Live Better Electrically - idsMED Steve Higgins.pdf · 2018-05-15 · Chapter Title Here Additional...
Transcript of Live Better Electrically - idsMED Steve Higgins.pdf · 2018-05-15 · Chapter Title Here Additional...
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Live Better Electrically
Steven L. Higgins, MD, FHRS
Chairman, Dept. of Cardiology
Director, Cardiac Electrophysiology
Scripps Memorial Hospital, La Jolla
San Diego, California
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Live Better Electrically
So, what exactly does that mean?
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Live Better Electrically
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Live Better Electrically
Electro-Acupuncture
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Live Better Electrically
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Live Better Electrically
Cardiac Electrophysiology (a specialty of cardiology that deals just with heart rhythm disorders)
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Year
Mortality Percent change
In the past half-century, we have made huge advances in heart disease
-80
-70
-60
-50
-40
-30
-20
-10
0
10
20
30
50 55 60 65 70 75 80 85 90 95 00 05 10
Coronary Heart Disease Stroke Non-CVD
Modified from National Heart, Lung
and Blood Institute data, NIH, 2010. 9
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5
10
15
20
25
30
35
40
45
40.9
21.8 16.5
10.4 3.4 3.1 2.8 0.3 0.3
Heart Disease Still #1 Cause of Death in U.S.
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• Obesity causes diabetes
• Cigarette smoking
• Aging population
• Genetics
4 reasons why heart disease mortality remains #1
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• Diet, exercise
4 reasons why heart disease mortality is improving
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• Diet, exercise
• Statins
• Stents
4 reasons why heart disease mortality is improving
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• Diet, exercise
• Statins
• Stents
• Defibrillators
4 reasons why heart disease mortality is improving
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Cardiac Implanted Electrical Devices (CIEDs) • Pacemakers • Defibrillators (ICD)
One Inch
Over 50 years of progress
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30 Years of ICD Implants by Year 1986-2016
0
50000
100000
150000
200000
250000
1986 1990 1995 2000 2005 2010 16
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1 Moss AJ. N Engl J Med. 1996;335:1933-40. 2 Buxton AE. N Engl J Med. 1999;341:1882-90. 3 Moss AF. N Engl J Med. 2002;346:877-83. 4 Moss AJ. Presented before ACC 51st Annual Scientific Sessions, Late Breaking Clinical Trials, March 19, 2002. 5 The AVID Investigators. N Engl J Med. 1997;337:1576-83.
Mortality Benefits in All ICD Trials
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20
40
60
80
MADIT MUSTT MADIT-II AVID
Overall Death
Arrhythmic Death
1 2 3, 4
54%
75%
55%
73%
31%
61%
27 Months 39 Months 20 Months
% M
ort
ali
ty R
ed
ucti
on
w/ I
CD
31%
56%
5
24 Months
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If Implanted Defibrillators are so great,
shouldn’t we all get one?
0
20
40
60
80
MADIT MUSTT MADIT-II AVID
Overall Death
Arrhythmic Death
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To prevent heart disease, which is more important to know
Cholesterol? Ejection fraction?
Schatz I et al. The Lancet 2001;358:351 Tribouilloy C et al. Eur Heart J 2007;554:339.
Reduced EF, mortality 46% at 5 years,
regardless of etiology
Elevated cholesterol, mortality 19%
at 5 years
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With the advent of statin therapy and angioplasty, marketing focused on cholesterol
AHA/ACC and industry partnership
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Normal echo
Low EF
(Cardiomyopathy)
EF = 65% EF = 15%
EF = Ejection Fraction the percentage of blood pumped out with each heartbeat
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MADIT Multicenter Automatic Defibrillator Implantation Trial
54% decrease in mortality with ICD P=0.009
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Why do people with low EF die suddenly?
Reentrant
Ventricular
Tachycardia
around scar
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Why do people with low EF die suddenly?
