chronic pathologies observed after 65 years of age. The prevention of sports traumatisms, as well as sports performance re-search, require the develop-ment of new methods in the effort to understand the be-havior of the musculoskeletal system.

This subtrack will have a parti-cular focus on methods for geometric and mechanical modeling of the musculoskele-tal system: finite element ap-proaches, direct and inverse dynamics in relation with gait analysis, modeling of the muscles and the neurocontrol activation system. Experimental approaches and quantitative functional investi-gation from medical data are also key issues that will be ad-dressed. Transversal links with the other BME tracks will be encouraged, since musculoske-letal modeling is related to bioimaging, mechanical pro-perties biologic tissues and biomaterials, neuroenginee-ring and biotherapy. In these related fields, light will be brought on specificities when considering the musculoskele-tal system. Example of research projects in this track:

Experimental and finite ele-ment analysis of a disc pros-thesis.

Subject specific modelling of cerebral palsy gait for op-

timization of therapeutic strategy.

Finite element mo-delling for osteoporosis fracture risk prediction.

UE 3.7c- Mechanical behavior of biologi-cal tissues

UE 3.8c – Non-linear aspects for the musculoskeletal modeling

UE 3.9c – Medical imaging & geometri-cal modeling

UE 3.10c – Muscular system modeling

UE 3.11c – Movement analysis & loco-motion

Subtrack courses

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Subtrack « Clinical BioMechanics (CBM) »

Contact Pr. Wafa SKALLI Arts & Métiers ParisTech Pr. Jean-Marc FERON Université Pierre & Marie Curie Christophe SAURET Arts & Métiers ParisTech CBM@bme-paris.org

The CBM track introduces BME students with life science back-grounds to engineering science tools and techniques, in order to provide them with a “language” that enables them to interact with students from engingeering science back-grounds on interdisciplinary projects. The CBM track trains life-science students to under-stand the mechanisms of the human body in engineering terms, in view of specializing in biomechanics, the musculo-skeletal system, cardiovascular and orthopedic medicine.

Since this program was intro-duced in France during the 1980s at Arts et Métiers – ParisTech, around 200 ortho-pedics surgeons have been trained there in clinical biome-chanics.

UE 3.7e – Mathematics

UE 3.8e – Statics

UE 3.9e– Kinematics

UE 3.10e– Strength of materials

UE 3.11e - Finite elements modeling

UE 3.12e - Kinematics of joints & gait analysis

UE 3.13e – Materials & structure beha-vior

Plus one additional course chosen from among courses of subtracks I2M, B2M, MS2 & BCS.

Subtrack courses

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Subtrack « Biofluid & the Cardiovascular System (BCS) »

Contact Pr. Antoine LAFONT Université Paris Descartes BCS@bme-paris.org

The aim of the Biofluid and cardiovascular system track is to educate and train scientists, physicians, and engineers in the physical, biological, and clinical bases of the cardiovas-cular system. The objective of this track is to enable them to develop innovative applica-tions in this field while em-ployed in the implantable car-diovascular medical device industry. This rapidly growing sector needs people with dou-ble training in fundamental bioengineering and clinical skills.

BCS courses are taught by en-gineers, researchers, cardiolo-gists, and cardiac surgeons familiar with therapeutic inno-vations in the cardiovascular domain. The aim is to create a link be-tween the clinical intuition and the bioengineering, in order to face new challenges in such areas as artery repair, cardiac valve pathologies, and treat-ment of cardiac insufficiency.

UE 3.7d - Study of biological flows

UE 3.8d - Cardiovascular system mode-ling

UE 3.9d - Tissues of the cardiovascular system

UE 3.10d - Biofluids & complex fluids in biology

UE 3.11d - Clinical aspects: stents, car-diac surgery, cardiovascular diseases

Subtrack courses

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http://www.bme-paris.org

Contact & Information

Master BME-Paris Centre universitaire des Saints-Pères 45 rue des Saints-Pères 75006 Paris France contact@bme-paris.org

Editors: Pr. S. Laporte, Pr. R. Barouki, B. Dallez Content design: S. Laporte, F. Collin Paris Descartes / ParisTech, June 2010

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