Lipid Metabolism- 1 Fatty Acid Oxidation
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Transcript of Lipid Metabolism- 1 Fatty Acid Oxidation
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
1/21
G`ttx @bho `fo _~h`bxadaxbk~caJkt`ncahrj 0
Jcnhahy`thcf cg rtc~ko g`t `fo c}ho`thcf
cg g`ttx `bhor
G`hr`a Em`thn JO5 \mO
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AG@__X @BHO
G@__X @BHO
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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BM2*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BCCM
G`ttx `bho
_mk |e` cg b`~nc}xa d~c{| hf g`ttx bho ?&=
Rc! `t |mxrhcacdhb`a |M g`ttx `bho k}hrtr `r `fhcf
BM2*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BM>*BCC*
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BM2 -BM>(f BCC*
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c~ jc~k oc{nak ncfor
BM2*BM>*BM>*BM>*BM>*BM:BM*BM>*BM:BM*-BM>(4*BCC*
[fr`t{~`tko G`ttx @bho
0=9>8!0> c~ 0=9-8!0>(
Ahfcakhb @bho
7
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Rcjk g`ttx bhor cg |mxrhcacdhb a hj|c~t`fbk
_~h`bxadaxbk~ca -_@D( c~ G@_ hr tmk
j`ic~ kfk~dx ~krk~wk hf tmk ncox
Ht hr jc~k kgghbhkft tc rtc~k kfk~dx hf
tmk gc~j cg_@D
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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Tmx G@_ fct B`~ncmxo~`tkr3
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8 eb`a |k~ d~`j bcj|`~ko htm
? eb`a |k~ d~`j cgb`~ncmxo~`tkr
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b`f nk rtc~ko htmc{t M>C
b`~ncmxo~`tkr `~k mxo~c|mhahb
0 d~`j b`~ncmo~`tkr9 > d~`jr M>C
Tmx G@_ fct B`~ncmxo~`tkr3 -Bcfthf{ko(
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Tm`t hr tmk j`rr cgb`~ncmxo~`tkr tm`t|~co{bkr 8
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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G@__X @BHO `r G[KAR
_mk j`ic~ g{ka {rko nx thrr{kr n{t Da{bcrk hrtmk j`ic~ bh~b{a`thfd G{ka
G{ka tx|k @jc{ft {rko# @jc{ft hf
0> mc{~r -eb`a( Ga{hor -eb`a(
G@ ;?< 2
Da{bcrk >=< =C 2 G@ % daxbk~ca
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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Mc~jcfkr tm`t `bthw`tk tmk
Mc~jcfk Rkfrhthwk Ah|`rk Da{b`dcf
K|hfk|m~hfk
Fc~k|hfk|m~hfk
@B_M
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G`tk cg Daxbk~ca
Daxbk~ca
Da{bcfkcdkfkrhr
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C}ho`thcf cg G`ttx @bhor
G`ttx @bhor `~k t~`fr|c~tko tc thrr{kr
nc{fo tc `an{jhf
Okd~`oko nx c}ho`thcf `t b`~ncf
gcaacko nx bak`w`dk cg tc b`~ncf {fhtr
C *BM>* *B*
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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C}ho`thcf cg G`ttx @bhor -cwk~whk(BM2 -BM>(f*BM>*BM>* BCC
*
BM2 -BM>(f *BM>*BM>*BC vBc@
C
BM2 -BM>(f *B*BM>*BC vBc@
BM2 -BM>(f *BC vBc@ % BM2*BC vBc@
@bthw`thcf cg G`ttx @bhor
Ichfhfd G&@ htm Bckfyxjk @
^BCvRBc@ -_mhckrtk~ ncfo(
G@ % MRBc@ % @_\ G@vBc@ % @J\ % \\h
\\h % M>C > \h
G@ % MRBc@ % @_\ G@vBc@ % @J\ % > \h@J\ % @_\ @O\ % @O\
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@bthw`thcf cg G`ttx @bhor -bcft&(
@_\ bcfwk~rhcf tc @J\ % > \h hr kp{hw`akft tcmxo~caxrhr cg > @_\ tc >@O\
Kfyxjk9 tmhcehf`rk -@bxa Bc@ Rxftmkt`rk(