Reentrant
Ventricular
Tachycardia
around scar
Catheter ablation to wall-off or destroy irritable area
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The Latest in Device Therapy Cardiac Resynchronization Therapy
CRT
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Next: without open heart surgery
Transvenous biventricular pacing 2nd Patient in World at Scripps, 2002
Atrial lead
Shocking Lead
Generator
Coronary Sinus Lead
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Cardiac Resynchronization Therapy Technique for Transvenous Approach
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Cardiac Resynchronization Therapy (CRT)
Works with pacemaker or defibrillator
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So why don’t we all get a “bivent” device?
Only works if low EF and wide QRS (bundle branch block)
In selected patients, CRT: • Improves EF an average of 5%, some back to normal
• Improves activity an average of 1 NYHA class
• Decreases mortality, even with just the pacemaker version
Cardiac Resynchronization Therapy (CRT)
Works with pacemaker or defibrillator
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Contak CD Trial Results Primary Endpoint
HF Progression Index
Imp
rov
em
en
t (%
)
-30
-20
-10
0
Death HF
Hosp VT/VF
23%
13%
9%
26%
Overall
21%
Worsening
HF
Modified from Higgins et al.
JACC 2003:42:1454-1459.
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So, who should get this new technology?
Atrial lead
Shocking Lead
Generator
Coronary Sinus Lead
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So, who should get this new technology?
Pacemaker Slow heart rate with symptoms (pulse below 30 or 3 second or more pause)
Biventricular Pacemaker (cardiac resynchronization therapy)
Above plus EF below 50 (normal 55-70) and plus wide EKG complex (over 120 msec)
Implantable defibrillator EF below 35%, that’s it!
Biventricular Defibrillator (Lexus)
Above plus wide EKG QRS complex (over 120 msec)
INDICATIONS
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Cardiology Simplified
1978 1st of 5 heart attacks, beginning at age 37
1988 Quadruple bypass surgery after 3rd heart attack
2001 (March) At least his 8th cardiac cath and stent
2001 (June) First ICD
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Cardiology Simplified
1978 1st of 5 heart attacks, beginning at age 37
1988 Quadruple bypass surgery after 3rd heart attack
2001 (March) At least his 8th cardiac cath and stent
2001 (June) First ICD
2007 ICD upgraded to biventricular device (with WiFi feature disabled)
2010 Artificial heart pump inserted, called LVAD (Left Ventricular Assist Device)
2012 Heart transplant, removing old heart, stents, ICD and leads 36
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Live Better Electrically Current Trends in EP
(EP = ElectroPhysiology = heart rhythm management)
2 Basic EP procedures to help you:
– Devices (pacemakers, defibrillators)
– Ablation (catheter based treatment)
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• SVT (supraventricular tach) 95%
• Atrial flutter 95%
• WPW 95%
• Some ventricular tachycardias 90%
• Atrial Fibrillation (AF) 60%
Arrhythmias Treated With Ablation
Approximate Success Rate
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The Normal Heartbeat
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Slow AVN pathway
Accessory pathway of WPW
CTI Isthmus for atrial flutter
The “Soul” of the Heart Where most arrhythmias begin
Fast AVN pathway (His)
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RF Ablation, 40 watts, first attempt, left lateral pathway
Delta wave of WPW
No delta wave;
Patient cured
A person’s life changed forever in one heartbeat
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How To Do An Ablation in 3 Easy Steps
Step 1. Find an EP doc to put in catheters
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Step 2. Reproduce and map the arrhythmia
How To Do An Ablation in 3 Easy Steps
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Cold (Cryo) Heat (RF)
How To Do An Ablation in 3 Easy Steps
Step 3. Ablate, ablate, ablate
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CTI Line for Atrial Flutter 47
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CTI Line for Atrial Flutter 48
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Atrial Fibrillation
Adapted from Feinberg WM. Arch Intern Med. 1995;155:469-473.
