Living Foundries
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Transcript of Living Foundries
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Living Foundries
Living Foundries
ChemicalsFuelsPharma
Complex
MaterialsDNA instruction set
PolymersCatalysts Heterogeneous, functional materials
Multi-cellular constructsSelf-repairing systemsSentinel Organisms
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Sugar
Cellulose
CO2
Coal
Molecules
Systems
Natural gas
“cell-like”factory
Disruptive capabilities in materials, therapeutics, sensors and manufacturing paradigms
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1 10 100 1,000 10,000 100,000 Complexity (# genes inserted/modified)
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bacterium
DARPA annual budget
Engineering Biology: Prohibitive Cost, Time, Complexity
Living Foundriesgenome rewritecomplex genetic
circuits
metabolic engineering
SOA
Problem: Engineering biology is prohibitively time and money intensive, blocking disruptive capabilities across materials, sensors, medicine and
manufacturing.
DuPont1,3 propanediol 2002
AmyrisArtemisinin2009
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“There was a gap between the sorts of systems we could visualize and what we could actually get into hardware in
a timely way.”Lynn Conway on VLSI
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Comparison: integrated circuit design and fab
Intel 4004Year - 1971
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dual-feedback oscillator
Artemisinic acid production in yeast
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Comparison: integrated circuit design and fab
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Conway and Mead Design Principles
• Simplification and Standardization• Raise abstraction level of design • Design Rules• Design Tools• Decoupling of Design and Fab • Access to rapid prototyping services (common infrastructure)• Enable open collaboration
Intel 4004Year - 1971
Technical
Structural
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Building a new technology base to enable transformative applications
Living Foundries: ATCG
Foundries
Demo New Capability
New tools to enable rapid engineering of biology
Enable scale and rapid prototyping of genetic designs never before
accessible
1000 Molecules 1000 new chemical
building blocks for new materials
100x faster DBT cycle for engineering biology
Fundamental shift in chemical/materials
industry
. . . Enable Impossible Projects
Living Foundries: 1000 Molecules
IMPACT:
Engage and Seed industrial/academic partnerships
Open up new avenues for innovationEnable access/new entrants
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BTOBiology as Technology
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Traditional DoD View of Biology
Biology = Medicine for the Warfighter
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Traditional DoD View of Biology
Biology = Medicine for the WarfighterTechnology
National Security
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www.darpa.mil
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