LISA-MARIE CRICHTON & ASSOCIATES

MARINE BIOTECHNOLOGY MANAGEMENT CONSULTANCY WITH SIGNIFICANT PARTNERS THE SOUTH PACIFIC REGION IN COMMERCIAL COLLABORATIONS

MARINE BIOTECHNOLOGY MANAGEMENT CONSULTING WITH SIGNIFICANT PARTNERS THE SOUTH PACIFIC REGION & COMMERCIAL COLLABORATIONS

A Private Sector Marine Biotechnology Management Consultant working in collaboration with Significant Partners from the South

Pacific Region and leading local and International Experienced World-Class Experts & Associates. We collaborate in innovative, commercially viable, sectors of the Marine Biotechnology industry in marine biotechnology product scientific research,

bioprospecting towards the discovery of“new-to-science” products for development and commercialisation.

We plan, design, manage and implement an integrated strategic approach to commercial collaborations in marine biotechnology for “new-to-science” biodiscovery, from scientific research and development, biotechnological processing and production through to

commercialisation. We collaborate in commercial partnerships for marine scientific research to develop and commercialise “new-to-science” marine biotechnology products for sales to commercially viable and emerging global markets, predominantly in Asia,

Europe, Scandinavia, USA and South America and selected emerging markets worldwide.

We specialise in a range of marine biotechnology products including pharmaceuticals, vitamins, minerals, supplements, cosmetics, hair and beauty products and accessories and products in the medicinal, agricultural and industrial sectors and the multitude of

associated industries from production and manufacturing to global supply chain distribution.

We integrate our global commercialisation strategies to suit each marine biotechnology product. This includes authentication, efficacy, packaging, labelling compliance with each individual countries compulsory Patent requirement for health and safety and

relevant international export market entry requirements for international Government products standards.

MANAGEMENT CONSULTING IN PRIVATE SECTOR COMMERCIAL COLLABORATIONS WITH SIGNIFICANT PARTNERS IN MARINE BIOTECHNOLOGY NEW PRODUCT

DEVELOPMENT

We work with a broad range of significant partners and associates in commercial development in the Marine Biotechnology industry. With a multitude of professionals working in associated sectors of marine biotechnology, including Innovation and increased

efficiency, efficacy, health and safety measures and the best scientific research methodologies and technologies with applications and uses to accelerate the quality and effectiveness of “new-to-science” marine biotechnology products.

We initiate, plan, design, develop, implement, manage and coordinate, potential commercial collaborations with significant partners in marine biotechnology products industry and the entire process from biodiscovery to commercialisation, through integrated, multi-

faceted strategies and synergies of mutually agreed cooperation.

We strategize, prioritise, organise and coordinate commercial collaborations in consortiums between significant partners, private sector entrepreneurs, private sector investors and biotechnology companies, scientific research and development experts. We

consult and negotiate the necessary and compulsory components, formalities, and protocols. We coordinate multi-faceted national and regional, sub-regional, inter-regional and international complex structural and lateral synergies for each individual commercial

activity between significant partners and associated consortiums in commercial collaborations.

MANAGEMENT CONSULTING IN COMMERCIAL COLLABORATIONS & CONSORTIUMS

COMMERCIAL COLLABORATIONS & CONSORTIUMS

Prospective Expressions of Interest in Commercially Viable Enterprises in Marine Biotechnology Product Development Consultations for potential commercial collaboration in marine biotechnology development Collaboration, development, planning and implementation of various activities to achieve definitive action in commercially

viable propositions from the marine biotechnology private sector industry Commercial Collaborations, Partnerships and Consortiums in Marine Biotechnology in the South Pacific Entrepreneurial Private Sector Initiatives in Collaborations for Marine Biotechnology Commercial Products Commercial Feasibility Studies and Assessments for Prospective Significant Partners and Investors Consortium Stakeholders Projects including Design, Management and Implementation Business Management and Administration, Audits, Transparency and Accountability Business Intelligence and Industry Trends for Commercial Marine Biotechnology Products Collaborative innovations in marine biotechnology development, genomics, molecular and chemical engineering, bioreactor

design bioprocess engineering and transgenic production, combined with efficient processing and production applications necessary to meet the needs of both discovery and bulk production of novel marine bio products

Working in partnership with a global connections inventing a new generation of tools and processes that will enable a greater understanding of the ocean and its resources and lead to the discovery of new bio products for the future, and designing methods

for their sustainable development.

