LIQUID DOSAGE FORMSLIQUID DOSAGE FORMS

PART IIPART II

PREPARATION OF PREPARATION OF MIXTURESMIXTURES

Rule preparation of Rule preparation of mixtures:mixtures:

• At preparation of dosage forms hold to the set At preparation of dosage forms hold to the set procedure of dissolution and mixing of procedure of dissolution and mixing of medications taking into account their physical medications taking into account their physical and chemical properties.and chemical properties.

• Always at first measure a distilled water. In the Always at first measure a distilled water. In the bottle in distilled water dissolve solid bottle in distilled water dissolve solid substances substances in a next sequence – at first in a next sequence – at first narcotic, poisonous, strong affective, then narcotic, poisonous, strong affective, then general list. general list. (at first – heavily soluble, and then (at first – heavily soluble, and then – easily soluble), – easily soluble), If sum of solid substances If sum of solid substances more than 3 % take into account the coefficient more than 3 % take into account the coefficient of increase of volume.of increase of volume.

• PercolationPercolation in a small bottle through in a small bottle through the double layers of gauze, or tamponthe double layers of gauze, or tampon

• Add the concentrated solutions from Add the concentrated solutions from the burette system, at first narcotics, the burette system, at first narcotics, after that general list in order after that general list in order according to the prescriptionaccording to the prescription

• Add not fragrant and non-flying Add not fragrant and non-flying liquids ( syrups, tinctures); then liquids ( syrups, tinctures); then alcoholic liquids, in the order of growth alcoholic liquids, in the order of growth of concentration of alcohol; are of concentration of alcohol; are fragrant and volatile liquids fragrant and volatile liquids

Rp: Analgіnі 3,0Rp: Analgіnі 3,0 Kalіі bromіdі 4,0 Kalіі bromіdі 4,0 Aquae purіfіcatae 200ml Aquae purіfіcatae 200ml Tіncturae Beladonnae 8ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10ml Tіncturae Valerіanae 10ml Mіsсe. Da. Mіsсe. Da.

Sіgna. 1 Sіgna. 1 soup-spoonsoup-spoon 3 3 times a times a dayday

WCP (reverse side):WCP (reverse side):Total volume: Total volume: 200200mlml+10+10mlml+8+8mlml=218=218mlml..

ConcentratedConcentrated solution solution Kalіі bromіdіKalіі bromіdі 20% (1:5)20% (1:5) 4,04,05=205=20mlml..

Analgіnі 3,0Analgіnі 3,0218 218 mlml – 3,0 – 3,0

100 100 mlml – Х – Х Х =Х = 1,7% 1,7% (1,7%(1,7% 3%) 3%)

Aquae purіfіcataeAquae purіfіcatae 200-20200-20 = 180 = 180 mlml

WCP (front side):WCP (front side):Date Date prescription № prescription № Aquae purіfіcatae 180ml Aquae purіfіcatae 180ml Analgіnі 3,0 Analgіnі 3,0 Solutіonіs Kalіі bromіdі (1:5) 20ml Solutіonіs Kalіі bromіdі (1:5) 20ml Tіncturae Beladonnae 8ml Tіncturae Beladonnae 8ml Tіncturae Valerіanae 10mlTіncturae Valerіanae 10ml V total = 218 mlV total = 218 ml

Has prepared: Has prepared: Has checked upHas checked up::

• In porcelain cup measure off 180ml of the In porcelain cup measure off 180ml of the cleared water and dissolve a 3,0 analgin. cleared water and dissolve a 3,0 analgin. Solution percolate through a piece of Solution percolate through a piece of wool wool in a small bottle for dispense. There in a small bottle for dispense. There measure off 20 ml of solution potassium measure off 20 ml of solution potassium bromide (1:5), then tincture of Belladonna, bromide (1:5), then tincture of Belladonna, in the last turn measure off the tincture of in the last turn measure off the tincture of valerian (prepared on a 70% alcohol). Will valerian (prepared on a 70% alcohol). Will glue on the number of recipe, label glue on the number of recipe, label "Mixture",, "before the use to shake" up."Mixture",, "before the use to shake" up.