Acb`thcf9 * c{tk~ jhtcbmcfo~h a jkjn~`fk
* jhtcbmcfo~h a j t~h} - gc~ rmc~t `fo
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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B@^FH_HFK RM[__AK
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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Kfk~dx Xhkao g~cj G@ C}ho`thcfBM2*-BM>(0?*BC*Bc@
7 G@OM>7 F@OM
7 @bktxa Bc@
BM2*BM>BM>*BC*Bc@
BM2*BC*Bc@ % BM2*BC*Bc@ % G@OM> % F@OM
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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Kfk~dx Xhkao g~cj G@ C}ho`thcf -bcft&(
C}ho`thcf cg B 07 G@__X @BHO
4 G@OM> ::::6 0? @_\
4 F@OM ::::6 >0 @_\
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@bthw thcf cg tmk @bho bcfr{jkr > @_\
Fkt 0>8 @_\ jcak |k~ jcak cg B07 G ttx @bho
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jkt`ncahyko hf tmk ncox
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B`~fhthfk Okghbhkfbhkr
Rkbcfo`~x okghbhkfbhkr9Ahwk~ ohrk`rk! j`af{t~hthcf! ~kp{h~kjkftr
Bcfdkfht`a Okghbhkfbhkr9 Kfyxjk! {|t`ek! t{n{a`~ ~k`nrc~|thcf
@nhahtx tc {rk G@ r g{ka
@bb{j{a`thcf cg G&@ `fo
n~`fbmko @bxa d~c{|r hf bkaar
C}ho`thcf cg {fr`t{~`tko G&@9 Cakhb @bhoBM2 -BM>(4*BM : BM -BM>(4*BCvBc@
2 ~c{forCg c}ho`thcf
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BM2 -BM>(4*BM : BM BM>*BCvBc@0>9bhr 2
hrcjk~`rk
BM2 -BM>(4 BM>*BM:BM*BCvBc@0>9t~`fr >
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C}ho`thcf cg [fr`t{~ tko G&@9 Ahfcakhb @bho
0=98!0>
2 Bxbakr cg c}ho thcf
2 @bktxa Bc@
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BM2*-BM>(?*BM:BM*BM>*BM>*BC*Bc@ - 0(?*BM:BM*BM:BM*BC*Bc@
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b`~ncfrBM2*-BM>(02*BCvBc@
Rh} Bxbakr cg c}ho`thcf
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@BM2*BM>*BvBc@ % 7 @bktxa Bc
\~c|hcfxa Bc@
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C}ho`thcf cg Wk~x Acfd Bm`hf G`ttx @bho hf \k~c}hrcjkr9
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C}ho`thcf cg G`ttx @bhorBM2 BM2a a
BM2-BM* BM>*BM>*BM>(2*BM*BM>*BCC*
BM2 BM2 CMa a a
BM2-BM* BM>*BM>*BM>(2*BM* BM*BCC*
BM2 BM2a aBM2-BM* BM>*BM>*BM>(2* BM*BCC
* % BC>
C}ho`thcf cg G`ttx @bhor -cwk~whk(BM2 -BM>(f*BM>*BM>* BCC
*
BM2 -BM>(f *BM>*BM>*BC vBc@
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BM2 -BM>(f *B*BM>*BC vBc@
BM2 -BM>(f *BC vBc@ % BM2*BC vBc@
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Ektcfk Ncohkr
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Ektcfk Ncohkr
Rxftmkrhr9
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Fkt ^k`bthcf 33
> @bktxa Bc@
@bktc`bkt`tk % > Bc@
Fkt ^k`bthcf
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@ow`ft`dk -\{~|crk( 3
* Gc~ tmk ahwk~
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\`ajhthb @bho
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8/3/2019 Lipid Metabolism- 1 Fatty Acid Oxidation
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[rk cg Ektcfk Ncohkr nx \k~h|mk~`a _hrr{kr9
Rekakt`a J{rbak! B`~oh`b J{rbak `fo
Hf N~`hf O{~hfd \~cacfdko G`rthfd -Rt`~w`thcf(
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G{ka jkt`ncahrj hf rt`~w`thcf
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