MARINE BIOTECHNOLOGY SCIENTIFIC RESEARCH AND DEVELOPMENT

MARINE BIOTECHNOLOGY RESEARCH AND DEVELOPMENT & PRIVATE SECTOR INVESTMENTS

We are experts in our field and understand the importance of marine biotechnology research and development (R & D). We have local and international specialists and experts, technologies and resources strategically collaborating in a multi-disciplinary and

holistic approach to marine biotechnology research and development, as an essentially important part of the bio-discovery process. Based on the a multitude of multi-sectoral disciplines associated with scientific marine research, from collection processes, multiple

screening and research and development methodologies.

These new technologies, have completely transformed scientific research and “new-to-science” discovery processes from 10 – 20 years of research in the laboratory, to a few seconds, with marine biotechnology products commercialised and patented within 2/3

years.. The impact of these innovations in the scientific and biotechnology community, has enabled faster, effective, safe and healthy quality marine biotechnology products. The number of patents in marine biotechnology products is increasing, as the ratio of new products or products with novel uses and characteristics. Combined with other biotechnology equipment has become more

commercially viable to prospective investors and collaborators, as the returns are much faster

This includes global spheres of influence in the marine biotechnology network of the world’s experienced, pioneering and leading Academics, Scientists, Researchers and Biotechnology Product developers. With years of relevant experience in the South Pacific Region and internationally, up to date with the latest industry developments including innovations and advances in technologies

used for various applications in Marine Biotechnology Research and Development (R & D), necessary.This, coupled with a genuine understanding of the challenges, needs and objectives of our prospective clients, ensures we deliver insightful and strategic solutions

in a cost effective commercial and efficient way.

MARINE BIOTECHNOLOGY RESEARCH & DEVELOPMENT &COMMERCIAL PRODUCT DEVELOPMENT

We advise prospective commercial partners to develop and formulate a commercial collaborative contract to negotiate with Significant Partners the South Pacific region. We bring together leading academics, scientific research and development industry, the Private sector, Small to Medium Size Enterprises (SMEs), Entrepreneurs, leading Biotechnology Companies and Associates from Marine Biotechnology Organisations to facilitate and implement strategies and management plans for the development of commercial “new-to-science” marine biotechnology products.

We develop, prepare, consult, advise and negotiate recommendations for commercial contractual collaborations.We facilitate consultations and negotiations in conjunction with expert specialised professional scientific, institutional and expert advice to ensure compliance with all regional compulsory requirements, relevant protocols, Licences, Permits, Intellectual Property Rights (IPRs), Patents WTO Trade, Environment and Biotechnology international regulations, including processing, packaging and labelling to international standards. This is essentially a commercial, private sector export-driven business.

We integrate the South Pacific Region’s complex, synergies in National and Regional Legal and Regulatory Frameworks including Regional and Multi-lateral Agreements and Conventions including the United Nations Convention on the Law of the Sea (UNCLOS) and the Convention on Biological Diversity (CBD), the International Seabed Authority (ISA) and Global Ocean Spatial Planning and uses.

We cover an extensive range of components necessary and compulsory Regional Legal and Regulatory Frameworks consistent with Trade Related Intellectual Property Rights (IPRs), Certificate of Origin and WTO regulations for contract formulation to negotiation.

GLOBAL MARINE BIOTECHNOLOGY INDUSTRY AND THE SOUTH PACIFIC REGION

Discovery of “new-to-science” ingredients sourced from biologically rich and diverse endemic marine ecosystems represents one of the most promising and highly visible outcomes of marine biotechnology research. Biochemical produced by marine invertebrates,

algae and bacteria, are very different than those from related terrestrial organisms and offer greater potential as new classes of medicines. Examples of marine-derived medicinal, include an antibiotic from a fungi, two closely related compounds from a sponge

that treat cancer and a neurotoxin from a snail that has painkiller properties making it 10,000 times more potent than morphine without the side effects. There are several more marine-derived or “sourced” compounds currently in clinical testing phases and it is likely that many more will advance to the clinic as more scientists look to the sea for these biotechnological uses, utilising the latest

innovations in marine biotechnology technologies for efficacy, health and safety.In addition to new medicines, other uses for marine-derived compounds include: Cosmetics (algae, crustacean and sea fan compounds), Nutritional Supplements (algae and fish

compounds), artificial bone (corals), and Industrial Applications (fluorescent compounds from jellyfish, novel glues from mussels, and heat resistant Enzymes from deep-sea bacteria).