Rp: Kalіі іodіdіRp: Kalіі іodіdі Natrіі bromіdі aa 5,0Natrіі bromіdі aa 5,0 Glucosі 15,0Glucosі 15,0 Aquae purіfіcatae Aquae purіfіcatae 18180ml0ml Mіsсe. Da. Sіgna. Mіsсe. Da. Sіgna. 1 tablespoon 3 times a 1 tablespoon 3 times a

day. day. AAt first t first determine the percentage of the total determine the percentage of the total

glucose mixture. glucose mixture. 180 ml - 15.0180 ml - 15.0100 ml – X X = 8,3%, more than 3%. 100 ml – X X = 8,3%, more than 3%.

15.015.00,69=10,35(0,69=10,35(ml), is much more tolerance than ml), is much more tolerance than in 3,6 ml. in 3,6 ml.

In this case calculation of amount of water for In this case calculation of amount of water for recipe conduct by such method : the recipe conduct by such method : the concentrated solution- sodiums bromide 20% concentrated solution- sodiums bromide 20% (1:5) and potassium bromide 20% (1:5) it is (1:5) and potassium bromide 20% (1:5) it is necessary to take for 25ml (5,0 necessary to take for 25ml (5,0 5=25); water: 5=25); water: 180ml-(25ml+25ml+10,35ml)=119,6ml180ml-(25ml+25ml+10,35ml)=119,6ml

Technology of preparation following: in porcelain Technology of preparation following: in porcelain cup measure off 120ml of water (better warm) cup measure off 120ml of water (better warm) and dissolve a 15.0 glucose, percolate solution in and dissolve a 15.0 glucose, percolate solution in a small bottle for dispense; there measure off for a small bottle for dispense; there measure off for 25ml 20% solution of potassium iodide and 20% 25ml 20% solution of potassium iodide and 20% concentrated solution-sodiumconcentrated solution-sodium

bromide. Labels are "Mixture", to "Keep in a cool bromide. Labels are "Mixture", to "Keep in a cool place", number of recipe.place", number of recipe.

WPCWPC

DateDate № № prescriptionprescription

Aquae purіfіcatae 120ml Aquae purіfіcatae 120ml

Glucosі 15,0Glucosі 15,0

Solutіonіs Kalіі іodіdі (1:5) 25mlSolutіonіs Kalіі іodіdі (1:5) 25ml

Solutіonіs NatrііSolutіonіs Natrіі bromіdі (1:5) bromіdі (1:5) 25ml25ml

VV total total =180 =180mlml

PreparedPrepared: :

CheckedChecked::

Rp: Kalіі bromіdіRp: Kalіі bromіdі Natrіі bromіdі aa 2,0Natrіі bromіdі aa 2,0 Aquae Menthae ad 200mlAquae Menthae ad 200ml Mіsсe. Da. Sіgna. По 1 столовій ложці 3 рази в день.Mіsсe. Da. Sіgna. По 1 столовій ложці 3 рази в день.

• In the case, when of the recipe as a solvent prescribed flavored In the case, when of the recipe as a solvent prescribed flavored water is allowed to use concentrated solutions of powdery water is allowed to use concentrated solutions of powdery substances and Capacity factor of increased do not use. substances and Capacity factor of increased do not use.

• Technology: measure off 200ml of water mint and dissolve in Technology: measure off 200ml of water mint and dissolve in it 2.0 sodium bromide and potassium bromide, and then it 2.0 sodium bromide and potassium bromide, and then filtered in the bottle for dispensing.filtered in the bottle for dispensing.

• WPCWPC DateDate № № prescriptionprescription Aquae Menthae 200mlAquae Menthae 200ml Kalіі bromіdі 2,0Kalіі bromіdі 2,0 Natrіі bromіdі 2,0Natrіі bromіdі 2,0 VV tot tot. = 200. = 200mlml

PreparedPrepared:: CheckedChecked::