Letchumi Thannimalay Senior Researcher SIRIM Berhad
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Transcript of Letchumi Thannimalay Senior Researcher SIRIM Berhad
LETCHUMI THANNIMALAYSENIOR RESEARCHERSIRIM BERHAD
GHS Classification Toolkit
GHS Review Conference for Southeast Asia
22nd May 2013
One World Hotel, Kuala Lumpur
Acute Toxicity
Skin corrosion/irritation
Serious eye damage / eye irritation
Skin / Respiratory sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
Specific target organ toxicity (Single exposure)
Specific target organ toxicity (Repeated exposure)
Aspiration hazard
Lung LungHeart
LiverStomach
Kidney KidneyGall bladder
Spleen
Oesophagus
Trachea
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Health Hazards
Classification of detergent for skin irritation/corrosion
Does the mixture as a whole have
data/information to evaluate skin
corrosion/irritation?Yes
Does the mixture contain one or more corrosive ingredients for which additive applies and where the sum of concentrations of ingredients classified as: Skin Category 1 ≥ 5%?
Yes
Category 1
Danger
No
Classification Not Possible
Does the mixture contain one or more corrosive or irritant ingredients for which additive applies and where the sum of concentrations of ingredients classified as:
Skin Category 1 ≥ 1% but < 5%; or
Skin Category 2 ≥10%; or
(10 x Skin Category 1) + Skin Category 2 ≥10%?
Yes
Category 2
Warning
No
Classification Not Possible
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Classification of detergent for eye damage/ irritation
Mixture:
Does the mixture as a whole or its ingredients have eye damage/irritation data?
Yes
Does the mixture contain one or more corrosive or irritant ingredients for which additive applies and where the sum of concentrations of ingredients classified as:
Eye Category 1 ≥ 3% ; or
Skin Category 1 + Eye Category 1: ≥3%?
Category 1
Danger
Yes
No
Classification Not PossibleDoes the mixture contain one or more corrosive or irritant ingredients for which additivity applies, and where the sum of concentrations of ingredients classified as:
(eye or skin Category 1≥ 1% but < 3% or
(eye Category 2/2A ≥ 10% or
((10 x eye Category 1) + eye Category 2A/2B≥ 10%
(Skin Category 1 + eye Category 1≥ 1% but < 3%, or
(10 x (Skin Category 1 + eye Category 1) + eye Category 2A/B ≥ 10%
Yes
Category 2A
Warning
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☺GHS Toolkit was developed to facilitate the classification and labelling of chemical mixtures for 16 physical hazards, 10 health hazards and three environmental hazards.
☺Contains 700 pure chemicals which were classified according to GHS.
☺Able to classify products/mixtures that contain large number of ingredients/chemicals such as detergent.
GHS Toolkit
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☺GHS Toolkit was developed according to Malaysia building block (DOSH-CLASS regulation).
☺The toolkit can predict the classification for the mixtures if the ingredients are available.
GHS TOOLKIT
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GHS Toolkit
Results of Classification for Laundry Detergent
MANUAL CLASSIFICATIONS AND RESULTS FROM THE TOOLKIT FOR HEALTH HAZARD AND ENVIRONMENTAL HAZARD
ADVANTAGES OF TOOLKIT
☺Classification of mixture will be based on the available test data for the raw materials of the mixture using concentration limits or summation method or additivity formula for the ingredients in the mixture.
☺Manual classifications are time consuming with a higher tendency to make mistakes.
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Using local detergent product that contains about 10 ingredients.
Experimental data were conducted (if available) for health and environmental hazards.
Manual classification were also conducted for the detergent product.
The results from the GHS Toolkit were compared with Experimental data and manual classification data.
Validation of the GHS TOOLKIT
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Validation of the GHS Toolkit Using Randomly Selected Mixtures for Health and
Environmental Hazard
1 0 0 ‐ ( ∑ C u n k n o w n i f > 1 0 % )A T E m i x = ∑
C iA T E i
n
(100-50% ) / ATE mix = (2/5.03) +(48/6.6)ATE mix = 50/((2/5.03) +(48/6.6))= 6.5 mg/l classified as Category 3 for acute toxicity inhalation of vapours.(Category 3 is in between 2 mg/l and 10 mg/l as shown in Table 1 in Appendix 4).
Validation for inhalation toxicity
Validation for mutagenicity
If the mixture has more than 1% of mutagenic Category 2 raw materials then the mixture is classified as Category 2. Although the raw material in the mixture, lead chromate, only consists of 2% mutagen, the whole mixture is considered as mutagen.
Validation for Mutagenicity
Validation for Aquatic Toxicity (chronic toxicity)
Validation of the GHS toolkit for aquatic toxicity was conducted using the mixture that contains 4,4’ Methylenedianiline 2% (category 3), disodium tetraborate anhydrous 74.5% (not classified), chloroaniline 0.5% (category 1) and methylstyrene 23% (category 2).
Summation method was used to classify aquatic toxicity (chronic).Step 1 Chronic 1 x M > 25% (M=1 because LC50= 0.46) (category 1 has 0.5% chemicals) 0.5% x 1 not more than 25% so it is not classified as Category 1Step 2 (M x 10x Chronic 1) + Chronic 2 > 25% (1 x 10 x 0.5) + 23% = 28% > 25% (the mixture is classified as Category 2)