MARINE BIOTECHNOLOGY SCIENTIFIC RESEARCH AND DEVELOPMENT OF COMMERCIALISATION OF MARINE BIOTECHNOLOGY PRODUCTS

STRATEGIES INTEGRATED INTO COMMERCIAL COLLABORATIONS

We make your bio-discovery and research and development process faster and more efficient. Using innovative analytical instruments, essential laboratory equipment supplies and bio-tools for researchers working in the fields of antibodies, cultures,

biology, electrophoresis, genomics, proteomics and others for new-to-science marine biotechnology discovery research and development (R&D) technologies. These technologies fast track the efficiency at which new to science gene species can be identified and scientifically characterised for their application and uses and sector of marine biotechnology authenticated for scientific efficacy

and applications for commercial development into the “new biotechnology product”.

This will accelerate your application with our complete portfolio of analytical technologies and laboratory products spanning research, discovery and production. With a strong focus on scientific research and development enabling scientists and laboratories advancing “new-to-science” bio-discoveries with novel tools to innovate and support their pioneering efforts. R&Dhelps companies

navigate every step of the product development process to bring new products to market with more predictability and efficiency and technologies to authenticate their efficacy. With integrated strategies to maximise value adding potential, includes bio-additives

applications with other existing products. We minimise risk with up to date, accurate analysis and commercial insights in the development planning and implementation phases. We provide practical strategies from world-class experts and work with the new realities marine bioprospecting and marine biotechnology development through to commercialisation as part of our Private Sector

Commercial Collaboration.

MARINE BIOTECHNOLOGY PRODUCTS “SOURCED” FROM THE SOUTH PACIFIC

Marine biotechnology involves the discovery and application of products and processes derived from marine organisms. Marine biotechnology's promising future reflects the tremendous biodiversity of the world's oceans and seas. The oceans and seas cover more than three-quarters of the earth's surface. Marine organisms account for a major share of the Earth's biological resources.

Most major groups of living organisms are primarily or exclusively marine. Science has identified close to 200,000 species of marine algae, animal bacteria, fungi and viruses, with perhaps as many as four times this number of organisms as yet unidentified. Tropical

marine environments harbour an especially wide diversity of animals and plants.

The scientific potential of marine biotechnology is reflected in the multitude of marine organisms’ and their unique qualities based on need to adapt themselves to the extremes of temperature, pressure and darkness that are found in the world's seas. The

demands of the marine environment have led these organisms to evolve unique structures, metabolic pathways, reproductive systems, and sensory and defence mechanisms.

Marine organisms are sessile and must employ sophisticated methods to compete for a place to anchor. Barnacles and mussels, which depend on their ability to attach to solid surfaces for survival, have developed bio-adhesives that stick to all kinds of wet

surfaces. Research into the ways that marine organisms adhere to wet surfaces, or prevent other organisms from adhering to them, is yielding useful new technologies.

SOUTH PACIFIC REGION MARINE BIOTECHNLOGY PRODUCTS INDUSTRY COMMERCIAL POTENTIAL & EXPORT DRIVEN GLOBAL MARKET INDICATORS

The potential to generate significant wealth and the equitable and sustainable management of these new revenue streams, capitalising on new employment opportunities and other indirect economic benefits is of critical importance. Opportunities for

commercial collaborations, partnerships, consortiums with the South Pacific Region.