U.S. population
Age, yr
<5 5-
9
10-
14
15-
19
20-
24
25-
29
30-
34
35-
39
40-
44
45-
49
50-
54
55-
59
60-
64
65-
69
70-
74
75-
79
80-
84
85-
89
90-
94
>95
U.S. population
x 1000
30,000
20,000
10,000
0
500
400
300
200
100
0
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Atrial Fibrillation
Adapted from Feinberg WM. Arch Intern Med. 1995;155:469-473.
U.S. population
Population with
atrial fibrillation
Age, yr
<5 5-
9
10-
14
15-
19
20-
24
25-
29
30-
34
35-
39
40-
44
45-
49
50-
54
55-
59
60-
64
65-
69
70-
74
75-
79
80-
84
85-
89
90-
94
>95
U.S. population
x 1000
Population with AF
x 1000
30,000
20,000
10,000
0
500
400
300
200
100
0
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Why treat AF?
Thromboembolism – A Devastating Risk
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Why treat AF?
To Prevent a Stroke!
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Why treat AF?
To Prevent a Stroke!
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What is your risk of stroke with AF?
CHADSVASc score CHADS-VASc
Risk
Score
Heart Failure or
LVEF < 40%
1
Hypertension 1
Age > 75 1+1
Diabetes 1
Stroke/TIA/ Thromboembolism
2
Vascular
Disease
1
Age 65 - 74 1
Female 1
• The score equals your chance of having a stroke in % per year
• The average person is <1%
• 2 or more points, usually results in recommendation to begin a daily anticoagulant
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How to treat AF? Cardioversion on meds
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Atrial septum
Ablation and Mapping Catheters for AF
How to treat AF? Catheter Ablation
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Live Better Electrically
• Cool New Treatments in EP
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Pacemaker/Defibrillator Advances
Leadless Pacemakers 60
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Leadless Pacemaker
• Single chamber pacemaker
– Battery lasts 15-25 years
– No lead or surgical scar
– Under FDA investigation, only San Diego site is Scripps
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Robotic assisted ablation procedures
• Here today at Scripps La Jolla, SPCI
• 2 Robots available – Amigo, Hansen
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Artificial Heart, LVAD (Left Ventricular Assist Device)
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Noninvasive Cardiac Ablation?
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Live Better Electrically
So, what is so great about Scripps?
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#19 Nationwide in Cardiology and Heart Surgery again (3rd year in top 20) The only SD hospital ever to be top 20 • Reputation score • Survival • Patient safety • High risk patient volume • Nurse staffing, Magnet recognition • Advanced technologies • Key patient services • Trauma center • Intensivist staffing
2013-14 2015-16 2014-15
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San Diego’s Best Heart Care Just Got Better.
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SPCI = Scripps Prebys Cardiovascular Institute
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Scripps Prebys Cardiovascular Institute San Diego’s first free standing heart hospital
• Completed, opened on SMH-LJ campus, March 2015
• Over 350,000 SF; 8 floors
• 167 cardiac patient rooms (59 CCU)
• New cath labs, EP labs and cardiac operating rooms
• Combined expertise of Scripps-LJ, Scripps Clinic, other Scripps
• New Outpatient AMP opened June 1, 2016
• $610 Million for SPCI/AMP/ER; Donations:
• $105 M for SPCI (Prebys +)
• $20 M for ER & Trauma Center
• Total of $154 M for cardiac campaign
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Scripps EP Program
• 6 EP Labs (plus 7 cath labs + 2 hybrid)
• More EP Labs than anywhere west of the Mississippi
• Volume = Quality
• Nearly 4000 EP studies a year
• 16 EP docs
• Investigational Trials
• Experienced Staff
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Paperback: Amazon, Barnes & Noble
EPUB: Amazon, iTunes
Website order
www.BookLiveBetterElectrically.com
Fung Summit affiliates use discount “LBE2” to save $5 off cost of $30
Live Better Electrically To learn more about EP:
Shameless plug for new book
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Live Better Electrically
Steven L. Higgins, MD, FHRS
Chairman, Dept. of Cardiology
Director, Cardiac Electrophysiology
Scripps Memorial Hospital, La Jolla
San Diego, California
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