The number of patents on marine biotechnology industry products in the following industry is substantial and an economic indicator of the unprecedented commercial potential of the unique marine genetic resources of the South Pacific Region. Patented products

sourced and derived from the South Pacific region includes ingredients and “new-to-science” bioactive ingredients with unique applications includes from the following industries:

Pharmaceutical industries and associated sectorsCosmeceutical industries and associated sectors, beauty products, cosmetics, anti-aging,

Nutraceuticals for nutrition, supplements, vitamins, naturopathy, remedial, pain relief, complementaryAgricultural products and multitude of associated sectorsIndustrial products and multitude of associated sectors

MARINE BIOTECHNOLOGY PRODUCTS IN THE COSMETICS INDUSTRY

MARINE BIOTECHNOLOGY PRODUCTS FOOD PROCESSING, PRODUCTION & PRESERVATION

MARINE BIOTECHNOLOGY PRODUCTS PHARMACEUTICALS VITAMINS AND SUPPLEMENTS

With successful “new-to-science” marine genetic resources, their microorganisms and the capabilities of the latest innovations in multiple screening of sampling, interpretation of characterisation and potential scientific applications and uses, screen with more in

depth and higher probability of success. Utilising biotechnology research and development technologies, for a multitude of scientific purposes in the development of new products, including synthesization, production and manufacturing technologies and

capabilities.

COMMERCIAL COLLABORATIONS AND CONSORTIUMS WITH THE SOUTH PACIFIC REGION

SIGNIFICANT PARTNERS IN MARINE BIOTECHNOLOGY INDUSTRY COMMERCIAL CONTRACTUAL AGREEMENTS

We bring together leading academics, scientists and research and development industry, private sector and biotechnology companies and Small to Medium Size (SMEs), Entrepreneurs, leading Biotechnology Companies and Associates from marine

biotechnology organizations to encourage the development of commercial marine biotechnology.

We develop, prepare, consult positions and advise and negotiate recommendations for commercial contractual collaborations.

Facilitate consultations and negotiations in conjunction with expert specialised legal advice to ensure compliance with all regional compulsory requirements, relevant protocols, licences, permits, intellectual property rights (IPRs), patents WTO regulations

Advise prospective commercial partners in the development and formulate a commercial collaborative contract to negotiate with Significant Partners.

We integrate the South Pacific Region’s complex, synergies in Regional and National Legal and Regulatory Frameworks for compliance.

We cover an extensive range of components necessary for contract formulation to negotiation.

COMMERCIAL COLLABORATIONS WITH SIGNIFICANT PARTNERS IN MARINE BIOTECHNOLOGY

Prospective collaborative partnership initiatives in marine biotechnology commercial research and development activities and projects (and each of its components) have the following details: (variable) an example or guideline:

1. Commercial Feasibility studies and Commercial Strategy Recommendations 2. Project information (Description of proposed commercial activity, aims and objectives, resources, input/output and

legalities)3. Companies using research on genetic resources (Biotech Company)4. Research organizations working with companies (R & D Institutions)5. Parties approving/sponsoring relevant research (Financial Arrangements)6. Access Benefit sharing terms (Incentives and Investment Strategy)7. Patents or other forms of Intellectual Property (IPRs) for Licencing (mutual protection)8. Common and scientific names of the source organism (Certified) 9. Geographical area where the organism was collected (Authenticated)10.Publications (depending on Private or Public Arrangements and Contractual)11.Databases (as per Contractual mutual Agreements for Private or Publicly funded)12.Commercialized products (Commercial Marketing and Sales Arrangements)

With world-class experienced industry experts and specialists, our integrated consulting teams bring you sustainable implementable strategies that integrate a multitude of relevant components in the complex global marine biotechnology industry and consistent with World Intellectual Property Rights (WIPO), Trade Agreements, Regional and Multilateral Environmental Agreements (MEA) s and World Trade Organisation (WTO) standards.

It is essentially consistent relevant National and Regional South Pacific Region Private Sector and Transnational Businesses and International Governments; Regional Organisations include the following compulsory components:

1. Precautionary Principle2. Prior Informed Consent3. Traditional Knowledge (TK)4. Interpretation5. Definitions6. Environmental Impact Assessments (EIA)7. Multi-lateral Environmental Agreements (MEA)8. Regulatory Legal Rules and Frameworks (RLRF)9. Commercial Partnerships in Areas beyond National Jurisdiction10.Biotechnology Health and Safety Standards11.Certificate of Origin (CO)12.Access and Benefit Sharing (ABS)13.Mutually Agreed Terms (MAT)14. Intellectual Property Rights (IPRs)15.Material Transfer Agreement (MTA) and IPRs16.Best Standard Practises (BSP)17. Intellectual Property Rights (IPRs) and 18. Trade Related Intellectual Property Rights (TRIP)s19.Patents, Royalties and Revenue Arrangements20.Licencing and Co-Licencing Collaborative Arrangements21.Trade Related Intellectual Property Rights (TRIP)s and Patents

Including a range of other relevant components depending on the complexity and variability of the Commercial Agreement.

Collaboration in Marine Biotechnology Industry Development Activities are already mapped out and reaffirmed in both the Convention on Biological Diversity (CBD) and the United Nations Convention on the Law Of the Sea, compared to other geographic biologically diverse parts of the world. In a unique situation that allows the mutually complementary established frameworks for

collaboration to be implemented into a series of Actions Plans with mutual economic benefit, and potentially commercially viable enterprise opportunities for all stakeholders.

Legally binding provisions as referred to in the United Nations Convention on the Law of the Sea (UNCLOS) and the United Nations Convention on Biological Diversity (CBD) With specific reference to the following Articles contained in the United Nations Convention

on the Law of the Sea (UNCLOS) consistent with South Pacific Regional Conventions integrated into the final text includes:

Maps of UNCLOS regions and Legal Status Limits of the Territorial Seas and Jurisdiction Ownership and Control Exclusive Economic Zones (EEZs) Regime of the Island Principles Governing the Area Development of Resources of the Area Protection and Preservation of the Marine Environment Global and Regional Cooperation and International Trade and Investment Technical Resources, Technology Transfer, Training and Capacity Building Monitoring and Environmental Assessment Marine Scientific Research within the Consistent with the South Pacific’s Global Ocean Spatial

Planning Conduct of Scientific Research Scientific Research Institutions or Equipment in the Marine Area Development and Transfer of Marine Technology General Provisions of International Cooperation and Collaboration in Marine Biotechnology

Advise and consulting on the feasibility of internationally agreed guidelines on environmental regulations, health and safety in marine biotechnology we integrate:

Risk assessment and risk mitigation and management andthe feasibility of guidelines which facilitates national legislation

Clarification of the relationship between the legal framework of Intellectual Property Rights (IPRs) and relevant Conventions referring to partnerships, collaborations in Marine Biotechnology the United Nations Convention on the Law of the Sea

(UNCLOS) and the Convention on Biological Diversity (CBD) and the International Sea Bed Authority (ISA) and the Pacific Island Countries and Pacific Island Country Territories with their security from France and the USA

Further develop, as necessary, the existing safety procedures to promote scientific development and categorization in the areas of risk assessment and risk management (information requirements; databases; procedures for assessing risks and conditions of release; establishment of safety conditions; monitoring and inspections, taking account of ongoing national,

regional and international initiatives and avoiding duplication wherever possible

Compile, update and develop compatible safety procedures into a framework of internationally agreed principles as a basis for guidelines to be applied on safety in biotechnology, including consideration of the need for and feasibility of an international agreement, and promote information exchange as a basis for further development, drawing on the work already undertaken

by international or other expert bodies

Deep Sea Mining Contractual Agreements in the South Pacific Region

Management Consultancy Advice and Services consistent with the requirements for

Commercial Collaborations for Commercial Contractual Collaborations for Licences and Permits and to obtain Mining of South Pacific Region Minerals and Marine Resources includes:

Consistent with facilitating existing enabling mechanisms that safeguard the interests of the country and its people while at the same time encouraging and facilitating mutually beneficial investment in both the Marine Biotechnology industry and Deep Sea

Minerals (DSM) exploration and mining in the region.

Certificate of OriginPrior Informed ConsentRegional Legal and Regulatory Frameworks (RLRF)Regulatory Frameworks for Commercial Collaborations in areas Beyond Nations Jurisdiction with the EEZs and CSCompliance and Consistency with all National and Regional Conventions and Multilateral Agreements and Conventions

Regional Legal and Regulatory Frameworks and Conventions consistent with the UN Convention on the Law of the SeaWTO Commercial Agreements and compulsory requirementsDevelopment of Strategy Exploration, Research, Development and mining of Specific Mining AreaObligations Prior to submit Mining Application presentation of the following compulsory documentationCommercial Feasibility StudyEnvironmental Impact Assessment (EIA) and Environmental Management planEnvironmental Liabilities and ResponsibilitiesSocial impact Assessment and Economic BenefitsFinancing Management, Revenue Recognition, Royalties, Transparency and AccountabilityProposed Participating Companies “entities” or consortiaExclusivity the rights granted to the Company to conduct Deep Sea Mining operations are exclusive within the Mining Area and include the exclusive right to mine and market Minerals extracted from the Mining Area. The State undertakes not to grant any rights to prospect for or to mine minerals in the Mining Area or market minerals from the Mining Area to any third party during the Term of a Licence and AgreementGrant of Access Rights Terms and Conditions and ObligationsGrant of Mining Development rights and Contractual Mining Agreements with National and Regional Regulatory AuthoritiesExisting Rights and Ownership and Control of Mining Permits under the Law of the SeaDefinitions and interpretation of Mining AgreementDuration of Mining Agreement and Termination ObligationsFinancial Management, Revenue Recognition and Conditions for Payment of Royalties

Royalty and Revenue Recognition on any other mineral or resource material including “new-to-science” marine genetic resources sourced from the AreaDisputes and Mechanisms regarding Royalty Payments

Production Statements with quantative specifications of quantity and type of mineral resources and other material extracted from deep-sea mining area and volume outputCustoms DutiesInsuranceSecurityMining or Private Sector Business Company rightsCompany and Development ObligationsHealth & safetyMining Closure/Post-Closure obligationsClosure Plan and Closure obligationsGuarantees for Closure expensesPost-Closure MonitoringThe Company shall in Consultation with local community leaders, develop and implement a post-closure monitoring committee, with the mandate to supervise the monitoring of geophysical stability, water quality, and rehabilitation of contaminated sites and restoration of land for post-closure use. The post-closure monitoring shall take place for a period after the cessation of Commercial production, the length of which shall be agreed in the Closure plan.Cooperation, Dispute resolution and ArbitrationAccess following Expiration or Termination of Licence, Permit or Contractual Agreement

GLOBAL CORPORATE STRATEGIC ALLIANCES IN THE MARINE BIOTECHNOLOGY INDUSTRY & GLOBAL SALES AND MARKETS

We are the PRIVATE SECTOR with an Integrated Strategic Global Commercial expert connections in all fields of Marine Biotechnology from Academics, Scientific Research and Development Experts, Biotech Companies, Marine Biotech Technologies, Innovative

Financial Arrangements Options and Innovative Marine Biotechnologists and Corporate Strategic Alliances to maximise global sales using our global marine biotechnology products branding and “niche marketing” strategies includes. Our global established networks

and spheres of influence include our networks in:

AUSTRALIA & NEW ZEALAND: Surfers Paradise, Australia

SOUTH PACIFIC REGION: Apia, Samoa, Suva, Fiji, Noumea, New Caledonia, Tahiti (all 21 Pacific Island Countries)

ASIA: Hong Kong, Beijing, China, Singapore, Tokyo, Japan (and Asian regional networks)

EUROPE: London, Ireland, Scotland, Amsterdam, Holland, Paris, France, Geneva, Switzerland, Bonn, Germany

USA & CANADA: Ontario, Canada, New York, San Diego, San Francisco, California, Washington, USA

SOUTH AMERICA: Rio de Janeiro, Sao Paolo, Brazil, Uruguay, Paraguay,

SCANDANAVIA: Copenhagen, Denmark, Stockholm, Sweden, Oslo, Norway, Finland

GLOBAL COMMERCIALISATION FOR DIRECT SALES TO INTERNATIONAL MARKETS

GLOBAL COMMERCIALISATION OF “new-to-science” MARINE BIOTECHNOOGY PRODUCTS

Consultancy and Management Services integrated into our collaborative Agreements include planning, design and direct sales for “new-to-science” Marine Biotechnology products for Global Commercialisation include:

Branding Marketing Advertising Campaigns Product Launches Direct Marketing and Sales to international markets